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Immunology and Infectious Disease Commons™
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Articles 1 - 30 of 244
Full-Text Articles in Immunology and Infectious Disease
Behavioral Interactions Between Spotted-Wing Drosophila (Drosophila Suzukii) And It's Parasitoid The Samba Wasp (Ganaspis Brasiliensis), Dominic Crowley
Behavioral Interactions Between Spotted-Wing Drosophila (Drosophila Suzukii) And It's Parasitoid The Samba Wasp (Ganaspis Brasiliensis), Dominic Crowley
Honors College
Past research has found that female Drosophila generally decrease their reproductive output in response to exposure to predators, including parasitoid wasps. However, no studies on behavioral changes induced by the endoparasitic wasp Ganaspis brasiliensis have been documented in the literature. G. brasiliensis has been identified as a biocontrol agent candidate against D. suzukii, with field trials currently underway across the contiguous United States. In this thesis, two experiments were performed: a behavioral observation assay measuring reproductive behaviors and an oviposition assay, a measure of reproductive activity. Female D. suzukii exposed to G. brasiliensis were observed to have depressed oviposition, producing …
Endothelial Interleukin-17 Receptor D (Il17rd) Promotes Western Diet-Induced Aortic Myeloid Cell Infiltration, Shivangi Pande
Endothelial Interleukin-17 Receptor D (Il17rd) Promotes Western Diet-Induced Aortic Myeloid Cell Infiltration, Shivangi Pande
Electronic Theses and Dissertations
The Interleukin-17 (IL17) family is a group of cytokines implicated in the etiology of several inflammatory diseases. Interleukin-17 receptor D (IL17RD), also known as Sef (similar expression to fibroblast growth factor), belonging to the family of IL17 receptors, has been shown to modulate IL17A-associated inflammatory phenotypes. The objective of this study was to test the hypothesis that IL17RD promotes endothelial cell activation and consequent monocyte adhesion. We utilized primary human aortic endothelial cells and demonstrated that RNAi targeting of IL17RD suppressed transcript levels by 83% compared to non-targeted controls. Further, RNAi knockdown of IL17RD decreased the adhesion of THP-1 cells …
Biophysical Factors Impacting Sea Lice Settlement And Survival, Eleanor R. Glahn
Biophysical Factors Impacting Sea Lice Settlement And Survival, Eleanor R. Glahn
Electronic Theses and Dissertations
Atlantic salmon (Salmo salar L.) aquaculture production in Maine is a valuable contributor to the economy, the expansion of which has been challenged by the parasitic salmon louse Lepeophtheirus salmonis. As planktonic organisms, the life of the salmon louse is primarily dictated by the physical conditions of the environment: the temperature for development time, salinity for survival, and current velocity for transport. Salmon lice are obligate parasites for whom the successful infection of a suitable host is critical to completion of their life cycle. However, little is understood about the effects of current velocity on infection success. Hydrodynamic …
Weaving An Interdisciplinary Microbiome Career Using Threads From Different Ecosystems, Sarah Hosler
Weaving An Interdisciplinary Microbiome Career Using Threads From Different Ecosystems, Sarah Hosler
Electronic Theses and Dissertations
Animals have trillions of microorganisms living in or on many body sites, these communities of microorganisms are called microbiomes. Microbiomes are typically host-specific, and a lot of information about the host can be determined from investigating them. Microbiome research has many real-world applications, and this thesis utilizes the One Health perspective, which acknowledges the connection of humans, animals, and environments, and emphasizes the need for collaborative, interdisciplinary research. The first interdisciplinary project is an investigation into the bacteria in wild and cultured Atlantic deep-sea scallop, Placopecten magellanicus larvae. Adults in hatcheries can be induced to spawn, but the last two …
Human Cryptosporidiosis: A Review And Staining Method, Amatullah Ahmad
