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Articles 901 - 930 of 1026
Full-Text Articles in Food Science
Hantzsch Pre-Column Derivatization For Simultaneous Determination Of Alendronate Sodium And Its Pharmacopoeial Related Impurity: Comparative Study With Synchronous Fluorometry Using Fluorescamine, A.F. El-Yazbi, E.I. El-Kimary, R.M. Youssef
Hantzsch Pre-Column Derivatization For Simultaneous Determination Of Alendronate Sodium And Its Pharmacopoeial Related Impurity: Comparative Study With Synchronous Fluorometry Using Fluorescamine, A.F. El-Yazbi, E.I. El-Kimary, R.M. Youssef
Journal of Food and Drug Analysis
High performance liquid chromatographic (HPLC) method with a pre-column derivatization based on Hantzsch condensation reaction was applied for simultaneous determination of alendronate sodium (ALN) and its main related impurity, 4-Aminobutanoic acid (ABA) at its pharmacopeial limit. The separation of colored condensation products of ALN and ABA were achieved on Agilent Zobrax Eclipse SB-C18 analytical column (250 × 4.6 mm, 5 μm) using a mobile phase composed of acetonitrile–0.1 M acetate buffer, pH 5.0 (15:85, v/v). The flow rate was 1 mL min−1. The detection was carried out at 340 nm using photo-diode array detector. Peak areas were used for the …
In Vitro Α-Amylase And Pancreatic Lipase Inhibitory Activity Of Cornus Mas L. And Cornus Alba L. Fruit Extracts, A. Świerczewska, T. Buchholz, M.F. Melzig, M.E. Czerwińska
In Vitro Α-Amylase And Pancreatic Lipase Inhibitory Activity Of Cornus Mas L. And Cornus Alba L. Fruit Extracts, A. Świerczewska, T. Buchholz, M.F. Melzig, M.E. Czerwińska
Journal of Food and Drug Analysis
Less-common fruits from Cornus spp. (Cornaceae), also named dogwoods, have shown antidiabetic, antibacterial and anti-allergic properties and are thus considered a source of phytochemicals that are beneficial to human health. The study aimed to compare the chemical compositions of the aqueous and ethanolic extracts of lyophilized fresh-picked and commercially available dried fruits of Cornus mas (Cm, cornelian cherry) and Cornus alba (Ca) fruits using HPLC-DAD-MS/MS method. Simultaneously, the α-amylase and pancreatic lipase (PL) inhibitory activities of the prepared extracts were compared by in vitro fluorescence assay based on the kinetic hydrolysis of starch or oleate ester of 4-methylumbelliferone (MUO), respectively. …
Comparative Study On Amount Of Nutraceuticals In By-Products From Solvent And Cold Pressing Methods Of Rice Bran Oil Processing, D. Wongwaiwech, M. Weerawatanakorn, S. Tharatha, C.-T. Ho
Comparative Study On Amount Of Nutraceuticals In By-Products From Solvent And Cold Pressing Methods Of Rice Bran Oil Processing, D. Wongwaiwech, M. Weerawatanakorn, S. Tharatha, C.-T. Ho
Journal of Food and Drug Analysis
Rice bran oil (RBO) has become a popular oil globally. However, the RBO extraction process leaves various residue products, which contain bioactive substances of varying potency which could be significant sources of functional ingredients for both food production and pharmaceutical manufacture. The objective of our study was to compare the bioactive substances in various by-products derived from the two rice bran oil processing methods; solvent extraction and cold pressing. The residues from solvent extraction processing contained up to 97.37 mg/100 g of γ-aminobutyric acid in defatted rice bran, and the rice acid oil contained high levels of vitamin E (tocopherols, …
Raman Spectroscopy Coupled With Chemometric Methods For The Discrimination Of Foreign Fats And Oils In Cream And Yogurt, Karacaglar N.N. Yazgan, T. Bulat, I.H. Boyaci, A. Topcu
Raman Spectroscopy Coupled With Chemometric Methods For The Discrimination Of Foreign Fats And Oils In Cream And Yogurt, Karacaglar N.N. Yazgan, T. Bulat, I.H. Boyaci, A. Topcu
Journal of Food and Drug Analysis
