Open Access. Powered by Scholars. Published by Universities.®
- Discipline
-
- Cell and Developmental Biology (24)
- Medicine and Health Sciences (24)
- Biology (21)
- Genetics (21)
- Biochemistry, Biophysics, and Structural Biology (20)
-
- Cell Biology (19)
- Microbiology (17)
- Molecular Biology (17)
- Medical Sciences (14)
- Medical Immunology (10)
- Medical Microbiology (10)
- Biotechnology (9)
- Genomics (9)
- Bioinformatics (6)
- Computational Biology (5)
- Ecology and Evolutionary Biology (5)
- Animal Sciences (4)
- Biodiversity (4)
- Developmental Biology (4)
- Genetic Processes (4)
- Laboratory and Basic Science Research (4)
- Medical Cell Biology (4)
- Molecular and Cellular Neuroscience (4)
- Neuroscience and Neurobiology (4)
- Plant Sciences (4)
- Diseases (3)
- Evolution (3)
- Institution
-
- University of Kentucky (15)
- University of Dayton (7)
- Rowan University (6)
- The Texas Medical Center Library (6)
- Georgia Southern University (4)
-
- University of Nebraska - Lincoln (4)
- Virginia Commonwealth University (4)
- California Polytechnic State University, San Luis Obispo (3)
- City University of New York (CUNY) (2)
- University of Montana (2)
- University of South Florida (2)
- Bowling Green State University (1)
- Claremont Colleges (1)
- East Tennessee State University (1)
- Gettysburg College (1)
- Himmelfarb Health Sciences Library, The George Washington University (1)
- Liberty University (1)
- Purdue University (1)
- SUNY Buffalo State University (1)
- Stony Brook University (1)
- The University of Southern Mississippi (1)
- University of Arkansas, Fayetteville (1)
- University of Connecticut (1)
- University of Nebraska Medical Center (1)
- University of New Hampshire (1)
- University of Rhode Island (1)
- University of San Diego (1)
- University of South Carolina (1)
- Washington University in St. Louis (1)
- Wofford College (1)
- Keyword
-
- Animals (8)
- Mice (6)
- Humans (5)
- Female (4)
- Inbred BALB C (4)
-
- Mice, Inbred BALB C (4)
- Genetics (3)
- Protein (3)
- Alzheimer's disease (2)
- Angiogenesis Inducing Agents (2)
- Animal (2)
- Antineoplastic Agents (2)
- B-Cell (2)
- Bacterial Proteins (2)
- Bioinformatics (2)
- Blotting (2)
- Blotting, Western (2)
- Borrelia burgdorferi (2)
- C. elegans (2)
- Cancer (2)
- Cell Survival (2)
- DNA polymerase (2)
- Disease Models (2)
- Disease Models, Animal (2)
- ETD (2)
- Epigenetics (2)
- Evolution (2)
- Inbred C57BL (2)
- Lyme Disease (2)
- Megabalanus coccopoma (2)
- Publication
-
- Microbiology, Immunology, and Molecular Genetics Faculty Publications (12)
- Biology Faculty Publications (8)
- Dissertations and Theses (Open Access) (6)
- Graduate School of Biomedical Sciences Theses and Dissertations (6)
- Theses and Dissertations (4)
-
- STAR Program Research Presentations (3)
- College of Graduate Studies: Theses & Dissertations (2)
- Honors College Theses (2)
- Publications and Research (2)
- Biochemistry and Molecular Medicine Faculty Publications (1)
- Biology Faculty Research (1)
- Biology Theses (1)
- Department of Entomology: Faculty Publications (1)
- Department of Food Science and Technology: Dissertations, Theses, and Student Research (1)
- Department of Molecular Genetics and Microbiology Faculty Publications (1)
- Electronic Theses and Dissertations (1)
- Graduate Student Theses, Dissertations, & Professional Papers (1)
- Graduate Theses and Dissertations (1)
- Honors Projects (1)
- Honors Scholar Theses (1)
- Honors Theses (1)
- Honors Theses and Capstones (1)
- International Journal of Speleology (1)
- Jay F. Storz Publications (1)
- Journal of the South Carolina Academy of Science (1)
- Molecular Biosciences Faculty Publications (1)
- School of Computing: Conference and Workshop Papers (1)
- Scripps Senior Theses (1)
- Senior Honors Projects (1)
- Senior Honors Theses (1)
- Publication Type
Articles 61 - 74 of 74
Full-Text Articles in Molecular Genetics
Developing Microbial Biomarkers To Non-Invasively Assess Health In Wild Elk (Cervus Canadensis) Populations, Samuel B. Pannoni
Developing Microbial Biomarkers To Non-Invasively Assess Health In Wild Elk (Cervus Canadensis) Populations, Samuel B. Pannoni
Undergraduate Theses, Professional Papers, and Capstone Artifacts
