Kinesiology Commons^™

Vitamin D3 Supplementation And Stress Fractures In High-Risk Collegiate Athletes - A Pilot Study, Kevin Williams, Christian Askew, Christopher Mazoue, Jeffrey Guy, Toni M. Torres-Mcgehee, J Benjamin Jackson Iii

Faculty Publications

INTRODUCTION: Vitamin D is paramount to bone health and little is known about vitamin D's role in the prevention of stress fractures in high-risk athletes. This study consists of a prospective, cross-sectional analysis accompanied by a retrospective review for control comparison of vitamin D3 supplementation in high-risk athletes. Our hypothesis is that supplemental vitamin D3 treatment will decrease the occurrence of stress fractures in high-risk collegiate athletes. MATERIALS AND METHODS: A total of 118 NCAA Division I athletes were recruited from 6 high-risk collegiate teams. Blood draws in August and February established baseline 25(OH)D levels. Subjects with serum 25(OH)D <30 ng/mL were supplemented with 50,000 IU of vitamin D3/week for 8 weeks. Treated subjects were re-tested to ensure serum 25(OH)D levels rose to sufficient status. All enrolled subjects were monitored for the development of stress fractures. A 5-year retrospective chart review of athletes from the same sports teams was conducted to determine the incidence of any reported stress fractures in the past. RESULTS: Prospective: 112 of the 118 enrolled subjects were tested in August. Sixty-one demonstrated vitamin D sufficiency (40.2 ng/mL ±8.28) and 51 were either insufficient or deficient (22.7 ng/mL ±4.89). Of the 118 enrolled subjects, 104 were tested in February. Fifty-six demonstrated vitamin D sufficiency (40.7 ng/mL ±9.47) and 48 were insufficient or deficient (21.6 ng/mL ±5.87). Two stress fractures were diagnosed amongst our cohort of 118 student athletes (1.69%). Retrospective: 34 stress fractures were diagnosed in 453 subjects from 01/2010-05/2015 (7.51%). Amongst our athletic teams, the cross-country team specifically demonstrated a statistically significant decrease in stress fracture incidence (p<0.05). We also found a statistically significant reduction in stress fracture incidence amongst the current overall cohort compared to our retrospective cohort (p<0.05). CONCLUSION: In our population, almost half of the tested athletes proved to be vitamin D deficient. Hypovitaminosis D was prevalent throughout the winter months compared with the summer. With vitamin D3 supplementation, the stress fracture rate in our overall cohort demonstrated a statistically significant decrease from 7.51% to 1.65% (p=0.009).

International Society Of Sports Nutrition Position Stand: Nutritional Considerations For Single-Stage Ultra-Marathon Training And Racing, Nicholas B. Tiller, Justin D. Roberts, Liam Beasley, Shaun Chapman, Jorge M. Pinto, Lee Smith, Melanie Wiffin, Mark Russell, S. Andy Sparks, Lauren Duckworth, John O'Hara, Louise Sutton, Jose Antonio, Darryn S. Willoughby, Michael D. Tarpey, Abbie E. Smith-Ryan, Michael J. Ormsbee, Todd A. Astorino, Richard B. Kreider, Graham R. Mcginnis, Jeffrey R. Stout, Johneric W. Smith, Shawn M. Arent Ph.D., Cscs*D, Fissn, Facsm, Fnak, Bill I. Campbell, Laurent Bannock

Faculty Publications

Background

In this Position Statement, the International Society of Sports Nutrition (ISSN) provides an objective and critical review of the literature pertinent to nutritional considerations for training and racing in single-stage ultra-marathon. Recommendations for Training. i) Ultra-marathon runners should aim to meet the caloric demands of training by following an individualized and periodized strategy, comprising a varied, food-first approach; ii) Athletes should plan and implement their nutrition strategy with sufficient time to permit adaptations that enhance fat oxidative capacity; iii) The evidence overwhelmingly supports the inclusion of a moderate-To-high carbohydrate diet (i.e., ~ 60% of energy intake, 5-8 g·kg-1·d-1) to …

Reproducibility And The Effects Of Exercise On The Endurance Index, Michael Dean Smith, Jr.

