Motor Control Commons^™

Sex Differences In Cancer Cachexia And A Novel Mitochondrial Target For Cancer-Induced Muscle Wasting, Seongkyun Lim

Graduate Theses and Dissertations

Cancer cachexia (CC) is a devastating wasting syndrome characterized by marked weight loss including skeletal muscle atrophy that affects approximately 80% of cancer patients. Current therapeutic treatments including pharmacological and nutritional intervention are insufficient to prevent or reverse it. Prior studies demonstrated lower muscle mass, impaired muscle function, and mitochondrial health in the development of CC. Specifically, mitochondrial fusion protein, Optic atrophy 1 (OPA1) which plays a significant role in skeletal muscle health, is suppressed in the development of CC. Furthermore, most pre-clinical CC studies were mainly focused on males although there are distinct phenotypical differences in skeletal muscle between …

A Time-Course Characterization Of Muscle Function And Mitochondrial Markers During Colorectal Cancer-Induced Cachexia In Tumor-Bearing Male Mice, Ana Cabrera Ayuso

Graduate Theses and Dissertations

Cachexia is a multisystemic and multifactorial syndrome prevalent in cancer patients. It is clinically defined by involuntary loss of >5% weight in a six-month window, despite nutritional interventions. A negative energy balance characterizes cancer cachexia (CC), it is associated with weakness and fatigue in skeletal muscle. Impaired muscle function is associated with lower quality of life in cancer patients. Defects in mitochondrial function are strongly associated with muscle wasting. This study explored muscular contractile function and mitochondrial quality control (MQC) markers in soleus, gastrocnemius, and tibialis anterior (TA) muscles of C26-induced male tumor-bearing mice during a 25-day time course. It …

Classroom Physical Activity Breaks Effect On Executive Function And Academic Achievement In Elementary School Students, Mark A. Bjornsen

Graduate Theses and Dissertations

Objectives: There were three aims in conducting this pilot study. First, determine the Plus Minus Task assessment's reliability to measure the executive function of shifting. Second, determine the feasibility and acceptability of CPAB by students and teachers. Finally, determine the preliminary dose-response of acute physical activity on shifting in elementary students. Methods: This was a pilot study of a classroom physical activity break intervention. Utilizing a withinsubject, cross-over design, students participated in a practice day and then all three treatment conditions: a 10-minute seated lesson (control condition) and 5 and 10 minutes (experimental conditions) of classroom physical activity breaks. A …

The Role Of Protein Degradation In Cancer Cachexia In Female Tumor Bearing Mice, Noah Thomas

Graduate Theses and Dissertations

Background: Cancer is a leading cause of death in the world in which half of the people affected by this disease die from its effects. Cancer-cachexia is a syndrome associated with the significant loss of skeletal muscle mass and function, which cannot be fully reversed by nutritional intervention alone and in turn, impairs the host. Cancer-cachexia affects 50-80% of cancer patients and is a primary cause of death accounting for 20-40% of cancer related deaths. Efforts to reverse the effects of cancer-related cachexia have been largely unsuccessful and have primarily focused on the late stages of CC. Methods: Lewis Lung …

Validity And Reliability Of A 5-Minute Web-Camera Based Eye Tracking Test To Assess Visual Memory And Cognition, Emily Bates

Graduate Theses and Dissertations

There are approximately 5.7 million Americans currently living with Alzheimer’s Disease (AD). Early detection of cognitive impairment allows for earlier treatment, potentially slowing or halting cognitive decline. A 30-min web-camera eye tracking assessment (30-min VPC) has been validated as a tool to predict AD risk. However, a shorter version would allow for greater scalability and improve user experience. The purpose of this study was to: 1) determine the validity of the 5-minute web-camera based VPC test with the 30-min test, 2) determine the test-retest reliability of the 5-min test, 3) compare the 5-minute test scores of cognitively intact adults (18-39 …

The Effectiveness Of Using Video Modeling Techniques To Improve Motor Skills For Preschool Children With Autism Spectrum Disorders, Atya Abdullah Hadadi