Human Cryptosporidiosis: A Review And Staining Method, Amatullah Ahmad
Honors College
Cryptosporidiosis is increasingly emerging as the most significant cause of infectious diarrhea in humans and livestock. In humans, studies show that Cryptosporidiosis disease is more prevalent in the immunocompromised and young ones. However, outbreaks from contaminated water sources have caused disease in healthy adults, too. Two main species of the protozoan causative agent,Cryptosporidium parvum and Cryptosporidium hominis are responsible for most human infections. Cattle, pets, mice, and other livestock can transmit theCryptosporidiumparvumvariantsto humans through fecal transmission. Other species of Cryptosporidium can infect domestic animals, but their host range is narrow; therefore, they are not of significant concern to human health. …
The Incidence Of Staphylococcus Aureus Mastitis In Maine Dairy Cattle, Morgan Belvin
The Incidence Of Staphylococcus Aureus Mastitis In Maine Dairy Cattle, Morgan Belvin
Honors College
This project investigated the factors surrounding the incidence of Staphylococcus aureus (SA) mastitis in Maine dairy cattle. This type of mastitis is driven by an antibiotic resistant pathogen that is very contagious among cattle, though farmers are often unaware of how common this type of mastitis is and that it could be present in their herds. My hypothesis was that specific farm factors, like milkers performing other tasks during milking, as well as the act of pre-dipping versus not pre-dipping, would explain the increase in SA mastitis. A thirty-seven-question IRB-approved survey was subsequently distributed to farmers in the University of …
Retroviral Infection Dynamics In Maine's Wild Turkeys, Stephanie A. Shea
Retroviral Infection Dynamics In Maine's Wild Turkeys, Stephanie A. Shea
Electronic Theses and Dissertations
Widespread wild turkey reintroductions in the late 1900s have led to increases in population density and geographic distribution across North America. This rapid population expansion has put them into proximity with closely-related wild and domestic avian species, increasing the risks of pathogen transmission. Lymphoproliferative disease virus (LPDV) is an avian oncogenic retrovirus detected in wild turkeys in 2009, and previously known to infect domestic turkeys. Following its initial detection, surveys reported variable LPDV prevalence across eastern North America with most wild turkeys being asymptomatic, however diagnostic cases revealed 10% mortality of LPDV-infected individuals. Given its recent detection, little is known …
Impact Of Probiotics On Black Soldier Fly Larvae Transmission Of Stenotrophomonas Maltophilia, Emily Marie Mclaughlin
Impact Of Probiotics On Black Soldier Fly Larvae Transmission Of Stenotrophomonas Maltophilia, Emily Marie Mclaughlin
Honors College
Stenotrophomonas maltophilia is an opportunistic pathogen which can cause a variety of infections, especially in immunocompromised individuals. It has recently been found that black soldier flies can act as carriers for S. maltophilia (Callegari et al., 2020). I have investigated how probiotics impact their vector capabilities. Black soldier fly larvae have been fed substrate spiked with S. maltophilia. After several days of feeding, the larvae were investigated by PCR and plating (Sveensson-Stadler et al., 2011). Two groups of larvae were fed with potatoes infected with S. maltophilia. Persistence of S. maltophilia was determined using PCR by taking samples …
Deciphering The Perpetual Fight Between Virus And Host: Utilizing Bioinformatics To Elucidate The Host's Genetic Mechanisms That Influence Jc Polyomavirus Infection, Michael P. Wilczek
Deciphering The Perpetual Fight Between Virus And Host: Utilizing Bioinformatics To Elucidate The Host's Genetic Mechanisms That Influence Jc Polyomavirus Infection, Michael P. Wilczek
Electronic Theses and Dissertations
