Kinesiology Commons^™

Intramuscular Nad⁺ Therapy And Neuroenergetic Symptom Modulation: An Exploratory Retrospective Human Pilot Study, Zachary J. Dickey Do, Kirtan Patel Bs, Randy Aldret Edd, Cscs, Atc, Navneet Sharma Md, Glenn Goodwin Do

Journal for Sports Neuroscience

Abstract

Background: Nicotinamide adenine dinucleotide (NAD⁺) is a central regulator of neuronal energy metabolism, mitochondrial function, and axonal integrity. Following mild traumatic brain injury (mTBI) and repetitive subconcussive exposure, neurons undergo a neurometabolic crisis characterized by impaired oxidative phosphorylation, increased ATP demand, and depletion of intracellular NAD⁺ pools. Pre clinical models demonstrate that NAD⁺ depletion contributes to central energy dysregulation, cognitive dysfunction, and axonal and neuronal degeneration through disruption of NAD⁺-dependent pathways including SIRT1-mediated mitochondrial resilience, PARP1-driven NAD⁺ consumption, and SARM1-associated axonal breakdown. Despite growing preclinical evidence supporting NAD⁺based neuroprotection, human clinical data remains absent.

Methods: A real-world clinical pilot …

Exploring The Spectrum Of Anxiety During Concussion Recovery: A Comprehensive Examination Of Symptom-Based Anxiety Disorders, Kori J. Durfee

Graduate Theses and Dissertations

Background: Anxiety is common following a concussion, arising from both psychosocial and physiological changes, and can manifest in diverse ways. Despite its complexity and association with worse outcomes, post-concussion anxiety is often assessed as a single construct. Characterizing anxiety presentations following injury may improve the identification of clinically meaningful symptoms and help inform future targeted interventions that can improve concussion outcomes. Purpose: The primary purpose was to determine if symptom-based anxiety disorders occur in adults with concussion and identify pre- and post-injury predictors associated with these disorders. Additionally, the clinical utility and predictive abilities of symptom-based anxiety disorders and variability …

Nonlinear Differences In Postural Sway Across Attentional Focus Conditions In Individuals With And Without Anterior Cruciate Ligament Reconstruction, Natalie L. Ferguson, Brian L. Cone, Christopher K. Rhea, Anne Beethe, Breanna Studenka

Rehabilitation Sciences Faculty Publications

BACKGROUND: The structure of variability in postural sway reflects the adaptability and health of the postural control system. Entropy quantifies this structure by measuring the regularity of repeated fluctuations over time. Although entropy has been used to examine sway in neurological populations, little is known about how sway complexity changes following anterior cruciate ligament reconstruction (ACLR). Attentional focus may also influence postural control, with external focus typically promoting more efficient and automatic regulation than internal focus.

AIM: To examine how attentional focus (internal vs. external) influences the structure of postural sway in individuals with and without ACLR.

METHODS: Forty-three participants …

Effect Of Hearing Status On Modified Balance Error Scoring System Performance, Matthew Brancaleone, Claire Akard, Jaclyn Caccese

Journal of Sports Medicine and Allied Health Sciences: Official Journal of the Ohio Athletic Trainers Association

OBJECTIVE
Concussion assessments typically include evaluations of self-reported symptoms, neurocognitive function, and postural control. Specifically, postural control is often assessed using the modified Balance Error Scoring System (mBESS). Although normative mBESS data exist, they may not be appropriate for all athletes, such as those who are deaf or hard-of-hearing (D/HoH). Given the relationship between the cochlea and the vestibular system, athletes who are D/HoH may exhibit differences in postural control due to potential vestibular dysfunction. Therefore, the objective of this study was to compare mBESS performance between athletes who are D/HoH and athletes who are hearing.

Pull Or Play? The Interpretation Of A Novel, Ai-Powered On-Field Decision Support Tool., Lynne Becker, Dafne Badilla, Osho Yonzon, Xiaoyu Wu, Roland Rocafort, Erik Viogan Phd, Devansh Manocha

Journal for Sports Neuroscience

The document titled "Pull or Play? The interpretation of a novel, AI-powered on-field decision support tool" explores the development and application of the Injury Impact Severity Score (IISS)™ for assessing traumatic brain injuries (TBIs), particularly in sports settings. It addresses the limitations of current assessment tools like the Glasgow Coma Scale (GCS) and proposes a more objective approach using patient-reported data and machine learning algorithms.

