Biomechanics Commons^™

Examining The Use Of Two-Dimensional Video Capture And A Pressure Sensing Walkway For Collection Of Obstacle Crossing Measures, Ashlyn M. Jendro

Graduate Theses and Dissertations

Obstacle crossing research is crucial for providing insights into how and why people trip and fall. However, a growing body of literature has proposed that laboratory-based studies may not directly translate into real-world settings due to the complex nature beyond the sterile lab. Unfortunately, the absence of real-world obstacle crossing literature is likely due to a lack of available validated methods for collection of data outside the laboratory. This dissertation explored two potential methodologies (i.e., 2D motion capture and a pressure sensing walkway) that are more portable and cost-effective for collecting real-world obstacle crossing measures. It is hypothesized that 2D …

Quantifying Physical Function: Moving Towards A New Definition And Better Assessment, Anthony Campitelli

Graduate Theses and Dissertations

Though poor physical function (PF) and disability are two of the most impactful problems facing older adults today, the field of kinesiology has not yet devised a method of measuring PF, thus limiting investigations with the potential to lead to improved PF interventions and assessments. This dissertation aimed to develop a single, continuous measure of PF using a latent variable modeling approach, and then use the generated scores to evaluate the role of lower body muscular power in PF assessment and to construct an improved PF assessment battery for predicting overall PF. Each aim of this dissertation was addressed through …

The Effect Of Gentle Yoga On Average Daily Step Count, Francesca D'Agrosa

Graduate Theses and Dissertations

While walking is a widely accessible form of exercise that is highly effective at increasing overall wellness (Kadir et al., 2019; Zhao et al., 2015) and is a recommended form of physical activity for overweight and obese individuals, studies still indicate low step counts and levels of physical activity in people with obesity (Shultz et al., 2011). Sedentary overweight individuals may avoid walking for several reasons, including physiological and/or biomechanical factors that make walking more difficult. This study attempted to explore and address these avoidant behaviors by employing a single-case ABAB reversal design to implement bi-weekly gentle yoga sessions over …

Sex Differences In Cancer Cachexia And A Novel Mitochondrial Target For Cancer-Induced Muscle Wasting, Seongkyun Lim

Graduate Theses and Dissertations

Cancer cachexia (CC) is a devastating wasting syndrome characterized by marked weight loss including skeletal muscle atrophy that affects approximately 80% of cancer patients. Current therapeutic treatments including pharmacological and nutritional intervention are insufficient to prevent or reverse it. Prior studies demonstrated lower muscle mass, impaired muscle function, and mitochondrial health in the development of CC. Specifically, mitochondrial fusion protein, Optic atrophy 1 (OPA1) which plays a significant role in skeletal muscle health, is suppressed in the development of CC. Furthermore, most pre-clinical CC studies were mainly focused on males although there are distinct phenotypical differences in skeletal muscle between …

Predictors Of Peak Elbow Valgus Torque In Collegiate Baseball Pitchers, Adam Richard Nebel

Graduate Theses and Dissertations

Context: The incidence of UCL tears in baseball is at an all-time high. ATs are in the position to identify those at risk and potentially prevent injury to the UCL. In baseball, research has associated elbow valgus torque as a potential predictor of injury risk. However, markerless analysis has not assessed possible predictors of injury to the UCL in baseball players. Objective: Identify the kinematic factors that influence peak elbow valgus torque through the sequence of a fastball pitch. Design: Cross-sectional study. Setting: Field study performed in university’s pitching development center. Participants: Division 1 collegiate baseball pitchers (N=21; 17RHP, 4LHP; …

Role Of Sex Differences On Cancer Cachexia Progression And Fibrosis During Cancer Cachexia Development, Wesley Haynie

Graduate Theses and Dissertations

Cancer cachexia is a multifactorial wasting syndrome characterized by losses in bodymass >5% and occurs in approximately 80% of all cancer patients. Chronic inflammation and fibrosis play roles in cancer cachexia and a greater understanding of these contributing pathways to this pathology will pave the way for potential therapeutic avenues. While inflammation and fibrosis have been researched in various models of cancer cachexia, little to no studies have been performed in both sexes as most previous studies focus on males. PURPOSE The purpose of these studies is to investigate the role of fibrosis on cancer cachexia development as well as …

A Radiographic Investigation Of Anthropometrics, Neck Posture, And Neck Strength In Individuals With Enlarged External Occipital Protuberances, Caleb Burruss

Graduate Theses and Dissertations

Overview: Enlarged external occipital protuberances (EEOPs) are found in 41% of young adults. These EEOPs have the potential to lead to pain throughout life and possibly surgery. Little is known of the pathophysiology or characteristics that could lead to these EEOPs. Purpose: The purpose of this study is to use radiographic measurements to investigate how anthropometrics, neck posture and neck strength in flexion and extension differ between those with and without an EEOP. Methods: 80 radiographs from three different studies were digitized and the marking of landmarks performed in ImageJ. The cut-off for an EEOP was established as any EOP …

