Immunology and Infectious Disease Commons^™

Hemidiaphragmatic Segmental Zoster Paresis, Terrence Sanvictores, Johnson Ukken

School of Medicine Faculty Research

The reactivation of latent varicella-zoster virus within infected neurons can lead to common clinical manifestations, including rash, acute neuritis, post-herpetic neuralgia, herpes zoster ophthalmicus, and Ramsay–Hunt syndrome. Segmental zoster paresis is an unusual neurologic complication of shingles that is defined by focal asymmetric motor weakness in the myotome corresponding to skin lesions of the dermatome. This case is a presentation of a patient who developed chronic hypoxia and severe atelectasis attributed to right-sided phrenic nerve paralysis secondary to herpes zoster infection.

Mapping Climatic And Environmental Determinants Of Parasitic Helminth Prevalence In Southeast Asia, Angelica Avisado

UNLV Theses, Dissertations, Professional Papers, and Capstones

Climate change is reshaping environmental conditions across Southeast Asia (SEA) through rising temperatures, altered precipitation patterns, and increased droughts. These changes alter transmission dynamics of neglected tropical diseases (NTDs) by shifting spatial distribution, increasing larval development rates, faster pathogen growth development, and increasing transmission rates. NTDs are a group of preventable and treatable infections that disproportionately affect more than 1 billion people globally, specifically in tropical and subtropical regions. A subgroup of NTDs, parasitic helminth infections (PHIs) - particularly schistosomiasis, soil-transmitted helminths, and lymphatic filariasis remains a public health concern in the Southeast Asian region. PHIs and their ecological responses …

Pathway-Based Polygenic Risk Score Analysis Of Brain Glial Indicates Cell-Type-Specific Roles In Alzheimer's Disease, Tyrell Pratt, Alice Lee, Jennifer Zheng, Faria Tavacoli, Hayley Ho, Tingwei Liu, Jingchun Chen

Undergraduate Research Symposium Posters

Background: Alzheimer's disease (AD) is a complex neurodegenerative disorder characterized by progressive cognitive decline and extensive brain pathology, including amyloid plaques, neurofibrillary tangles, and neuroinflammation. This study aims to identify any glial cell type-specific pathways associated with AD.

Methods: We first investigated the correlation between AD and the genetic risk of glia-specific pathways using pathway-based polygenic risk score (PRS) with PRSet software in the discovery data (ADc1234ADA) adjusted by the top two principal components (PC1, PC2) (Model 1), followed by additional adjustment with sex, age, and APOE ε4 count in Model 2. Further PRSet analyses were replicated in independent data …

Glial-Specific Genes Are Strongly Associated With Alzheimer's Disease By Gene-Based Polygenic Risk Score Analysis, Jennifer Zheng, Faria Tavacoli, Tyrell Pratt, Alice Lee, Tingwei Liu, Jingchun Chen

Undergraduate Research Symposium Posters

Methods: Gene-based PRSs were constructed in AD cases and controls within each gene of the glial cells, according to the GWAS summary statistics of European ancestry. In detail, gene-based PRSs were first calculated for each glial cell type-specific gene for AD cases and controls in the discovery dataset (ADc1234ADA) using PRSet software. A meta-analysis with a fixed model was performed when the signal in both datasets was in the same direction. Bonferroni corrections for multiple testing (at α = .05) were used to determine significance within each of the three glial groups. Forest plots were used to visualize the results …

Effect Of Macronutrients On A Rat Model Of Clostridioides Difficile Infection, Stephanie Yang, Maria Niamba, Rose Jiang, Ashton Wippel, Efren Heredia, Liliko Watanabe, Katrina Valadez, Erica Bacab, Ernesto Abel-Santos

Undergraduate Research Symposium Posters

Clostridioides difficile (C. diff) is an anaerobic, spore forming, gram-positive bacteria. C. diff is the causative agent of C. difficile infections (CDIs) and is recognized as the leading cause of nosocomial infective diarrhea worldwide. CDI is associated with the use of antibiotics that alter the gut microbiome and C. diff resides in the large intestine where onset of the disease then occurs. Having observed the impacts of CDI on mice models, the Abel-Santos lab now shifts to observing this infectious disease in rat models. Establishing the infectious dosage at 109 spores, this study aims to identify the correlation between diet …