The composition of the intestinal bacterial community (intestinal microbiome) of mammals is associated with changes in diet, stress, disease and physical condition of the animal. The relationship between health and the microbiome has been extensively demonstrated in studies of humans and mice; this provides strong support for its potential utility in wildlife. When managing elk (Cervus canadensis), federal and state agencies currently must rely on invasive sampling and coarse demographic data on which to base their decisions. By developing microbiome-based biomarkers that vary as a function of elk body condition and disease (i.e. microbial biomarkers), we hope to …
Up Regulation Of Heat Shock Protein 70b (Hsp70b) And Ssa1 In Chlamydomonas Reinhardtii Via Hsp70a-Rbcs2 And Psad Promoter, B. Kirtley Amos
Up Regulation Of Heat Shock Protein 70b (Hsp70b) And Ssa1 In Chlamydomonas Reinhardtii Via Hsp70a-Rbcs2 And Psad Promoter, B. Kirtley Amos
Theses and Dissertations--Biosystems and Agricultural Engineering
Fabrication of effective algae cultivation systems adjacent to coal-fired power plants to fixate waste CO2 would represent a sizable step towards achieving a carbon neutral energy cycle. However, emission gas would elevate the algal cultivation system temperature and decreases its pH without expensive preprocessing. Increased temperature and acidity constitutes a profound stress on the algae. Although stressed algae produce heat shock proteins (HSPs) that promote protein folding and protect against stress, the ordinary biological response is insufficient to protect against coal flue gas. Experimental upregulation of HSPs could make algae respond to the stress caused by high temperatures and …
The Role Of Batf2 In Lps/Ifnγ Polarized Macrophages, Marie A. Gehman
The Role Of Batf2 In Lps/Ifnγ Polarized Macrophages, Marie A. Gehman
Theses and Dissertations--Microbiology, Immunology, and Molecular Genetics
Transcription factors regulate distinct macrophage functions by regulating gene expression in response to micro-environmental cues. This functional plasticity is critical for regulating innate and adaptive immune responses during infection and during chronic disease processes including inflammatory diseases and cancer. Microarray analysis of macrophages polarized to a pro-inflammatory (M1) phenotype with LPS and IFNγ revealed that basic leucine zipper transcription factor ATF-like 2 (Batf2), a member of the AP1 transcription factors, is selectively upregulated in M1 macrophages compared to anti-inflammatory IL-4-polarized (M2) macrophages. The initial hypothesis was that Batf2 is a master regulator of gene expression that orchestrates M1 polarization. To …
Parental Rna Interference Of Genes Involved In Embryonic Development Of The Western Corn Rootworm, Diabrotica Virgifera Virgifera Leconte, Chitvan Khajuria, Ana Maria Vélez, Murugesan Rangasamy, Haichuan Wang, Elane Fishilevich, Meghan L.F. Frey, Newton Portilho Carneiro, Premchand Gandra, Kenneth E. Narva, B. D. Siegfried
Parental Rna Interference Of Genes Involved In Embryonic Development Of The Western Corn Rootworm, Diabrotica Virgifera Virgifera Leconte, Chitvan Khajuria, Ana Maria Vélez, Murugesan Rangasamy, Haichuan Wang, Elane Fishilevich, Meghan L.F. Frey, Newton Portilho Carneiro, Premchand Gandra, Kenneth E. Narva, B. D. Siegfried
Department of Entomology: Faculty Publications
RNA interference (RNAi) is being developed as a potential tool for insect pest management and one of the most likely target pest species for transgenic plants that express double stranded RNA (dsRNA) is the western corn rootworm. Thus far, most genes proposed as targets for RNAi in rootworm cause lethality in the larval stage. In this study, we describe RNAi-mediated knockdown of two developmental genes, hunchback (hb) and brahma (brm), in the western corn rootworm delivered via dsRNA fed to adult females. dsRNA feeding caused a significant decrease in hb and brm transcripts in the adult …
A Therapeutic Approach For Senile Dementias: Neuroangiogenesis, Charles T. Ambrose
A Therapeutic Approach For Senile Dementias: Neuroangiogenesis, Charles T. Ambrose
Microbiology, Immunology, and Molecular Genetics Faculty Publications
