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Full-Text Articles in Immunology and Infectious Disease

Concepts In Animal Parasitology, Chapter 11: Trypanosoma (Genus) [Protozoa, Trypanosomatidae], Ana Maria Jansen, Samanta C. Chagas Xavier, André Luiz Rodrigues Roque Jan 2024

Concepts In Animal Parasitology, Chapter 11: Trypanosoma (Genus) [Protozoa, Trypanosomatidae], Ana Maria Jansen, Samanta C. Chagas Xavier, André Luiz Rodrigues Roque

Concepts in Animal Parasitology

An overview of the genus Trypanosoma, protozoan flagellate parasites. Covers the classification, development, life cycles, and effect on human and domestic animal health.

Chapter 11 in Concepts in Animal Parasitology on the genus Trypanosoma by Ana Maria Jansen, Samanta C. Chagas Xavier, and André Luiz Rodrigues Roque. 2024. S. L. Gardner and S. A. Gardner, editors. Zea Books, Lincoln, Nebraska, United States. doi: 10.32873/unl.dc.ciap011


Concepts In Animal Parasitology, Chapter 12: Leishmania (Genus) And Leishmaniasis [Protozoa, Trypanosomatidae], Mary Ann Mcdowell, Jennifer Robichaud Jan 2024

Concepts In Animal Parasitology, Chapter 12: Leishmania (Genus) And Leishmaniasis [Protozoa, Trypanosomatidae], Mary Ann Mcdowell, Jennifer Robichaud

Concepts in Animal Parasitology

An overview of the genus Leishmania, protozoan flagellate parasites. Covers the classification, development, life cycles, and effect on human and domestic animal health, including a discussion of the human disease leishmaniasis as well as animal models and immunology.

Chapter 12 in Concepts in Animal Parasitology on the genus Leishmania and leishmaniasis by Mary Ann McDowell and Jennifer Robichaud. 2024. S. L. Gardner and S. A. Gardner, editors. Zea Books, Lincoln, Nebraska, United States. doi: 10.32873/unl.dc.ciap012


Concepts In Animal Parasitology, Chapter 13: Myxozoa (Subphylum), Terrence L. Miller Jan 2024

Concepts In Animal Parasitology, Chapter 13: Myxozoa (Subphylum), Terrence L. Miller

Concepts in Animal Parasitology

Recent phylogenetic and protein expression analyses have revealed the diverse group of obligate endoparasites of the subphylum Myxozoa are morphologically simplified, although highly specialized, cnidarians. Covered here are the classification and host associations of these animals, life cycle stages, infection dynamics, diagnostics, and the effect on aquatic host animal health, including whirling disease.

Chapter 13 in Concepts in Animal Parasitology on the subphylum Myxozoa by Terrence L. Miller. 2024. S. L. Gardner and S. A. Gardner, editors. Zea Books, Lincoln, Nebraska, United States. doi: 10.32873/unl.dc.ciap013


Concepts In Animal Parasitology, Chapter 14: Mesozoa (Phylum Dicyemida And Phylum Orthonecta) [Mesozoa], Sarah R. Catalano Jan 2024

Concepts In Animal Parasitology, Chapter 14: Mesozoa (Phylum Dicyemida And Phylum Orthonecta) [Mesozoa], Sarah R. Catalano

Concepts in Animal Parasitology

An overview of the Mesozoa, parasites of marine invertebrates such as squid, octopus, and cuttlefish. Discusses the taxonomic classification, position in the Tree of Life, morphology, life cycle (inlcuding the secondary nematogen), hosts, patterns of infection, and molecular analyses, collection, and staining methods.

Chapter 14 in Concepts in Animal Parasitology on the Mesozoa (phylum Dicyemida and phylum Orthonectida) by Sarah R. Catalano. 2024. S. L. Gardner and S. A. Gardner, editors. Zea Books, Lincoln, Nebraska, United States. doi: 10.32873/unl.dc.ciap014


Concepts In Animal Parasitology, Chapter 15: Introduction To Endoparasitic Platyhelminths (Phylum Platyhelminthes), Larry S. Roberts, John J. Janovy Jr., Steven A. Nadler, Scott L. Gardner Jan 2024

Concepts In Animal Parasitology, Chapter 15: Introduction To Endoparasitic Platyhelminths (Phylum Platyhelminthes), Larry S. Roberts, John J. Janovy Jr., Steven A. Nadler, Scott L. Gardner

Concepts in Animal Parasitology

An introduction to the endoparasitic forms of platyhelminths, referred to colloquially at times as flatworms. Platyhelminths include monogeneans, cestodes (tapeworms), and trematodes (flukes). Covers their general morphology and a brief overview of their systematics.

