Immunology of Infectious Disease Commons^™

Immunity And Immunopathology In Acute Viral Infections, Shalini Sharma

Doctoral Dissertations

Herpetic stromal keratitis (HSK) is an immunopathological and tissue destructive corneal lesion caused by herpes simplex virus (HSV) infection, which induces an intense inflammatory response and finally leads to blindness. Accumulating evidence using the murine model has shown that Th-1 phenotype CD4⁺ T cells orchestrating the inflammation mainly contribute to the immunopathological reaction in HSV-1 infected cornea. Initially various innate immune cells recruit and produce numerous inflammatory and angiogenic molecules into the corneal stroma those in turn drive the corneal immunopathology.

While the basic principles of immunity to the influenza A viruses (IAV) are probably similar for all vertebrates, …