Graduate Theses and Dissertations

Beside the main syndromes of socialization and communication for individuals with autism spectrum disorders, they also have impairments in motor skills, such as ball skills (catching and throwing) and postural stability (standing and walking balance). The main objective of this dissertation is to improve motor skills for preschooler children with ASD through use of video-modeling techniques. A secondary objective of this research was to find a correlation between the development and improvement of ball skills and balance tasks. Twenty-six children with ASD were divided into two groups. Twenty-six children with ASD from 3-5 years old participated in two groups: one …

Examining The Relationship Between State Anxiety And Vestibular And Ocular Motor Impairments And Symptoms In High School Athletes With Concussion, Mallory Kathleen Mcelroy

Graduate Theses and Dissertations

Anxiety has been associated with vestibular and ocular motor impairment in the general population. However, there is limited research regarding the connection between the vestibular and ocular motor systems and anxiety following sport-related concussion (SRC). OBJECTIVE: The purpose of this study is to compare state anxiety between concussed adolescent male and female athletes with and without vestibular and ocular motor impairments and symptoms. DESIGN: Prospective, repeated measures SUBJECTS: Thirty adolescent athletes between the ages of 15-18 years, diagnosed with a SRC completed the STAI-State at initial and medical clearance clinical visit. These adolescent athletes were categorized into vestibular and ocular …

Comparing Reaction Time And Postural Stabilization Based On Activity Groups In Older Adults, Lauren Marie Merk

Graduate Theses and Dissertations

The purpose of this study was to compare reaction time and postural stabilization between activity groups in older adults. These variables are important because older adults are at a high fall risk and two major contributors to fall risk are postural stabilization and reaction time. This study examined if the activity group of an older adult had any influence on reaction time and postural stabilization. Fifty-nine older adults aged 66.46 ± 9.47 years old were used in the study. Thirteen subjects were in the master’s athletes which are individuals over the age of 40 who competed in a nationally sanctioned …

The Effects Of Hypohydration On Neurocognitive, Balance, Vestibular Ocular Motor Functions And Mood State, Satoshi Iida

Graduate Theses and Dissertations

Inconsistent findings have been observed on the impact of hydration state on cognitive functions. The isolated effect of hypohydration on neurocognitive performance, balance, vestibular ocular motor function and mood outcomes in widely used concussion assessment tools has not been studied. The purpose of this study was to investigate how hypohydration affected the results in concussion testing batteries. A single-blind randomized crossover design was used. Thirteen healthy males (22 ± 4y, 180.9 ± 5.7cm) without history of concussion within the past six months or any condition or disease that could influence outcome measurements participated in this study. Each subject completed concussion …

The Relationship Among Ankle Function, Functional Capacity, And Body Composition To Balance In Geriatric Populations, Joseph Robert Chaney

Graduate Theses and Dissertations

The primary purpose of this research study was to identify significant relationships among measures of ankle strength, ankle range of motion, body composition, and functional capacity to balance ability in geriatric populations which may potentially assist in identifying older individuals with increased risk of falling. A battery of five test (ankle strength assessments, ankle range of motion , DXA, functional fitness, and balance) were administered to 20 participants (6 males, 14 females, mean age 69.78 ± 3.98) that had indicated to be at least 65 years of age or older and no history of falls within the previous 12 months. …

Effect Of Handedness On Gross Motor Skill Acquisition Among College Undergraduates, Anthony Paul Parish

Graduate Theses and Dissertations

There is little applicable research investigating educational adaptation for handedness and even less research dealing with physical skill development. Given that PE teachers and students frequently rely on demonstrations to enhance learning, this study sought to determine if the congruence between teacher and student handedness is important? It was hypothesized that performance and form scores of left-handers that see a right-handed demonstration would be significantly higher than those of right-handers that see a left-handed demonstration.

A lacrosse shot was demonstrated to a group of 69 college-aged participants that were equally split in numbers between male and female and left and …