Chapter 15 in Concepts in Animal Parasitology, an introduction to endoparasitic platyhelminths, by Larry S. Roberts, John J. Janovy, Jr., Steve Nadler, and Scott L. Gardner. 2024. S. L. Gardner and S. A. Gardner, editors. Zea Books, Lincoln, Nebraska, United States. doi: 10.32873/unl.dc.ciap015


Concepts In Animal Parasitology, Chapter 16: Introduction To Cestodes (Class Cestoda) [Platyhelminthes, Cestoda], Scott L. Gardner Jan 2024

Concepts In Animal Parasitology, Chapter 16: Introduction To Cestodes (Class Cestoda) [Platyhelminthes, Cestoda], Scott L. Gardner

Concepts in Animal Parasitology

An overview of cestodes (tapeworms) focusing on a description of their general morphology.

Chapter 16 in Concepts in Animal Parasitology, an introduction to cestodes (class Cestoda), by Scott L. Gardner. 2024. S. L. Gardner and S. A. Gardner, editors. Zea Books, Lincoln, Nebraska, United States. doi: 10.32873/unl.dc.ciap016


Concepts In Animal Parasitology, Chapter 18: Taenia (Genus) [Platyhelminthes, Cestoda, Eucestoda], Sumiya Ganzorig, Scott L. Gardner Jan 2024

Concepts In Animal Parasitology, Chapter 18: Taenia (Genus) [Platyhelminthes, Cestoda, Eucestoda], Sumiya Ganzorig, Scott L. Gardner

Concepts in Animal Parasitology

Discusses the cestode (tapeworm) genus Taenia, several species of which infect humans, including their general morphology, the asexual reproduction of the metacestodes, identifcation, systematics, phylogeny, distribution, hosts, and their medical and veterinary importance.

Chapter 18 in Concepts in Animal Parasitology on the genus Taenia by Sumiya Ganzorig and Scott L. Gardner. 2024. S. L. Gardner and S. A. Gardner, editors. Zea Books, Lincoln, Nebraska, United States. doi: 10.32873/unl.dc.ciap018


Concepts In Animal Parasitology, Chapter 19: Echinococcus (Genus) [Platyhelminthes, Cestoda, Eucestoda], Akira Ito, Scott L. Gardner Jan 2024

Concepts In Animal Parasitology, Chapter 19: Echinococcus (Genus) [Platyhelminthes, Cestoda, Eucestoda], Akira Ito, Scott L. Gardner

Concepts in Animal Parasitology

Discusses the cestode (tapeworm) genus Echinococcus, several species of which infect humans, including their general morphology, taxonomy, systematics, life cycles, host range, and medical and veterinary importance.

Chapter 19 in Concepts in Animal Parasitology on the family Proteocephalidae La Rue, 1911 by Tomáš Scholz and Roman Kuchta. 2024. S. L. Gardner and S. A. Gardner, editors. Zea Books, Lincoln, Nebraska, United States. doi: 10.32873/unl.dc.ciap019


Concepts In Animal Parasitology, Chapter 20: Proteocephalidae La Rue, 1911 (Family) [Platyhelminthes, Cestoda, Eucestoda], Tomáš Scholz, Roman L. Kuchta Jan 2024

Concepts In Animal Parasitology, Chapter 20: Proteocephalidae La Rue, 1911 (Family) [Platyhelminthes, Cestoda, Eucestoda], Tomáš Scholz, Roman L. Kuchta

Concepts in Animal Parasitology

An overview of the cestode (tapeworm) family Proteocephalidae La Rue, 1911, including a discussion of the current classification, general morphology, species diversity, life cycles, host associations, geographical distribution, phylogenetic relationships, and selected Nearctic taxa.

