Open Access. Powered by Scholars. Published by Universities.®
- Discipline
-
- Genetics (3171)
- Medicine and Health Sciences (2902)
- Biology (1703)
- Molecular Genetics (1693)
- Ecology and Evolutionary Biology (1387)
-
- Cell and Developmental Biology (1363)
- Medical Sciences (1293)
- Animal Sciences (1200)
- Medical Specialties (1198)
- Genomics (1178)
- Biochemistry, Biophysics, and Structural Biology (1111)
- Microbiology (1074)
- Plant Sciences (939)
- Bioinformatics (905)
- Physical Sciences and Mathematics (778)
- Computational Biology (761)
- Molecular Biology (732)
- Biological Phenomena, Cell Phenomena, and Immunity (640)
- Medical Genetics (567)
- Cell Biology (565)
- Agriculture (546)
- Diseases (461)
- Meat Science (457)
- Social and Behavioral Sciences (451)
- Biomedical Informatics (436)
- Medical Immunology (435)
- Forest Sciences (414)
- Biochemistry (413)
- Institution
-
- University of Nebraska - Lincoln (1202)
- The Texas Medical Center Library (853)
- University of Kentucky (638)
- Utah State University (387)
- Old Dominion University (275)
-
- City University of New York (CUNY) (246)
- Nova Southeastern University (239)
- Dartmouth College (212)
- Department of Primary Industries and Regional Development, Western Australia (201)
- COBRA (166)
- Wayne State University (159)
- Virginia Commonwealth University (156)
- Louisiana State University (155)
- University of Nevada, Las Vegas (149)
- Providence (146)
- Clemson University (137)
- University of Arkansas, Fayetteville (130)
- University of Dayton (129)
- University of Texas Rio Grande Valley (121)
- University of South Carolina (103)
- Himmelfarb Health Sciences Library, The George Washington University (98)
- Rowan University (98)
- The University of Southern Mississippi (96)
- Portland State University (95)
- University of South Florida (83)
- University of Connecticut (77)
- Loma Linda University (76)
- Thomas Jefferson University (71)
- University of New Hampshire (71)
- West Virginia University (70)
- Keyword
-
- Humans (633)
- Genetics (522)
- Animals (371)
- Genomics (291)
- Female (221)
-
- Male (194)
- Mice (193)
- Bioinformatics (181)
- Gene expression (178)
- Genome (170)
- DNA (161)
- Genetic (145)
- Mutation (129)
- Epigenetics (128)
- Phenotype (118)
- Evolution (117)
- Drosophila (113)
- Cancer (108)
- Metabolism (106)
- Population genetics (103)
- Western Australia (97)
- Polymorphism (91)
- RNA (91)
- Genome-Wide Association Study (85)
- Phylogeny (85)
- Genes (81)
- Transcriptome (78)
- Drosophila melanogaster (77)
- Polymorphism, Single Nucleotide (77)
- Child (74)
- Publication Year
- Publication
-
- Department of Animal Science: Faculty Publications (460)
- Faculty, Staff and Students Publications (408)
- Aspen Bibliography (332)
- Dissertations and Theses (Open Access) (269)
- Nebraska Center for Virology: Faculty Publications (264)
-
- Theses and Dissertations (262)
- Biology Faculty Publications (218)
- Dartmouth Scholarship (191)
- Biology Faculty Articles (186)
- Faculty, Staff and Student Publications (173)
- Microbiology, Immunology, and Molecular Genetics Faculty Publications (153)
- Articles, Abstracts, and Reports (144)
- Electronic Theses and Dissertations (122)
- Publications and Research (120)
- Journal of the Department of Agriculture, Western Australia, Series 4 (104)
- Occasional Papers of the Museum of Natural Science, Louisiana State University (94)
- Dissertations, Theses, and Capstone Projects (86)
- Faculty Publications (84)
- All Dissertations (76)
- Loma Linda University Electronic Theses, Dissertations & Projects (76)
- Biological Sciences Faculty Publications (73)
- USF Tampa Graduate Theses and Dissertations (68)
- Human Biology Open Access Pre-Prints (67)
- Graduate Theses and Dissertations (66)
- Honors Theses (64)
- School of Medicine Publications (64)
- Markey Cancer Center Faculty Publications (62)
- Master's Theses (60)
- Graduate Theses, Dissertations, and Problem Reports (ETD) (59)
- Masters Theses (58)
- Publication Type
- File Type
Articles 6841 - 6870 of 9787
Full-Text Articles in Genetics and Genomics
Development Of A Quantitative Real-Time Polymerase Chain Reaction (Rt-Pcr) Assay For Plant Species, Kayla Curtis, Heather Miller Coyle
Development Of A Quantitative Real-Time Polymerase Chain Reaction (Rt-Pcr) Assay For Plant Species, Kayla Curtis, Heather Miller Coyle
Forensic Science Publications