Key points include:

• Background: TBIs are a significant health concern with under-reported cases and a lack of effective research. Current assessment tools like the GCS have limitations in accuracy and speed, especially in dynamic …

Repetitive Subconcussive Head Impacts In Sports And Their Impact On Brain Anatomy And Function: A Systematic Review, Lukas Hack, Bhagyashree Singh, Ferdinand Binkofski, Ingo Helmich

Exercise and Sport Studies: Faculty Publications

Repetitive subconcussive head impacts occur regularly in sports. However, the exact relationship between their biomechanical properties and their consequences on brain structure and function has not been clarified yet. We therefore reviewed prospective cohort studies that objectively reported the biomechanical characteristics of repetitive subconcussive head impacts and their impact on brain anatomy and function. Only studies with a pre- to post-measurement design were included. Twenty-four studies met the inclusion criteria. Structural white matter alterations, such as reduced fractional anisotropy and an increase in mean diffusivity values, seem to be evident in athletes exposed to repetitive subconcussive head impacts exceeding 10 …

Barriers To Implementation Of Post-Concussion Grade Exercise Tests, Tyler Beauregard

Journal of Sports Medicine and Allied Health Sciences: Official Journal of the Ohio Athletic Trainers Association

OBJECTIVE

The purpose of this study was to assess the potential barriers to sports physical therapy and athletic training clinicians implementing graded exertional tests, specifically for their patients following concussion.

Quality Improvement Of A Post-Concussion Recovery Protocol, Halle Strege, Kaitlyn Burnham, Laura L. Harris

Journal of Sports Medicine and Allied Health Sciences: Official Journal of the Ohio Athletic Trainers Association

OBJECTIVE

To determine the effectiveness of a post-concussion recovery protocol in an adolescent athletic population.

Neurocognitive Performance Differences Between Athletes Who Are Deaf Or Hard-Of-Hearing And Athletes Who Are Hearing, Matthew P. Brancaleone, Jaclyn Caccese, James Onate

Journal of Sports Medicine and Allied Health Sciences: Official Journal of the Ohio Athletic Trainers Association

OBJECTIVE

There are over 71,000 college students in the United States who are deaf or hard-of-hearing (D/HoH), with many participating in athletics. Athletes who are D/HoH have similar concussion rates to athletes who are hearing at the collegiate level. Differences in neurocognitive baseline performance between athletes who are D/HoH and athletes who are hearing may exist due to misunderstanding of written English instructions or differences in sensory processing. Therefore, the purpose of this study was to compare neurocognitive performance between athletes who are hearing and athletes who are D/HoH.

Effects Of Caffeine On Measures Of Clinical Outcome And Recovery Following Mild Traumatic Brain Injury In Adolescents, Jacob Michael Eade

Theses and Dissertations

OBJECTIVE: The overarching purpose of this study was to investigate the influence of habitual caffeine consumption on mTBI outcomes in adolescents. BACKGROUND: Adolescents who suffer an mTBI have an increased risk for neurological impairment and symptomology. Thus, it is important to elucidate modifiable lifestyle factors that have the potential to influence injury outcomes and recovery. Caffeine is a legal psychoactive compound prevalent among the adolescent population. Marketed as an ergogenic aid caffeine coincides with recreational activities where incidence of mTBI is high. However, no human study has explored the influence of caffeine consumption on mTBI pathology. It was hypothesized that …

Unreported Concussions Within Law Enforcement Officers, Bailee Faulkner, Jennifer Walker, Audrey Wagstaff

Journal of Sports Medicine and Allied Health Sciences: Official Journal of the Ohio Athletic Trainers Association

OBJECTIVE

Understand the degree to which concussions go unreported among members of the Law Enforcement community.

The Value Of The Vestibular/Ocular Motor Screening (Voms) In Evaluating Adolescent Patients With Concussions, Laura Harris, Kirstin Antonaros, Hayley Cole, Patrick Daniels, Kurtis Gould, Trent Ivey, Alexa Lewis, Alexis Maxwell, Paul Miles

Journal of Sports Medicine and Allied Health Sciences: Official Journal of the Ohio Athletic Trainers Association

OBJECTIVE

To determine the VOMS can differentiate between typical and protracted recoveries in adolescent patients.