Nucleic Acid Extraction Of Human Immunodeficiency Virus From Municipal Wastewater, Fritz Vanderford, Hayley Baker, Ching-Lan Chang

Undergraduate Research Symposium Lightning Talks

In 2021, globally there were ~ 38.4 million people living with Human immunodeficiency virus (HIV), ~650,000 people died from acquired immunodeficiency syndrome (AIDS) related illnesses, ~1.5 million people acquired HIV. In the US, ~1.9 million people had HIV at the end of 2019, ~30,635 people were diagnosed with HIV in 2020.

Trends In Utilization Of Human Papillomavirus Vaccines And The Incidence Of Malignant Cervical Cancer In The U.S. Population: A Secondary Analysis, Myah Luna, Soumya Upadhyay

Healthcare Administration and Policy Faculty Research

Background: Human papillomavirus (HPV) is a sexually transmitted infection, and HPV types 16 and 18 are responsible for approximately 66% of all U.S. cervical cancer cases in women. The quadrivalent HPV vaccine was licensed in mid-2006, and it was designed to target and protect against HPV types 6, 11, 16, and 18. The aim of this study is to examine the utilization rate of the HPV vaccine, and the trends and incidence rate of malignant cervical cancer across the United States. Methods: This study utilized data from Surveillance, Epidemiology, and End Results (SEER) and the National Immunization Survey's (NIS) teenage …

Increasing Human Papillomavirus Vaccination Intent And Knowledge Through An Educational Intervention, Angelica E. Musumeci

UNLV Theses, Dissertations, Professional Papers, and Capstones

Human papillomavirus (HPV) is a widely discussed topic in healthcare as it affects patients of all genders and ages who partake in sexual activity. The most significant concern it poses to those at risk is HPV-related cancer. Fortunately, a vaccination exists that targets specific strains associated with these types of cancers. Despite evidence-based research supporting the vaccination’s efficacy and safety, lack of awareness and misinformation diminish the receipt of the vaccine and drive the lack of protection. Thus, educational interventions directed at parents and caregivers, which aims to improve their understanding of HPV and the vaccination’s benefits, is key to …

The Effect Of Covid-19 On The Low-Wage Workforce Nationwide, Katie Gilbertson

Undergraduate Research Symposium Podium Presentations

Key Takeaways: 1. Each low-wage occupation pays less than the mean hourly wage in their respective MSA. 2. Least amount of wage variance among MSAs in 2019. 3. In Las Vegas 2/3 of occupational wages increased, but employment dropped in 14/15 occupations. Leisure and hospitality occupations hardest hit and slowest to recover.

Social Determinants Of Disease: Hiv And Covid-19 Experiences, Raiza M. Beltran, Ian W. Holloway, Chenglin Hong, Ayako Miyashita, Luisita Cordero, Elizabeth Wu, Katherine Burris, Paula M. Frew

Epidemiology & Biostatistics Faculty Research

Purpose of Review: The differential impact of the COVID-19 and HIV pandemics on marginalized communities has renewed calls for more robust and deeper investigation into structural and social causes of health inequities contributing to these infections, including underlying factors related to systematic racism. Using the Social Determinants of Health (SDOH) framework, we analyzed parallel and divergent factors associated with COVID-19 and HIV/AIDS and the prevalence of disparate disease in diverse communities. We utilized PRISMA guidelines to identify relevant literature (N = 210 articles) that resulted in a review of 125 articles included in our synthesis. Recent Findings: With racial health …

Barriers And Facilitators In Rehabilitation In Chronic Diseases And After Surgery: Is It A Matter Of Adherence?, Elijah E. Sanches, Emily Aupers, Nasser Sakran, James Navalta, Tomasz Kostka, Sjaak Pouwels