In order to facilitate optimal plant DNA quantitation and identification, an assay has been developed that uses generic plant PCR primers that amplify a region in the chloroplast genome of plant samples. The assay uses the SYBR green detection dye to detect the PCR product with a universal PCR primer set to the large subunit of ribulose bisphosphate carboxylase, rbcL, but can be used with any of the universal barcode primers for land plants (rbcL, matK, trnH, psbA). Standard dilutions of control wheat DNA of varying concentrations were tested to create a standard curve. Several plant DNA extractions of different …
Heterogeneity, Not Randomness, Sets Challenges For Quantitative Genetics And Epidemiology: A Response To Davey Smith’S “Gloomy Prospect”, Peter J. Taylor
Heterogeneity, Not Randomness, Sets Challenges For Quantitative Genetics And Epidemiology: A Response To Davey Smith’S “Gloomy Prospect”, Peter J. Taylor
Working Papers on Science in a Changing World
Social epidemiologist Davey Smith (2011) argues that epidemiologists should accept a gloomy prospect: considerable randomness at the individual level means that they should keep their focus on modifiable causes of disease at the population level. The difficulty epidemiology has had in moving from significant population-level risk factors to improved prediction of cases at an individual level is analogous to the lack of success in the search for systematic aspects of the non-shared environmental influences that human quantitative genetics claims overshadow common environmental influences (e.g., the family’s socioeconomic status which siblings have in common). This article responds to the argument and …
Multilocus Coalescent Analyses Reveal The Demographic History Of Mouse Lemur Sister Species., Christopher Blair, Kellie L. Heckman, Amy L. Russell, Anne D. Yoder
Multilocus Coalescent Analyses Reveal The Demographic History Of Mouse Lemur Sister Species., Christopher Blair, Kellie L. Heckman, Amy L. Russell, Anne D. Yoder
Publications and Research
Debate continues as to whether allopatric speciation or peripatric speciation through a founder effect is the predominant force driving evolution in vertebrates. The mouse lemurs of Madagascar are a system in which evolution has generated a large number of species over a relatively recent time frame. Here, we examine speciation patterns in a pair of sister species of mouse lemur, Microcebus murinus and M. griseorufus. These two species have ranges that are disparately proportioned in size, with M. murinus showing a much more extensive range that marginally overlaps that of M. griseorufus. Given that these two species are …
Five Fundamental Gaps In Nature-Nurture Science, Peter J. Taylor
Five Fundamental Gaps In Nature-Nurture Science, Peter J. Taylor
Working Papers on Science in a Changing World
Difficulties identifying causally relevant genetic variants underlying patterns of human variation have been given competing interpretations. The debate is illuminated in this article by drawing attention to the issue of underlying heterogeneity—the possibility that genetic and environmental factors or entities underlying a trait are heterogeneous—as well as four other fundamental gaps in the methods and interpretation of classical quantitative genetics: "Genetic" and "environmental" fractions of variation in traits are distinct from measurable genetic and environmental factors underlying the traits’ development; Standard formulas for partitioning variation in human traits are unreliable; Methods for translation from fractions of variation to measurable …
Deletion Mutant Library For Investigation Of Functional Outputs Of Cyclic Diguanylate Metabolism In Pseudomonas Aeruginosa Pa14, Dae-Gon Ha, Megan E. Richman, George A. O'Toole
Deletion Mutant Library For Investigation Of Functional Outputs Of Cyclic Diguanylate Metabolism In Pseudomonas Aeruginosa Pa14, Dae-Gon Ha, Megan E. Richman, George A. O'Toole
Dartmouth Scholarship
We constructed a library of in-frame deletion mutants targeting each gene in Pseudomonas aeruginosa PA14 predicted to participate in cyclic di-GMP (c-di-GMP) metabolism (biosynthesis or degradation) to provide a toolkit to assist investigators studying c-di-GMP-mediated regulation by this microbe. We present phenotypic assessments of each mutant, including biofilm formation, exopolysaccharide (EPS) production, swimming motility, swarming motility, and twitch motility, as a means to initially characterize these mutants and to demonstrate the potential utility of this library.
