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Articles 1 - 13 of 13
Full-Text Articles in Other Genetics and Genomics
Hnrnpa2 Mediated Acetylation Reduces Telomere Length In Response To Mitochondrial Dysfunction, Manti Guha, Satish Srinivasan, F. Bradley Johnson, Gordon Ruthel, Kip Guja, Miguel Garcia-Diaz, Brett A. Kaufman, M. Rebecca Glineburg, Jikang Fang, Hiroshi Nakagawa, Jeelan Basha, Tapas Kundu, Narayan G. Avadhani
Hnrnpa2 Mediated Acetylation Reduces Telomere Length In Response To Mitochondrial Dysfunction, Manti Guha, Satish Srinivasan, F. Bradley Johnson, Gordon Ruthel, Kip Guja, Miguel Garcia-Diaz, Brett A. Kaufman, M. Rebecca Glineburg, Jikang Fang, Hiroshi Nakagawa, Jeelan Basha, Tapas Kundu, Narayan G. Avadhani
Biology, Chemistry, and Environmental Sciences Faculty Articles and Research
Telomeres protect against chromosomal damage. Accelerated telomere loss has been associated with premature aging syndromes such as Werner’s syndrome and Dyskeratosis Congenita, while, progressive telomere loss activates a DNA damage response leading to chromosomal instability, typically observed in cancer cells and senescent cells. Therefore, identifying mechanisms of telomere length maintenance is critical for understanding human pathologies. In this paper we demonstrate that mitochondrial dysfunction plays a causal role in telomere shortening. Furthermore, hnRNPA2, a mitochondrial stress responsive lysine acetyltransferase (KAT) acetylates telomere histone H4at lysine 8 of (H4K8) and this acetylation is associated with telomere attrition. Cells containing dysfunctional mitochondria …
Work-Type Influences Perceived Livestock Herding Success In Australian Working Kelpies, Jonathan B. Early, Elizabeth R. Arnott, Lisa J. Mascord, Diane Van Rooy, Paul Mcgreevy, Claire M. Wade
Work-Type Influences Perceived Livestock Herding Success In Australian Working Kelpies, Jonathan B. Early, Elizabeth R. Arnott, Lisa J. Mascord, Diane Van Rooy, Paul Mcgreevy, Claire M. Wade
Genetics Collection
Background
Working dog handlers and breeders have very different behavioural requirements in the animals that they employ for managing livestock. The Australian Working Kelpie breed may be used in several working contexts, notably yards, paddocks and a combination of both. The working context influences the skillsets required and gives rise to three corresponding work-types: Yard, Paddock and Utility Kelpies. In particular, dogs used for working stock in the confines of yards and trucks interact with stock more forcefully than those mustering in larger areas (paddocks) where they can herd stock effectively from a greater distance. This article explores owner assessments …
Repeat-Associated Non-Aug (Ran) Translation And Other Molecular Mechanisms In Fragile X Tremor Ataxia Syndrome, M. Rebecca Glineburg, Peter K. Todd, Nicolas Charlet-Berguerand, Chantal Sellier
Repeat-Associated Non-Aug (Ran) Translation And Other Molecular Mechanisms In Fragile X Tremor Ataxia Syndrome, M. Rebecca Glineburg, Peter K. Todd, Nicolas Charlet-Berguerand, Chantal Sellier
Biology, Chemistry, and Environmental Sciences Faculty Articles and Research
Fragile X-associated tremor/ataxia syndrome (FXTAS) is a late-onset inherited neurodegenerative disorder characterized by progressive intention tremor, gait ataxia and dementia associated with mild brain atrophy. The cause of FXTAS is a premutation expansion, of 55 to 200 CGG repeats localized within the 5′UTR of FMR1. These repeats are transcribed in the sense and antisense directions into mutants RNAs, which have increased expression in FXTAS. Furthermore, CGG sense and CCG antisense expanded repeats are translated into novel proteins despite their localization in putatively non-coding regions of the transcript. Here we focus on two proposed disease mechanisms for FXTAS: 1) RNA …
45442 (Gmr18d08), Neha Gogia, Ankita Sarkar, Amit Singh
45442 (Gmr18d08), Neha Gogia, Ankita Sarkar, Amit Singh
Dpp Enhancer Sequences Utilized in GMR Line
dpp enhancer - 45442
- Id - GMR 18D08
- Location - 2L:2446783,2449086
- Base pairs – 2303 bp
