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- Cultured muscle cells (2)
- Novel small molecule (2)
- Skeletal muscle (2)
- Aged skeletal muscle (1)
- Ankle joint kinematics (1)
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- Ankle mobility (1)
- Ankle sprain (1)
- Anterior knee pain (1)
- Articular cartilage (1)
- Barefoot running (1)
- Beach Boys (1)
- Biomarkers (1)
- Chronic ankle instability patients (1)
- Concentric exercise (1)
- Deep tissue healing (1)
- Diabetic Neuropathy (1)
- Differences in gait (1)
- Eccentric exercise (1)
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- Fibroblast activity (1)
- Fibroblast proliferation (1)
- Foot strike angle (1)
- Hyaluronic acid (1)
- IP-10 (1)
- Immunohistochemistry (1)
- Injury (1)
- Knee pain (1)
- Low-cost alternatives (1)
- Lower extremities (1)
- Marketed below-knee prosthetics (1)
Articles 1 - 16 of 16
Full-Text Articles in Kinesiology
The Effect Of Deep Tissue Heating On Skeletal Muscle Pgc1 A Protein Expression During Muscle Atrophy, Kaitlin Abbott, Dr. Allen Percell
The Effect Of Deep Tissue Heating On Skeletal Muscle Pgc1 A Protein Expression During Muscle Atrophy, Kaitlin Abbott, Dr. Allen Percell
Journal of Undergraduate Research
Through this project, we aimed to determine if repeated heat stress is a viable treatment to reduce or slow muscle atrophy in human muscle subjected to disuse. Specifically, I investigated how repeated heat stress affects the expression of PGC1-a, a gene that is an upstream regulator of mitochondrial biogenesis. This protein promotes muscle growth and normally is triggered by environmental factors including the metabolic needs (energy, temperature, stress, etc.) of the muscle. If it could be increased in the muscle, it could potentially lead to the preservation of muscle strength and function in a variety of disease states. These include …
The Effect Of Repeated Heat Stress On Mitochondrial Protein Content In Human Skeletal Muscle, Amy Twitchell, Robert Hyldahl
The Effect Of Repeated Heat Stress On Mitochondrial Protein Content In Human Skeletal Muscle, Amy Twitchell, Robert Hyldahl
Journal of Undergraduate Research
Exercise has been known to improve mitochondrial function and increase its content in muscle. However, those who suffer from certain diseases such as Chronic Obstructive Pulmonary Disease (COPD) and Type II Diabetes often experience concomitant exercise intolerance. In vitro research suggests that the application of a mild heat stress may be sufficient to activate some of the same signaling proteins that become active during exercise, possibly leading to mitochondrial biogenesis in skeletal muscle. However, this has not yet been confirmed to occur in human skeletal muscle. Therefore, the purpose of this study was to investigate the effect of heat therapy …
Effect Of Restricted Ankle Mobility On Muscle Reaction Time And Ankle Joint Kinematics To A Simulated Ankle Sprain During Walking In Chronic Ankle Instability Patients, Brandon Winward, Ty Hopkins
Effect Of Restricted Ankle Mobility On Muscle Reaction Time And Ankle Joint Kinematics To A Simulated Ankle Sprain During Walking In Chronic Ankle Instability Patients, Brandon Winward, Ty Hopkins
Journal of Undergraduate Research
Inversion ankle sprains are common and are caused by sudden inversion stresses during weight-bearing movement which causes the foot to roll under and inward.1 Ankle sprains result in tearing or stretching of ligaments and muscles, which reduces ankle stability.2 After a single ankle sprain, up to 80% of people suffer repeated sprains, which often develop into chronic ankle instability (CAI).3 Research has shown CAI patients often exhibit delayed lower leg muscle reaction time and restricted dorsiflexion range of motion (DROM).2
Dysregulation Of Tenascin C And Hyaluronic Acid In Aged Skeletal Muscle, Alex Holland, Alan Parcel
Dysregulation Of Tenascin C And Hyaluronic Acid In Aged Skeletal Muscle, Alex Holland, Alan Parcel
Journal of Undergraduate Research
Satellite cells are the progenitor stem cells of skeletal muscle (SM) that reside between the sarcolemma and basal lamina. This space is referred to as the satellite cell niche. Following injury, quiescent satellite cells are activated, proliferate then migrate and fuse to the injured region of muscle to support regeneration (3). Satellite cells in muscle tissue from older subjects migrate at less than half the speed of those in young tissue (2). This may contribute to the diminished regenerative response observed in older subjects. Tenascin C (TNC) has been identified as a de-adhesion protein that is upregulated in the satellite …
If The Beach Boys Were Diabetic, They Would Sing About Good Vibrations!, Peterson Jordan, Brent Feland
If The Beach Boys Were Diabetic, They Would Sing About Good Vibrations!, Peterson Jordan, Brent Feland
Journal of Undergraduate Research
One in every four Americans suffer from Diabetic Neuropathy in the lower extremities. This research has a lot to do with the pain and anguish of one fourth of the American people. This pain can cause depression and other mental illnesses, because it reduces the patient’s physical activity by a land slide. This can be traumatic for the patient and the family. This neuropathy in the lower extremities causes nerve damage in the foot and leg area. Doctors have found that it is due to a lack of blood to the nerves, causing the nerve endings to slowly die. This …
Do Certain Biomarkers Accurately Reflect Articular Cartilage Change Due To Physical Activity?, Alyssia Evans, Matthew Seeley
Do Certain Biomarkers Accurately Reflect Articular Cartilage Change Due To Physical Activity?, Alyssia Evans, Matthew Seeley
Journal of Undergraduate Research
Knee injury and pathology are common problems for Americans who are physically active; they affect half of all Americans who are over the age of 65, and the related annual costs are nearly twenty billion dollars. Knee pain alters running and walking neuromechanics1, and may be deleterious to knee articular cartilage. Researchers have hypothesized that if abnormal gait mechanics, due to knee pain persist, the resulting mechanical and physiological circumstances could influence genesis and progression rate of chronic knee joint pathologies, including knee osteoarthritis.