Alzheimer's disease (AD) and related senile dementias (SDs) represent a growing medical and economic crisis in this country. Apart from cautioning persons about risk factors, no practical, effective therapy is currently available. Much of the recent research in AD has been based on the amyloid cascade theory. Another approach assumes a vascular basis for SDs. This paper presents evidence from a score of studies that cerebral capillary density (CCD) declines during old age in animals and people as well as in AD. Neuroangiogenic (NAG) factors initiate and maintain capillaries in the brain. Thus a waning level of these factors and …
Characterization Of The Interactions Between Staphylococcal Phage 80 Alpha Scaffold And Capsid Proteins, Laura Klenow
Characterization Of The Interactions Between Staphylococcal Phage 80 Alpha Scaffold And Capsid Proteins, Laura Klenow
Theses and Dissertations
Staphylococcal phage 80α can serve as a helper bacteriophage for a family of mobile genetic elements called Staphylococcus aureus pathogenicity islands (SaPIs). The prototype island, SaPI1, is able to hijack the 80α capsid assembly process and redirect capsid formation to yield smaller, phage-like transducing particles carrying SaPI DNA. Capsid size redirection is accomplished through two SaPI1-encoded gene products, CpmA and an alternate scaffold protein, CpmB. The normal 80α scaffold and the SaPI1 CpmB scaffold share a small block of conserved residues at their C-termini, several of which had been shown to be essential for CpmB function. This led to the …
Characterization Of Transfer Of The Mobile Genomic Island Encoding Methicillin Resistance Among Staphylococci, Melissa D. Ray
Characterization Of Transfer Of The Mobile Genomic Island Encoding Methicillin Resistance Among Staphylococci, Melissa D. Ray
Theses and Dissertations
The gene encoding methicillin resistance in Staphylococcus aureus (MRSA) is carried in the chromosome on a large genomic island called SCCmec and is always inserted at the att site within orfX. SCCmec has been designated a mobile genetic element but a mechanism by which it moves among different strains and species of staphylococci has never been demonstrated. This work shows that bacteriophage 80α is capable of transducing SCCmec into a recipient cell, after which it can integrate into the bacterial chromosome via homologous recombination. More importantly, this work characterizes a conjugative mechanism of SCCmec transfer. …
Investigating The Role Of The Nucleosome Remodeling Factor Nurf As A Regulator Of Gene Expression, Aiman S. Alhazmi
Investigating The Role Of The Nucleosome Remodeling Factor Nurf As A Regulator Of Gene Expression, Aiman S. Alhazmi
Theses and Dissertations
The nucleosome remodeling factor (NURF) is an evolutionary conserved ATP-dependent chromatin remodeling factor. It was first isolated from Drosophila as a complex with enzymatic activity that once recruited to nucleosome, it slides the nucleosome to provide accessibility for transcription factors. Since then, numerous works from animal models and cell lines show the role of NURF as a regulator of gene expression. NURF interacts with H3K4me3 and sequence specific transcription factors that recruit the complex to promoter regions. Whether this is the only mechanism by which NURF regulates gene expression is not known. However, other ATP-dependent chromatin remodeling complexes are known …
Functional Characterization Of Rai1 In Zebrafish, Joshua S. Beach
Functional Characterization Of Rai1 In Zebrafish, Joshua S. Beach
Theses and Dissertations
Smith-Magenis Syndrome (SMS; OMIM #182290) is a multiple congenital abnormality and intellectual disability (ID) disorder caused by either an interstitial deletion of the 17p11.2 region containing the retinoic acid induced-1 (RAI1) gene or a mutation of the RAI1 gene. Individuals diagnosed with SMS typically present characteristics such as ID, self-injurious behavior, sleep disturbance, ocular and otolaryngological abnormalities, craniofacial and skeletal abnormalities, neurological and behavioral abnormalities, as well as other systemic defects and manifestations. Previous work by Vyas in 2009 showed temporal expression of rai1 in zebrafish embryos as early as 9 hpf. We hypothesize that there is maternal …
Developing A Gene Editing System To Study Haplodiploidy In The Jewel Wasp, Nasonia Vitripennis, Emily A. Muller
Developing A Gene Editing System To Study Haplodiploidy In The Jewel Wasp, Nasonia Vitripennis, Emily A. Muller
Scripps Senior Theses