45437 (Gmr18b08), Neha Gogia, Ankita Sarkar, Amit Singh
45437 (Gmr18b08), Neha Gogia, Ankita Sarkar, Amit Singh
Dpp Enhancer Sequences Utilized in GMR Line
dpp enhancer - 45437
- Id - GMR18B08
- Location - 2L:2455899,2457734
- Base pairs – 1835 bp
47472 (Gmr16g02), Neha Gogia, Ankita Sarkar, Amit Singh
47472 (Gmr16g02), Neha Gogia, Ankita Sarkar, Amit Singh
Dpp Enhancer Sequences Utilized in GMR Line
dpp enhancer - 47472
- Id - GMR16G02
- Location 2L:2425041, 2428154
- Base pairs – 3113 bp
48770 (Gmr17e04), Neha Gogia, Ankita Sarkar, Amit Singh
48770 (Gmr17e04), Neha Gogia, Ankita Sarkar, Amit Singh
Dpp Enhancer Sequences Utilized in GMR Line
dpp enhancer - 48770
- Id - GMR17E04
- Location 2L: 2428913..2432834
- Base pairs – 3921 bp
48784 (Gmr17g08), Neha Gogia, Ankita Sarkar, Amit Singh
48784 (Gmr17g08), Neha Gogia, Ankita Sarkar, Amit Singh
Dpp Enhancer Sequences Utilized in GMR Line
dpp enhancer - 48784
- Id - GMR 17G08
- Location 2L:2450278,2451074
- Base pairs – 796 bp
49283 (Gmr19c03), Neha Gogia, Ankita Sarkar, Amit Singh
49283 (Gmr19c03), Neha Gogia, Ankita Sarkar, Amit Singh
Dpp Enhancer Sequences Utilized in GMR Line
dpp enhancer - 49283
- Id - GMR19C03
- Location - 2L:2440970,2444735
- Base pairs – 3765 bp
48839 (Gmr19b04), Neha Gogia, Ankita Sarkar, Amit Singh
48839 (Gmr19b04), Neha Gogia, Ankita Sarkar, Amit Singh
Dpp Enhancer Sequences Utilized in GMR Line
dpp enhancer - 48839
- Id - GMR19B04,
- Location - 2L:2432214,2435785
- Base pairs – 3571 bp
45833 (Gmr19d09), Neha Gogia, Ankita Sarkar, Amit Singh
45833 (Gmr19d09), Neha Gogia, Ankita Sarkar, Amit Singh
Dpp Enhancer Sequences Utilized in GMR Line
dpp enhancer - 45833
- Id - GMR19D09
- Location - 2L:2435128,2438996
- Base pairs – 3868 bp
Mrub_1675, Mrub_1676, Mrub_1677, And Mrub_1679 Genes Are Orthologs Of B_3458, B_3457, B_3456, And B_3454 Genes In E. Coli, Respectively, Coding For Abc Transporters. Mrub_1678 And B_3455, Though Perform Similar Tasks, Are Not Orthologous, Ravi Patel, Alaina Hofmann, Dr. Lori Scott
Mrub_1675, Mrub_1676, Mrub_1677, And Mrub_1679 Genes Are Orthologs Of B_3458, B_3457, B_3456, And B_3454 Genes In E. Coli, Respectively, Coding For Abc Transporters. Mrub_1678 And B_3455, Though Perform Similar Tasks, Are Not Orthologous, Ravi Patel, Alaina Hofmann, Dr. Lori Scott
Meiothermus ruber Genome Analysis Project
In this project we investigated the biological function of the genes Mrub_1675, Mrub_1676, Mrub_1677, and Mrub_1679 (KEGG map number 02010). We predict these genes encode components of a Branched chain amino acid (ABC) transporter: Mrub_1675 (DNA coordinates 1711022..1712185 on the reverse strand) encodes the permease component, Mrub_1676 (DNA coordinates 1712313..1713170) encodes for the NBD (aka nucleotide binding domain), Mrub_1677 (DNA coordinates 1713167..1714075 on the reverse strand) encodes the NBD (aka nucleotide binding domain), Mrub_1678 (DNA coordinates 1713167..1714075 on the reverse strand) encodes the TMD (aka transmembrane domain) and Mrub_1679 (DNA coordinates 1714781..1715485 on the reverse strand) encodes …
Methylation-Based Enrichment Facilitates Low-Cost, Noninvasive Genomic Scale Sequencing Of Populations From Feces, Kenneth L. Chiou, Christina M. Bergey
Methylation-Based Enrichment Facilitates Low-Cost, Noninvasive Genomic Scale Sequencing Of Populations From Feces, Kenneth L. Chiou, Christina M. Bergey
Public Health Resources
Obtaining high-quality samples from wild animals is a major obstacle for genomic studies of many taxa, particularly at the population level, as collection methods for such samples are typically invasive. DNA from feces is easy to obtain noninvasively, but is dominated by bacterial and other non-host DNA. The high proportion of non-host DNA drastically reduces the efficiency of high-throughput sequencing for host animal genomics. To address this issue, we developed an inexpensive capture method for enriching host DNA from noninvasive fecal samples. Our method exploits natural differences in CpG-methylation density between vertebrate and bacterial genomes to preferentially bind and isolate …