Kinesiology Commons^™

Running Decreases Knee Intra-Articular Cytokine And Cartilage Oligomeric Matrix Concentrations: A Pilot Study, Robert D. Hyldahl, Alyssa Evans, Sunku Kwon, Sarah T. Ridge, Eric Robinson, J. Ty Hopkins, Matthew K. Seeley

Faculty Publications

Introduction Regular exercise protects against degenerative joint disorders, yet the mechanisms that underlie these benefits are poorly understood. Chronic, low-grade inflammation is widely implicated in the onset and progression of degenerative joint disease.

Purpose To examine the effect of running on knee intra-articular and circulating markers of inflammation and cartilage turnover in healthy men and women.

Methods Six recreational runners completed a running (30 min) and control (unloaded for 30 min) session in a counterbalanced order. Synovial fluid (SF) and serum samples were taken before and after each session. Cytokine concentration was measured in SF and serum using a multiplexed …

The Effects Of Experimental Anterior Knee Pain On Bilateral Ground Reaction Forces During Running, Emily Rachel Cronk

Theses and Dissertations

The purpose of this study was to examine the independent effects of anterior knee pain (AKP) on bilateral ground reaction force (GRF) during running, with a focus on GRF applied to the uninvolved leg, which, prior to this study, had never been evaluated. Twelve volunteers completed three data collection sessions, that corresponded to one of three conditions (control, sham, and pain), in a counterbalanced order. For each session, subjects ran for five minutes. For the pain and sham sessions, respectively, hypertonic and isotonic saline were infused into the infrapatellar fat pad of the right leg during the running, while no …

The Differences In Time To Stability, Foot Muscle Size, And Toe Flexor Strength Between Cheerleaders And Gymnasts, Kelsey Renee Garner

Theses and Dissertations

Context: There has been recent speculation that the intrinsic muscles of the foot may play a larger role in lower extremity control and injury than previously believed. Multiple studies have shown that certain intrinsic muscles increase in size and strength after transitioning to minimalist shoe running, theoretically decreasing injury risk. There are currently no studies that examine the effect that training barefoot has in other athletic populations. Objective: Our purpose was to compare the intrinsic and extrinsic foot muscle size and strength in gymnasts (who predominantly train barefoot) and cheerleaders (who predominantly train shod). Another purpose was to measure time …

Biomechanical Analysis Of Gait Termination In 11–17 Year Old Youth At Preferred And Fast Walking Speeds, Sarah T. Ridge, John Henley, Kurt Manal, Freeman Miller, James G. Richards

Faculty Publications

In populations where walking and/or stopping can be difficult, such as in children with cerebral palsy, the ability to quickly stop walking may be beyond the child’s capabilities. Gait termination may be improved with physical therapy. However, without a greater understanding of the mechanical requirements of this skill, treatment planning is difficult. The purpose of this study was to understand how healthy children successfully terminate gait in one step when walking quickly, which can be challenging even for healthy children. Lower extremity kinematic and kinetic data were collected from 15 youth as they performed walking, planned, and unplanned stopping tasks. …

Association Between Expanded Normal Weight Obesity And Insulin Resistance Among U.S. Adults In The National Health And Nutrition Examination Survey, Keilah Elizabeth Martinez

Theses and Dissertations

The purpose of this investigation was to expand the evaluation of Normal Weight Obesity (NWO) and its association with insulin resistance using a nationally representative sample of U.S. adults. A cross-sectional study including 5,983 subjects was conducted. Body fat percentage was assessed using dual energy X-ray absorptiometry (DXA). Expanded Normal Weight Obesity (eNWO) categories (pairings of BMI and body fat percentage classifications) were determined by standard cut-points for BMI and the gender specific median for body fat percentage. Homeostatic Model Assessment-Insulin Resistance (HOMA-IR) levels were used to index insulin resistance. Mean ± SE values were as follows: BMI: 27.9 ± …

Validity And Reliability Of A Photographic Method Of Assessing Body Composition, Elizabeth Z. Macdonald

Theses and Dissertations

The LeanScreenTM app uses photographs and touchscreen technology of an iPad or iPhone to estimate body composition using the Department of Defense (DoD) prediction equations that use cirumference measurements of the neck, abdomen, waist, and hips. The purpose of this study was to determine the validity and reliability of the LeanScreenTM app in 148 weight-stable adults (82 men, 66 women) who were normal weight, overweight, or obese as defined by body mass index. The percent body fat (%BF) of each subject was estimated during one visit using dual-energy x-ray absorptiometery (DXA) as the criterion measure, and three field methods: the …