The adulteration of milk fat in dairy products with cheaper non-milk based fats or oils is frequently encountered in the dairy industry. In this study, Raman spectroscopy with chemometric was used for the discrimination of foreign fats and oils in milk cream and yogurt. Firstly, binary mixtures of cream and oils (corn and sunflower oil), and vegetable fat blends which are potentially or currently used by the dairy industry were prepared. All fat or oil samples and their binary mixtures were examined by using Raman spectroscopy. Then, fat content of skim milk was adjusted to 3% (w/w) by the milk …
Prioritization Of Pesticides In Crops With A Semi-Quantitative Risk Ranking Method For Taiwan Postmarket Monitoring Program, W.-C. Chou, W.-R. Tsai, H.-H. Chang, S.-Y. Lu, K.-F. Lin, P. Lin
Prioritization Of Pesticides In Crops With A Semi-Quantitative Risk Ranking Method For Taiwan Postmarket Monitoring Program, W.-C. Chou, W.-R. Tsai, H.-H. Chang, S.-Y. Lu, K.-F. Lin, P. Lin
Journal of Food and Drug Analysis
A risk-based prioritization of chemical hazards in monitoring programs allows regulatory agencies to focus on the most potentially concerned items involving human health risk. In this study, a risk-based matrix, with a scoring method using multiple factors for severity and probability of exposure, was employed to identify the pesticides presented in crops that may pose the greatest risk to human health. Both the probability of exposure and the severity were assessed for 91 pesticides detected in a Taiwanese postmarketing monitoring program. Probability of exposure was evaluated based on the probability of consumption and evidence of pesticide residues in crops. Severity …
Effect Of Sinapic Acid On Aripiprazole Pharmacokinetics In Rats: Possible Food Drug Interaction, M. Raish, A. Ahmad, M.A. Ansari, K.M. Alkharfy, A. Ahad, A. Khan, F.I. Aljenobi, N. Ali, A.M. Al-Mohizea
Effect Of Sinapic Acid On Aripiprazole Pharmacokinetics In Rats: Possible Food Drug Interaction, M. Raish, A. Ahmad, M.A. Ansari, K.M. Alkharfy, A. Ahad, A. Khan, F.I. Aljenobi, N. Ali, A.M. Al-Mohizea
Journal of Food and Drug Analysis
Dietary supplements and foods can interact with various drugs, leading to possible clinical concerns. This study aimed to investigate the effect of orally administered sinapic acid (SA) on the pharmacokinetics of aripiprazole (APZ) in rats and its possible modulatory effects on hepatic cytochrome P450 (CYP3A2 and CYP2D6) expression in the liver tissues. Single dose and multiple dose parallel groups of wistar rats were categorized into six groups (n = 6 each) which abstained from food for 12 h prior to the experiment, while water was allowed ad libitum. The investigation was carried out for single dose: Group I was treated …
Catechin Rich Butanol Fraction Extracted From Acacia Catechu L. (A Thirst Quencher) Exhibits Immunostimulatory Potential, M.A. Sunil, V.S. Sunitha, A. Ashitha, S. Neethu, S.J. Midhun, E.K. Radhakrishnan, M. Jyothis
Catechin Rich Butanol Fraction Extracted From Acacia Catechu L. (A Thirst Quencher) Exhibits Immunostimulatory Potential, M.A. Sunil, V.S. Sunitha, A. Ashitha, S. Neethu, S.J. Midhun, E.K. Radhakrishnan, M. Jyothis
Journal of Food and Drug Analysis
Acacia catechu L., (Fabaceae) named as “catechu” is a plant, the decoction of heartwood of which is daily consumed as thirst quencher by a good percentage of the population in South India. The plant is mainly distributed in India and other Asian countries. It has been used in Indian traditional medicine for the treatment of asthma, bronchitis, colic, diarrhea, boils, skin afflictions, sores and stomatitis. The present investigation was aimed to study the immunomodulatory effects of different fractions of ethanol extract of A. catechu heartwood and HPLC analysis of the active fraction. Three fractions namely, butanol, chloroform and ethyl acetate …