Chapter 20 in Concepts in Animal Parasitology on the family Proteocephalidae La Rue, 1911 by Tomáš Scholz and Roman Kuchta. 2024. S. L. Gardner and S. A. Gardner, editors. Zea Books, Lincoln, Nebraska, United States. doi: 10.32873/unl.dc.ciap020


Concepts In Animal Parasitology, Chapter 21: Bothriocephalidea Kuchta Et Al., 2008 (Order) [Platyhelminthes, Cestoda, Eucestoda], Jorge Falcón-Ordaz, Luis García-Prieto Jan 2024

Concepts In Animal Parasitology, Chapter 21: Bothriocephalidea Kuchta Et Al., 2008 (Order) [Platyhelminthes, Cestoda, Eucestoda], Jorge Falcón-Ordaz, Luis García-Prieto

Concepts in Animal Parasitology

An overview of the cestode (tapeworm) order Bothriocephalidea Kuchta et al., 2008, including a discussion of the main morphological characteristics, the description and summary of a representative species, Schyzocotyle acheilognathi (Yamaguti, 1934) Brabec et al., 2015 (also known as the Asian fish tapeworm), including its prevalence, life cycles, host range, and zoogeography.

Chapter 21 in Concepts in Animal Parasitology by Jorge Falcón-Ordaz and Luis García-Prieto. 2024. S. L. Gardner and S. A. Gardner, editors. Zea Books, Lincoln, Nebraska, United States. doi: 10.32873/unl.dc.ciap021


Concepts In Animal Parasitology, Chapter 22: Diphyllobothriidea Kuchta Et Al., 2008 (Order): The Broad Tapeworms [Platyhelminthes, Cestoda, Eucestoda], Tomáš Scholz, Roman L. Kuchta Jan 2024

Concepts In Animal Parasitology, Chapter 22: Diphyllobothriidea Kuchta Et Al., 2008 (Order): The Broad Tapeworms [Platyhelminthes, Cestoda, Eucestoda], Tomáš Scholz, Roman L. Kuchta

Concepts in Animal Parasitology

Broad tapeworms are among the largest tapeworms on Earth and some species have been known as human parasites for a long time. However, species diversity of these usually large-sized tapeworms is still poorly known, partly because of the existence of numerous unresolved taxonomic problems. They currently get some attention due to several cases of human infection in non-endemic areas due to importation of unfrozen fish.

Includes an overview of the cestode order Diphyllobothriidea Kuchta et al., 2008, the group's taxonomic history, current classification, general morphology, species diversity, life cycles, host associations, geographic distribution, phylogenetic relationships, and selected taxa from the …


Concepts In Animal Parasitology, Chapter 17: Cyclophyllidea Beneden In Braun, 1900 (Order) [Platyhelminthes, Cestoda, Eucestoda], Scott L. Gardner Jan 2024

Concepts In Animal Parasitology, Chapter 17: Cyclophyllidea Beneden In Braun, 1900 (Order) [Platyhelminthes, Cestoda, Eucestoda], Scott L. Gardner

Concepts in Animal Parasitology

A very brief overview of the Cyclophyllidea, an order of cestode (tapeworm) parasites that includes important human pathogens, including the genera Hymenolepis, Taenia, and Echinococcus.

Chapter 17 in Concepts in Animal Parasitology, by Scott L. Gardner. 2024. S. L. Gardner and S. A. Gardner, editors. Zea Books, Lincoln, Nebraska, United States. doi: 10.32873/unl.dc.ciap017


Concepts In Animal Parasitology, Chapter 23: Trypanorhyncha Diesing, 1863 (Order) [Platyhelminthes, Cestoda, Eucestoda], Francisco Zaragoza-Tapia, Scott Monks Jan 2024

Concepts In Animal Parasitology, Chapter 23: Trypanorhyncha Diesing, 1863 (Order) [Platyhelminthes, Cestoda, Eucestoda], Francisco Zaragoza-Tapia, Scott Monks

Concepts in Animal Parasitology

An overview of the cestode (tapeworm) order Trypanorhyncha Diesing, 1863, common parasites of marine fish, including general morphology, taxonomy, phylogenetic relationships, lists of genera within the subordinate superfamilies, and their life cycle and zoogeography.