Neural Activation In Blood-Flow-Restricted Versus Non-Blood-Flow-Restricted Exercise: An Fmri Study, Tiffany Dawn Devries

Theses and Dissertations

Functional magnetic resonance imaging (fMRI) can be used to track neural activation in the brain during functional activities. The purpose of this study was to investigate brain neural responses to blood flow restricted (BFR) versus control handgrip exercise. Using a randomized crossover design, 25 subjects (12 males, 13 females) completed handgrip exercises during two conditions: BFR vs. control. To familiarize participants with the exercise conditions, one week prior to MRI scanning participants completed each exercise condition once on separate days, with 72 hours between days. The following week fMRI scans were performed at the same time of day, separated by …

The Effect Of Whole Body Vibration On Exercise-Induced Muscle Damage And Delayed-Onset Muscle Soreness, Ryan Darin Magoffin

Theses and Dissertations

Current scientific evidence suggests that when whole body vibration (WBV) is used as a warm-up prior to performing eccentric exercise, delayed-onset muscle soreness (DOMS) is mitigated and strength loss recovers faster. These benefits were observed primarily in nonresistance-trained individuals. The aim of this study was to determine if WBV could mitigate soreness and expedite strength recovery for resistance-trained individuals when used as a warm-up prior to eccentric exercise. Thirty resistance-trained males completed 300 maximal eccentric contractions of the quadriceps after warming up with (WBV) or without (CON) WBV. Both CON and WBV experienced significant isometric (27.8% and 30.5%, respectively) and …

Neural Response To Food Cues After Moderate And Vigorous Exercise In Women: A Randomized Crossover Trial, Jillesa Anderson

Theses and Dissertations

PURPOSE: This study examined the effect of different intensities of acute exercise on attention allocation to visual food cues, postexercise energy intake, and subjective measures of hunger in women. METHODS: This crossover study utilized treatment conditions that were randomized and counter-balanced. Fifty-two adult women, 18-29 years, were compared under three separate conditions: no exercise, 45 min of moderate-intensity exercise at 3.9 METs and 22.5 min of vigorous-intensity exercise at 7.8 METs. To measure attention allocation to visual food cues, participants were shown a passive viewing task consisting of a continual stream of pictures of food (high and low calorie) and …

Acute Changes In Running Mechanics Across Footwear With Various Heel-To-Toe Height Differences, Daniel C. Moody

Theses and Dissertations

There are many different types of footwear available for runners in today's market. Many of these shoes claim to improve a runner's efficiency by altering their stride mechanics. Minimalist footwear claims to aid runners in running more on their forefeet whereas more traditional footwear provides more cushioning specifically for a heel-first landing. The purpose of this research was to determine if runners who were accustomed to running in traditional footwear would acutely alter their running biomechanics when they ran barefoot or in various types of minimalist footwear. Twelve subjects, who were accustomed to running in traditional 12 mm heel/toe differential …

Movement Competency's Relationship To Health Related Quality Of Life In Older Adults, Shaun M. Fulton

Theses and Dissertations

The purpose of this study was to investigate the relationship between movement competency and health related quality of life (HRQOL) in adults aged 55 to 75 years. Seventy-eight, male (40) and female (38), subjects completed the study. Their mean (SD) age, height, and mass were 64.9 (5.8) years and 63.6 (4.9) years, 1.8 (.08) m and 1.7 (.07) m, 82.6 (11.8) kg and 70.3 (17.9) kg, for male and female, respectively. Subjects completed several tests in 3 categories: movement competency (Functional Movement Screen^TM [FMS] [all 7 tests], sitting-rising test [SRT]); physical activity level (Physical Activity Scale for the Elderly …

Morphology Of Human Myoblasts In Cultured Muscle Cells By The Novel Small Molecule Sgi, Ryan Matekel, Robert Hyldahl