Salivary Microrna As A Concussion Biomarker And The Implications For Athletic Trainers' Practices, Thomas Richard Campbell

Rehabilitation Sciences Theses & Dissertations

Many concussions are sustained globally each year; however, research suggests that a large number may go undiagnosed due to a reliance on subjective information from patients and limitations of current objective measures. Recently, efforts have been focused on identifying clinical biomarkers of concussions, including salivary microRNA (miRNA), to improve healthcare professionals’ concussion management practices. Even if salivary miRNA were shown to be a valid and reliable measure for managing concussions, healthcare professionals, such as athletic trainers (ATs), must be familiar with the tool and have positive attitudes toward the implementation into clinical practice. Therefore, the purpose of this dissertation was …

Do Female University Varsity Athletes Have A Greater Risk Of Injury Within A Competitive Varsity Season?, Aidan K. Comeau, Eric C. Parent, Michael D. Kennedy

International Journal of Exercise Science

International Journal of Exercise Science 16(6): 129-147, 2023. Previous varsity sport injury research has analyzed how acute and chronic injury severity, type, and location differs between sport and sexes, with limited research in time to injury. Canadian university varsity sport injury research is especially sparse and mostly retrospective. Thus, we aimed to understand injury differences in male and female competitive university athletes competing in the same sport. Athletes who competed on the basketball, volleyball, soccer, ice hockey, football (male), rugby (female), and wrestling teams were eligible for the study. There were 182 male and 113 female athletes who provided informed …

Teammate Social Support For Female Athletes Recovering From Sports-Related Concussion, Brianna Iltshishin, Jennifer Robertson-Wilson, Michael Cinelli

Theses and Dissertations (Comprehensive)

Objective: Social support is a complex, multi-dimensional construct that is a vital coping mechanism for athletes experiencing sports-related concussion (SRC). Typically reported sources of social support include coaches, athletic therapist, and family/friends. This qualitative study, guided by a phenomenological orientation, aimed to understand previously concussed female athletes’ perceptions of the social support provided by their teammates. The study also explored how social support, or lack of social support, affected athletes as they navigated their concussion recovery.

Methods: Five participants were recruited through purposive and snowball sampling. Data collection consisted of background questionnaires and one semi-structured one-on-one interview. Interviews were transcribed …

Evaluating The Effects Of Cardiorespiratory Fitness Level And Gender On Outcomes Of The Buffalo Concussion Bike Test, Katie Stephenson

Graduate Theses and Dissertations

Background: Accurate assessment of concussion is crucial for creating a treatment plan. The Buffalo Concussion Bike Test (BCBT) is a 30-minute graded exercise protocol for a stationary bicycle. Previously this assessment has been reportedly used to screen for exercise intolerance secondary to autonomic dysfunction; however, the original purpose of the assessment was to find a sub-symptom threshold for exercise rehabilitation during concussion recovery. Starting resistance for the BCBT protocol is based solely on body mass. Other factors such as cardiorespiratory fitness level and sex have been noted to effect outcomes on similar assessments and are not considered in the BCBT …

Psychophysiological Biomarkers Of Concussion Recovery, Adam Todd Harrison

Theses and Dissertations

Each ach year a growing number of individuals report lingering deficits months-years following concussion. Persistent post-concussion symptoms (PPCS) can negatively impact day-today activities and if left untreated may manifest in severe neurological sequelae resulting in long-term cognitive impairment or advanced neurological degeneration (i.e., CTE). Current clinical diagnostic and prognostic assessments (e.g., symptom reports and neurocognitive testing) lack the sensitivity to quantify neurological function. Accordingly, there is a critical need to identify objective biomarkers specific to PPCS to improve an individual’s quality of life and prevent severe long-term neurological dysfunction.

Psychophysiological measurements (e.g., EEG derived event-related potentials, heart rate variability, and …

The Correlation Between Acl Injury & Concussion, Brandon Michael Phillips

Theses and Dissertations--Kinesiology and Health Promotion

Concussion (also known as mild traumatic brain injury) is a neurological injury that occurs after a blow to the head or neck area and can have affects to movement based on the severity of the injury. Mild traumatic brain injury has possible linkage to an increased risk of anterior cruciate ligament (ACL) injury. The purpose of this thesis was to assess the impact of prior concussion on lower extremity mechanics that are associated with risk of ACL injury. A total of 11 individuals with prior history of concussion and 11 healthy individuals without prior history of concussion (56.5 months since …