Chapter 23 in Concepts in Animal Parasitology by Francisco Zaragoza-Tapia and Scott Monks. 2024. S. L. Gardner and S. A. Gardner, editors. Zea Books, Lincoln, Nebraska, United States. doi: 10.32873/unl.dc.ciap023


Concepts In Animal Parasitology, Chapter 24: Cathetocephalidea Schmidt And Beveridge, 1990 (Order) [Platyhelminthes, Cestoda, Eucestoda], Luis García-Prieto, Omar Lagunas-Calvo, Brenda Atziri García-García, Berenice Adán-Torres Jan 2024

Concepts In Animal Parasitology, Chapter 24: Cathetocephalidea Schmidt And Beveridge, 1990 (Order) [Platyhelminthes, Cestoda, Eucestoda], Luis García-Prieto, Omar Lagunas-Calvo, Brenda Atziri García-García, Berenice Adán-Torres

Concepts in Animal Parasitology

An overview of the cestode (tapeworm) order Cathetocephalidea Schmidt and Beveridge, 1990, parasites of the spiral intestine (also called the spiral valve) of sharks. Includes a discussion of their main morphological characteristics, the species in the order, a description and summary of a representative species, Cathetocephalus resendezi Caira et al., 2005, and life cycles.

Chapter 24 in Concepts in Animal Parasitology by Luis García-Prieto, Omar Lagunas-Calvo, Brenda Atziri García-García, and Berenice Adán-Torres. 2024. S. L. Gardner and S. A. Gardner, editors. Zea Books, Lincoln, Nebraska, United States. doi: 10.32873/unl.dc.ciap024


Concepts In Animal Parasitology, Chapter 25: Diphyllidea Van Beneden In Carus, 1863 (Order) [Platyhelminthes, Cestoda, Eucestoda], Luis García-Prieto, Brenda Atziri García-García, Omar Lagunas-Calvo, Berenice Adán-Torres Jan 2024

Concepts In Animal Parasitology, Chapter 25: Diphyllidea Van Beneden In Carus, 1863 (Order) [Platyhelminthes, Cestoda, Eucestoda], Luis García-Prieto, Brenda Atziri García-García, Omar Lagunas-Calvo, Berenice Adán-Torres

Concepts in Animal Parasitology

An overview of the cestode (tapeworm) order Diphyllidea van Beneden in Carus, 1863, a group of small and polyzoic cestodes inhabiting the spiral valve of elasmobranchs that occurs worldwide. Includes a discussion of the main morphological characteristics, species in the order, including a description and summary of a representative species, Halysioncum mexicanum (Tyler & Caira, 1999) Caira et al., 2013, and the life cycle.

Chapter 25 in Concepts in Animal Parasitology by Luis García-Prieto, Brenda Atziri García-García, Omar Lagunas-Calvo, and Berenice Adán-Torres. 2024. S. L. Gardner and S. A. Gardner, editors. Zea Books, Lincoln, Nebraska, United States. doi: 10.32873/unl.dc.ciap025


Concepts In Animal Parasitology, Chapter 26: Lecanicephalidea Hyman, 1951 (Order) [Platyhelminthes, Cestoda, Eucestoda], Luis García-Prieto, Berenice Adán-Torres, Omar Lagunas-Calvo, Brenda Atziri García-García Jan 2024

Concepts In Animal Parasitology, Chapter 26: Lecanicephalidea Hyman, 1951 (Order) [Platyhelminthes, Cestoda, Eucestoda], Luis García-Prieto, Berenice Adán-Torres, Omar Lagunas-Calvo, Brenda Atziri García-García

Concepts in Animal Parasitology

An overview of the cestode (tapeworm) order Lecanicephalidea Hyman, 1951, mainly parasites of the spiral intestine of batoid elasmobranchs, with worldwide distribution. Includes discussion of their main morphological characteristics, taxonomy, description and summary of a representative species, Aberrapex senticosum Jensen, 2001, and life cycles. These worms are remarkably diverse in their morphology.

Chapter 26 in Concepts in Animal Parasitology by Luis García-Prieto, Berenice Adán-Torres, Omar Lagunas-Calvo, and Brenda Atziri García-García. 2024. S. L. Gardner and S. A. Gardner, editors. Zea Books, Lincoln, Nebraska, United States. doi: 10.32873/unl.dc.ciap026


Concepts In Animal Parasitology, Chapter 28: Phyllobothriidea Caira Et Al., 2014 (Order) [Platyhelminthes, Cestoda, Eucestoda], Brenda Atziri García-García, Omar Lagunas-Calvo, Berenice Adán-Torres, Luis García-Prieto Jan 2024