Hymenopteran insects, which include all ants, bees and wasps, reproduce through a poorly understood form of reproduction known as haplodiploidy. A promising experimental system for understanding this developmental process is the jewel wasp, Nasonia vitripennis. A critical aspect of using Nasonia as a model is establishing an effective means for editing specific genes of interest so that their functions can be studied through genetic means. For my thesis research, I performed a pilot study of the gene editing method known as CRISPR in Nasonia. I targeted the single heterochromatin protein 1 (HP1) gene present in the Nasonia genome …
Helping To Resolve Taxonomic Conflicts Within The Genus Amblyomma (Acari:Ixodidae) From A Molecular Perspective, Paula Lado
College of Graduate Studies: Theses & Dissertations
This work sought to reassess the taxonomic status of Amblyomma parvum Aragao, 1908 and of the A. maculatum group of ticks Camicas, 1998. By using different molecular markers, 12SrDNA, 16SrDNA, DL, COI, COII (mitochondrial) and ITS2 (nuclear), I analyzed the systematic relationships between these taxa and their closest relatives. Phylogenetic analyses by maximum parsimony, maximum likelihood, and Bayesian analysis were performed in order to determine relationships among species and populations, and to determine the evolutionary history of these ixodids. The data obtained supported the hypothesis of cryptic speciation occurring within A. parvum, with the northern populations of Central America being …
The Role Of Artificial Structures In Facilitating Range Expansion Of The Introduced Barnacle Megabalanus Coccopoma In The Southeastern U.S.A., Alicia M. Reigel
The Role Of Artificial Structures In Facilitating Range Expansion Of The Introduced Barnacle Megabalanus Coccopoma In The Southeastern U.S.A., Alicia M. Reigel
College of Graduate Studies: Theses & Dissertations
The barnacle Megabalanus coccopoma is a recent invader of the southeastern U.S.A. from the tropical eastern Pacific. In Georgia, M. coccopoma populations along the immediate coastline often suffer extensive mortality during the winter, but population rebuilding is common after these events suggesting that there may be nearby larval sources. I investigated the hypothesis that artificial structures (i.e., buoys, towers), occurring far enough offshore of Georgia for water temperatures to be moderated by the Gulf Stream, provide refuges for breeding adults of M. coccopoma and can serve as the larval source. I investigated this hypothesis by first developing thirteen microsatellite primer …
The Role Of Dksa In The Stringent Response In The Lyme Disease Spirochete Borrelia Burgdorferi, Britney Cheff
The Role Of Dksa In The Stringent Response In The Lyme Disease Spirochete Borrelia Burgdorferi, Britney Cheff
Graduate Student Theses, Dissertations, & Professional Papers
Borrelia burgdorferi, the bacterium that causes Lyme disease, is maintained in nature through an enzootic cycle that includes a tick vector and a vertebrate host. The bacterium is acquired by an Ixodes tick from an infected vertebrate. The bacterium alters its gene expression to adapt to different environments of the tick and vertebrate. Between tick feedings, B. burgdorferi must contend with nutrient stress. The stringent response is a physiological mechanism when bacteria switch from “thriving” to “surviving” mode in response to limited nutrient resources; it is mediated by an increase in the nucleotide alarmone guanosine penta- or tetraphosphate, abbreviated …
Effects Of Proline And Glycine On The Cnidocyte Discharge Of Hydra Magnipapillata, Janine R. Appleton
Effects Of Proline And Glycine On The Cnidocyte Discharge Of Hydra Magnipapillata, Janine R. Appleton
Honors Theses and Capstones
The sense of taste enables animals to utilize environmental cues to detect favorable foods. Through specialized sensory receptors, Cnidarians employ stinging cells called cnidocytes to perform a variety of activities such as locomotion, capturing prey, inducing of feeding responses, and defense. Their discharge is highly regulated by mechanical and chemical signals that are mediated by a complex system including the opsin and taste pathways. Taste 1 Receptors (T1R) have previously been isolated in vertebrates but only until recently, have been noted in invertebrates. Receptors specific to L- amino acids corresponding to the taste sensation of umami, were studied to determine …