The Influence Of Adhd On Concussion In Ncaa College Athletes, Brett Steven Gunn

Theses and Dissertations

Evidence suggests attention deficit/hyperactivity disorder (ADHD) may be associated with an increased incidence of concussion; however, no study has cross-sectionally (Aim 1) and longitudinally (Aim 2) assessed the associations of ADHD with concussion. Additionally, there is reason to expect cognitive alterations following concussion in athletes with ADHD. Further, there is currently no study that has evaluated the influence of common medications often taken to mitigate some symptoms of ADHD, such as methylphenidate and amphetamines. Therefore, we sought to longitudinally assess cognitive profiles (Aim 3) of athletes with ADHD taking medication (ADHD+Rx) and not taking medication (ADHD_uRx) at baseline, 24-48 hours …

Do Memory Test Scores Improve After Organized Sport Activity?, Olivia B. Smith, Erika Smith-Goodwin, Jennifer Walker

Journal of Sports Medicine and Allied Health Sciences: Official Journal of the Ohio Athletic Trainers Association

Please enjoy Volume 7, Issue 1 of the JSMAHS. In this issue, you will find Professional, Graduate, and Undergraduate research abstracts, and case reports.

Thank you for viewing this 7^th Annual OATA Special Edition.

The Impact Of Multiple Concussions On The Lives Of Student-Athletes, Jenny L. Toonstra, Andrea E. Cripps, Lauren R. Meyers

Journal of Sports Medicine and Allied Health Sciences: Official Journal of the Ohio Athletic Trainers Association

Please enjoy Volume 7, Issue 1 of the JSMAHS. In this issue, you will find Professional, Graduate, and Undergraduate research abstracts, and case reports.

Thank you for viewing this 7^th Annual OATA Special Edition.

The Effect Of Concussion History On Lower Extremity Injury Risk In High School And Collegiate Athletes: A Systematic Review And Meta-Analysis, Vanessa Ramirez, Ryan Mccann, Eric Schussler, Jessica Martinez

College of Health Sciences Posters

Sport-related concussions are a prevalent injury that result in sensorimotor dysfunction and altered neuromuscular control. Individuals recovering from a concussion display decreased postural sway during balance assessment and may possess prolonged balance deficits after return-to-play (RTP). Athletes who are experiencing impairments following RTP after a concussion may be at increased risk of lower extremity (LE) injury. The purpose of this study was to conduct a systematic review and meta-analysis of studies examining risk of LE musculoskeletal injury following a concussion in high school and collegiate athletes. An electronic database search of PubMed, CINAHL, MEDLINE, and SPORTDiscus was conducted on November …

Identification Of Chronic Postural Stability Impairments Associated With History Of Concussion, Nicholas Reilly

Rehabilitation Sciences Theses & Dissertations

Concussion is the most common form of traumatic brain injury (TBI). However, there is a disproportionate level of understanding between the acute and chronic impairments associated with traumatic brain injury. Specifically, problems maintaining balance during standing and walking are cardinal signs of acute concussion, but the temporal extent to which postural control deficits remain following the initial injury are not well defined or understood. The purpose of the projects composing this dissertation was to examine the long-term effects of a prior history of concussion on static (i.e. standing) and dynamic (i.e. gait) postural control. To address this, healthy adults aged …

Sleep Quality And Prevalence Of Anxiety And Depression In Young Adults With Concussion History, Jessica Barrack

Theses and Dissertations

Background: Concussions are a growing public health concern, and emerging long-term health risks may negatively impact an individual’s quality of life. With concussions, there can be a multitude of signs and symptoms, but frequent long-term sequelae of concussions including mood disturbances (e.g. trait anxiety and depression) and sleep disturbances (e.g. difficulties initiating and maintaining sleep) are given less attention. Few clinicians address mood and sleep disturbances in their concussion assessment and management plan, potentially placing individuals at risk for prolonged disturbances beyond recovery. Purpose: To examine the relationship between sleep disturbances (sleep quality) and mood disturbances (trait anxiety and depression) …

Effect Of Neck Strength On Simulated Head Impacts During Falls In Female Ice Hockey Players, Brittany Pennock, Derek Kivi, Carlos Zerpa

International Journal of Exercise Science

International Journal of Exercise Science 14(1): 446-461, 2021. This study examined the effect of isometric cervical strength and impact location of the hockey helmet in mitigating the risk of concussions for two different mechanisms of injury from a fall during head impact simulation testing. Isometric cervical strength was measured on 25 female hockey players to compute and model neck strength on a mechanical neckform. A dual-rail vertical drop system with a helmet mounted on a surrogate headform simulated the mechanisms of injury causing concussions on female ice hockey players. Measures of peak linear acceleration and risk of injury due to …

Survey Of Prevention And Intervention Strategies Reducing Return To Play Post-Concussion In Division 1 Football, Joseph F. Clark, Enna Selmanovic, Kip Drewry, Jon Vincent, Aaron Himmler, Bob Mangine, Kim Hasselfeld, Jane Khoury, David Polanski, Jon Divine

Journal for Sports Neuroscience

Abstract.