Concepts In Animal Parasitology, Chapter 28: Phyllobothriidea Caira Et Al., 2014 (Order) [Platyhelminthes, Cestoda, Eucestoda], Brenda Atziri García-García, Omar Lagunas-Calvo, Berenice Adán-Torres, Luis García-Prieto

Concepts in Animal Parasitology

An overview of the acetabulate cestode (tapeworm) order Phyllobothriidea Caira et al., 2014, parasites of the spiral valve or spiral intestine of sharks and occasionally batoid rays. Includes a discussion of their main morphological characteristics, a description and summary of a representative species, Paraorygmatobothrium prionacis (Yamaguti, 1934) Ruhnke, 1993, taxonomy (much of which is yet uncertain), and life cycles.

Chapter 28 in Concepts in Animal Parasitology by Brenda Atziri García-García, Omar Lagunas-Calvo, Berenice Adán-Torres, and Luis García-Prieto. 2024. S. L. Gardner and S. A. Gardner, editors. Zea Books, Lincoln, Nebraska, United States. doi: 10.32873/unl.dc.ciap028


Concepts In Animal Parasitology, Chapter 29: Rhinebothriidea Healy Et Al., 2009 (Order) [Platyhelminthes, Cestoda, Eucestoda], Omar Lagunas-Calvo, Brenda Atziri García-García, Berenice Adán-Torres, Luis García-Prieto Jan 2024

Concepts In Animal Parasitology, Chapter 29: Rhinebothriidea Healy Et Al., 2009 (Order) [Platyhelminthes, Cestoda, Eucestoda], Omar Lagunas-Calvo, Brenda Atziri García-García, Berenice Adán-Torres, Luis García-Prieto

Concepts in Animal Parasitology

An overview of the cestode (tapeworm) order Rhinebothriidea Healy et al., 2009, small worms that occur in the spiral intestine (valve) of rays (Batoidea) from marine and freshwater habitats worldwide. Includes discussion of their main morphological characteristics, a description and summary of a epresentative species, Anthocephalum currani Ruhnke and Seaman 2009, taxonomy, life cycle, and zoogeography.

Chapter 29 in Concepts in Animal Parasitology by Omar Lagunas-Calvo, Brenda Atziri García-García, Berenice Adán-Torres, and Luis García-Prieto. 2024. S. L. Gardner and S. A. Gardner, editors. Zea Books, Lincoln, Nebraska, United States. doi: 10.32873/unl.dc.ciap029


Innovations In Molecular Biomarkers And Biomaterial-Based Immunotherapies For Head & Neck Cancer, Sarah Anne Wong, Victoria A Manon, Simon Young, Chi T Viet Jan 2024

Innovations In Molecular Biomarkers And Biomaterial-Based Immunotherapies For Head & Neck Cancer, Sarah Anne Wong, Victoria A Manon, Simon Young, Chi T Viet

Faculty, Staff and Student Publications

Purpose of review: Oral squamous cell carcinoma (OSCC) survival rates have remained stagnant due to a lack of targeted therapies and diagnostic tools. Patient risk is currently determined solely through clinicopathologic features, primarily tumor staging, which lacks the necessary precision to stratify patients by risk and accurately dictate adjuvant treatment. Similarly, conventional OSCC therapies have well-established toxicities and limited efficacy.

Recent findings: Recent studies show that patient risk can now be assessed using non-invasive techniques, at earlier time points, and with greater accuracy using molecular biomarker panels. Additionally, novel immunotherapies not only utilize the host's immune response to combat disease …


Genital Tract Infections, The Vaginal Microbiome And Gestational Age At Birth Among Pregnant Women In South Africa: A Cohort Study Protocol, Ranjana M.S. Gigi, Mandisa M. Mdingi, Hyunsul Jung, Shantelle Claassen-Weitz, Lukas Bütikofer, Jeffrey D. Klausner, Christina A. Muzny, Christopher M. Taylor, Janneke H.H.M. Van De Wijgert, Remco P.H. Peters, Nicola Low Dec 2023

Genital Tract Infections, The Vaginal Microbiome And Gestational Age At Birth Among Pregnant Women In South Africa: A Cohort Study Protocol, Ranjana M.S. Gigi, Mandisa M. Mdingi, Hyunsul Jung, Shantelle Claassen-Weitz, Lukas Bütikofer, Jeffrey D. Klausner, Christina A. Muzny, Christopher M. Taylor, Janneke H.H.M. Van De Wijgert, Remco P.H. Peters, Nicola Low