How To Get The Most From Microarray Data: Advice From Reverse Genomics, Ivan P. Gorlov, Ji-Yeon Yang, Jinyoung Byun, Christopher Logothetis, Olga Y. Gorlova, Kim-Anh Do, Christopher Amos
How To Get The Most From Microarray Data: Advice From Reverse Genomics, Ivan P. Gorlov, Ji-Yeon Yang, Jinyoung Byun, Christopher Logothetis, Olga Y. Gorlova, Kim-Anh Do, Christopher Amos
Dartmouth Scholarship
Whole-genome profiling of gene expression is a powerful tool for identifying cancer-associated genes. Genes differentially expressed between normal and tumorous tissues are usually considered to be cancer associated. We recently demonstrated that the analysis of interindividual variation in gene expression can be useful for identifying cancer associated genes. The goal of this study was to identify the best microarray data–derived predictor of known cancer associated genes. We found that the traditional approach of identifying cancer genes—identifying differentially expressed genes—is not very efficient. The analysis of interindividual variation of gene expression in tumor samples identifies cancer-associated genes more effectively. The results …
Proteins Associated With Sf3a60 In T. Brucei, Benson Nyambega, Claudia Helbig, Daniel K. Masiga, Christine Clayton, Mariano J. Levin
Proteins Associated With Sf3a60 In T. Brucei, Benson Nyambega, Claudia Helbig, Daniel K. Masiga, Christine Clayton, Mariano J. Levin
All Peer-Reviewed Publications
Trypanosoma brucei relies on Spliced leader trans splicing to generate functional messenger RNAs. Trans splicing joins the specialized SL exon from the SL RNA to pre-mRNAs and is mediated by the trans-spliceosome, which is made up of small nuclear ribonucleoprotein particles and non-snRNP factors. Although the trans spliceosome is essential for trypanosomatid gene expression, not all spliceosomal protein factors are known and of these, only a few are completely characterized. In this study, we have characterized the trypanosome Splicing Factor, SF3a60, the only currently annotated SF3a component. As expected, epitope-tagged SF3a60 localizes in the trypanosome nucleus. SF3a60 is essential for …
Investigating A Role For The Ccaat/Enhancer-Binding Protein Δ In The Developing Zebrafish, Alisha Jennifer Beirl
Investigating A Role For The Ccaat/Enhancer-Binding Protein Δ In The Developing Zebrafish, Alisha Jennifer Beirl
Dissertations and Theses
The CCAAT/enhancer-binding protein delta (C/EBPδ) is a highly conserved transcription factor capable of regulating numerous cell fate processes, such as cell growth, differentiation, proliferation and apoptosis. C/EBPδ is inducible during cellular stress responses, including inflammation and responses to growth factor deprivation or thermal stress. C/EBPδ is stress-inducible in a diversity of fishes, including the zebrafish Danio rerio; however, little is known about its role in fish development. Here I show that overexpression of C/EBPδ leads to severe developmental defects, including reduced body length, edema, liver malformation and retinal abnormalities. The proportion of individuals that display developmental abnormalities is significantly …
Draft Genome Sequence Of Xylella Fastidiosa Pear Leaf Scorch Strain In Taiwan, C.-C. Su, W.-L. Deng, F.-J. Jan, C.-J. Chang, Hong Huang, J. Chen
Draft Genome Sequence Of Xylella Fastidiosa Pear Leaf Scorch Strain In Taiwan, C.-C. Su, W.-L. Deng, F.-J. Jan, C.-J. Chang, Hong Huang, J. Chen
School of Information Faculty Publications
The draft genome sequence of Xylella fastidiosa pear leaf scorch strain PLS229, isolated from the pear cultivar Hengshan (Pyrus pyrifolia) in Taiwan, is reported here. The bacterium has a genome size of 2,733,013 bp, with a G+C content of 53.1%. The PLS229 genome was annotated and has 3,259 open reading frames and 50 RNA genes.
Interaction Between Allelic Variations In Vitamin D Receptor And Retinoid X Receptor Genes On Metabolic Traits, Karani S. Vimaleswaran, Alana Cavadino, Diane J. Berry, Massimo Mangino, Peter Andrews, Jason H. Moore
Interaction Between Allelic Variations In Vitamin D Receptor And Retinoid X Receptor Genes On Metabolic Traits, Karani S. Vimaleswaran, Alana Cavadino, Diane J. Berry, Massimo Mangino, Peter Andrews, Jason H. Moore
Dartmouth Scholarship
Low vitamin D status has been shown to be a risk factor for several metabolic traits such as obesity, diabetes and cardiovascular disease. The biological actions of 1, 25-dihydroxyvitamin D, are mediated through the vitamin D receptor (VDR), which heterodimerizes with retinoid X receptor, gamma (RXRG). Hence, we examined the potential interactions between the tagging polymorphisms in the VDR (22 tag SNPs) and RXRG (23 tag SNPs) genes on metabolic outcomes such as body mass index, waist circumference, waist-hip ratio (WHR), high- and low-density lipoprotein (LDL) cholesterols, serum triglycerides, systolic and diastolic blood pressures and glycated haemoglobin in the 1958 …
Integrated Assessment Of Predicted Mhc Binding And Cross-Conservation With Self Reveals Patterns Of Viral Camouflage, Lu He, Anne S. De Groot, Andres H. Gutierrez, William D. Martin, Lenny Moise, Chris Bailey-Kellogg
Integrated Assessment Of Predicted Mhc Binding And Cross-Conservation With Self Reveals Patterns Of Viral Camouflage, Lu He, Anne S. De Groot, Andres H. Gutierrez, William D. Martin, Lenny Moise, Chris Bailey-Kellogg
Dartmouth Scholarship
Immune recognition of foreign proteins by T cells hinges on the formation of a ternary complex sandwiching a constituent peptide of the protein between a major histocompatibility complex (MHC) molecule and a T cell receptor (TCR). Viruses have evolved means of "camouflaging" themselves, avoiding immune recognition by reducing the MHC and/or TCR binding of their constituent peptides. Computer-driven T cell epitope mapping tools have been used to evaluate the degree to which articular viruses have used this means of avoiding immune response, but most such analyses focus on MHC-facing ‘agretopes'. Here we set out a new means of evaluating the …
Is Sickle Cell Trait As Benign As Is Usually Assumed?, Carroll Nicole Flansburg
Is Sickle Cell Trait As Benign As Is Usually Assumed?, Carroll Nicole Flansburg
USF Tampa Graduate Theses and Dissertations
Abstract
Introduction Sickle cell trait carriers may experience sickling events, which can cause severe health problems. Some sickle cell haplotypes contain genetic modifiers that are associated with increased levels of fetal hemoglobin, which is resistant to sickling. The aim of this study is to determine if sickle cell trait individuals who do not carry these modifiers are more likely to experience sickling episodes than those who do carry the modifiers.