Introduction

Sports related concussion, also considered mTBI, has remained in the public eye due to heightened fear concerning playing football and other collision based sports. Concussion prevention, as well as rehabilitating the brain after a concussion, is a high priority for many sports medical practitioners as well as for athletes. For these reasons, researchers associated with the American Athletic Conference (AAC) have surveyed concussion incidence in football. One of the AAC teams engaged in regular neurovisual training (NVT) and concluded this training program is associated with faster return to play post-injury in this observational cohort study.

Methods

The …

An Objective Method To Assess And Recommend Exertion And Exercise Targets For Return To Play Post Concussion, Joseph F. Clark Phd Atc, Robert E. Mangine Pt Med Atc, Kimberly A. Hasselfeld Ms, Violet T. Schramm, Angelo J. Colosimo Md, Aaron Kuehn-Himmler At Ms, Gerald M. Holloway Ms Atc, Faniel Fosselman Do Mba, Jon Vincent, Nicole Giordano, Jon G. Divine Md Ms

Journal for Sports Neuroscience

Introduction.

Concussions are of significant concern for athletic trainers, and there is a critical need to objectively and safely allow an athlete to return to play. In sports the objective is return as safely and soon as possible. Exertion is a consideration regarding progressing an athlete back to play. The ability to exert in cardiovascular and strength and conditioning contexts are two critical steps in most return to play protocols. Being able to make objective recommendations is urgently needed, as trial and error leads to unnecessary risk of eliciting symptoms and/or causing setbacks.

Objective.

The object of this paper is …

Effectiveness Of A Computerized Cognitive Training Program For Reducing Head Impact Kinematics In Youth Ice Hockey Players, Melissa S. Difabio, Thomas A. Buckley

International Journal of Exercise Science

International Journal of Exercise Science 14(1): 149-161, 2021. Cognitive training (CT) is an effective technique to improve neurological performance, but has not been investigated as a head impact primary prevention strategy. The purpose of this study was to investigate the CT’s effectiveness in reducing head impact kinematics in youth ice hockey players. Twenty youth were divided into two groups: a CT and Control group. The CT group performed two 30-minute sessions of IntelliGym CT weekly for 20 weeks and the control group performed two 30-minute sessions weekly evaluating hockey videos. The dependent variables, number of head impacts, cumulative linear acceleration …

Effects Of A Dual-Task Paradigm On Tandem Gait Performance, Courtney Angela Perry

Cal Poly Humboldt theses and projects

In concussion management, a variety of cognitive and motor control tests, like the tandem gait, have been used for assessing the presence of a concussion injury at the sideline and through recovery. More recently, research suggests that introducing a secondary cognitive retention task during tandem gait (i.e., dual task) may provide a better assessment of concussion. The purpose of this study was to determine if a tandem gait test paired with a 6-digit retention is a valid and reliable tool. Participants completed three trials of both the single-task (ST) and dual-task (DT) tandem gait tests, and their average (MEAN) and …

Validation Of A Machine Learning Brain Electrical Activity-Based Index To Aid In Diagnosing Concussion Among Athletes, Jeffery J. Bazarian, Robert J. Elbin, Douglas J. Casa, Gillian A. Hotz, Christopher Neville, Rebecca M. Lopez, David M. Schnyer, Susan Yeargin Ph.D., Atc

Faculty Publications

Importance An objective, reliable indicator of the presence and severity of concussive brain injury and of the readiness for the return to activity has the potential to reduce concussion-related disability.

Objective To validate the classification accuracy of a previously derived, machine learning, multimodal, brain electrical activity–based Concussion Index in an independent cohort of athletes with concussion.

Design, Setting, and Participants This prospective diagnostic cohort study was conducted at 10 clinical sites (ie, US universities and high schools) between February 4, 2017, and March 20, 2019. A cohort comprising a consecutive sample of 207 athletes aged 13 to 25 years with …