School of Medicine Faculty Publications

Introduction Preterm birth complications are the most common cause of death in children under 5 years. The presence of multiple microorganisms and genital tract inflammation could be the common mechanism driving early onset of labour. South Africa has high levels of preterm birth, genital tract infections and HIV infection among pregnant women. We plan to investigate associations between the presence of multiple lower genital tract microorganisms in pregnancy and gestational age at birth. Methods and analysis This cohort study enrols around 600 pregnant women at one public healthcare facility in East London, South Africa. Eligible women are ≥18 years and …


The Potential Of Stem Cell Therapy In Multiple Sclerosis Treatment: A Review, Sorina Amarculesei, Ava O'Meara Cushen, Cathy Brougham Dec 2023

The Potential Of Stem Cell Therapy In Multiple Sclerosis Treatment: A Review, Sorina Amarculesei, Ava O'Meara Cushen, Cathy Brougham

SURE Journal: Science Undergraduate Research Experience Journal

Multiple Sclerosis is an autoimmune and neurodegenerative disease of the central nervous system. There are currently 2.8 million people living with Multiple Sclerosis worldwide, including 9000 people in Ireland, with a prevalence of 193 per 100,000 people. Symptoms of Multiple Sclerosis include sensory loss, fatigue, cognitive dysfunction, spasticity, depression, optic neuritis, gait ataxia, diplopia, and loss of bladder control. Currently, there is no standardised treatment or cure for Multiple Sclerosis with many strategies focusing on symptoms. Stem cells have emerged as promising approaches for Multiple Sclerosis therapeutics. Clinical trials primarily focus on mesenchymal stem cell-based therapies for Multiple Sclerosis. Furthermore, …


Treatment Response Of Gingival Squamous-Cell Carcinoma To Palliative Intent Immunotherapy, Natalia Trehan, Angelina Debbas, Mykaihla Sternick, Jennifer Johnson, James Gates Dec 2023

Treatment Response Of Gingival Squamous-Cell Carcinoma To Palliative Intent Immunotherapy, Natalia Trehan, Angelina Debbas, Mykaihla Sternick, Jennifer Johnson, James Gates

Department of Medical Oncology Faculty Papers

The use of PD-1 immune checkpoint inhibitor medications has become a common practice in the treatment of recurrent and metastatic head and neck squamous-cell carcinomas. Success in this setting has led to the investigation of their efficacy in locally advanced cases as a part of first-line therapy. In this report, we detail the treatment response to palliative intent immunotherapy of three geriatric patients with mandibular gingival squamous-cell carcinoma who decided against surgical intervention. Patient #1 was treated with pembrolizumab, a PD-1 inhibitor, and displayed complete clinical and radiologic response of the gingival mass after three months of treatment, which is …


Towards A Mode Of Action For The Anti-Schistosomal Aryl Hydantoins, Thomas Schulze Dec 2023

Towards A Mode Of Action For The Anti-Schistosomal Aryl Hydantoins, Thomas Schulze

Theses & Dissertations

Schistosomiasis is a significant human disease caused by the helminth parasite Schistosoma mansoni. Praziquantel remains the only clinically used treatment, yet it is rapidly metabolized and only effective against the adult stage worm infection. Ro 13-3978 (AR02) is a potent antischistosomal compound with activity against multiple S. mansoni life stages; however, it manifests anti-androgenic activity. Additionally, the mechanism of action for worm clearance remains unknown. The structure of Ro 13-3979 was used to generate optimized derivatives, including AR102, that show increased potency towards worms, reduced off-target anti-androgen effects, and extended half-life thereby increasing the feasibility for a single-dose curative treatment. …


Role Of Gonadotropin-Releasing Hormone 2 And Its Receptor In Human Reproductive Cancers, Dr. Amy T. Desaulniers, Brett White Dec 2023

Role Of Gonadotropin-Releasing Hormone 2 And Its Receptor In Human Reproductive Cancers, Dr. Amy T. Desaulniers, Brett White