Methods: Participants were eligible for inclusion in this study if they were male, 18 years of age or older, a sickle cell trait carrier, and had previously played any level …
Cd46-Mediated Transduction Of A Species D Adenovirus Vaccine Improves Mucosal Vaccine Efficacy, Zenaido T. Camacho, Michael A. Barry, Eric A. Weaver
Cd46-Mediated Transduction Of A Species D Adenovirus Vaccine Improves Mucosal Vaccine Efficacy, Zenaido T. Camacho, Michael A. Barry, Eric A. Weaver
Nebraska Center for Virology: Faculty Publications
The high levels of preexisting immunity against Adenovirus type 5 (Ad5) have deemed Ad5 unusable for translation as a human vaccine vector. Low seroprevalent alternative viral vectors may be less impacted by preexisting immunity, but they may also have significantly different phenotypes from that of Ad5. In this study we compare species D Ads (26, 28, and 48) to the species C Ad5. In vitro transduction studies show striking differences between the species C and D viruses. Most notably, Ad26 transduced human dendritic cells much more effectively than Ad5. In vivo imaging studies showed strikingly different transgene expression profiles. The …
Drosophila Snap-29 Is An Essential Snare That Binds Multiple Proteins Involved In Membrane Traffic, Hao Xu, Mahmood Mohtashami, Bryan Stewart, Gabrielle Boulianne, William S. Trimble
Drosophila Snap-29 Is An Essential Snare That Binds Multiple Proteins Involved In Membrane Traffic, Hao Xu, Mahmood Mohtashami, Bryan Stewart, Gabrielle Boulianne, William S. Trimble
Faculty Publications
Each membrane fusion event along the secretory and endocytic pathways requires a specific set of SNAREs to assemble into a 4-helical coiled-coil, the so-called trans-SNARE complex. Although most SNAREs contribute one helix to the trans-SNARE complex, members of the SNAP-25 family contribute two helixes. We report the characterization of the Drosophila homologue of SNAP-29 (dSNAP-29), which is expressed throughout development. Unlike the other SNAP-25 like proteins in fruit fly (i.e., dSNAP-25 and dSNAP-24), which form SDS-resistant SNARE complexes with their cognate SNAREs, dSNAP-29 does not participate in any SDS-resistant complexes, despite its interaction with dsyntaxin1 and dsyntaxin 16 in vitro. …
P-11 Cytosolic Carboxypeptidase 5 (Ccp5) And Cilia Development In Zebrafish, Philip Giddings
P-11 Cytosolic Carboxypeptidase 5 (Ccp5) And Cilia Development In Zebrafish, Philip Giddings
Honors Scholars & Undergraduate Research Poster Symposium Programs
My research project is focused around a specific gene—cytosolic carboxypeptidase 5 (CCP5). Previous research suggests that the CCP5 gene is essential for the modification of α-tubulin which is necessary for normal growth of cilia in the olfactory pit of zebrafish. It is my goal to confirm the role of the CCP5 gene in olfactory ciliary growth using scanning electron microscopy. Using a CCP5-MO to knockdown, the gene I can compare the resulting phenotype to that of a control specimen in order to determine any visible differences with respect to cilia morphology.
