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Factors Associated With Candida Albicans Dissemination Via The Intestinal Mucosa, Emily Rochac Argueta
Factors Associated With Candida Albicans Dissemination Via The Intestinal Mucosa, Emily Rochac Argueta
Legacy Theses & Dissertations (2009 - 2024)
A murine model that established GI colonization of Candida albicans and eventual dissemination was identified to be lacking by Koh and others. Koh’s model specifically employed a tailored combination of neutropenia, intestinal damage, and microbiome dysbiosis that would allow C. albicans to gain an opportunistic advantage. His model provided new opportunities to study the details of C. albicans pathogenesis with a focus on the innate immune mechanisms responsible for controlling C. albicans within the intestinal mucosa. The long-term goal of this research project was to specifically study the factors associated with Candida albicans dissemination via the intestinal mucosa. The model …