Sex-Based Differences In Acvr2b And Grb10 Expression In Skeletal Muscle During Induced Cancer Cachexia And Disuse, Lauren Martinez

Graduate Theses and Dissertations

Background: Muscle atrophy is the shrinkage of muscle fibers that are largely maintained by a balance of protein synthesis and degradation. Imbalances in protein synthesis and degradation are observed in different muscle atrophy disorders such as cancer cachexia and disuse. These forms of muscle atrophy produce distinct wasting pathologies that are influenced by biological sex. Activin receptor type-2B (ACVR2B) and Growth factor receptor-bound protein 10 (GRB10) have been identified as genes that potentially regulate muscle mass while also displaying sexually dimorphic differences. Purpose: To examine the influence of ACVR2B and GRB10 throughout the development of cancer cachexia and disuse-induced atrophy …

Mitochondrial Contributions To Disuse Atrophy: Let’S Talk About Sex, Megan Rosa-Caldwell

Graduate Theses and Dissertations

Skeletal muscle atrophy is a hallmark of many pathologies and is associated with disease prognosis, quality of life, and mortality. Specifically, lack of contractile activity of the muscle can result in disuse-associated atrophy. Disuse-induced atrophy is a common phenomenon in intensive care unit (ICU) patients and significantly impacts patient prognosis and ability to transition of out of intensive care. However, effective therapeutics to mitigate disuse-associated atrophy do not exist, clearly demonstrating the scientific and clinical need to further understand mechanisms contributing to disuse atrophy. In particular, a significant portion of the scientific literature has utilized male models, yet there is …

The Role Of Protein Degradation In Cancer Cachexia In Female Tumor Bearing Mice, Noah Thomas

Graduate Theses and Dissertations

Background: Cancer is a leading cause of death in the world in which half of the people affected by this disease die from its effects. Cancer-cachexia is a syndrome associated with the significant loss of skeletal muscle mass and function, which cannot be fully reversed by nutritional intervention alone and in turn, impairs the host. Cancer-cachexia affects 50-80% of cancer patients and is a primary cause of death accounting for 20-40% of cancer related deaths. Efforts to reverse the effects of cancer-related cachexia have been largely unsuccessful and have primarily focused on the late stages of CC. Methods: Lewis Lung …

Preliminary Study: Leucine Supplementation Exacerbates Muscle Wasting Independent Of The Ubiquitin-Proteasome System, Katarina Bejarano

Graduate Theses and Dissertations

Cancer cachexia is the rapid, drastic loss of muscle mass associated with cancer and is not reversible by conventional nutritional means (Brown et al., 2018; Brown et al., 2017). It occurs in ~80% of cancer patients and is responsible for 20-40% of cancer-related deaths (Brown et al., 2018; Brown et al., 2017). This condition leaves patients with fatigue, functional impairment, reduced quality of life, and a decrease in survival rates. Cachexia occurs through an imbalance between protein degradation and protein synthesis (Brown et al., 2018), which is associated with inflammation and altered metabolic processes.

Several studies have investigated the effects …

Assessing The Repeatability Of Clinical Tests In People With And Without Flexion-Induced Neck Pain, Ashton Human

Graduate Theses and Dissertations

The accessibility of mobile technology has improved productivity but can contribute to musculoskeletal disorders due to the posture associated with using such devices. Neck flexion, a posture assumed by smartphone users, has been shown as a risk factor for the development of clinical neck pain if sustained for prolonged periods. Determining the individuals who are naturally more predisposed to develop flexion-induced neck pain can aid in the prevention and treatment of musculoskeletal disorders. The purpose of this thesis is to assess the repeatability of clinical tests between trials over the course of two days in young adults who do and …

Serum Myostatin And Igf-1 As Biomarkers Of Sarcopenia: A Proof-Of-Concept Design, Ashley Binns

Graduate Theses and Dissertations

The population comprising older adults is growing exponentially, as are healthcare related costs. Nearly $20 billion is annually expensed by older adults for health-related issues affiliated with age-related decline in skeletal muscle mass. Yet, diagnostic criteria are not readily utilized in clinical practice. PURPOSE: Therefore, the purpose of this study was to provide evidence for use of blood biomarkers (myostatin, IGF-1) to predict appendicular skeletal muscle mass (ASM) among middle-aged and older adults. METHODS: A cross-sectional study was conducted among 106 individuals (n = 68 females; n = 38 males) aged ≥ 40 years of age (60.1 ± 11.1 y) …