Gene Discovery And Data Sharing In Genome Wide Association Analyses: Lessons Form Aids Genetic Restriction Genes, Stephen J. O'Brien, Anton Svitin, Sergey Malov, Nikolay Cherkasov, Pavel Dobrynin, Paul Geerts, Jennifer L. Troyer, Sher L. Hendrickson, Efe Sezgin, Holli Hutcheson
Gene Discovery And Data Sharing In Genome Wide Association Analyses: Lessons Form Aids Genetic Restriction Genes, Stephen J. O'Brien, Anton Svitin, Sergey Malov, Nikolay Cherkasov, Pavel Dobrynin, Paul Geerts, Jennifer L. Troyer, Sher L. Hendrickson, Efe Sezgin, Holli Hutcheson
Biology Faculty Articles
As genome wide association studies plus whole genome sequence analyses for complex human disease determinants are expanding, it seems useful to develop strategies to facilitate large data sharing, rapid replication and validation of provocative statistical associations that straddle the threshold for genome wide significance. At this conference, we shall announce GWATCH, (Genome Wide Association Tracks Chromosome Highway) a web based data release platform that can freely display and inspect unabridged genome tracked association data without compromising privacy or Informed Consent constrictions, allowing for rapid discovery and replication opportunities. We illustrate the utility with HIV-AIDS resistance genes screened in combined large …
Notes On The Avifauna Of The Floodplain Forest Of The Rio Mamoré, Beni, Bolivia, With A Description Of The Juvenile Plumage Of Unicolored Thrush (Turdus Haplochrous) (Aves: Turdidae), Ryan S. Terrill, Miguel Angel Aponte Justiniano, Michael G. Harvey, Glenn F. Seeholzer, Rosa Ines Strem
Notes On The Avifauna Of The Floodplain Forest Of The Rio Mamoré, Beni, Bolivia, With A Description Of The Juvenile Plumage Of Unicolored Thrush (Turdus Haplochrous) (Aves: Turdidae), Ryan S. Terrill, Miguel Angel Aponte Justiniano, Michael G. Harvey, Glenn F. Seeholzer, Rosa Ines Strem
Occasional Papers of the Museum of Natural Science, Louisiana State University
Notes on the avifauna of the floodplain forest of the Rio Mamoré, Beni, Bolivia, with a description of the Juvenile plumage of Unicolored Thrush (Turdus haplochrous) – The floodplain forest along the Rio Mamoré is an isolated stretch of riverine forest in the matrix of flooded grassland and gallery forest of the Llanos de Moxos in the department of Beni, Bolivia and contains an understudied avifauna. This habitat potentially represents a stronghold for certain bird taxa. During Dec 2010-Jan 2011, we conducted daily audiovisual censuses, targeted collecting with shotguns, and general collecting with mist-nets for birds at a …
Did Pre-Clovis People Inhabit The Paisley Caves (And Why Does It Matter)?, Stuart J. Fiedel
Did Pre-Clovis People Inhabit The Paisley Caves (And Why Does It Matter)?, Stuart J. Fiedel
Human Biology Open Access Pre-Prints
The date and processes of initial human colonization of the Americas are crucial issues for the understanding of human biological and cultural development. For example, Soares et al. (2009) cited the American archaeological record to validate their proposed revision of the human mitochondrial molecular clock. Their suggested mutation rate puts the date of rapid expansion of Native American clades at around 13,500–15,000 cal BP. Similarly, Poznik et al. (2013) have used the “high-confidence archaeological dating” of the initial peopling of the Americas to calibrate the rates of both Y-chromosome and mtDNA mutation and thereby to reconcile the ages of the …
Student Identity Considerations And Implications Associated With Socioscientific Issues Instruction, Mitchel James Ruzek
Student Identity Considerations And Implications Associated With Socioscientific Issues Instruction, Mitchel James Ruzek
USF Tampa Graduate Theses and Dissertations
The purpose of this investigation was to explore how aspects of identity, perceived levels of controversy, and the strength of a student's attachment to their controversial identity relate to conceptual understanding and knowledge acquisition during socioscientific issues (SSI) based instruction in a biology classroom. The knowledge gained from this study will have the capacity to enhance our understanding of the role that attachment to identity plays during SSI negotiation. Additionally, insight was gained into the role played by aspects of identity in conceptual understanding of scientifically controversial topics during SSI based instruction.
This study contributed to the existing knowledge base …
Comparing Partial Least Square Approaches In Gene-Or Region-Based Association Study For Multiple Quantitative Phenotypes, Zhongshang Yuan, Xiaoshuai Zhang, Fangyu Li, Jinghua Zhao, Fuzhong Xue
Comparing Partial Least Square Approaches In Gene-Or Region-Based Association Study For Multiple Quantitative Phenotypes, Zhongshang Yuan, Xiaoshuai Zhang, Fangyu Li, Jinghua Zhao, Fuzhong Xue
Human Biology Open Access Pre-Prints
On thinking quantitatively of complex diseases, there are at least three statistical strategies for association study: single SNP on single trait, gene-or region (with multiple SNPs) on single trait and on multiple traits. The third of which is the most general in dissecting the genetic mechanism underlying complex diseases underpinning multiple quantitative traits. Gene-or region association methods based on partial least square (PLS) approaches have been shown to have apparent power advantage. However, few attempts are developed for multiple quantitative phenotypes or traits underlying a condition or disease, and the performance of various PLS approaches used in association study for …
The Boiling Springs Lake Metavirome: Charting The Viral Sequence-Space Of An Extreme Environment Microbial Ecosystem, Geoffrey Scott Diemer
The Boiling Springs Lake Metavirome: Charting The Viral Sequence-Space Of An Extreme Environment Microbial Ecosystem, Geoffrey Scott Diemer
Dissertations and Theses
Viruses are the most abundant organisms on Earth, yet their collective evolutionary history, biodiversity and functional capacity is not well understood. Viral metagenomics offers a potential means of establishing a more comprehensive view of virus diversity and evolution, as vast amounts of new sequence data becomes available for comparative analysis.