Theses and Dissertations

Background: The Endurance Index (EI%) is a method to objectively assess a muscle’s ability to resist fatigue. The purpose of these studies was to determine the reproducibility of the EI% and determine the influence of muscular fatigue on the EI%. Methods Study 1: sixteen apparently healthy participants (18-30yrs) completed three nonconsecutive visits each with 3 bouts of 5-minute electrical muscle stimulations (EMS) and accelerometer-based mechanomyography (aMMG) of the vastus lateralis at 4 Hz and low amperage (25-35mA) on the hamstrings of the dominant leg; peak torque was measured at each visit. Study 2: fifteen apparently healthy participants (ages 18-30yrs) …

Differential Cholinergic Modulation Of Prelimbic And Thalamic Input To The Basolateral Amygdala, Sarah Catherine Tryon

Theses and Dissertations

The basolateral amygdala (BL) is critical for emotional memory acquisition and expression. It receives afferent projections from both cortical and subcortical regions that send glutamatergic transmission to the BL. This input conveys information necessary for survival, including information about one’s behavioral state and environment. How this information is integrated and processed by the BL, however, remains largely unknown. Interestingly, the BL receives the densest amount of cholinergic innervation from the basal forebrain. This acetylcholine (ACh) can modulate emotional memories, but how it modulates specific afferent inputs to the BL is unexplored. To answer this question, we used brain slice field …

The Effect Of Patient Financial Liability On Physical Therapy Utilization And Patient Reported Outcomes For Patients With Low Back Pain: An Instrumental Variable Analysis, Adam D. Lutz

Theses and Dissertations

Low back pain (LBP) is the most common orthopedic complaint managed by physical therapists in the United States. Insurance plans that require greater patient financial liability per physical therapy visit are thought to disincentivize participation in recommended physical therapy plans of care. The primary purpose of this investigation was to use instrumental variable regression to investigate the effect of insurancemediated patient financial liability per visit on physical therapy visit count and functional patient reported outcomes. The secondary purpose of the study was to examine the generalizability of results to the broader excluded patient population—and beyond to patients that seek physical …

Leveraging For-Cause Physical Activity Events For Physical Activity Promotion: An Investigation Using Self-Determination Theory, John A. Bernhart

Theses and Dissertations

Motivating individuals to live active lifestyles remains a challenging but important public health issue. For-cause physical activity events reach large groups of people, many of whom are not regularly active. However, little research has applied established health behavior theories to explain participation in for-cause events. Therefore, the purpose of this dissertation was to investigate participation in for-cause events through the lens of Self-Determination Theory (SDT).

The first study recruited participants (n=207) registered in a for-cause PA event (i.e., 5K distance or shorter) to complete online surveys that assessed need satisfaction for autonomy, competence, and relatedness; intrinsic motivation; altruism; PA behavior; …

The Role Of Ampk In The Regulation Of Skeletal Muscle Proteostasis During Cancer Cachexia, Dennis K. Fix

Theses and Dissertations

Cancer-induced cachexia is a debilitating disease that diminishes quality of life due to severe loss of skeletal muscle mass and function. Skeletal muscle proteostasis fluctuates diurnally depending on different fasting and feeding durations as well as in response to activity and exercise stimuli. Nutrient availability is key in the net loss and gain of skeletal muscle protein. The adenosine monophosphate protein kinase (AMPK) is a nutrient sensitive kinase that has long been established as a critical regulator of both protein synthesis and protein degradation. AMPK is capable of being activated by many different stimuli as well as diseases such as …

Effects Of Spinal Manipulation On Brain Activation In Individuals With Chronic Low Back Pain, Max K. Jordon

Theses and Dissertations

Chronic low back pain (cLBP) continues to be one of the most common health conditions in the United States. Despite an enormous amount of research, there are no treatments for this condition that consistently improve outcomes. For decades health professionals have incorporated spinal manipulative therapy (SMT) into their practice, but the evidence to date has shown that SMT has only small to modest effect sizes when treating cLBP. One way to improve the effectiveness of SMT is by getting a better understanding of its underlying mechanisms so that the intervention be more specifically targeted to the appropriate individual.