Multiclass Analysis Of Antimicrobial Drugs In Shrimp Muscle By Ultra High Performance Liquid Chromatography-Tandem Mass Spectrometry, S. Susakate, S. Poapolathep, C. Chokejaroenrat, P. Tanhan, J. Hajslova, M. Giorgi, K. Saimek, Z. Zhang, A. Poapolathep
Multiclass Analysis Of Antimicrobial Drugs In Shrimp Muscle By Ultra High Performance Liquid Chromatography-Tandem Mass Spectrometry, S. Susakate, S. Poapolathep, C. Chokejaroenrat, P. Tanhan, J. Hajslova, M. Giorgi, K. Saimek, Z. Zhang, A. Poapolathep
Journal of Food and Drug Analysis
A reliable, selective and rapid multiclass method has been developed for the simultaneous determination of 55 antibacterial drug residues in shrimp muscle samples by ultra high performance liquid chromatography-tandem mass spectrometry. The investigated compounds comprise of eight different classes, namely fluoroquinolones, sulfonamides and synergistic agents, tetracyclines, macrolides, lincosamides, penicillins, nitroimidazole and amphenicols. A simple liquid extraction procedure was developed consisting of extraction with a mixture of acetonitrile and ethylenediaminetetraacetic acid (EDTA), followed by a defatting step with n-hexane. Chromatographic conditions were optimized, obtaining a running time 74.3% to 113.3%. For precision test, relative standard deviations (RSD, %) were lower than …
Rgo-Ns Sers-Based Coupled Chemometric Prediction Of Acetamiprid Residue In Green Tea, M.M. Hassan, Q. Chen, F.Y.H. Kutsanedzie, H. Li, M. Zareef, Y. Xu, M. Yang, A.A. Agyekum
Rgo-Ns Sers-Based Coupled Chemometric Prediction Of Acetamiprid Residue In Green Tea, M.M. Hassan, Q. Chen, F.Y.H. Kutsanedzie, H. Li, M. Zareef, Y. Xu, M. Yang, A.A. Agyekum
Journal of Food and Drug Analysis
Pesticide residue in food is of grave concern in recent years. In this paper, a rapid, sensitive, SERS (Surface-enhanced Raman scattering) active reduced-graphene-oxide-gold-nano-star (rGO-NS) nano-composite nanosensor was developed for the detection of acetamiprid (AC) residue in green tea. Different concentrations of AC combined with rGO-NS nano-composite electro-statically, yielded a strong SERS signal linearly with increasing concentration of AC ranging from 1.0 × 10−4 to 1.0 × 103 μg/mL indicating the potential of rGO-NS nano-composite to detect AC in green tea. Genetic algorithm-partial least squares regression (GA-PLS) algorithm was used to develop a quantitative model for AC residue prediction. The GA-PLS …
Development And Validation Of A New Analytical Hplc Method For Simultaneous Determination Of The Antidiabetic Drugs, Metformin And Gliclazide, A. Gedawy, H. Al-Salami, C.R. Dass
Development And Validation Of A New Analytical Hplc Method For Simultaneous Determination Of The Antidiabetic Drugs, Metformin And Gliclazide, A. Gedawy, H. Al-Salami, C.R. Dass
Journal of Food and Drug Analysis
An efficient and simple HPLC method has been developed and validated for the simultaneous determination of gliclazide and metformin hydrochloride in bulk and was applied on marketed metformin and gliclazide products. The mobile phase used for the chromatographic runs consisted of 20 mM ammonium formate buffer (pH 3.5) and acetonitrile (45:55, v/v) The separation was achieved on an Alltima CN (250 mm × 4.6 mm x5μ) column using isocratic mode. Drug peaks were well separated and were detected by a UV detector at 227 nm. The method was linear at the concentration range 1.25–150 μg/ml for gliclazide and 2.5–150 μg/ml …
A Rapid Lc-Ms/Ms Method For Simultaneous Determination Of Quetiapine And Duloxetine In Rat Plasma And Its Application To Pharmacokinetic Interaction Study, X. Chen, C. Liang, L. Cui, J. Le, Z. Qian, R. Zhang, Z. Hong, Y. Chai
A Rapid Lc-Ms/Ms Method For Simultaneous Determination Of Quetiapine And Duloxetine In Rat Plasma And Its Application To Pharmacokinetic Interaction Study, X. Chen, C. Liang, L. Cui, J. Le, Z. Qian, R. Zhang, Z. Hong, Y. Chai
Journal of Food and Drug Analysis