Comparative Plasma Proteomics In Muscle Atrophy Induced By Cancer Cachexia And Hindlimb Unloading, Kirsten Rene Dunlap

Graduate Theses and Dissertations

Introduction: Muscle atrophy results from a dysfunction in protein turnover that leads to loss of mass and function and occurs concurrently with multiple pathologies such as cancer and extended bed rest. Atrophy reduces overall quality of life while increasing morbidity and mortality. Currently, efficacious therapeutic interventions to treat and prevent muscle wasting in all its forms are lacking, however if conserved mechanisms can be identified between wasting conditions, this would aid in the development of multipurpose therapeutics to ameliorate this pathology. Purpose: To examine circulating factors present across atrophic pathologies. Methods: 35 male C57BL/6J mice were assigned to hindlimb unloading …

Validation Of A 5-Minute Vpc Test To Assess And Compare Cognitively Intact Individuals And Individuals With Cognitive Impairments, Spencer Smith

Graduate Theses and Dissertations

The prevalence of cognitive impairments in the older adult population is growing. Finding treatment solutions to impede a cognitive decline can possibly lead to fewer cases of mild cognitive impairment, dementia, and Alzheimer’s disease. A Visual Paired Comparison (VPC) could serve as a tool to predict, monitor, and regulate people who are susceptible to a cognitive decline. The purpose of this study was to 1) to determine the validity of the Neurotrack 5-minute VPC test with the Neurotrack 30-minute VPC test, 2) to determine the test-retest reliability of the Neurotrack 5-minute VPC test, 3) to compare Neurotrack 5-minute VPC scores …

Validity And Reliability Of A 5-Minute Web-Camera Based Eye Tracking Test To Assess Visual Memory And Cognition, Emily Bates

Graduate Theses and Dissertations

There are approximately 5.7 million Americans currently living with Alzheimer’s Disease (AD). Early detection of cognitive impairment allows for earlier treatment, potentially slowing or halting cognitive decline. A 30-min web-camera eye tracking assessment (30-min VPC) has been validated as a tool to predict AD risk. However, a shorter version would allow for greater scalability and improve user experience. The purpose of this study was to: 1) determine the validity of the 5-minute web-camera based VPC test with the 30-min test, 2) determine the test-retest reliability of the 5-min test, 3) compare the 5-minute test scores of cognitively intact adults (18-39 …

The Impact Of Upc Placement On The Biomechanical Injury Risk Factors Associated With Cashier Work, Marcus Payne

Graduate Theses and Dissertations

The purpose of this study was to investigate the impact of UPC placement on upper-body kinematics and muscle activity associated with cashier work. Seventeen female participants who had worked at least 1000 hours as a cashier and did not meet any exclusion criteria were recruited. Multi-sided UPC items, which included extra and/or larger barcodes, were compared to items with a traditional UPC placement. Two mock carts of eighteen items were scanned for each UPC type. Electromyography was applied bilaterally to the biceps brachii, middle deltoid, flexor digitorum superficialis, and upper trapezius muscles. Cumulative and peak muscle activity were calculated for …

Effect Of Passive Heating On Males And Females With Elevated Arterial Stiffness, Forrest Blake Robinson

Graduate Theses and Dissertations

Context: Cardiovascular disease (CVD) is one of the leading causes of mortality in the United States, accounting for about 1 in every 4 deaths annually. Studies have shown that passive heating does have some degree of effect on arterial stiffness, but not much is known about populations with higher stiffness. Objective: To examine the independent effect of core temperature increase during passive heating on arterial stiffness. Methods: Participants visited the lab three times; one familiarization and two experimental trials. The experimental trials consisted of subjects being passively heated in an environment of 40°C / 40% relative humidity (HEAT) or normal …

Impacts Of Micrornas On Skeletal Muscle Protein Synthesis And Mitochondrial Quality, David Lee

Graduate Theses and Dissertations

microRNA (miRNA) post-transcriptional modification is becoming a well-established mechanism for controlling mRNA translation. microRNAs -1, -133, and -206 are under the control of skeletal muscle promoters and affect muscle plasticity and metabolic health. A detailed review on the generation and processing of miRNAs with a view to skeletal muscle brings up intriguing connections in the transcriptional connections between multiple miRNAs. Additionally, exciting new research has defined a role of miRNAs in skeletal muscle mitochondria showing an additional, direct link to metabolic function. Multiple investigations in models of exercise, aging, hypertrophy, and injury have shown how these interventions can affect miRNA …

Effects Of An In-Season Resistance Training Program On Lower Extremity Power Output In Collegiate Basketball Players, Kevin Lee King