Kinesiology and Nutrition Sciences Faculty Research

Although it has been generally acknowledged that participating in rehabilitation programs is better for chronic diseases or post-surgery, the adherence rates of these programs remain lower than expected. According to the World Health Organization (WHO), adherence has been defined as follows: "the extent to which a person's behavior corresponds with agreed recommendations from a healthcare provider." In general, rehabilitation is well investigated, and in chronic diseases like chronic obstructive pulmonary disease (COPD), cardiovascular disease, neuromuscular disease, cancer, and even psychiatric diseases like depression, it has been shown that exercise therapy, in particular, has beneficial effects on morbidity, mortality, and convalescence …

The Alzheimer’S Disease Drug Development Landscape, Pieter Van Bokhoven, Arno De Wilde, Lisa Vermunt, Prisca S. Leferink, Sasja Heetveld, Jeffrey Cummings, Philip Scheltens, Everard G.B. Vijverberg

Brain Health Faculty Research

Background: Alzheimer’s disease (AD) is a devastating neurodegenerative disease leading to dementia. The field has made significant progress over the last 15 years. AD diagnosis has shifted from syndromal, based on signs and symptoms, to a biomarker construct based on the pathological hallmarks of the disease: amyloid β deposition, pathologic tau, and neurodegeneration. Numerous genetic risk factors for sporadic AD have been identified, providing further insight into the molecular underpinnings of the disease. For the last two decades, however, drug development for AD has been proven to be particularly challenging. Here, we provide a unique overview of the drug development …

Factors Associated With The Appropriate Use Of Ultra-Broad Spectrum Antibiotics, Meropenem, For Suspected Healthcare-Associated Pneumonia, Nathan Kirsch, Jane Ha, Hee Taik Kang, Tina Frisch, Ji Won Yoo, Craig Grossman, Neema Oroomchi, Hidenobu Shigemitsu, Chad Cross, Mutsumi Kioka

Department of Internal Medicine Faculty Research

ABSTRACT: Pneumonia is a common disease-causing hospitalization. When a healthcare-associated infection is suspected, antibiotics that provide coverage for multi-drug resistant (MDR) or extended-spectrum beta-lactamase (ESBL) bacteria are frequently prescribed. Limited data is available for guidance on using meropenem as a first-line empiric antimicrobial in hospitalized patients with risk factors for MDR/ESBL bacterial infections. This was a single-center, retrospective study designed and conducted to identify factors associated with positive cultures for MDR/ESBL pathogens in hospitalized patients with suspected healthcare-associated pneumonia.Of the 246 patients, 103 patients (41%) received meropenem. Among patients prescribed meropenem, MDR/ESBL pathogens were detected in only 20 patients (13%). …

Covid-19: Tougher On Women?, Aika Dietz

Research Briefs

Women are receiving the worst effects of the COVID-19 recession.

Scald Injury-Induced T Cell Dysfunction Can Be Mitigated By Gr1+ Cell Depletion And Blockage Of Cd47/Cd172a Signaling, Nadine Beckmann, Franziska Huber, Marc Hanschen, Barbara St. Pierre Schneider, Vanessa Nomelli, Charles C. Caldwell

Nursing Faculty Research

Infection is a common and severe complication of burn injury: Sepsis accounts for 47% of postburn mortality. Burn-induced T cell suppression likely contributes to the increased infection susceptibility in burn patients. However, little is known about the kinetics of T cell dysfunction after burn and its underlying mechanisms. In this study, we show in a murine scald injury model that T cell activation of both CD4+ and CD8+ T cells as well as T cell cytokine production is suppressed acutely and persistently for at least 11 days after burn injury. Purified T cells from scald-injured mice exhibit normal T cell …

Comatose Within 6 Weeks, But Still Alive After 3 Years, Creutzfeldt‐Jakob Disease With Unusual Progression, Julia Kathleen Christopher, Brian Khong, Amin Abolfazli, Antonio Liu

School of Medicine Faculty Research

Creutzfeldt‐Jakob disease (CJD) should still be considered in a patient presenting with rapidly progressive dementia and negative CSF 14‐3‐3 protein and RT‐QulC. Treatable causes of encephalopathy must be ruled out. Neurodegenerative diseases must also be considered.