While biomechanical …

Physical Activity Of Preschoolers With Developmental Disabilities And Delays, Michaela A. Schenkelberg

Theses and Dissertations

Children with developmental disabilities and delays are at greater risk for developing overweight and obesity compared to typically developing peers. Participation in regular physical activity is a modifiable behavior that is consistently associated with improved weight status and other positive health outcomes. Previous studies have identified numerous individual- and environmental-level factors that associate with physical activity among school-age children with and without disabilities. However, little is known about physical activity behaviors and related correlates among preschool-aged children with disabilities (ages 3 – 5 years), especially while they are in preschool settings. Therefore, the overall purpose of this dissertation was to …

International Comparison Of The Levels And Potential Correlates Of Objectively Measured Sedentary Time And Physical Activity Among Three-To-Four-Year-Old Children, Kaiseree I. Dias, James White, Russell Jago, Greet Cardon, Rachel Davey, Kathleen F. Janz, Russell R. Pate, Jardena J. Puder, John J. Reilly, Ruth Kipping

Faculty Publications

Physical activity (PA) patterns track from childhood through to adulthood. The study aimed to determine the levels and correlates of sedentary time (ST), total PA (TPA), and moderate-to-vigorous PA (MVPA) in preschool-aged children. We conducted cross-sectional analyses of 1052 children aged three-to-four-years-old from six studies included in the International Children’s Accelerometry Database. Multilevel linear regression models adjusting for age, gender, season, minutes of wear time, and study clustering effects were used to estimate associations between age, gender, country, season, ethnicity, parental education, day of the week, time of sunrise, time of sunset, and hours of daylight and the daily minutes …

Cardiorespiratory Fitness And The Risk Of First Acute Myocardial Infarction: The Hunt Study, Rajesh Shigdel, Håvard Dalen, Xuemei Sui, Carl J. Lavie, Ulrik Wisløff, Linda Ernstsen

Faculty Publications

Background

The majority of studies evaluating cardiorespiratory fitness (CRF) as a cardiovascular risk factor use cardiovascular mortality and not cardiovascular disease events as the primary end point, and generally do not include women. The aim of this study was to investigate the association of estimated CRF (eCRF) with the risk of first acute myocardial infarction (AMI).

Methods and Results

We included 26 163 participants (51.5% women) from the HUNT study (Nord‐Trøndelag Health Study), with a mean age of 55.7 years, without cardiovascular disease at baseline. Baseline eCRF was grouped into tertiles. AMI was derived from hospital records and deaths from …

The Effects Of Teacrine® And Caffeine On Endurance And Cognitive Performance During A Simulated Match In High-Level Soccer Players, Marissa L. Bello, Alan J. Walker, Bridget A. Mcfadden, David J. Sanders, Shawn M. Arent Ph.D., Cscs*D, Fissn, Facsm, Fnak

Faculty Publications

Background: Theacrine (1,3,7,9-tetramethyluric-acid) is a pure alkaloid with a similar structure to caffeine and acts comparably as an adenosine receptor antagonist. Early studies have shown non-habituating effects, including increases in energy and focus in response to Teacrine®, the compound containing pure theacrine. The purpose of this study was to determine and compare the effects of Teacrine® and caffeine on cognitive performance and time-to-exhaustion during a simulated soccer game in high-level male and female athletes. Methods: Male and female soccer players (N = 24; M Age = 20.96 ± 2.05y, M MaleVO2max = 55.31 ± 3.39 mL/O 2 /kg, M FemaleVO2max …

Moderating Effect Of The Neighborhood Physical Activity Environment On The Relation Between Psychosocial Factors And Physical Activity In Children: A Longitudinal Study, Natalie Colabianchi, Morgan N. Clennin, Marsha Dowda, Kerry L. Mciver, Rod K. Dishman, Dwayne E. Porter, Russell R. Pate

Faculty Publications

Background Few studies have examined the moderating role of neighbourhood environments on the relation between psychosocial factors and physical activity, and results of these studies are mixed. This study examined this relationship in 636 fifth to seventh graders from South Carolina, USA.

