Open Access. Powered by Scholars. Published by Universities.®
Immunology of Infectious Disease Commons™
Open Access. Powered by Scholars. Published by Universities.®
- Institution
- Keyword
-
- Aging (1)
- Antiretroviral (1)
- Aspergillus fumigatus; innate immunity; superinfection; LysMD3 (1)
- Biology (1)
- COVID-19 (1)
-
- Coevolution (1)
- Drosophila melanogaster (1)
- Ebola virus (1)
- Endocytosis (1)
- Gene expression (1)
- HIV (1)
- Human Immunodeficiency Virus -1 (1)
- Innate immunity (1)
- Interferon stimulated genes (ISG) (1)
- Metabolism (1)
- Off-target effects (1)
- RNA interference (1)
- Restriction factors (1)
- SARS-CoV-2 (1)
- SiRNA (1)
- Simian Immunodeficiency Virus (1)
- Single-fly respirometry (1)
- Small HERC family (1)
- Target specificity (1)
- Treatment (1)
- Vaccine (1)
- Virus infection (1)
- Virus replication (1)
- Wuhan (1)
- Publication
- Publication Type
Articles 1 - 5 of 5
Full-Text Articles in Immunology of Infectious Disease
Sars-Cov-2: Tale Of A Microscopic Murderer, Josiah P. Garner
Sars-Cov-2: Tale Of A Microscopic Murderer, Josiah P. Garner
Quest
Independent Study
Research in progress for BIOL1406: Biology for Science Majors I
Faculty Mentor: Amina Tassa, Ph.D.
I am delighted to introduce Josiah Garner’s “SARS-CoV-2: Tale of a Microscopic Murderer.” This independent study assignment explores the impact of a novel, deadly, and worldwide virus. The assignment also examines the fast development of vaccines to control the spread and reduce the symptoms of the virus.
Josiah’s paper focuses on the early history of the emergence of COVID-19, the world response, and vaccine development. He demonstrates critical thinking skills and effectively utilizes various research methods to obtain and communicate his information. Josiah …
Molecular Characterization Of The Antiviral Properties Of The Small Herc Family Of Proteins, Ermela Paparisto
Molecular Characterization Of The Antiviral Properties Of The Small Herc Family Of Proteins, Ermela Paparisto
Electronic Thesis and Dissertation Repository
Although viruses are obligate intracellular parasites, they have their own evolutionary trajectory, their genomes are in a constant battle to overcome the defenses of the host. This thesis investigates the role of the small HERC family of proteins in the battle against two deadly viruses: Human Immunodeficiency Virus -1 (HIV) and Zaire ebolavirus (EBOV). Although their discovery occurred decades ago, little knowledge is available about the small HERC family, their functions, and modes of interactions with other cellular proteins. In the first chapter, the structural evolution of the small HERC family and related functional changes that have occurred over time …
Rna Virus-Mediated Changes In Organismal Oxygen Consumption Rate In Young And Old Drosophila Melanogaster Males, Eli Hagedorn, Dean Bunnell, Beate Henschel, Daniel Smith Jr, Stephanie Dickinson, Andrew Brown, Maria De Luca, Ashley Turner, Stanislava Chtarbanova
Rna Virus-Mediated Changes In Organismal Oxygen Consumption Rate In Young And Old Drosophila Melanogaster Males, Eli Hagedorn, Dean Bunnell, Beate Henschel, Daniel Smith Jr, Stephanie Dickinson, Andrew Brown, Maria De Luca, Ashley Turner, Stanislava Chtarbanova
Research, Publications & Creative Work
Aging is accompanied by increased susceptibility to infections including with viral pathogens resulting in higher morbidity and mortality among the elderly. Significant changes in host metabolism can take place following virus infection. Efficient immune responses are energetically costly, and viruses divert host molecular resources to promote their own replication. Virus-induced metabolic reprogramming could impact infection outcomes, however, how this is affected by aging and impacts organismal survival remains poorly understood. RNA virus infection of Drosophila melanogaster with Flock House virus (FHV) is an effective model to study antiviral responses with age, where older flies die faster than younger flies due …
The Immune Modulation On Innate Immunity, From Pathogen Recognition To Fungal Clearance., Ko-Wei Liu
The Immune Modulation On Innate Immunity, From Pathogen Recognition To Fungal Clearance., Ko-Wei Liu
Dartmouth College Ph.D Dissertations
The human lung is not sterile but a complex environment with various microorganisms. Besides commensals in the lung, hundreds to thousands of individual microbiomes enter the lung every day but without causing the symptom. Host innate immunity plays an important role in maintaining homeostasis of the lung environment and as the first defense line against pathogens. Aspergillus fumigatus (A. fumigatus) is a saprophytic filamentous fungus that can cause human disease in immune compromised patients. However, with functional innate immunity, immune cells can quickly recognize pathogen associated molecular patterns (PAMPs) from A. fumigatus through pattern recognition receptors (PRRs). The activation of …
Proposing An Rna Interference (Rnai)-Based Treatment For Human Immunodeficiency Virus (Hiv) By Analyzing The Post-Transcriptional Gene Targeting Of Sars-Cov-2, Hepatitis C Virus, And A549 Lung Cancer Cells, Arjun Jagdeesh
Undergraduate Research Posters
Human Immunodeficiency Virus (HIV) is a retrovirus that infects CD4+ T cell lymphocytes in humans, leading to the development of Acquired Immunodeficiency Syndrome (AIDS) if left untreated. While current treatment methods, including antiretroviral combination treatments, effectively limit HIV replication, HIV can evade these treatments due to its high mutation rate. Long-term antiretroviral treatment can also be toxic to patients, meaning patients would benefit from a new mechanism of HIV treatment. RNA interference (RNAi) is an antiviral pathway found in mammals, plants, and insects that involves a small-interfering RNA that is incorporated into a protein complex called the RNA-induced Silencing Complex …