JC polyomavirus (JCPyV) is a human-specific pathogen that infects 50-80% of the population, and can cause a deadly, demyelinating disease, known as progressive multifocal leukoencephalopathy (PML). In most of the population, JCPyV persistently infects the kidneys but during immunosuppression, it can reactivate and spread to the central nervous system (CNS), causing PML. In the CNS, JCPyV targets two cell types, astrocytes, and oligodendrocytes. Due to the hallmark pathology of oligodendrocyte lysis observed in disease, oligodendrocytes were thought to be the main cell type involved during JCPyV infection. However, recent evidence suggests that astrocytes are targeted by the virus and act …
Lexicographic Sensitivity Functions For Nonsmooth Models In Mathematical Biology, Matthew D. Ackley
Lexicographic Sensitivity Functions For Nonsmooth Models In Mathematical Biology, Matthew D. Ackley
Electronic Theses and Dissertations
Systems of ordinary differential equations (ODEs) may be used to model a wide variety of real-world phenomena in biology and engineering. Classical sensitivity theory is well-established and concerns itself with quantifying the responsiveness of such models to changes in parameter values. By performing a sensitivity analysis, a variety of insights can be gained into a model (and hence, the real-world system that it represents); in particular, the information gained can uncover a system's most important aspects, for use in design, control or optimization of the system. However, while the results of such analysis are desirable, the approach that classical theory …
Biophysical And Stable Isotopic Profiles Of The Salmon Louse Lepeophtheirus Salmonis (Krøyer, 1837), Emma Taccardi
Biophysical And Stable Isotopic Profiles Of The Salmon Louse Lepeophtheirus Salmonis (Krøyer, 1837), Emma Taccardi
Electronic Theses and Dissertations
The salmon louse Lepeophtheirus salmonis is a parasitic copepod that infects wild and farmed salmonids throughout the northern hemisphere. L. salmonis represents the largest economic hurdle of the Atlantic salmon (Salmo salar) industry, with an estimated annual cost of nearly $1 billion globally due to production losses and anti-parasitic control measures. Salmon farming in Maine has existed for decades and is a critical economic driver, yet the region is underrepresented in global sea lice research. The aim of this work was to examine parasites in the context of animal trophic transfer and characterize physiological condition by quantifying the …
The Role Of The Bps Immunity Repressor In The Regulation Of Pathogenic Mycobacterium Chelonae Gene Expression, Emma Freeman
The Role Of The Bps Immunity Repressor In The Regulation Of Pathogenic Mycobacterium Chelonae Gene Expression, Emma Freeman
Honors College
Mycobacterium tuberculosis is the leading cause of death by an infectious disease (MacNeil, 2019). In 2018, 10 million people developed tuberculosis and half a million infections were resistant to antibiotics (WHO, 2019). Nearly all members of the M. tuberculosis complex are lysogens, meaning they carry prophage, or integrated viral genomes within the host genome (Fan et al., 2016). The non-pathogenic vaccine strain (M. bovis Bacillus Calmette–Guérin (BCG)) is the exception, which suggests prophage play a role in virulence (Fan et al., 2016). Because not all prophage encode obvious virulence genes, we hypothesize that prophage impact bacterial virulence by altering bacterial …
Characterization Of Ncf1 Mutants In A Zebrafish Model Of Innate Immune Function With Human Influenza A Virus Infection, Lily Charpentier
Characterization Of Ncf1 Mutants In A Zebrafish Model Of Innate Immune Function With Human Influenza A Virus Infection, Lily Charpentier
Honors College
Seasonal influenza A virus (IAV) infections and their associated respiratory diseases are the cause of an estimated 650,000 deaths each year, according to the World Health Organization. The zebrafish (Danio rerio) is a powerful vertebrate model to study innate immune function and host-pathogen interactions as the function of neutrophils and other phagocytes can be characterized in vivo. Preliminary studies have shown an increase in neutrophil respiratory burst activity to eliminate the invading pathogen, yet little is known of all of the mechanisms involved in neutrophil function. The NADPH oxidase complex, of which neutrophil cytosolic factor 1 (Ncf1) is a key …