Methods From 2010 to 2013, children and their parent/guardian completed annual self-reported surveys assessing psychosocial factors, and children wore accelerometers for 1 week each year. Neighbourhood environments were classified as supportive or non-supportive for physical activity (PA) based on in-person audits of facilities near children’s homes and windshield surveys of children’s streets. Growth curve analyses were completed to …

Identification Of Factors Contributing To Musculoskeletal Injuries In Military Basic Trainees, Amy Fraley Hand

Theses and Dissertations

Due to the physical activity requirements of the United States (U.S.) Armed Forces, there is a concerning incidence rate of musculoskeletal injuries in military personnel. In the basic trainee population specifically, multiple studies have reported a range of exercise- related injury incidence from 14% to 42% in males and 27% to 61.7% in females. Depending on the severity, these injuries can exclude basic trainees from participation, ultimately altering career trajectory and creating the possibility of long-term disability. The studies of this dissertation examine variations in muscle strength, flexibility, and dynamic postural control as a means to identify those basic trainees …

Effect Of Trb3 On Skeletal Muscle Mass Regulation And Exercise-Induced Adaptation, Ran Hee Choi

Theses and Dissertations

Skeletal muscle, which composes over 40% of body mass, is responsible for daily locomotion and energy metabolism. It is a malleable tissue that can adapt its structure and function in response to internal and external environmental stimuli. Changing muscle mass and energy substrate utilization is a common skeletal muscle adaptation in response to various pathological conditions, including type 2 diabetes and obesity. Failure to maintain skeletal muscle mass and function has been correlated with increasing morbidity and mortality, as well as poor quality of life. Hence, maintenance of skeletal muscle integrity is a recommended strategy in achieving better quality of …

The Regulation Of Skeletal Muscle Fatigue During The Progression Of Cancer Cachexia, Brandon N. Vanderveen

Theses and Dissertations

Cachexia is the unintentional loss of body weight secondary to chronic disease and is prevalent is roughly 50% of cancer patients. The loss of body weight and skeletal muscle mass is reduced functional capacity associated with reduced life quality. The etiology of cachexia is multimodal and complex; however, cachexia has been linked to several systemic (e.g. chronic inflammation, hypogonadism, anemia, insulin resistance) and behavioral (e.g. anorexia, inactivity) changes that can compound to accelerate muscle mass and body weight loss. While several inflammatory cytokines are associated with cachexia’s disease progression, our laboratory has established that Interleukin-6 (IL-6) is a key regulator …

Be Your Best S.E.L.F., Rachel Wood, Casey Hasenbein

Senior Theses

The goal of our thesis was to use our knowledge as Exercise Science students and personal trainers to improve the health of an underserved population in South Carolina. We created a voluntary exercise and self-defense program for the girls residing at Epworth Children’s Home. The program began on October 1, 2018 and concluded on April 29, 2019 with data collecting taking place between October 8th and March 18th. Every other week SASS Defense taught their self-defense program, and on the alternating weeks we facilitated an exercise class. The program also included a mentorship aspect to create a supportive social environment …

Group-Based Physical Activity Trajectories In Children Transitioning From Elementary To High School, Russell R. Pate, Michaela A. Schenkelberg, Marsha Dowda, Kerry L. Mciver

Faculty Publications

Background

Physical activity has been observed repeatedly to decline as children transition into adolescence; however, few studies have explored the possibility that sub-groups of children experience unique patterns of change during this transition. The purpose of this longitudinal study was to examine the physical activity trajectories in clusters of youth transitioning from 5th to 11th grade.

Methods

Participants (n = 652) were recruited as 5th graders (ages 10–12 years) from elementary schools (n = 21) in two school districts. Demographic, anthropometric, and physical activity data were collected once per year when children were in 5th, 6th, 7th, 9th, and 11th …

Neighborhood Socioeconomic Environment And Its Influence On Cardiorespiratory Fitness And Physical Activity In Youth, Morgan N. Clennin

Theses and Dissertations

Among youth, inadequate cardiorespiratory fitness and physical inactivity are powerful markers of health associated with numerous health outcomes across the lifespan. Unfortunately, a majority of U.S. youth have inadequate cardiorespiratory fitness levels and do not meet physical activity guidelines. While previous research has identified several individual-level factors associated with youth cardiorespiratory fitness and physical activity, environmental factors have been increasingly recognized. Of particular interest is the neighborhood socioeconomic environment, which has been consistently associated with several health outcomes among adults. However, little is known regarding the relationship between the neighborhood socioeconomic environment, cardiorespiratory fitness, and physical activity among younger populations. …