Global Trends And Gaps In Research Related To Latent Tuberculosis Infection, Liling Chaw, Lung-Chang Chien, Justin Wong, Ken Takahashi, David Koh, Ro-Ting Lin

Environmental & Global Health Faculty Research

Background There is a global commitment to eliminating tuberculosis (TB). It is critical to detect and treat cases of latent TB infection (LTBI), the reservoir of new TB cases. Our study assesses trends in publication of LTBI-related research. Methods We used the keywords (“latent tuberculosis” OR “LTBI” OR “latent TB”) to search the Web of Science for LTBI-related articles published 1995–2018, then classified the results into three research areas: laboratory sciences, clinical research, and public health. We calculated the proportions of LTBI-related articles in each area to three areas combined, the average rates of LTBI-related to all scientific and TB-related …

Identifiying High Risk Areas Of Zika Virus Infection By Meteorological Factors In Columbia, Lung-Chang Chien, Francisco Sy, Adriana Perez

Environmental & Global Health Faculty Research

Background Several Zika virus (ZIKV) outbreaks have occurred since October 2015. Because there is no effective treatment for ZIKV infection, developing an effective surveillance and warning system is currently a high priority to prevent ZIKV infection. Despite Aedes mosquitos having been known to spread ZIKV, the calculation approach is diverse, and only applied to local areas. This study used meteorological measurements to monitor ZIKV infection due to the high correlation between climate change and Aedes mosquitos and the convenience to obtain meteorological data from weather monitoring stations. Methods This study applied the Bayesian structured additive regression modeling approach to include …

Patient And Provider Perspectives On How Trust Influences Maternal Vaccine Acceptance Among Pregnant Women In Kenya, Stacy W. Nganga, Nancy A. Otieno, Maxwell Adero, Dominic Ouma, Sandra S. Chaves, Jennifer R. Verani, Marc-Alain Widdowson, Andrew Wilson, Irina Bergenfeld, Courtni Andrews, Vincent L. Fenimore, Ines Gonzalez-Casanova, Paula M. Frew, Saad B. Omer, Fauzia A. Malik

Environmental & Global Health Faculty Research

Background Pregnant women and newborns are at high risk for infectious diseases. Altered immunity status during pregnancy and challenges fully vaccinating newborns contribute to this medical reality. Maternal immunization is a strategy to protect pregnant women and their newborns. This study aimed to find out how patient-provider relationships affect maternal vaccine uptake, particularly in the context of a lower middle- income country where limited research in this area exists. Methods We conducted semi-structured, in-depth narrative interviews of both providers and pregnant women from four sites in Kenya: Siaya, Nairobi, Mombasa, and Marsabit. Interviews were conducted in either English or one …

Surveillance On The Endemic Of Zika Virus Infection By Meteorological Factors In Colombia: A Population-Based Spatial And Temporal Study, Lung-Chang Chien, Ro-Ting Lin, Yunqi Liao, Francisco S. Sy, Adriana Pérez

School of Public Health Faculty Research

Background Zika virus (ZIKV) infection is a pandemic and a public health emergency. It is transmitted by mosquitoes, primarily the Aedes genus. In light of no treatment currently, it is crucial to develop effective vector control programs to prevent the spread of ZIKV infection earlier when observing possible risk factors, such as weather conditions enhancing mosquito breeding and surviving. Methods This study collected daily meteorological measurements and weekly ZIKV infectious cases among 32 departments of Colombia from January 2015–December 2016. This study applied the distributed lag nonlinear model to estimate the association between the number of ZIKA virus infection and …

Nevada Desert Dust With Heavy Metals Suppresses Igm Antibody Production, Deborah E. Keil, Brenda J. Buck, Dirk Goossens, Brett Mclaurin, Lacey Murphy, Mallory Leetham-Spencer, Yuanxin Teng, James E. Pollard, Russell Gerads, Jamie C. Dewitt