In Vivo Imaging Of The Respiratory Burst Response To Influenza A Virus Infection, James Thomas Seuch
In Vivo Imaging Of The Respiratory Burst Response To Influenza A Virus Infection, James Thomas Seuch
Honors College
The CDC estimated that seasonal influenza A virus (IAV) infections resulted in 490,600 hospitalizations and 34,200 deaths in the US in the 2018-2019 season. The longterm goal of our research is to understand how to improve innate immune responses to IAV. During IAV infection, neutrophils and macrophages initiate a respiratory burst response where reactive oxygen species (ROS) are generated to destroy the pathogen and recruit additional immune cells. While ROS molecules, such as hydrogen peroxide, help clear the virus, the signaling cascade can also lead to excess neutrophil recruitment, hyperinflammation, and tissue damage. Regulatory mechanisms that trigger overactivation of neutrophils …
College Of Natural Sciences, Forestry, And Agriculture_Bio 431 Emerging Infectious Diseases Covid-19 Response Email, Allison Gardner
College Of Natural Sciences, Forestry, And Agriculture_Bio 431 Emerging Infectious Diseases Covid-19 Response Email, Allison Gardner
College of Natural Sciences, Forestry, and Agriculture
Email from Allison Gardner, Assistant Professor, School of Biology and Ecology, University of Maine to the Provost Office regarding Professor Gardner's teaching BIO 431 Emerging Infectious Diseases in the Spring 2020 Semester and the incorporation of updates and discussion of COVID-19 into the course. Also, includes submission of interest in teaching a course on the COVID-19 pandemic in Spring 2022.
Identification Of Chromatin Regulators Perturbed In Hematopoietic Stem And Progenitor Cell Aging, Eraj S. Khokhar
Identification Of Chromatin Regulators Perturbed In Hematopoietic Stem And Progenitor Cell Aging, Eraj S. Khokhar
Electronic Theses and Dissertations
As lifespan is increasing globally, there is a critical need to identify strategies to extend healthspan and prevent chronic diseases into older age. The long-term goal of my research is to identify novel strategies to ameliorate aging-induced decline in hematopoietic stem cell (HSC) function. HSCs give rise to all mature blood and immune cells. With age, HSCs undergo defects in their differentiation ability which correlates with a decline in immune function. Comprehensive knowledge of gene regulatory and epigenetic mechanisms underlying this defect is a barrier to developing therapies to ameliorate aging-associated decline in HSC function. Therefore, my project focuses on …
Intravital Imaging In A Zebrafish Model Elucidates Interactions Between Mucosal Immunity And Pathogenic Fungi, Linda S. Archambault
Intravital Imaging In A Zebrafish Model Elucidates Interactions Between Mucosal Immunity And Pathogenic Fungi, Linda S. Archambault
Electronic Theses and Dissertations
Candida yeasts are common commensals that can cause mucosal disease and life-threatening systemic infections. While many of the components required for defense against Candida albicans infection are well established, questions remain about how various host cells at mucosal sites assess threats and coordinate defenses to prevent normally commensal organisms from becoming pathogenic. Using two Candida species, C. albicans and C. parapsilosis, which differ in their abilities to damage epithelial tissues, we used traditional methods (pathogen CFU, host survival, and host cytokine expression) combined with high-resolution intravital imaging of transparent zebrafish larvae to illuminate host-pathogen interactions at the cellular level …
The Infection Dynamics Of Sea Lice On Atlantic Salmon (Salmo Salar) In Cobscook Bay, Maine, Usa, Catherine Anne Frederick
The Infection Dynamics Of Sea Lice On Atlantic Salmon (Salmo Salar) In Cobscook Bay, Maine, Usa, Catherine Anne Frederick
Electronic Theses and Dissertations