Effects Of Protein Supplementation On Performance And Recovery In Resistance And Endurance Training, Harry P. Cintineo, Michelle A. Arent, Jose Antonio, Shawn M. Arent Ph.D., Cscs*D, Fissn, Facsm, Fnak

Faculty Publications

There is robust evidence which shows that consuming protein pre- and/or post-workout induces a significant rise in muscle protein synthesis. It should be noted, however, that total daily caloric and protein intake over the long term play the most crucial dietary roles in facilitating adaptations to exercise. However, once these factors are accounted for, it appears that peri-exercise protein intake, particularly in the post-training period, plays a potentially useful role in terms of optimizing physical performance and positively influencing the subsequent recovery processes for both resistance training and endurance exercise. Factors that affect the utility of pre- or post-workout feeding …

Barriers And Facilitators To Compliance With A State Healthy Eating Policy In Early Care And Education Centers, Daniel A. Zaltz, Russell R. Pate, Jennifer R. O'Neill, Brian Neelon, Sara E. Benjamin-Neelon

Faculty Publications

Background: Early care and education (ECE) policies can improve childhood obesity risk factors. We evaluated barriers and facilitators to implementing mandatory nutrition standards for foods provided in South Carolina ECE centers serving lowincome children, comparing centers participating in the Child and Adult Care Food Program (CACFP) with non-CACFP centers.

Methods: We mailed 261 surveys (demographics, policies and practices, barriers and facilitators) to center directors after new state nutrition standards were implemented in South Carolina. We conducted univariate and bivariate analyses to explore relationships between barriers, facilitators, and center-level characteristics, by CACFP status.

Results: We received 163 surveys (62% response rate). …

Andale Pittsburgh: Results Of A Promotoraled, Home-Based Intervention To Promote A Healthy Weight In Latino Preschool Children, Sharon E. Taverno Ross, Bethany Barone Gibbs, Patricia I. Documet, Russell R. Pate

Faculty Publications

Background: Latino preschool children have higher rates of obesity than preschool children from other racial/ ethnic groups; however, few effective, culturally appropriate interventions exist targeting this group. The purpose of this study was to test the feasibility of a 10-week, promotora-mediated, home-based intervention to promote a healthy weight in Latino preschool children.

Methods: Trained promotoras (community health workers) delivered 10, 90-min weekly interactive and tailored sessions to Latino families living in Allegheny County. Participants were recruited through promotoras’ own social networks and community gatherings, flyers, and word of mouth. Primary outcome measures included child body mass index (BMI) z-score and …

Stepping It Up: Walking Behaviors In Children Transitioning From 5th To 7th Grade, Sharon E. Taverno Ross, Morgan N. Clennin, Marsha Dowda, Natalie Colabianchi, Russell R. Pate

Faculty Publications

The purpose of this study was to (1) describe children’s walking behaviors in 5th to 7th grade and change over time and (2) examine associations between walking behaviors and Walk Score®. Participants consisted of n = 586 students from the Transitions and Activity Changes in Kids (TRACK) Study. Children reported any walking behavior (e.g., exercise and transportation) over the past five days. Walk Score was calculated based on children’s home address. Descriptive statistics summarized walking behaviors by gender and time, and repeated measure mixed models examined the relationship between walking behaviors and Walk Score. Approximately 46.8% and 19.2% of 5th …

The Application Of An Implementation Science Framework To Comprehensive School Physical Activity Programs: Be A Champion!, Justin B. Moore, Russell L. Carson, Collin A. Webster, Camelia Renee Singletary, Darla M. Castelli, Russell R. Pate, Michael W. Beets, Aaron Beighle

Faculty Publications

Comprehensive school physical activity programs (CSPAPs) have been endorsed as a promising strategy to increase youth physical activity (PA) in school settings. A CSPAP is a five-component approach, which includes opportunities before, during, and after school for PA. Extensive resources are available to public health practitioners and school officials regarding what should be implemented, but little guidance and few resources are available regarding how to effectively implement a CSPAP. Implementation science provides a number of conceptual frameworks that can guide implementation of a CSPAP, but few published studies have employed an implementation science framework to a CSPAP. Therefore, we developed …

The Effects Of Exercise Training On Cardiovascular-Related Circulating Micrornas, Jacob Luther Barber

Theses and Dissertations

PURPOSE: MicroRNAs (miRNAs) are small regulatory RNAs that post transcriptionally modify mRNAs and control gene expression. Circulating miRNAs are significantly altered following a single session of exercise, however the effects of exercise training on the circulating miRNA profile is unclear. Therefore, the purpose of the present study was to determine the effects of endurance exercise training on the abundance of targeted circulating miRNAs and the association of changes in miRNA levels with concomitant changes in cardiometabolic traits, in a subsample of adults from the HERITAGE Family Study.