Combinations of new antidepressants like duloxetine and second-generation antipsychotics like quetiapine are used in clinical treatment of major depressive disorder, as well as in forensic toxicology scenarios. The drug–drug interaction (DDI) between quetiapine and duloxetine is worthy of attention to avoid unnecessary adverse effects. However, no pharmacokinetic DDI studies of quetiapine and duloxetine have been reported. In the present study, a rapid and sensitive liquid chromatography tandem mass spectrometry (LC-MS/MS) method was developed for simultaneous determination of quetiapine and duloxetine in rat plasma. A one-step protein precipitation with acetonitrile was applied for sample preparation. The analytes were eluted on an …
Abelmoschus Esculentus Subfractions Improved Nephropathy With Regulating Dipeptidyl Peptidase-4 And Type 1 Glucagon-Like Peptide Receptor In Type 2 Diabetic Rats, C.-H. Peng, H.-C. Lin, C.-L. Lin, C.-J. Wang, C.-N. Huang
Abelmoschus Esculentus Subfractions Improved Nephropathy With Regulating Dipeptidyl Peptidase-4 And Type 1 Glucagon-Like Peptide Receptor In Type 2 Diabetic Rats, C.-H. Peng, H.-C. Lin, C.-L. Lin, C.-J. Wang, C.-N. Huang
Journal of Food and Drug Analysis
Abelmoschus esculentus (AE) has been used in traditional medicine to ameliorate hyperglycemia, but its mucilage increased bioassay difficulties. We have obtained a series of AE subfractions. Among them F1 and F2 regulated dipeptidyl peptidase-4 (DPP-4) and type 1 glucagon-like peptide receptor (GLP-1R), the treatment targets for type 2 diabetes. F1, F2 and fraction residues (FR) showed advantage on different aspects, which attenuates insulin resistance and metabolic disorder in vivo, and prevents renal-tubular change in vitro. In the present study, using type 2 diabetes model induced by high fat diet (HFD) and streptozotocin (STZ), we aim to investigate whether AE prevent …
Encapsulation Of Babchi Essential Oil Into Microsponges: Physicochemical Properties, Cytotoxic Evaluation And Anti-Microbial Activity, G. Wadhwa, S. Kumar, V. Mittal, R. Rao
Encapsulation Of Babchi Essential Oil Into Microsponges: Physicochemical Properties, Cytotoxic Evaluation And Anti-Microbial Activity, G. Wadhwa, S. Kumar, V. Mittal, R. Rao
Journal of Food and Drug Analysis
Babchi essential oil (BEO) is a valuable essential oil reported to possess a variety of biological activities such as antitumor, anti inflammatory, immunomodulatory, antioxidant, antifungal and antibacterial properties. Due to its anti-microbial properties, this oil possesses an immense potential for the treatment of dermatological disorders. Further, it has minimal tendency to develop resistance, a common issue with most of the antibiotics. However, its highly viscous nature and poor stability in the presence of light, air and high temperature, limits its practical applications. To surmount these issues, this research aims to encapsulate BEO in ethyl cellulose (EC) microsponges for enhanced stability, …
Rubiscolin-6 Activates Opioid Receptors To Enhance Glucose Uptake In Skeletal Muscle, T.S. Kairupan, K.-C. Cheng, A. Asakawa, H. Amitani, T. Yagi, K. Ataka, N.T. Rokot, N.H. Kapantow, I. Kato, A. Inui
Rubiscolin-6 Activates Opioid Receptors To Enhance Glucose Uptake In Skeletal Muscle, T.S. Kairupan, K.-C. Cheng, A. Asakawa, H. Amitani, T. Yagi, K. Ataka, N.T. Rokot, N.H. Kapantow, I. Kato, A. Inui
Journal of Food and Drug Analysis
Rubiscolin-6 is an opioid peptide derived from plant ribulose bisphosphate carboxylase/oxygenase (Rubisco). It has been demonstrated that opioid receptors could control glucose homeostasis in skeletal muscle independent of insulin action. Therefore, Rubiscolin-6 may be involved in the control of glucose metabolism. In the present study, we investigated the effect of rubiscolin-6 on glucose uptake in skeletal muscle. Rubiscolin-6-induced glucose uptake was measured using the fluorescent indicator 2-[N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl) amino]-2-deoxyglucose (2-NBDG) in L6 and C2C12 cell lines. The protein expressions of glucose transporter 4 (GLUT4) and AMP-activated protein kinase (AMPK) in L6 cells were observed by Western blotting. The in vivo effects …
