Kinesiology Commons^™

Blockade Of Tgf-Ss Signaling Through The Activin Type Iib Receptor With The Small Molecule, Sgi-1252, Jordan David Fuqua

Theses and Dissertations

Antagonism of the activin receptor signaling pathway represents a promising potential therapy for the muscular dystrophies and other muscle wasting disorders (i.e., cachexia or sarcopenia). Previous research has shown that antagonism of activin signaling promotes muscle growth, attenuates muscle wasting, and restores function in both wild type and diseased animals. Our laboratory has recently developed a novel small molecule (SGI-1252) that inhibits activin downstream (i.e., Smad2/3 phosphorylation) signaling. Purpose: In this study we determined how eight weeks of orally administered SGI-1252 affected TGF-ß signaling, whole body mass, individual limb muscle mass, and muscle fiber cross sectional area (CSA). Methods: Wild-type …

The Effect Of Aerobic Exercise Versus Inactivity On Nitric Oxide Concentration And Synthesis In An Elderly Population, Samantha Burton

Theses and Dissertations

CONTEXT: Nitric Oxide (NO) is an endothelial-derived vasoactive molecule that causes an increase in blood flow and oxygen delivery to tissue. A reduction in NO bioavailability has been found to occur in adults over the age of 60 and can be reversed pharmacologically by improving NO synthase (NOS) activity. Reversing these age-related changes with alternative interventions, such as aerobic exercise, has shown some promising results. OBJECTIVE: To quantify blood NO-bioavailability (as measured by blood nitrite levels) in a population of aerobically trained elderly men and compare these data to a group of age-matched, inactive individuals. In addition, we measured the …

The Effect Of Foot Strengthening Exercise On Dynamic Function Of The Medial Longitudinal Arch In Runners: A Preliminary Report, Jarom Bridges

Theses and Dissertations

Therapeutic exercise has previously been shown to alter the static height of the medial longitudinal arch (MLA). It is still unknown, however, if these effects carry over into dynamic activities. PURPOSE: To determine if an 8-week foot strengthening exercise program increases static arch height and reduces vertical deformation of the MLA during mid-stance in running.METHODS: Thirty-four recreational runners (17 males, 17 females) have completed this ongoing study (age 24.06 ± 3.61 years, body mass 68.63 ± 12.95 kg, and height 173.34 ± 9.54 cm). To date, 22 subjects have been assigned to the control group (8 weeks of normal running) …

Strength Training And Body Composition In Middle-Age Women, Rachelle Burrup

Theses and Dissertations

OBJECTIVE: The purpose of this study was to examine the relationship between strength training and body composition before and after controlling for several covariates. A cross-sectional study including 257 female subjects was conducted. METHODS: Subjects' level of involvement in strength training was determined via questionnaire. Body composition was assessed using dual energy X-ray absorptiometry (DXA). Diet was assessed using 7-d weighed food records. RESULTS: Strong linear relationships between subjects' level of involvement in strength training and body composition were identified. For each additional day of strength training reported per week, body fat was 1.32 percentage points lower (F = 14.8, …

The Effect Of Training In Minimalist Running Shoes On Running Economy, Sarah T. Ridge, Tyler Standifird, Jessica Rivera, A. Wayne Johnson, Ulrike H. Mitchell, Iain Hunter

Faculty Publications

The purpose of this study was to examine the effect of minimalist running shoes on oxygen uptake during running before and after a 10-week transition from traditional to minimalist running shoes. Twenty-five recreational runners (no previous experience in minimalist running shoes) participated in submaximal VO2 testing at a self-selected pace while wearing traditional and minimalist running shoes. Ten of the 25 runners gradually transitioned to minimalist running shoes over 10 weeks (experimental group), while the other 15 maintained their typical training regimen (control group). All participants repeated submaximal VO2 testing at the end of 10 weeks. Testing included a 3 …

Meat Intake And Insulin Resistance In Women Without Type 2 Diabetes, Larry A. Tucker, James D. Lecheminant, Bruce W. Bailey

Faculty Publications

Purpose. To examine the relationship between meat intake and insulin resistance (IR) in 292 nondiabetic women. Methods. IR was evaluated using the homeostasis model assessment (HOMA). Diet was assessed via 7-day weighed food records. Servings of very lean meat (VLM) and regular meat (meat) were indexed using the ADA Exchange Lists Program. Physical activity was assessed using accelerometers and body fat was measured using the Bod Pod. Results. Meat intake was directly related to HOMA (F = 7.4; P = 0.007). Women with moderate or high meat intakes had significantly higher HOMA levels than their counterparts. Adjusting for body fat …

Lower Extremity Neuromechanics During A Forward-Side Jump Following Functional Fatigue In Patients With Ankle Instability, Hyun Kim

Theses and Dissertations

Ankle instability (AI) and fatigue impair neuromuscular control as well as dynamic joint stability of the lower extremity. No one has comprehensively examined the effects of AI and fatigue on neuromechanics of the lower extremity during a functional activity. Deficits associated with AI and fatigue could be additive in increasing the risk for injury in patients with AI. PURPOSE: To examine the interaction of AI and fatigue on lower extremity muscle activity, kinematic, and kinetic patterns during a forward-side jump. METHODS: 25 AI (23.3 ± 1.9 yrs, 176.5 ± 10.5 cm, 70.9 ± 11.4 kg), and 25 matched control subjects …