Metagenomic DNA from virus-sized particles (smaller than 0.2 microns in diameter) was isolated from approximately 20 liters of sediment obtained from Boiling Springs Lake (BSL) and sequenced. BSL is a large, acidic hot-spring (with a pH of 2.2, and temperatures ranging from 50°C to 96°C) located in Lassen Volcanic National …
Responsible Integration Of Biological And Psychosocial Models: Comments On “Genetic Associations With Intimate Partner Violence In A Sample Of Hazardous Drinking Men In Batterer Intervention Programs”, Antonia Abbey
Psychology Faculty Research Publications
Despite research demonstrating that gene expression differs in response to social environmental circumstances, deterministic views of biology are common. Stuart and colleagues (this issue) encourage readers to think about genetic factors in the same dynamic and probabilistic manner that they consider other causes of intimate partner violence. Given that participants had co-occurring alcohol problems, future studies should evaluate how different genetic polymorphisms uniquely and synergistically contribute to heavy drinking and aggression under different socio-environmental conditions. Psychological expectancies have a powerful impact on behavior, thus extreme caution is required before labeling people as genetically predisposed to violence.
Genetic Origins Of Lactase Persistence And The Spread Of Pastoralism In Africa, Michael Campbell
Genetic Origins Of Lactase Persistence And The Spread Of Pastoralism In Africa, Michael Campbell
Department of Biology Faculty Publications
In humans, the ability to digest lactose, the sugar in milk, declines after weaning because of decreasing levels of the enzyme lactase-phlorizin hydrolase, encoded by LCT. However, some individuals maintain high enzyme amounts and are able to digest lactose into adulthood (i.e., they have the lactase-persistence [LP] trait). It is thought that selection has played a major role in maintaining this genetically determined phenotypic trait in different human populations that practice pastoralism. To identify variants associated with the LP trait and to study its evolutionary history in Africa, we sequenced MCM6 introns 9 and 13 and ∼2 kb of the …
Genetic Canine Agression, Isabella O'Toole
Genetic Canine Agression, Isabella O'Toole
Thinking Matters Symposium Archive
Canine aggression can pose a serious concern for public and animal welfare. Most of what we know about aggression comes from bite statistics, expert opinions and breed-specific aggressiveness. These sources can often be misleading due to biases toward large or powerful breeds. In this review, I will examine a study that suggest a small number of genes control aggression.
Cluster M Mycobacteriophages Bongo, Pegleg, And Rey With Unusually Large Repertoires Of Trna Isotypes, Welkin H. Pope, Kirk R. Anders, Madison Baird, Charles A. Bowman, Michelle M. Boyle, Gregory W. Broussard, Tiffany Chow, Kari L. Clase, Shannon Cooper, Kathleen A. Cornely, Randall J. Dejong, Veronique A. Delesalle, Lisa Deng, David Dunbar, Nicholas P. Edgington, Christina M. Ferreira, Kathleen Weston Hafer, Grant A. Hartzog, J. Robert Hatherill, Lee E. Hughes, Khristina Ipapo, Greg P. Krukonis, Christopher G. Meier, Denise L. Monti, Matthew R. Olm, Shallee T. Page, Craig L. Peebles, Claire A. Rinehart, Michael R. Rubin, Daniel A. Russell, Erin R. Sanders, Morgan Schoer, Christopher D. Shaffer, James Wherley, Edwin Vazquez, Han Yuan, Daiyuan Zhang, Steven G. Cresawn, Deborah Jacobs-Sera, Roger W. Hendrix, Graham F. Hatfull
Cluster M Mycobacteriophages Bongo, Pegleg, And Rey With Unusually Large Repertoires Of Trna Isotypes, Welkin H. Pope, Kirk R. Anders, Madison Baird, Charles A. Bowman, Michelle M. Boyle, Gregory W. Broussard, Tiffany Chow, Kari L. Clase, Shannon Cooper, Kathleen A. Cornely, Randall J. Dejong, Veronique A. Delesalle, Lisa Deng, David Dunbar, Nicholas P. Edgington, Christina M. Ferreira, Kathleen Weston Hafer, Grant A. Hartzog, J. Robert Hatherill, Lee E. Hughes, Khristina Ipapo, Greg P. Krukonis, Christopher G. Meier, Denise L. Monti, Matthew R. Olm, Shallee T. Page, Craig L. Peebles, Claire A. Rinehart, Michael R. Rubin, Daniel A. Russell, Erin R. Sanders, Morgan Schoer, Christopher D. Shaffer, James Wherley, Edwin Vazquez, Han Yuan, Daiyuan Zhang, Steven G. Cresawn, Deborah Jacobs-Sera, Roger W. Hendrix, Graham F. Hatfull
