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Articles 61 - 69 of 69

Full-Text Articles in Exercise Science

Imaging Of Transplanted Pancreatic Islets In Vivo, P. Joo Ho Tai, C. Foster, C. Hasil, C.W.J. Melling, D. White Dec 2007

Imaging Of Transplanted Pancreatic Islets In Vivo, P. Joo Ho Tai, C. Foster, C. Hasil, C.W.J. Melling, D. White

Jamie Melling

No abstract provided.

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An Assessment Of High School Coaches Knowledge Of Sport-Related Concussion, Erin M. O'Donoghue Apr 2007

An Assessment Of High School Coaches Knowledge Of Sport-Related Concussion, Erin M. O'Donoghue

Human Movement Sciences & Special Education Theses & Dissertations

Sport-related concussion is a common occurrence in high-risk sports and can occur during participation in all sports. The purpose of this study was to assess the knowledge base high school athletic coaches possess about concussion signs and symptoms in regards to recognition, management, and prevention of this condition. A 25 question demographic questionnaire was used to gather background information and a 24 question multiple-choice assessment was used to determine knowledge of recognition, management, and prevention of sport-related concussion. A panel of eight experts in the fields of sport-related concussion and/or survey research reviewed and modified the survey instrument, which were …

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Exercise-Mediated Regulation Of Hsp70 Gene Expression Following Exercise Training, C.W. Melling, David Thorp, Kevin Milne, Matthew Krause, Earl Noble Dec 2006

Exercise-Mediated Regulation Of Hsp70 Gene Expression Following Exercise Training, C.W. Melling, David Thorp, Kevin Milne, Matthew Krause, Earl Noble

Jamie Melling

An issue central to understanding the biological benefits associated with regular exercise training is to elucidate the intracellular mechanisms governing exercise-conferred cardioprotection. Heat shock proteins (HSPs), most notably the inducible 70-kDa HSP family member Hsp70, are believed to participate in the protection of the myocardium during cardiovascular stress. Following acute exercise, activation of PKA mediates the suppression of an intermediary protein kinase, ERK1/2, which phosphorylates and suppresses the activation of the heat shock transcription factor 1 (HSF1). However, following exercise training, ERK1/2 has been reported to regulate the transcriptional activation of several genes involved in cell growth and proliferation and …

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Pka-Mediated Erk1/2 Inactivation And Hsp70 Gene Expression Following Exercise, C.W. Melling, Matthew Krause, Earl Noble Dec 2005

Pka-Mediated Erk1/2 Inactivation And Hsp70 Gene Expression Following Exercise, C.W. Melling, Matthew Krause, Earl Noble

Jamie Melling

Exercise induces the expression of the cardioprotective protein, Hsp70, through the activation of its transcription factor HSF1. Recently, we reported that administration of a protein kinase A (PKA) inhibitor suppressed exercise-induced hsp70 gene expression, suggesting a role for PKA in the regulation of HSF1 activation in vivo. While the mechanism by which PKA regulates HSF1 is unclear, studies in vitro have reported that HSF1 is phosphorylated on two serine residues by mitogen activated protein kinases (MAPKs); ERK1/2 (ser307) and JNK/SAPK (ser363). As PKA is a regulator of these protein kinases, the current study examined the role of PKA in their …

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Imaging Islets Labeled Wth Magnetic Nanoparticules At 1.5 Tesla, J.H. Tai, Paula Foster, Alma Rosales, Biao Feng, Craig Ha, Violetta Martinez, Soha Ramadan, Jonatan Snir, C.W. Melling, Savita Dhanvantari, Brian Rutt, David White Dec 2005

Imaging Islets Labeled Wth Magnetic Nanoparticules At 1.5 Tesla, J.H. Tai, Paula Foster, Alma Rosales, Biao Feng, Craig Ha, Violetta Martinez, Soha Ramadan, Jonatan Snir, C.W. Melling, Savita Dhanvantari, Brian Rutt, David White

