Food Chemistry Commons^™

Biotransformation Of Polymethoxyflavones And Its Implication On Biological Activities, Minqi Wang

Doctoral Dissertations

In this thesis, the tissue distribution and in vivo biotransformation of nobiletin in rodents were demonstrated on three types of rodents, i.e.A-J female mice, CD-1 male mice and male F344 male rats. The effects of colonic metabolites of CD-1 mice on colonic carcinogenesis and inflammation were determined. In order to mimic the long-term dietary consumption of PMFs from food or dietary supplements, we applied oral administration by mixing PMFs with standard diet to rodents who have free access to food. Moreover, nobiletin (NBT), one of the most abundant PMFs in nature, and its major metabolties were incubated with mice …