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Articles 31 - 35 of 35
Full-Text Articles in Molecular Genetics
Genetic Structure Of Yonahlossee Salamander Populations., Joshua Andrew Rudd
Genetic Structure Of Yonahlossee Salamander Populations., Joshua Andrew Rudd
Electronic Theses and Dissertations
Plethodon yonahlossee is the largest eastern Plethodontid salamander. It has been classified as a species of greatest conservation need by the Tennessee Wildlife Resources Agency (TWRA). Found only in mountainous areas along the borders of Tennessee, North Carolina, and Virginia, populations of the yonahlossee are considered to be rare and local throughout their range. Genetic differentiation among populations of any species is usually attributable to long-standing, extrinsic barriers to gene flow. Because of their disjunct population structure and some observed morphological variation, genetic differentiation among yonahlossee populations is expected. A genetic structure study of yonahlossee was conducted to identify any …
Differential Expression Of Genes During Diapause In The Flesh Fly, Sarcophaga Crassipalpis., Puja Karki
Differential Expression Of Genes During Diapause In The Flesh Fly, Sarcophaga Crassipalpis., Puja Karki
Electronic Theses and Dissertations
The objective of this study was to identify genes that are differentially regulated during diapause when compared with nondiapausing pupae in Sarcophaga crassipalpis. The results of a Suppression Subtractive Hybridization procedure was used to indentify genes that are differentially regulated in both diapause and nondiapausing states while suppressing genes that are common to both states. Randomly picked colonies from both subtractive libraries were isolated and the inserts sequenced. The sequences were analyzed using the bioinformatics tools NCBI, BlastX, Clustal W, etc. Out of 384 clones, 59 genes were found to be upregulated during diapause and 37 genes were found …
1, Structural And Functional Studies Of Human Replication Protein A; 2 Dna Damage Responses And Dna Repair Defects In Laminopathy-Based Premature Aging., Yiyong Liu
Electronic Theses and Dissertations
The genome of mammalian cells is under constant attack from DNA-damaging agents. To maintain genomic integrity, cells activate an array of pathways primarily consisting of DNA repair and DNA damage checkpoints. Human replication protein A (RPA), a single-stranded DNA (ssDNA) binding protein, is essential for almost all DNA metabolic pathways. However, the role of RPA in nucleotide excision repair (NER), a DNA repair pathway for removing bulky DNA lesions, remains elusive. In this study, the binding of RPA to a battery of well-defined ssDNA substrates has been systematically examined using fluorescence spectroscopy. The results showed that RPA has a lower …
Mechanism Of Transcriptional Regulation Of C-Reactive Protein Gene Expression., Bhavya Voleti
Mechanism Of Transcriptional Regulation Of C-Reactive Protein Gene Expression., Bhavya Voleti
Electronic Theses and Dissertations
C-reactive protein (CRP) is an acute phase protein produced by hepatocytes whose serum concentration increases in inflammatory conditions including cardiovascular complications. Statins that are used in the treatment of cardiovascular diseases to reduce cholesterol also lower serum CRP levels. In human hepatoma Hep3B cells, CRP is induced in response to cytokines IL-6 and IL-1β. The objective of the study was to determine the mechanism of regulation of CRP gene expression in Hep3B cells in response to cytokines and to determine the effect of statins on CRP expression. Key findings of our research were: 1. IL-1β-activated NF-κB p50/p65 acted synergistically with …
Characterization Of The Group Ii Intron Gs. Int1 From The Thermophilic Bacterium Geobacillus Stearothermophilus., Huijing Sun
Characterization Of The Group Ii Intron Gs. Int1 From The Thermophilic Bacterium Geobacillus Stearothermophilus., Huijing Sun
Electronic Theses and Dissertations
Group II Introns are small segments of DNA that reside in the chromosome of bacteria or the organelles of primitive eukaryotes. These elements have some very interesting properties. First, they are retrotransposons that can move from one location to a new location in DNA via a reverse transcription mechanism. Second, they form a large ribozyme that mediates self-splicing of the intron from pre-mRNA. A Group II Intron type protein with similarity to reverse transcriptase was discovered in the thermophilic bacterium Geobacillus stearothermophilus strain 10 (Vellore et al., 2004, Appl. Environ. Microbiol. 70: 7140-7147). Numerous copies of the intron, …