Sea lice (Lepeophtheirus and Caligus spp) are parasitic copepods that infect the external surfaces of fish hosts. Salmon lice (L. salmonis) outbreaks are commonly reported by operations in Canada, Norway, Scotland, Ireland, and the United States and are a primary concern in aquaculture because of their fish health and economic impacts. When farmed fish mortalities and treatments are accounted for, annual losses from sea louse infestations exceed $300,000,000 (Costello 2009). Farms experiencing sea lice infections risk on-site re-infection and transmission to wild populations and other farms that are hydrographically connected. In Maine, Atlantic salmon farms are located in the northeast, …
Host Mediated Mechanisms Of Fungal Cell Spread In A Transparent Zebrafish Infection Model, Allison Scherer
Host Mediated Mechanisms Of Fungal Cell Spread In A Transparent Zebrafish Infection Model, Allison Scherer
Electronic Theses and Dissertations
Innate immunity has developed elegant processes for the detection and clearance of invasive fungal pathogens. Disseminated candidiasis is of significant concern for those with suppressed immune systems or indwelling medical equipment, and mortality in these groups approaches 70%. Poor patient outcomes have spurred the need to understand how this non-motile pathogen spreads in the host. Technical limitations have previously hindered our ability to visualize the role of innate immunity and host tissue barriers in the spread of C. albicans in vivo. Using the zebrafish model to overcome these limitations, we have examined three potential host-mediated mechanisms of dissemination: movement …
The Effect Of Wild Blueberry Anthocyanins And Phenolic Acids On Innate Immunity: The Compliment System, Vasiliki Papakotsi
The Effect Of Wild Blueberry Anthocyanins And Phenolic Acids On Innate Immunity: The Compliment System, Vasiliki Papakotsi
Electronic Theses and Dissertations
Ingestion of berries containing polyphenols is associated with lower risk of inflammatory, metabolic, cardiovascular and degenerative diseases. Diet has been shown to modulate the activation of the complement system, a set of over 50 proteins present in the circulation and tissues that reacts in response to damage or microbial encounter and is critical for the maintenance of homeostasis. Imbalanced activation is tightly correlated with inflammation and various pathologies. Wild blueberries are a rich source of anthocyanins and phenolic acids, which can be found in plasma shortly after consumption. Given the involvement of both complement and polyphenols in the modulation of …
Investigating Present-Day Health Issues Of The American Lobster (Homarus Americanus), Deborah A. Bouchard
Investigating Present-Day Health Issues Of The American Lobster (Homarus Americanus), Deborah A. Bouchard
Electronic Theses and Dissertations
The American lobster, Homarus americanus, H. Milne Edwards, 1837, supports the most economically valuable fishery along the North Atlantic coast of North America. A collapse in lobster populations in Southern New England (SNE) has coincided with increasing ocean temperatures and emerging diseases. This research investigated the etiologies of limp lobster disease (LLD) and epizootic shell disease (ESD), two diseases that continue to cause significant mortality in natural lobster populations. Mortality from LLD is associated with the bacteria Photobacterium indicum and is more intense in impounded lobsters. To more clearly define the community ecology of this suspected opportunistic pathogen, the microbial …
Toward Chagas Disease Elimination: Neonatal Screening For Congenital Transmission In Rural Communities, Pamela Marie Pennington, Jose Guillermo Juarez, Margarita Rivera Arrivillaga, Sandra De Urioste-Stone, Katherine Doktor, Joe P. Bryan, Clara Yaseli Escobar, Celia Cordon-Rosales
Toward Chagas Disease Elimination: Neonatal Screening For Congenital Transmission In Rural Communities, Pamela Marie Pennington, Jose Guillermo Juarez, Margarita Rivera Arrivillaga, Sandra De Urioste-Stone, Katherine Doktor, Joe P. Bryan, Clara Yaseli Escobar, Celia Cordon-Rosales
Forest Resources Faculty Scholarship