Eccentric Vs. Concentric Exercise Intervention During Extreme Post-Surgery Weight Loss, Joshua Kelley, Lance Davidson
Eccentric Vs. Concentric Exercise Intervention During Extreme Post-Surgery Weight Loss, Joshua Kelley, Lance Davidson
Journal of Undergraduate Research
In the past decade severe obesity (body mass index of greater than 35 kg/m²) has increased by 70 percent and is considered the fastest growing BMI category in the United States. Severe obesity has been linked with a low quality of life and a variety of comorbidities. As a result, the amount of various weight loss surgeries have dramatically increased, enabling individuals to lose large amounts of weight in a short period of time. Following Roux-en-Y-Gastric-Bypass surgery, 30-35 percent of the total weight lost is considered muscle mass or fat free mass (FFM) and a 20-40 percent decrease in muscular …
The Role Of Ip-10 In Muscle Regeneration And Repair After Injury, Jacob Parmley, Robert Hyldahl
The Role Of Ip-10 In Muscle Regeneration And Repair After Injury, Jacob Parmley, Robert Hyldahl
Journal of Undergraduate Research
The repair and regeneration processes of skeletal muscle rely on the activation, proliferation and differentiation of skeletal muscle stem cells (satellite cells), which are necessary sources for muscle increase (hypertrophy) and regeneration (Stewart, 2006). A muscles ability to regenerate diminishes due to age or various diseases, such as muscular dystrophy (Mariol, 2001). Interventions aimed at altering the skeletal muscle environment to optimize muscle stem cell activity and regenerative processes represents a promising approach to enhance muscle regenerative capacity. Recent data from our lab has identified increased levels of the cytokine Interferon Gamma-Inducible Protein 10 (IP-10) during the muscle regenerative period …
Examining Differences In Gait Between Marketed Below-Knee Prosthetics And Low-Cost Alternatives, Kelly Bickham, Dustin Bruening
Examining Differences In Gait Between Marketed Below-Knee Prosthetics And Low-Cost Alternatives, Kelly Bickham, Dustin Bruening
Journal of Undergraduate Research
Perhaps one of the greatest challenges that accompany the incredible advances in science and technology is making them accessible where they need to be. According to the Amputee Coalition of America (ACA), there are over 2 million American amputees, with an additional 185,000 lower extremity amputees every year [2]. In Africa, Asia and Latin America, where incomes are lower and fewer people are insured, there as many as 30 million amputees. Only a fraction of the world amputee population has access to a prosthetic limb, let alone can afford anything considered state-of-the-art. In order to help address the huge demand, …
Fibroblast Proliferation In Response To Treatment By A Novel Tgf-Beta Pathway Inhibitor, Coray Preece, Robert Hyldahl
Fibroblast Proliferation In Response To Treatment By A Novel Tgf-Beta Pathway Inhibitor, Coray Preece, Robert Hyldahl
Journal of Undergraduate Research
Fibroblasts play a key role in repairing injured tissue by secreting collagen and growth factors into the tissue. In states of disease and overuse, fibroblast activity (i.e. greater fibroblast content and collagen secreting activity) can lead to skeletal muscle fibrosis, in which myofibers are replaced by collagen, decreasing strength and muscle elasticity. It has been shown in previous studies that TGF-beta signaling directly increases fibroblast proliferation and collagen secretion. It has also been shown that inhibition of TGF-beta signaling reduces known symptoms of muscular dystrophies including decreased fibrosis and increased muscular strength. SGI-1252 is a novel small molecule that our …
Morphology Of Human Myoblasts In Cultured Muscle Cells By The Novel Small Molecule Sgi, Ryan Matekel, Robert Hyldahl
Morphology Of Human Myoblasts In Cultured Muscle Cells By The Novel Small Molecule Sgi, Ryan Matekel, Robert Hyldahl
Journal of Undergraduate Research
Muscle wasting is a symptom of cancer, AIDS, renal failure, heart failure, aging, prolonged bed rest, and has been seen in rodent models for burn, and kidney disease (Han, 2013). Muscle wasting negatively impacts quality of life by decreasing functional independence and increasing morbidity and mortality (Anker, 1997). Muscle wasting is an especially serious issue given that the body weight of an average human is 40-50 percent skeletal muscle (Han, 2013). Myostatin is a protein that negatively regulates muscle mass and is primarily expressed within skeletal muscle (Lee & McPherron, 2001). Genetic studies have shown that inhibition of myostatin signaling …
Evidence For Regulatory T Cell In Skeletal Muscle Repair, Amanda Gier, Robert Hyldahl
Evidence For Regulatory T Cell In Skeletal Muscle Repair, Amanda Gier, Robert Hyldahl
Journal of Undergraduate Research
Testing multiple immunohistochemistry protocols, I was unsuccessful at identifying Tregulatory cells in human skeletal muscle samples. A total of 5 months was dedicated to this original project before I was reassigned to look into the presence of CD8+ cells in skeletal muscle. The new project proved to be fruitful as I was able to confidently identify CD8+ cells and analyze their presence in the process of skeletal muscle repair. Furthermore, the data I collected has be incorporated into a paper Dr. Robert Hyldahl is currently working on titled “Skeletal muscle inflammation following repeated bouts of lengthening contractions in humans.”