Chemistry & Biochemistry Faculty Publications
Genomic analysis of a large set of phages infecting the common host Mycobacterium smegmatis mc2155 shows that they span considerable genetic diversity. There are more than 20 distinct types that lack nucleotide similarity with each other, and there is considerable diversity within most of the groups. Three newly isolated temperate mycobacteriophages, Bongo, PegLeg, and Rey, constitute a new group (cluster M), with the closely related phages Bongo and PegLeg forming subcluster M1 and the more distantly related Rey forming subcluster M2. The cluster M mycobacteriophages have siphoviral morphologies with unusually long tails, are homoimmune, and have larger than average genomes …
Cluster M Mycobacteriophages Bongo, Pegleg, And Rey With Unusually Large Repertoires Of Trna Isotopes, Welkin H. Pope, Kirk R. Anders, Madison Baird, Charles A. Bowman, Michelle M. Boyle, Gregory W. Broussard, Tiffany Chow, Kari L. Clase, Shannon Cooper, Kathleen A. Cornely, Randall J. Dejong, Veronique A. Delesalle, Lisa Deng, David Dunbar, Nicholas P. Edgington, Christina M. Ferreira, Kathleen Weston Hafer, Grant A. Hartzog, J. Robert Hatherill, Lee E. Hughes, Khristina Ipapo, Gregory P. Krukonis, Christopher G. Meier, Denise L. Monti, Matthew R. Olm, Shallee T. Page, Craig L. Peebles, Claire A. Rinehart, Michael R. Rubin, Daniel A. Russell, Erin R. Sanders, Morgan Schoer, Christopher D. Shaffer, James Wherley, Edwin Vazquez, Han Yuan, Daiyuan Zhang, Steven G. Cresawn, Deborah Jacobs-Sera, Roger W. Hendrix, Graham F. Hatfull
Cluster M Mycobacteriophages Bongo, Pegleg, And Rey With Unusually Large Repertoires Of Trna Isotopes, Welkin H. Pope, Kirk R. Anders, Madison Baird, Charles A. Bowman, Michelle M. Boyle, Gregory W. Broussard, Tiffany Chow, Kari L. Clase, Shannon Cooper, Kathleen A. Cornely, Randall J. Dejong, Veronique A. Delesalle, Lisa Deng, David Dunbar, Nicholas P. Edgington, Christina M. Ferreira, Kathleen Weston Hafer, Grant A. Hartzog, J. Robert Hatherill, Lee E. Hughes, Khristina Ipapo, Gregory P. Krukonis, Christopher G. Meier, Denise L. Monti, Matthew R. Olm, Shallee T. Page, Craig L. Peebles, Claire A. Rinehart, Michael R. Rubin, Daniel A. Russell, Erin R. Sanders, Morgan Schoer, Christopher D. Shaffer, James Wherley, Edwin Vazquez, Han Yuan, Daiyuan Zhang, Steven G. Cresawn, Deborah Jacobs-Sera, Roger W. Hendrix, Graham F. Hatfull
Biology Faculty Publications
Genomic analysis of a large set of phages infecting the common hostMycobacterium smegmatis mc2155 shows that they span considerable genetic diversity. There are more than 20 distinct types that lack nucleotide similarity with each other, and there is considerable diversity within most of the groups. Three newly isolated temperate mycobacteriophages, Bongo, PegLeg, and Rey, constitute a new group (cluster M), with the closely related phages Bongo and PegLeg forming subcluster M1 and the more distantly related Rey forming subcluster M2. The cluster M mycobacteriophages have siphoviral morphologies with unusually long tails, are homoimmune, and have larger than average …
Deep Rna Sequencing Reveals Hidden Features And Dynamics Of Early Gene Transcription In Paramecium Bursaria Chlorella Virus 1, Guillaume Blanc, Michael Mozar, Irina V. Agarkova, James R. Gurnon, Giane Yanai-Balser, Janet M. Rowe, Yuannan Xia, Jean-Jack Riethoven, David D. Dunigan, James L. Van Etten
Deep Rna Sequencing Reveals Hidden Features And Dynamics Of Early Gene Transcription In Paramecium Bursaria Chlorella Virus 1, Guillaume Blanc, Michael Mozar, Irina V. Agarkova, James R. Gurnon, Giane Yanai-Balser, Janet M. Rowe, Yuannan Xia, Jean-Jack Riethoven, David D. Dunigan, James L. Van Etten
Nebraska Center for Virology: Faculty Publications