The Rapid And Sensitive Detection Of Edible Bird's Nest (Aerodramus Fuciphagus) In Processed Food By A Loop-Mediated Isothermal Amplification (Lamp) Assay, M.-S. Lee, J.-Y. Huang, Y.-Y. Lien, S.-C. Sheu
The Rapid And Sensitive Detection Of Edible Bird's Nest (Aerodramus Fuciphagus) In Processed Food By A Loop-Mediated Isothermal Amplification (Lamp) Assay, M.-S. Lee, J.-Y. Huang, Y.-Y. Lien, S.-C. Sheu
Journal of Food and Drug Analysis
Edible bird's nest (EBN) is a well-known and precious traditional Chinese herbal material (CHM). Because of this, preventing the adulteration of EBN efficiently and precisely is crucial to protect consumers’ interests and health. In this study, a loop-mediated isothermal amplification (LAMP) assay was developed for the detection of EBN using specifically designed LAMP primers. The results demonstrated that the identification of EBN by LAMP assay was specific and rapid (within 1 h). It had no cross-reaction with EBN adulterants, including white fungus, egg white and pig skin, in different ratios. The relative detection limit was 0.01% EBN in the adulterants. …
Ubiquitin-Protein Ligase E3a (Ube3a) As A New Biomarker Of Cardiac Hypertrophy In Cell Models, K.-C. Cheng, Y. Li, W.-T. Chang, Z.-C. Chen, J.-T. Cheng, C.-C. Tsai
Ubiquitin-Protein Ligase E3a (Ube3a) As A New Biomarker Of Cardiac Hypertrophy In Cell Models, K.-C. Cheng, Y. Li, W.-T. Chang, Z.-C. Chen, J.-T. Cheng, C.-C. Tsai
Journal of Food and Drug Analysis
Cardiac hypertrophy is widely diagnosed in clinical cardiac disorders. The pathophysiology of hypertrophy is complex and multifactorial, a series of molecular and cellular changes are participated, such as activation of different signaling pathways, a switch of fetal gene program in the myocardium, and apoptosis. Some biomarkers have been applied to assess cardiac hypertrophy including atrial natriuretic peptides (ANP), brain/B-type natriuretic peptides (BNP), and α- or β- Myosin Heavy Chain (MHC) in addition to others. Recently, ubiquitin-protein ligase E3A (UBE3A) has been observed to increase in cardiac hypertrophy. Therefore, UBE3A as a new biomarker seems valuable in the clinic. The cardiac …
Antidepressant And Anxiolytic Effects Of The Proprietary Chinese Medicine Shexiang Baoxin Pill In Mice With Chronic Unpredictable Mild Stress, X.-D. Zhou, D.-D. Shi, Z.-J. Zhang
Antidepressant And Anxiolytic Effects Of The Proprietary Chinese Medicine Shexiang Baoxin Pill In Mice With Chronic Unpredictable Mild Stress, X.-D. Zhou, D.-D. Shi, Z.-J. Zhang
Journal of Food and Drug Analysis
Depression and anxiety often co-occur with cardiac diseases. The Shexiang Baoxin pill (SBP) is a proprietary Chinese medicine initially used to treat cardiac conditions. This study explored whether SBP has antidepressant and anxiolytic effects in addition to hormonal and psychotropic mechanisms. Mice underwent 6 weeks of chronic unpredictable mild stress (CUMS) to induce depression- and anxiety-like behavior. During the 6-week experiment, mice received SBP at intragastric doses of 20.25 mg/kg or 40.5 mg/kg daily. Animals were then tested for depression in sucrose preference, forced-swimming, and tail suspension paradigms, and for anxiety in open field and elevated plus maze tests. Both …
Novel Technologies In Detection, Treatment And Prevention Of Substance Use Disorders, H. Moulahoum, F. Zihnioglu, S. Timur, H. Coskunol
Novel Technologies In Detection, Treatment And Prevention Of Substance Use Disorders, H. Moulahoum, F. Zihnioglu, S. Timur, H. Coskunol
Journal of Food and Drug Analysis