Journal of Undergraduate Research

Muscle wasting is a symptom of cancer, AIDS, renal failure, heart failure, aging, prolonged bed rest, and has been seen in rodent models for burn, and kidney disease (Han, 2013). Muscle wasting negatively impacts quality of life by decreasing functional independence and increasing morbidity and mortality (Anker, 1997). Muscle wasting is an especially serious issue given that the body weight of an average human is 40-50 percent skeletal muscle (Han, 2013). Myostatin is a protein that negatively regulates muscle mass and is primarily expressed within skeletal muscle (Lee & McPherron, 2001). Genetic studies have shown that inhibition of myostatin signaling …

Evidence For Regulatory T Cell In Skeletal Muscle Repair, Amanda Gier, Robert Hyldahl

Journal of Undergraduate Research

Testing multiple immunohistochemistry protocols, I was unsuccessful at identifying Tregulatory cells in human skeletal muscle samples. A total of 5 months was dedicated to this original project before I was reassigned to look into the presence of CD8+ cells in skeletal muscle. The new project proved to be fruitful as I was able to confidently identify CD8+ cells and analyze their presence in the process of skeletal muscle repair. Furthermore, the data I collected has be incorporated into a paper Dr. Robert Hyldahl is currently working on titled “Skeletal muscle inflammation following repeated bouts of lengthening contractions in humans.”

Effect Of Myostatin Pathway Inhibition On Fibroblast Activity Using A Novel Small Molecule, Seth Hampton, Dr. Robert Hyldahl

Journal of Undergraduate Research

Fibroblasts play a key role in repairing injured tissue by secreting collagen and growth factors into the tissue. In states of disease and overuse, fibroblast activity can become overly abundant and can lead to skeletal muscle fibrosis, decreasing strength and muscle elasticity. This fibrotic condition can lead to muscle wasting disorders, such as muscular dystrophies, that severely decrease the length and quality of life. Previous studies have shown that the TGF-beta signaling family directly increases fibroblast proliferation. It has also been shown that inhibition of myostatin, a member of the TGF-beta family, reduces symptoms of muscular dystrophies and decreases fibrosis. …

Effects Of Transcutaneous Electrical Nerve Stimulation On Quadriceps Activation And Walking Mechanics In Patients With Anterior Knee Pain, Brian Wiseman, J. Ty Hopkins

Journal of Undergraduate Research

More than ten million people in the U.S. suffer from knee pain, and one in every two people may develop chronic knee pain by age 85.³ Knee pain is also 1 of 5 leading causes of disability among adults, and alters muscle function and walking mechanics, which in turn, decreases quality of life.⁶ To alleviate the effects of knee pain and its consequences, transcutaneous electrical nerve stimulation (TENS) is often used to decrease perceived pain⁵ and increase quadriceps activation.⁷ However, it is unclear whether these benefits could offer potential improvement for walking mechanics. Therefore, the purpose …

Foot Strike Angle Changes During Shod, Minimalist, And Barefoot Running, And Correlation To Injury, Ani Henriksen, Dr. Sarah Ridge

Journal of Undergraduate Research

Running is a popular form of exercise. With high incidence of injury, runners are always looking for the next cure to stay injury free. Many webpages offer conflicting advice about shoes and foot strike. Although recommendations vary, barefoot running and use of minimalist shoes has increased. With the change in footwear, many runners have reported injuries from improper technique and repetitive loading. With the use of current technology we analyzed movements of the foot ignored by other studies. This project analyzed foot strike movement in the frontal plane to help us better understand the ideal foot strike technique for running …

Ambulation Speed And Corresponding Mechanics Are Associated With Changes In Serum Cartilage Oligomeric Matrix Protein, W. Matt Denning, Michael Becker Pardo, Jason G. Winward, Iain Hunter, Sarah T. Ridge, J. Ty Hopkins, C. Shane Reese, Allen C. Parcell, Matthew K. Seeley

Faculty Publications

Because serum cartilage oligomeric matrix protein (COMP) has been used to reflect articular cartilage condition, we aimed to identify walking and running mechanics that are associated with changes in serum COMP. Eighteen subjects (9 male, 9 female; age = 23 ± 2 yrs.; mass = 68.3 ± 9.6 kg; height = 1.70 ± 0.08 m) completed 4000 steps on an instrumented treadmill on three separate days. Each day corresponded to a different ambulation speed: slow (preferred walking speed), medium (+50% of slow), and fast (+100% of slow). Synchronized ground reaction force and video data were collected to evaluate walking mechanics. …