Graduate Theses and Dissertations

The purpose of this study was to evaluate changes in muscle power performance in a horizontal (forward movement), vertical, and lateral directions in collegiate basketball players due to the presence of an in-season resistance training program (ISRTP). Four basketball teams were recruited for this study. Two women's basketball teams and two men's basketball teams participated with one team in each gender participating in an ISRTP and one team not participating in an ISRTP. Fifty-three collegiate basketball players (Females= 29, Males= 24) were successfully recruited for this project. Subjects were assessed for lower extremity muscle power and muscle strength at pre-season, …

The Effects Of Apoe Knock Out On Skeletal Muscle Regeneration: A Look Into Markers Of Protein Synthesis And Satellite Cell Function, Joshua Eden Ragland

Graduate Theses and Dissertations

ApoE helps regulate serum cholesterol levels by adding in transport of cholesterol into the cells, as well as, to the liver. ApoE knockout mice (ApoE KO) present a model that demonstrates the effects of hypercholesterolemia. Damage to muscle stimulates a complex regenerative response. The effects of high cholesterol on this regenerative response are not known. PURPOSE: To determine if skeletal muscle regeneration is altered in apoE KO mice by measuring protein synthesis regulator IGF-1, Akt, mTOR, and p70S6K, cell cycle regulator cyclin D1, and myogenic regulatory factors myoD and myogenin. METHODS: Female C57/BL6 (WT) and apoE KO were assigned to …

The Use Of Cortisol And Hba1c As Biomarkers Of Stress In University Administrators, Jacilyn Marie Olson

Graduate Theses and Dissertations

PURPOSE: The purpose of this study was to explore the impact of perceived stress and cardiorespiratory fitness on cortisol and HbA1c, biomarkers of stress, in a group of select university administrators. The impact of gender on these relationships was of special concern. METHODS: University administrators with job titles of Chancellor, Provost, Vice Chancellors and Vice Provosts of the university, and Deans and Associate Deans at the college level were recruited. Twenty-five administrators (15 males and 10 females) agreed to participate and completed a battery of assessments that included completion of the University Administrative Concerns Questionnaire, a finger-stick blood test for …

Effects Of Head Position And Head-Supported Mass On Nerve Function Of The Flexor Carpi Radialis Muscle In Healthy Individuals, Bethany Lauren Shivers

Graduate Theses and Dissertations

Long-term exposure to head-supported mass (HSM) has been linked with spinal degeneration including foraminal stenosis and disc deterioration. Anecdotally, HSM has also been linked to neck and arm pain and muscle atrophy, but nerve function has not been tested specifically. The combined effect of various head positions and HSM may be sufficient to compress the nerve root in aviators and Soldiers during job performance, potentially leading to short- and long-term neuromuscular effects. The Hoffmann (H) reflex, a well-established measure of nerve function, has shown to be sensitive to changes in nerve root space which occurs with different head positions. This …

Athletic Training Students' Ability To Identify Scapular Dyskinesis, Priscilla M. Dwelly

Graduate Theses and Dissertations

Scapular dyskinesis refers to abnormal movement patterns of the scapula, which have been associated with injury. Previous investigations have validated the scapular dyskinesis test as a visual assessment method using physicians, physical therapists, and certified athletic trainers. Through educational programs, athletic training students should be taught what scapular dyskinesis is and how to identify it. Therefore, the purpose of this investigation was to (a) evaluate entry-level graduate athletic training students' ability to identify scapular dyskinesis, (b) assess their reliability, and (c) determine if they were able to correctly identify the muscles involved in rehabilitating an individual with scapular dyskinesis. Follow-up …

The Effects Of A Lumbopelvic Hip Complex Conditioning Program On Dynamic Knee Valgus In Female Tennis Players, Katelyn Marie Roling

Graduate Theses and Dissertations

Female athletes have a four-to-six times greater risk of sustaining a lower extremity injury than their male counterparts (Hewett, 2000). One explanation for the discrepancy in injury rates is increased dynamic knee valgus angles caused by neuromuscular imbalances of the lumbopelvic hip complex (LPHC). The purpose of this study was to determine if implementing a LPHC conditioning program improved neuromuscular deficiencies. Seven female collegiate tennis players competitive at the NCAA Division I level volunteered for the study (19.7 + .95 years, 167.3 + 7.4 cm, and 60.72 kg + 6.71 kg). The subjects participated in a 16 week LPHC conditioning …

Kinematic And Electromyographic Description Of Baseball And Softball Catching, Hillary Ann Plummer

Graduate Theses and Dissertations

The catcher is actively involved, defensively, in every pitch that is thrown during the duration of a baseball or softball game. Because catchers play such an active role, the outcome of the game can be decided on their ability to keep base runners from stealing and advancing into scoring position. The ability to throw out a stealing runner is a necessary skill that catchers must possess in order to be successful at their position. To keep a base runner from stealing catchers have the option of throwing down to second base from either their stance or their knees. Despite the …