Substance use disorders are a widely recognized problem, which affects various levels of communities and influenced the world socioeconomically. Its source is deeply embedded in the global population. In order to fight against such an adversary, governments have spared no efforts in implementing substance abuse treatment centers and funding research to develop treatments and prevention procedures. In this review, we will discuss the use of immunological-based treatments and detection kit technologies. We will be detailing the steps followed to produce performant antibodies (antigens, carriers, and adjuvants) focusing on cocaine and methamphetamine as examples. Furthermore, part of this review is dedicated …
Determination Of Sulfamonomethoxine In Tilapia (Oreochromis Niloticus × Oreochromis Mossambicus) By Liquid Chromatography-Tandem Mass Spectrometry And Its Application Pharmacokinetics Study, T.-A. Kung, S.-H. Lee, W.-H. Wang
Determination Of Sulfamonomethoxine In Tilapia (Oreochromis Niloticus × Oreochromis Mossambicus) By Liquid Chromatography-Tandem Mass Spectrometry And Its Application Pharmacokinetics Study, T.-A. Kung, S.-H. Lee, W.-H. Wang
Journal of Food and Drug Analysis
A precise and reliable analytical method to measure trace levels of sulfamonomethoxine (SMM) and N4-acetyl metabolite in tilapia samples using liquid chromatography-tandem mass spectrometry was developed. Optimized chromatographic separation was performed on C18 reversed-phase columns using gradient elution with methanol and 5 mmol/L of an ammonium acetate aqueous solution (adjusted to pH 3.5 using formic acid). This study investigated the pharmacokinetic properties and tissue distribution of SMM and its major metabolite N4-acetyl sulfamonomethoxine (AC-SMM) in tilapia after a single dose of 100 mg kg−1 body weight of orally administered SMM. Blood and tissues were collected between 0.5 and 192 h …
Identification Of Baicalin From Bofutsushosan And Daisaikoto As A Potent Inducer Of Glucose Uptake And Modulator Of Insulin Signaling-Associated Pathways, Y.-T. Kuo, C.-C. Lin, H.-T. Kuo, J.-H. Hung, C.-H. Liu, A. Jassey, M.-H. Yen, S.-J. Wu, L.-T. Lin
Identification Of Baicalin From Bofutsushosan And Daisaikoto As A Potent Inducer Of Glucose Uptake And Modulator Of Insulin Signaling-Associated Pathways, Y.-T. Kuo, C.-C. Lin, H.-T. Kuo, J.-H. Hung, C.-H. Liu, A. Jassey, M.-H. Yen, S.-J. Wu, L.-T. Lin
Journal of Food and Drug Analysis
Type 2 diabetes mellitus (T2DM) is a chronic disease characterized by hyperglycemia that can lead to long-term complications including heart diseases, stroke, retinopathy, and renal failure. Treatment strategies include stimulating glucose uptake and controlling blood glucose level. Bofutsushosan (BOF) and Daisaikoto (DAI) are two herb-based kampo medicines that have been demonstrated to improve metabolism-associated disorders including obesity, hyperlipidemia, and nonalcoholic fatty liver. Given their bioactivities against metabolic syndromes, we explored in this study the effect of BOF and DAI extracts on glucose absorption and used them as source to identify phytochemical stimulator of glucose absorption. Glucose uptake and mechanistic studies …
Rapid Screening Of Sulfonamides In Dietary Supplements Based On Extracted Common Ion Chromatogram And Neutral Loss Scan By Lc-Q/Tof-Mass Spectrometry, N.-Y. Ki, J. Hur, B.H. Kim, K.H. Kim, B.J. Moon, H.B. Oh, J. Hong
Rapid Screening Of Sulfonamides In Dietary Supplements Based On Extracted Common Ion Chromatogram And Neutral Loss Scan By Lc-Q/Tof-Mass Spectrometry, N.-Y. Ki, J. Hur, B.H. Kim, K.H. Kim, B.J. Moon, H.B. Oh, J. Hong
Journal of Food and Drug Analysis