Effect Of Myostatin Pathway Inhibition On Fibroblast Activity Using A Novel Small Molecule, Seth Hampton, Dr. Robert Hyldahl
Effect Of Myostatin Pathway Inhibition On Fibroblast Activity Using A Novel Small Molecule, Seth Hampton, Dr. Robert Hyldahl
Journal of Undergraduate Research
Fibroblasts play a key role in repairing injured tissue by secreting collagen and growth factors into the tissue. In states of disease and overuse, fibroblast activity can become overly abundant and can lead to skeletal muscle fibrosis, decreasing strength and muscle elasticity. This fibrotic condition can lead to muscle wasting disorders, such as muscular dystrophies, that severely decrease the length and quality of life. Previous studies have shown that the TGF-beta signaling family directly increases fibroblast proliferation. It has also been shown that inhibition of myostatin, a member of the TGF-beta family, reduces symptoms of muscular dystrophies and decreases fibrosis. …
Effects Of Transcutaneous Electrical Nerve Stimulation On Quadriceps Activation And Walking Mechanics In Patients With Anterior Knee Pain, Brian Wiseman, J. Ty Hopkins
Effects Of Transcutaneous Electrical Nerve Stimulation On Quadriceps Activation And Walking Mechanics In Patients With Anterior Knee Pain, Brian Wiseman, J. Ty Hopkins
Journal of Undergraduate Research
More than ten million people in the U.S. suffer from knee pain, and one in every two people may develop chronic knee pain by age 85.3 Knee pain is also 1 of 5 leading causes of disability among adults, and alters muscle function and walking mechanics, which in turn, decreases quality of life.6 To alleviate the effects of knee pain and its consequences, transcutaneous electrical nerve stimulation (TENS) is often used to decrease perceived pain5 and increase quadriceps activation.7 However, it is unclear whether these benefits could offer potential improvement for walking mechanics. Therefore, the purpose …
Foot Strike Angle Changes During Shod, Minimalist, And Barefoot Running, And Correlation To Injury, Ani Henriksen, Dr. Sarah Ridge
Foot Strike Angle Changes During Shod, Minimalist, And Barefoot Running, And Correlation To Injury, Ani Henriksen, Dr. Sarah Ridge
Journal of Undergraduate Research
Running is a popular form of exercise. With high incidence of injury, runners are always looking for the next cure to stay injury free. Many webpages offer conflicting advice about shoes and foot strike. Although recommendations vary, barefoot running and use of minimalist shoes has increased. With the change in footwear, many runners have reported injuries from improper technique and repetitive loading. With the use of current technology we analyzed movements of the foot ignored by other studies. This project analyzed foot strike movement in the frontal plane to help us better understand the ideal foot strike technique for running …
Inhibition Of The Myostatin Signaling Pathway In Cultured Muscle Cells By A Novel Small Molecule, Ryan Matekel, Robert Hyldahl
Inhibition Of The Myostatin Signaling Pathway In Cultured Muscle Cells By A Novel Small Molecule, Ryan Matekel, Robert Hyldahl
Journal of Undergraduate Research
Muscle wasting is a symptom of cancer, AIDS, renal failure, heart failure, aging, prolonged bed rest, and has been seen in rodent models for burn, and kidney disease (Han, 2013). Muscle wasting negatively impacts quality of life by decreasing functional independence and increasing morbidity and mortality (Anker, 1997). Myostatin is a protein that negatively regulates muscle mass and is primarily expressed within skeletal muscle (Lee & McPherron, 2001). It exerts its effect by binding to a receptor and initiating a signaling cascade that involves phosphorylation of two kinase proteins called SMAD-2 and SMAD-3 (Sartori et al., 2009). Genetic studies have …