Jamie Melling

We have developed a magnetic resonance imaging (MRI) technique for imaging Feridex (superparamagnetic iron oxide [SPIO])-labeled islets of Langerhans using a standard clinical 1.5-Tesla (T) scanner and employing steady-state acquisition imaging sequence (3DFIESTA). Both porcine and rat islets were labeled with SPIO by a transfection technique using a combination of poly-l-lysine and electroporation. Electron microscopy demonstrated presence of SPIO particles within the individual islet cells, including beta-cells and particles trapped between cell membranes. Our labeling method produced a transfection rate of 860 pg to 3.4 ng iron per islet, dependent on the size of the islet. The labeling procedure did …

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Castration Inhibits The Exercise-Induced Accumulation Of Hsp70 In Male Rodent Cardiac Muscle Tissue, Kevin Milne, David Thorp, C.W. Melling, Earl Noble Dec 2004

Castration Inhibits The Exercise-Induced Accumulation Of Hsp70 In Male Rodent Cardiac Muscle Tissue, Kevin Milne, David Thorp, C.W. Melling, Earl Noble

Jamie Melling

Intense exercise leads to accumulation of the inducible member of the 70-kDa family of heat shock proteins, Hsp70, in male, but not female, hearts. Estrogen is at least partially responsible for this difference. Because androgen receptors are expressed in the heart and castration leads to decreases in calcium regulatory proteins and altered cardiac function, testosterone (T) or its metabolites could also be involved. We hypothesized that removal of endogenous T production through castration would reduce cardiac Hsp70 accumulation after an acute exercise bout, whereas castrated animals supplemented with 5α-dihydrotestosterone (DHT) would show the intact male response. Fifty-four 8-wk-old male Sprague-Dawley …

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An Assessment Of High School Coaches Knowledge Of Exercise-Induced Asthma, Shannon L. Wilson Apr 2004

An Assessment Of High School Coaches Knowledge Of Exercise-Induced Asthma, Shannon L. Wilson

Human Movement Sciences & Special Education Theses & Dissertations

Exercise-induced asthma (EIA) is a common disorder that occurs in individuals who compete in recreational activities. The purpose of this study was to determine the knowledge of EIA for high school athletic coaches. A 22 question demographic instrument was used for background information, and an 18 question multiple-choice assessment was used to assess knowledge of prevention, recognition and management of EIA. A panel of experts reviewed and modified the survey instruments, which were piloted at a local private high school prior to distribution. The survey was distributed to 250 high school coaches in the Hampton Roads area during a fall …

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Regulation Of Myocardial Hsp70 Gene Expression Following Exercise, C.W. Melling, David Thorp, Earl Noble Dec 2003

Regulation Of Myocardial Hsp70 Gene Expression Following Exercise, C.W. Melling, David Thorp, Earl Noble

Jamie Melling

No abstract provided.

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The Short-Term Effects Of Grade 1 And 2 Joint Mobilizations On Subject Pain Range Of Motion And Muscle Activity In The Pathological Lumbar Spine, Sean Hanrahan Apr 2003

The Short-Term Effects Of Grade 1 And 2 Joint Mobilizations On Subject Pain Range Of Motion And Muscle Activity In The Pathological Lumbar Spine, Sean Hanrahan

Human Movement Sciences & Special Education Theses & Dissertations

The purpose of this study was to examine the short-term effects of Grades 1 and 2 posteroanterior joint mobilizations (JM) at the pathological lumbar spine on subject pain, range of motion (ROM), and muscle force. All subjects were determined to have sustained mechanical dysfunction of the lumbar spine of less than 48 hours as assessed through a standardized evaluation. Subjects were randomly assigned to a group; the control group received ice and stretching while the experimental group received JM in addition to ice and stretching. The JM's were performed at 3 consecutive lumbar segments surrounding the area of greatest discomfort. …

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