METHODS: This exploratory analysis examined 20 previously sedentary adults from the HERITAGE Family …

Cortical Damage And Disconnection Contribute To Post-Stroke Sensorimotor Impairment, Shafagh Yazdani

Theses and Dissertations

BACKGROUND. Stroke is a cerebrovascular event that causes permanent damage to brain regions and decreases in connectivity (disconnection) between brain regions. Most stroke survivors have permanent difficulties performing functional motor tasks, thus research into how damage and disconnection produce difficulties performing motor tasks can help guide post-stroke rehabilitation. Previous studies have examined the extent to which cortical damage produces motor impairments, but the extent to which disconnection produces motor impairments remains unclear. Furthermore, studies have focused on how motor impairments contribute to difficulties performing motor tasks, whereas the role of visuospatial impairments has received little attention. Neuroimaging techniques for quantifying …

Enhancing Dancing: Examining The Potency Of A Combined Action Observation And Brain Stimulation Intervention, Melissa B. Kolar

Theses and Dissertations

Research supports the idea that action observation (AO)-based training can be an effective component of physical training and rehabilitation. While much is known about the benefits of AO for simple movements, less is known about the utility of AO-based training for complex, whole-body sequences of movements. Additionally, positive motor performance and neurophysiological findings are associated with anodal-transcranial direct current stimulation (A-tDCS). Therefore, it may be valuable to investigate the combination of these two approaches to further enhance motor learning. It is unknown how this combination, utilizing an alternative electrode arrangement of t-DCS (bihemispheric anodal corticomotor tDCS [BAC-tDCS]), would affect learning …

The Effects Of Exercise Mode And Intensity On Energy Expenditure During And After Exercise In Resistance Trained Males, George Lewis Grieve

Theses and Dissertations

Purpose: The purpose of this study was to examine the effects of exercise mode and intensity on energy expenditure (EE) during and after five time-matched aerobic and resistance exercise protocols in resistance trained males.

Methods: 14 resistance trained males (mean ± SD; age = 24.2 ± 4.0 yr; body mass = 84.7 ± 13.3 kg; height = 181.2 ± 8.8 cm; and body fat = 15.9 ± 4.6%) completed five separate protocols: continuous aerobic (continuous), high intensity interval aerobic (HIIT), strength endurance (2x20), traditional resistance (3x10), and high intensity resistance (4x6). EE was measured before, during, immediately post (0-30 minutes), …

The Effects Of Modifiable Lifestyle Behaviors On Lipoprotein Particle Concentration And Size, Ryan R. Porter

Theses and Dissertations

Lipoprotein concentrations are well established biological markers associated with cardiovascular disease (CVD) risk. Recent research has placed great importance on the various functions of the different lipoprotein subfractions (small and large low-density lipoprotein particles [LDL-P]; small, medium and large high-density lipoprotein particles [HDL-P]). Modifiable lifestyle behaviors such as exercise, diet, and sleep have been shown to have direct effects on CVD risk, in part by altering blood lipid and lipoprotein profiles. The overall goal of this dissertation was to determine if specific modifiable lifestyle behaviors were associated with the concentration and size of lipoprotein subfractions.

Two studies, both utilizing a …

Calibration Of An Accelerometer For Measurement Of Very Light Intensity Physical Activity In Children, Joseph S. Gorab

Theses and Dissertations

Obesity prevalence is continuing to rise in children in the United States. Decreased physical activity has long been thought to be a cause of this trend. As such, much of the accelerometer study has been focused on moderate to vigorous physical activity (MVPA). More recently, time spent in sedentary behavior has received much attention as well. There is an abundance of time spent in light intensity physical activity, and yet comparatively little focus has been placed on it in the field of accelerometer study. The purpose of this study was to generate an accelerometer count cut-point for the ActiGraph GT3X+ …