School of Veterinary and Biomedical Sciences: Faculty Publications

Gonadotropin-releasing hormone (GnRH1) and its receptor (GnRHR1) drive reproduction by regulating gonadotropins. Another form, GnRH2, and its receptor (GnRHR2), also exist in mammals. In humans, GnRH2 and GnRHR2 genes are present, but coding errors in the GnRHR2 gene are predicted to hinder full-length protein production. Nonetheless, mounting evidence supports the presence of a functional GnRHR2 in humans. GnRH2 and its receptor have been identified throughout the body, including peripheral reproductive tissues like the ovary, uterus, breast, and prostate. In addition, GnRH2 and its receptor have been detected in a wide number of reproductive cancer cells in humans. Notably, GnRH2 analogues …


Association Of Chlamydia Trachomatis Burden With The Vaginal Microbiota, Bacterial Vaginosis, And Metronidazole Treatment, Caleb M. Ardizzone, Christopher M. Taylor, Evelyn Toh, Rebecca A. Lillis, Jacob H. Elnaggar, John W. Lammons, Patricia Dehon Mott, Emily L. Duffy, Li Shen, Alison J. Quayle Dec 2023

Association Of Chlamydia Trachomatis Burden With The Vaginal Microbiota, Bacterial Vaginosis, And Metronidazole Treatment, Caleb M. Ardizzone, Christopher M. Taylor, Evelyn Toh, Rebecca A. Lillis, Jacob H. Elnaggar, John W. Lammons, Patricia Dehon Mott, Emily L. Duffy, Li Shen, Alison J. Quayle

School of Graduate Studies Faculty Publications

Bacterial vaginosis (BV), a dysbiosis of the vaginal microbiota, is a common coinfection with Chlamydia trachomatis (Ct), and BV-associated bacteria (BVAB) and their products have been implicated in aiding Ct evade natural immunity. Here, we determined if a non-optimal vaginal microbiota was associated with a higher genital Ct burden and if metronidazole, a standard treatment for BV, would reduce Ct burden or aid in natural clearance of Ct infection. Cervicovaginal samples were collected from women at enrollment and, if testing positive for Ct infection, at a follow-up visit approximately one week later. Cervical Ct burden was assessed by inclusion forming …


The Defined Tlr3 Agonist, Nexavant, Exhibits Anti-Cancer Efficacy And Potentiates Anti-Pd-1 Antibody Therapy By Enhancing Immune Cell Infiltration, Seung-Hwan Lee, Young-Ho Choi, Soon Myung Kang, Min-Gyu Lee, Arnaud Debin, Eric Perouzel, Seung-Beom Hong, Dong-Ho Kim Dec 2023

The Defined Tlr3 Agonist, Nexavant, Exhibits Anti-Cancer Efficacy And Potentiates Anti-Pd-1 Antibody Therapy By Enhancing Immune Cell Infiltration, Seung-Hwan Lee, Young-Ho Choi, Soon Myung Kang, Min-Gyu Lee, Arnaud Debin, Eric Perouzel, Seung-Beom Hong, Dong-Ho Kim

Faculty, Staff and Student Publications

Nexavant was reported as an alternative to the TLR3 agonist of Poly(I:C) and its derivatives. The physicochemical properties, signaling pathways, anti-cancer effects, and mechanisms of Nexavant were investigated. The distinctive characteristics of Nexavant compared to that of Poly(I:C) were demonstrated by precise quantification, enhanced thermostability, and increased resistance to RNase A. Unlike Poly(I:C), which activates TLR3, RIG-I, and MDA5, Nexavant stimulates signaling through TLR3 and RIG-I but not through MDA5. Compared to Poly(I:C), an intratumoral Nexavant treatment led to a unique immune response, immune cell infiltration, and suppression of tumor growth in various animal cancer models. Nexavant therapy outperformed anti-PD-1 …


+Protective Roles For Interferon-Gamma In Astrocytes During Chronic Autoimmunity, Brandon C. Smith Dec 2023

+Protective Roles For Interferon-Gamma In Astrocytes During Chronic Autoimmunity, Brandon C. Smith

ETD Archive

Multiple sclerosis (MS) is an inflammatory and neurodegenerative disease of the central nervous system (CNS). Infiltrating inflammatory immune cells perpetuate demyelination and axonal damage in the CNS and significantly contribute to pathology and clinical deficits. Interferon (IFN)γ is classically described as deleterious in acute CNS autoimmunity, we and others have shown astrocytic IFNγ signaling also has a neuroprotective role. We found IFNγ signaling on astrocytes upregulates subunits of the immunoproteasome (iP) and programmed death ligand 1 (PD-L1), both of which serve protective roles during autoimmunity. Astrocyte-specific knockouts of Ifngr1 resulted in increased clinical severity in the MS murine model, experimental …