Will Ultrasound Performed With The Rich-Mar Autosound™ Be As Effective At Increasing Tissue Temperature As Ultrasound Performed With A Traditional Machine?, Heather Diane Black

Theses and Dissertations

STUDY DESIGN: Randomized crossover experiment. OBJECTIVE: To determine whether the Rich-Mar AutoSound™ would be as effective as traditional ultrasound at increasing the temperature of the triceps surae muscle during a 10-min, 1 MHz, 1.0 W/cm2 ultrasound treatment. BACKGROUND: The AutoSound™ is a hands-free ultrasound device that is strapped on the body and left for the duration of the ultrasound treatment. It requires no clinician during the actual ultrasound treatment, thus freeing the clinician to perform other tasks and reducing clinician error during treatments. METHODS: 16 healthy subjects (6 males, 10 females, age = 22 ± 1.6 yrs, height = 173.2 …

Inhibition Of The Myostatin Signaling Pathway In Cultured Muscle Cells By A Novel Small Molecule, Ryan Matekel, Robert Hyldahl

Journal of Undergraduate Research

Muscle wasting is a symptom of cancer, AIDS, renal failure, heart failure, aging, prolonged bed rest, and has been seen in rodent models for burn, and kidney disease (Han, 2013). Muscle wasting negatively impacts quality of life by decreasing functional independence and increasing morbidity and mortality (Anker, 1997). Myostatin is a protein that negatively regulates muscle mass and is primarily expressed within skeletal muscle (Lee & McPherron, 2001). It exerts its effect by binding to a receptor and initiating a signaling cascade that involves phosphorylation of two kinase proteins called SMAD-2 and SMAD-3 (Sartori et al., 2009). Genetic studies have …

Slow Walking On A Treadmill Desk Does Not Negatively Affect Executive Abilities: An Examination Of Cognitive Control, Conflict Adaptation, Response Inhibition, And Post-Error Slowing, Michael J. Larson, James D. Lecheminant, Kaylie Carbine, Kyle R. Hill, Edward Christenson, Travis Masterson, Rick Lecheminant

Faculty Publications

An increasing trend in the workplace is for employees to walk on treadmills while working to attain known health benefits; however, the effect of walking on a treadmill during cognitive control and executive function tasks is not well known. We compared the cognitive control processes of conflict adaptation (i.e., congruency sequence effects—improved performance following high-conflict relative to low-conflict trials), post-error slowing (i.e., Rabbitt effect), and response inhibition during treadmill walking (1.5 mph) relative to sitting. Understanding the influence of treadmill desks on these cognitive processes may have implications for worker health and productivity. Sixty-nine individuals were randomized to either a …

Cognitive And Typing Outcomes Measured Simultaneously With Slow Treadmill Walking Or Sitting: Implications For Treadmill Desks, James D. Lecheminant, Michael D. Larson, Kyle Hill, Kaylie Carbine, Travis Masterson, Ed Christenson

Faculty Publications

Purpose

This study compared cognitive (attention, learning, and memory) and typing outcomes during slow treadmill walking or sitting. Seventy-five healthy individuals were randomly assigned to a treadmill walking group (n=37; 23 female) or sitting group (n=38; 17 female).

Methods

The treadmill walking group completed a series of tests while walking at 1.5 mph. The sitting group performed the same tests while sitting at a standard desk. Tests performed by both groups included: the Rey Auditory Verbal Learning Test and a modified version of the Paced Auditory Serial Attention Test. In addition, typing performance was evaluated.

Results

Participants in the treadmill …

Sex Differences In Whole Body Gait Kinematics At Preferred Speeds, Dustin A. Bruening, R. Frimenko, C. Goodyear, A. Fullenkamp

Faculty Publications

Studies on human perception have identified pelvis and torso motion as key discriminators between male and female gaits. However, while most observers would advocate that men and women walk differently, consistent findings and explanations of sex differences in gait kinematics across modern empirical studies are rare. In the present study we evaluated sex differences in whole body gait kinematics from a large sample of subjects (55 men, 36 women) walking at self selected speeds. We analyzed the data through comparisons of discrete metrics and whole curve analyses. Results showed that in the frontal plane, women walked with greater pelvic obliquity …

Dairy Consumption And Insulin Resistance: The Role Of Body Fat, Physical Activity, And Energy Intake, Larry A. Tucker, Andrea Erickson, James D. Lecheminant, Bruce W. Bailey

Faculty Publications

The relationship between dairy consumption and insulin resistance was ascertained in 272 middle-aged, nondiabetic women using a cross-sectional design. Participants kept 7-day, weighed food records to report their diets, including dairy intake. Insulin resistance was assessed using the homeostatic model assessment (HOMA). The Bod Pod was used to measure body fat percentage, and accelerometry for 7 days was used to objectively index physical activity. Regression analysis was used to determine the extent to which mean HOMA levels differed across low, moderate, and high dairy intake categories. Results showed that women in the highest quartile of dairy consumption had significantly greater …