Chagas disease is a neglected tropical disease that continues to affect populations living in extreme poverty in Latin America. After successful vector control programs, congenital transmission remains as a challenge to disease elimination. We used the PRECEDE-PROCEED planning model to develop strategies for neonatal screening of congenital Chagas disease in rural communities of Guatemala. These communities have persistent high triatomine infestations and low access to healthcare. We used mixed methods with multiple stakeholders to identify and address maternal-infant health behaviors through semi-structured interviews, participatory group meetings, archival reviews and a cross-sectional survey in high risk communities. From December 2015 to …
Expression Profiling Of Non-Coding Rna By Environmental Interactions In Innate Immunity, Jacob R. Longfellow
Expression Profiling Of Non-Coding Rna By Environmental Interactions In Innate Immunity, Jacob R. Longfellow
Electronic Theses and Dissertations
Cystic fibrosis (CF) is a genetic disorder that affects 30,000 people in the United States and currently has no cure. Although CF affects all of the body’s systems, it is largely characterized as a lung disease. CF is caused by a mutation in both copies of the gene for cystic fibrosis transmembrane conductance regulator (CFTR). A mutation in the CFTR gene leads to improper movement of chloride ions and water into the airways, which dysregulates the airway surface liquid volume and composition. Individuals with CF are prone to lung infections due to inefficient bacterial clearance and by the age of …
Dynamic Host-Pathogen Interactions Result In Fungal Epitope Unmasking, Alex Hopke
Dynamic Host-Pathogen Interactions Result In Fungal Epitope Unmasking, Alex Hopke
Electronic Theses and Dissertations
Molecular camouflage is used by a diverse set of pathogens to disguise their identity and avoid recognition by protective host receptors. The opportunistic fungal pathogen Candida albicans is a good example, as it masks the inflammatory component β-glucan in its cell wall to evade detection by the immune receptor Dectin-1. Interestingly, it has been seen that β-glucan becomes unmasked during infection in vivo, though the underlying mechanisms remained unclear. Exposure levels of this epitope may be important, as Dectin-1 mediates protection from some strains of C. albicans and alterations in the organization and composition of the Candida cell wall …
Infectious Spleen And Kidney Necrosis Virus (Isknv) Used A Novel Strategy To Modulate The Mitochondria/ Caspases -Mediated Cell Death Pathway Via Ros Signaling In A Fish Cell Line, Jiann R. Hong
2nd International Conference of Fish & Shellfish Immunology
No abstract provided.
Mannose-Specific Immunoglobulin M In The Mucus Of Fugu Takifugu Rubripes Is Utilized By A Monogenean Parasite Heterobothrium Okamotoi For Host Recognition, Shigeyuki Tsutsui
Mannose-Specific Immunoglobulin M In The Mucus Of Fugu Takifugu Rubripes Is Utilized By A Monogenean Parasite Heterobothrium Okamotoi For Host Recognition, Shigeyuki Tsutsui
2nd International Conference of Fish & Shellfish Immunology
No abstract provided.
Effects Of Piscine Reovirus Infection On Innate Immune Signalling In Salmon, Mark Polinski
Effects Of Piscine Reovirus Infection On Innate Immune Signalling In Salmon, Mark Polinski
2nd International Conference of Fish & Shellfish Immunology
No abstract provided.
Disparate Developmental Patterns Of Immune Responses To Bacterial And Viral Infections In Fish, Pierre Boudinot
Disparate Developmental Patterns Of Immune Responses To Bacterial And Viral Infections In Fish, Pierre Boudinot
2nd International Conference of Fish & Shellfish Immunology
No abstract provided.
Immune Responses To Alum In The Japanese Pufferfish (Takifugu Rubripes), Masahiro Sakai, Takashi Morimoto, Gouranga Biswas, Tomoya Kono, Jun-Ichi Hikima Dr.
Immune Responses To Alum In The Japanese Pufferfish (Takifugu Rubripes), Masahiro Sakai, Takashi Morimoto, Gouranga Biswas, Tomoya Kono, Jun-Ichi Hikima Dr.
2nd International Conference of Fish & Shellfish Immunology
No abstract provided.
Looking Through Transgenic Zebrafish To Reveal Novel Mechanisms Of Host-Parasite Interaction: In Vivo Real-Time Imaging Of A Trypanosome Infection, Maria Forlenza
2nd International Conference of Fish & Shellfish Immunology
No abstract provided.