Paramecium bursaria chlorella virus 1 (PBCV-1) is the prototype of the genus Chlorovirus (family Phycodnaviridae) that infects the unicellular, eukaryotic green alga Chlorella variabilis NC64A. The 331-kb PBCV-1 genome contains 416 major open reading frames. A mRNA-seq approach was used to analyze PBCV-1 transcriptomes at 6 progressive times during the first hour of infection. The alignment of 17 million reads to the PBCV-1 genome allowed the construction of single-base transcriptome maps. Significant transcription was detected for a subset of 50 viral genes as soon as 7 min after infection. By 20 min post infection (p.i.), transcripts were detected for …
Chip-Seq And Rna-Seq Reveal An Amrz-Mediated Mechanism For Cyclic Di-Gmp Synthesis And Biofilm Development By Pseudomonas Aeruginosa, Christopher J. Jones, David Newsom, Benjamin Kelly, Yasuhiko Irie, Laura K. Jennings, Binjie Xu, Dominique H. Limoli, Joe J. Harrison, Matthew R. Parsek, Peter White, Daniel J. Wozniak
Chip-Seq And Rna-Seq Reveal An Amrz-Mediated Mechanism For Cyclic Di-Gmp Synthesis And Biofilm Development By Pseudomonas Aeruginosa, Christopher J. Jones, David Newsom, Benjamin Kelly, Yasuhiko Irie, Laura K. Jennings, Binjie Xu, Dominique H. Limoli, Joe J. Harrison, Matthew R. Parsek, Peter White, Daniel J. Wozniak
Biology Faculty Publications
The transcription factor AmrZ regulates genes important for P. aeruginosa virulence, including type IV pili, extracellular polysaccharides, and the flagellum; however, the global effect of AmrZ on gene expression remains unknown, and therefore, AmrZ may directly regulate many additional genes that are crucial for infection. Compared to the wild type strain, a ΔamrZ mutant exhibits a rugose colony phenotype, which is commonly observed in variants that accumulate the intracellular second messenger cyclic diguanylate (c-di-GMP). Cyclic di-GMP is produced by diguanylate cyclases (DGC) and degraded by phosphodiesterases (PDE). We hypothesized that AmrZ limits the intracellular accumulation of c-di-GMP through transcriptional repression …
Vaccines Within Vaccines: The Use Of Adenovirus Types 4 And 7 As Influenza Vaccine Vectors, Eric A. Weaver
Vaccines Within Vaccines: The Use Of Adenovirus Types 4 And 7 As Influenza Vaccine Vectors, Eric A. Weaver
Nebraska Center for Virology: Faculty Publications
Adenovirus Types 4 and 7 (Ad4 and Ad7) are associated with acute respiratory distress (ARD). In order to prevent widespread Ad-associated ARD (Ad-ARD) the United States military immunizes new recruits using a safe and effective lyophilized wildtype Ad4 and Ad7 delivered orally in an enteric-coated capsule. We cloned Ad4 and Ad7 and modified them to express either a GFP-Luciferase (GFPLuc) fusion gene or a centralized influenza H1 hemagglutinin (HA1-con). BALB/c mice were injected with GFPLuc expressing viruses intramuscularly (i.m.) and intranasally (i.n.). Ad4 induced significantly higher luciferase expression levels as compared with Ad7 by both routes. Ad7 transduction was restored …
Notes On Bird Species In Bamboo In Northern Madre De Dios, Peru, Including The First Peruvian Record Of Acre Tody-Tyrant (Hemitriccus Cohnhafti), Michael G. Harvey, Daniel F. Lane, Justin Hite, Ryan S. Terrill, Sheila Figueroa Ramírez, Brian Tilston Smith, John Klicka, Walter Vargas Campos
Notes On Bird Species In Bamboo In Northern Madre De Dios, Peru, Including The First Peruvian Record Of Acre Tody-Tyrant (Hemitriccus Cohnhafti), Michael G. Harvey, Daniel F. Lane, Justin Hite, Ryan S. Terrill, Sheila Figueroa Ramírez, Brian Tilston Smith, John Klicka, Walter Vargas Campos
Occasional Papers of the Museum of Natural Science, Louisiana State University
In the southwestern Amazon Basin, large areas of habitat are comprised predominantly of Guadua bamboo. Many bird species occur in or specialize on Guadua-dominated habitats, but little is known about the taxonomy, distribution, and evolutionary history of this avian assemblage. During 2011, we surveyed the surroundings of Iberia, an area with many large Guadua stands in the southern Peruvian Amazon. We found many Guadua specialist bird species and discovered a surprising Andean element to the local avifauna. We present information on Guadua specialists, Andean species, birds of open habitats, and avian migration and reproduction. We provide accounts for species …