Geoscience Faculty Research

Systemic health effects from exposure to a complex natural dust containing heavy metals from the Nellis Dunes Recreation Area (NDRA) near Las Vegas, NV, were evaluated. Several toxicological parameters were examined following lung exposure to emissive dust from three geologic sediment types heavily used for recreational off-road activities: yellow sand very rich in arsenic (termed CBN 5); a shallow cover of loose dune sand overlying a gravelly subsoil bordering dune fields (termed CBN 6); and brown claystone and siltstone (termed CBN 7). Adult female B6C3F1 mice were exposed by oropharyngeal administration to these three types of geogenic dusts at 0.01–100 …

Emerging Infectious Disease And The Imperiled Relict Leopard Frog, Anthony Wayne Waddle

UNLV Theses, Dissertations, Professional Papers, and Capstones

The disease chytridiomycosis, caused by the aquatic fungal pathogen Batrachochytrium dendrobatidis (Bd), has emerged as a major contributing factor for worldwide amphibian declines. Although relatively recently described, the impacts from the disease this pathogen causes have been definitively tied to amphibian declines, including some that occurred decades ago. In some cases, declines of individual species occurred with little documentation and are thus poorly understood. The relict leopard frog (Rana onca = Lithobates onca) has experienced such a decline and by the latter part of the 20th century only occurred in two general areas in southern Nevada. Recent research has found …

Secondary Data Analysis: A Non-Pharmacology Treatment For Individuals Living With Hiv/Aids, Joseph Jean, Carolee Dodge-Francis Ed.D

McNair Poster Presentations

At the end of 2015, 36.7 million people were living with HIV/AIDS world wide (WHO, 2017). Living with this disease puts individuals at increased risk for mental and physical health complications. Opportunistic infections and increased serious mental health conductions are common (NIH, 2016). Advances in antiretroviral therapies have been made to increase life expectancy but often times can adversely affect the individuals quality of life. Complementary and alternative medicine (CAM) is one way to help improve quality of life. One form of CAM, massage therapy may offer benefits to PLWHA in terms of ability to cope with stress.

Leukocyte Responsiveness To Exercise In Hcmv+ Individuals, Jared Nicholas Wilson

UNLV Theses, Dissertations, Professional Papers, and Capstones

Introduction: Emerging research suggests that the lymphocyte immune response during exercise is amplified in individuals who are positive for human cytomegalovirus (HCMV+). However, the responses of monocytes and neutrophils in HCMV+ individuals are unknown. HCMV, a type of herpes virus, infects 50% or more of the adult population in the United States. This virus can become a cause for concern in individuals who have a compromised immune system, which has been shown to occur after high-intensity exercise.

Purpose: The purpose of this study was to characterize the lymphocyte, monocyte, and neutrophil responses to exercise in HCMV+ individuals.

Methods: Participants were …

Lack Of Awareness Of Human Immunodeficiency Virus (Hiv) Infection: Problems And Solutions With Self-Reported Hiv Serostatus Of Men Who Have Sex With Men, Travis H. Sanchez, Colleen F. Kelley, Eli Rosenberg, Nicole Luisi, Brandon O'Hara, Rodriques Lambert, Raphael Coleman, Paula M. Frew, Laura F. Salazar, Sijia Tao, William Clarke, Carlos Del Rio, Patrick S. Sullivan

Environmental & Global Health Faculty Research

Background. Lack of human immunodeficiency virus (HIV) infection awareness may be a driver of racial disparities in HIV infection among men who have sex with men (MSM). Lack of awareness is typically measured by comparing HIV test result to self-reported HIV status. This measure may be subject to reporting bias and alternatives are needed.Methods. The InvolveMENt study examined HIV disparities between black and white MSM from Atlanta. Among HIV-positive participants who did not report knowing they were positive, we examined other measures of awareness: … See full text for complete abstract.