Intestinal Microbiome, Fecal Fermentation Profile, And Health Indices In Hiv Infected Men Versus Non-Infected Controls, Mary Andreae, Mary C. Andreae Mrs Dec 2023

Intestinal Microbiome, Fecal Fermentation Profile, And Health Indices In Hiv Infected Men Versus Non-Infected Controls, Mary Andreae, Mary C. Andreae Mrs

Electronic Theses and Dissertations

Many HIV-positive (HIV+) males on Highly Active Anti-Retroviral Therapy (HAART) experience metabolic abnormalities, including Non-Alcoholic Fatty Liver Disease (NAFLD) and lipodystrophy. The intestinal microbiota and short chain fatty acids (SCFA), participate in bidirectional communication with their host. Dysbiosis in HIV+ males on HAART demonstrate a Prevotella-rich enterotype shaped by multiple factors including, medications, adiposity, diet, intestinal permeability, and lifestyle; our objective was to investigate these factors. 19 HIV+ and 21 HIV- males were enrolled. BMI and hip-to-waist ratio (H:W) were obtained, and FibroScan for liver health. Intestinal permeability markers Claudin-21, flagellin, and intestinal fatty acid binding protein (IFABP) in …


Immunization With The Amino-Terminus Region Of Dense Granule Protein 6 (Gra6) Of Toxoplasma Gondii Activates Cd8+ Cytotoxic T Cells Capable Of Removing Tissue Cysts Of The Parasite Through Antigen Presentation By Human Hla-A2.1, Rajesh Mani, Corinne Mercier, Marie-France Delauw, Yasuhiro Suzuki Dec 2023

Immunization With The Amino-Terminus Region Of Dense Granule Protein 6 (Gra6) Of Toxoplasma Gondii Activates Cd8+ Cytotoxic T Cells Capable Of Removing Tissue Cysts Of The Parasite Through Antigen Presentation By Human Hla-A2.1, Rajesh Mani, Corinne Mercier, Marie-France Delauw, Yasuhiro Suzuki

Markey Cancer Center Faculty Publications

CD8þ T cells from HLA-A2.1-transgenic mice, but not wild-type mice, immunized with the amino- terminus region (aa 41e152) of dense granule protein 6 (GRA6Nt) of Toxoplasma gondii secreted large amounts of perforin and granzyme B in response to GRA6Nt through antigen presentation by HLA-A2.1 in vitro. When those CD8þ T cells were transferred into chronically infected HLA-A2.1-expressing NSG mice deficient in T cells, cerebral cyst burden of the recipients of HLA-A2.1-transgenic T cells, but not of WT T cells, became significantly less than that of control mice with no cell transfer. Furthermore, the significant reduction of the cyst burden by …


Re: Incidence Of Sars-Cov-2 Breakthrough Infections After Vaccination In Adults: A Population-Based Survey Through 1 March 2023, Stacia M Desantis, Ashraf Yaseen, Tianyao Hao, Luis León-Novelo, Yashar Talebi, Melissa A Valerio-Shewmaker, Cesar L Pinzon Gomez, Sarah E Messiah, Harold W Kohl, Steven H Kelder, Jessica A Ross, Lindsay N Padilla, Mark Silberman, Samantha Wylie, David Lakey, Jennifer A Shuford, Stephen J Pont, Eric Boerwinkle, Michael D Swartz Dec 2023

Re: Incidence Of Sars-Cov-2 Breakthrough Infections After Vaccination In Adults: A Population-Based Survey Through 1 March 2023, Stacia M Desantis, Ashraf Yaseen, Tianyao Hao, Luis León-Novelo, Yashar Talebi, Melissa A Valerio-Shewmaker, Cesar L Pinzon Gomez, Sarah E Messiah, Harold W Kohl, Steven H Kelder, Jessica A Ross, Lindsay N Padilla, Mark Silberman, Samantha Wylie, David Lakey, Jennifer A Shuford, Stephen J Pont, Eric Boerwinkle, Michael D Swartz

Faculty, Staff and Student Publications

No abstract provided.