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Immunology of Infectious Disease Commons™
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Full-Text Articles in Immunology of Infectious Disease
Neutralizing Antibodies Against The Ricin Toxin Binding Subunit (Rtb), Anastasiya Yermakova
Neutralizing Antibodies Against The Ricin Toxin Binding Subunit (Rtb), Anastasiya Yermakova
Legacy Theses & Dissertations (2009 - 2024)
Ricin is a toxin that is naturally produced by the seeds of the castor bean plant Ricinus communis, and is part of a family of A-B toxins that includes Shiga, cholera, and anthrax toxins. The toxin consists of two subunits, RTA and RTB, which are linked by a disulfide bond. RTA is an RNA N-glycosidase that selectively targets and inactivates 28S ribosomal RNA, thereby arresting protein synthesis and leading to cell death. RTB is a galactose/ N-acetylgalactosamine-specific lectin that mediates attachment, entry, and intracellular trafficking of ricin in host cells. Currently, there is no approved vaccine or therapeutics available against …
Humoral Immunity To Ehrlichial Infection : Identification And Characterization Of An Igm+ Memory B Cell Population, Jennifer Lynne Yates
Humoral Immunity To Ehrlichial Infection : Identification And Characterization Of An Igm+ Memory B Cell Population, Jennifer Lynne Yates
Legacy Theses & Dissertations (2009 - 2024)
Immunological memory is a fundamental concept that is key to generating and maintaining immunity to pathogens. Humoral memory resides in part in antigen-specific memory B cells, which are classically defined as class-switched, somatically mutated, long-lived cells that are highly responsive to specific antigen challenge. Despite the focus on class-switched memory B cells, several studies have validated the existence of IgM memory B cells, and have demonstrated distinct functions of IgM and IgG memory B cell subsets. Based on the expression of CD11c, we have identified a large population of IgM memory B cells using a natural model of infection by …