Analysis Of The Morbidity And Mortality Of Severe Influenza Infection In Clark County, Nevada For The 2010-2011 Influenza Season, Kindra St. Jacques, Patricia Cruz, Brian Labus

Nevada Journal of Public Health

Throughout the duration of any influenza season, influenza strains have the ability to evolve through mutation causing alterations in virulence. These changes may result in severe illness or death among susceptible populations; therefore, it is important to closely monitor influenza-associated hospitalizations and deaths. The University of Nevada, Las Vegas in collaboration with the Southern Nevada Health District analyzed data from the hospitalized influenza morbidity and mortality surveillance project for Clark County for the 2010-2011 influenza season. Among the study population (N= 158): the influenza strain type was found to be significantly associated with deaths (n= 25), vaccination status was not …

Understanding Racial Hiv/Sti Disparities In Black And White Men Who Have Sex With Men: A Multilevel Approach, Patrick S. Sullivan, John Peterson, Eli S. Rosenberg, Colleen F. Kelley, Hannah Cooper, Adam Vaughan, Laura F. Salazar, Paula M. Frew, Gina Wingood, Ralph Diclemente, Carlos Del Rio, Mark Mulligan, Travis H. Sanchez

Environmental & Global Health Faculty Research

Background The reasons for black/white disparities in HIV epidemics among men who have sex with men have puzzled researchers for decades. Understanding reasons for these disparities requires looking beyond individual-level behavioral risk to a more comprehensive framework. Methods and Findings

From (Un)Willingness To Involvement: Development Of A Successful Study Brand For Recruitment Of Diverse Msm To A Longitudinal Hiv Research, Paula M. Frew, Victoria A. Williams, Eve T. Shapiro, Travis Sanchez, Eli S. Rosenberg, Vincent L. Fenimore, Patrick S. Sullivan

Environmental & Global Health Faculty Research

Background. HIV continues to be a major concern among MSM, yet Black MSM have not been enrolled in HIV research studies in proportionate numbers to White MSM. We developed an HIV prevention research brand strategy for MSM. Methods. Questionnaires and focus groups were conducted with 54 participants. Descriptive statistics and chi-square analyses were performed and qualitative data were transcribed and content analyzed to identify common themes. Results. Formative research results indicated that younger Black MSM (18–29 years) were less likely to think about joining prevention studies compared to older (≥30 years) Black MSM (, ). Qualitative and quantitative results indicate …

Enrollment In Yfv Vaccine Trial: An Evaluation Of Recruitment Outcomes Associated With A Randomized Controlled Double-Blind Trial Of A Live Attenuated Yellow Fever Vaccine, Paula M. Frew, Eve T. Shapiro, Lu Lu, Srilatha Edupuganti, Harry L. Keyserling, Mark J. Mulligan

Environmental & Global Health Faculty Research

This investigation evaluated several factors associated with diverse participant enrollment of a clinical trial assessing safety, immunogenicity, and comparative viremia associated with administration of 17-D live, attenuated yellow fever vaccine given alone or in combination with human immune globulin. We obtained baseline participant information (e.g., sociodemographic, medical) and followed recruitment outcomes from 2005 to 2007. Of 355 potential Yellow Fever vaccine study participants, 231 cases were analyzed. Strong interest in study participation was observed among racial and ethnically diverse persons with 36.34% eligible following initial study screening, resulting in 18.75% enrollment. The percentage of white participants increased from 63.66% (prescreened …

Measuring Population Transmission Potential For Hiv: An Alternative Metric Of Transmission Risk In Men Who Have Sex With Men (Msm) In The Us, Colleen F. Kelley, Eli S. Rosenberg, Brandon M. O'Hara, Paula M. Frew, Travis Sanchez, John L. Peterson, Carlos Del Rio, Patrick S. Sullivan

Environmental & Global Health Faculty Research

Background Various metrics for HIV burden and treatment success [e.g. HIV prevalence, community viral load (CVL), population viral load (PVL), percent of HIV-positive persons with undetectable viral load] have important public health limitations for understanding disparities. Methods and Findings Using data from an ongoing HIV incidence cohort of black and white men who have sex with men (MSM), we propose a new metric to measure the prevalence of those at risk of transmitting HIV and illustrate its value. …See full text for complete abstract.