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Immunology of Infectious Disease Commons™
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Full-Text Articles in Immunology of Infectious Disease
Enterobactin-Based Immune Interventions Against Gram-Negative Bacterial Infections, Huiwen Wang
Enterobactin-Based Immune Interventions Against Gram-Negative Bacterial Infections, Huiwen Wang
Doctoral Dissertations
Enterobactin (Ent)-mediated iron acquisition is critical for many Gram-negative bacteria to survive in the host. Given the bacteriostatic effect of lipocalin-2 resulting from its potent Ent-binding ability, immune interventions directly targeting Ent is a promising antimicrobial strategy against Gram-negative bacterial infections. Moreover, hyperimmune egg yolk antibody is an emerging passive immune agent for the control of bacterial infections. Oral administration of anti-Ent egg yolk antibody may confer passive immune protection against Ent-dependent enteric pathogens. In this dissertation study, multidisciplinary approaches in conjunction with different model systems (in vitro, in vivo, and ex vivo) were used to …
Role Of Surface Antigens Of Mycobacterium Spp. In Diagnosis, Ashutosh Wadhwa
Role Of Surface Antigens Of Mycobacterium Spp. In Diagnosis, Ashutosh Wadhwa
Doctoral Dissertations
Mycobacterial species are ubiquitous in nature and a worldwide concern for human and animal health. The major mycobacterial infections in animals are Johne’s disease (JD) and bovine tuberculosis (bTB). Controlling these infections is difficult due to the lack of highly sensitive and sensitive diagnostic test. Currently available diagnostic tests have to be carried out in laboratory settings with well experienced and trained examiners. My goal is to develop a sensitive on-site (in-field) device for diagnosis of Johne’s disease and bovine tuberculosis. The specific aims of this thesis were (1) to review currently-used or recently developed diagnostic tests for mycobacterial infections, …