There is an increasing amount of dietary supplements that are adulterated with diuretics and anti-diabetic drugs; this has become a global problem due to the wide distribution of dietary supplements and the serious negative health effects of the adulterants. In this study, a rapid screening method was developed for detection and confirmation of 35 sulfonamides in supplements by ultra-high performance liquid chromatography quadrupole/time of flight mass spectrometry. For effective extraction of sulfonamides from dietary supplements, four extraction protocols including HLB and WAX solid-phase extraction, Quick Easy Cheap Effective Rugged and Safe method, and pH-controlled liquid–liquid extraction were evaluated, and pH-controlled …
In Vivo Pro-Angiogenic Effects Of Dracorhodin Perchlorate In Zebrafish Embryos: A Novel Bioactivity Evaluation Platform For Commercial Dragon Blood Samples, P. Krishnaraj, Y. Chang, T.-J. Ho, N.-C. Lu, M.-D. Lin, H.-P. Chen
In Vivo Pro-Angiogenic Effects Of Dracorhodin Perchlorate In Zebrafish Embryos: A Novel Bioactivity Evaluation Platform For Commercial Dragon Blood Samples, P. Krishnaraj, Y. Chang, T.-J. Ho, N.-C. Lu, M.-D. Lin, H.-P. Chen
Journal of Food and Drug Analysis
Dragon blood has been used in wound treatment for many years and can be obtained from several distinct plant species. Dracorhodin, the active substituent of dragon blood, is a characteristic compound of the palm tree, Daemonorops draco. At present, the only method to evaluate the quality of commercial dragon blood samples is a HPLC method which determines the amount of dracorhodin in a dragon blood sample. In this study, we used zebrafish embryos as a platform to demonstrate the in vivo pro-angiogenic activity of dracorhodin perchlorate, the chemically synthesized analog of dracorhodin. By using this platform, three different commercial dragon …
Applications Of Cyclic Peptide Nanotubes (Cpnts), W.-H. Hsieh, J. Liaw
Applications Of Cyclic Peptide Nanotubes (Cpnts), W.-H. Hsieh, J. Liaw
Journal of Food and Drug Analysis
Self-assembled cyclic peptide nanotubes (cPNTs) have recently drawn particular attention as one of the most intriguing nanostructures in the field of nanotechnology. Given their unique features including high surface area, increased drug loading, environmental stability, enhanced permeation, and modifiable drug release, these hollow tubular structures can be constructed with cyclic di-, tri-, tetra-, hexa-, octa-, and decapeptides with various amino acid sequences, enantiomers, and functionalized side chains and can be applied for antiviral and antibacterial drugs, drug delivery and gene delivery vectors, organic electronic devices, and ionic or molecular channels. Recent publications have presented promising results regarding the use of …
Novel Inspection Of Sugar Residue And Origin In Honey Based On The 13c/12c Isotopic Ratio And Protein Content, C.-T. Chen, B.-Y. Chen, Y.-S. Nai, Y.-M. Chang, K.-H. Chen, Y.-W. Chen
Novel Inspection Of Sugar Residue And Origin In Honey Based On The 13c/12c Isotopic Ratio And Protein Content, C.-T. Chen, B.-Y. Chen, Y.-S. Nai, Y.-M. Chang, K.-H. Chen, Y.-W. Chen
Journal of Food and Drug Analysis
Regarding the honey industry, market prices are strongly affected by the origin and composition of products. In particular, the adulteration of honey can be divided into cases of honey being mixed with artificial syrup, the different origin of the adulteration and the presence of cane sugar residue. Unfortunately, recent studies mentioned that most honey is mixed with artificial syrups. Thus, determining such unnaturally present sugar is necessary to maintain the trust of the consuming populations. To investigate the possibility of syrup augmentation, this study first clarifies two points of great importance. First, long-term feeding of cane sugar to honey bee …
Ccm111 Prevents Hepatic Fibrosis Via Cooperative Inhibition Of Tgf-Β Wnt And Stat3 Signaling Pathways, I.-Y. Lin, Y.-S. Chiou, L.-C. Wu, C.-Y. Tsai, C.-T. Chen, W.-C. Chuang, M.-C. Lee, C.-C. Lin, T.-T. Lin, S.-C. Chen, M.-H. Pan, N. Ma
Ccm111 Prevents Hepatic Fibrosis Via Cooperative Inhibition Of Tgf-Β Wnt And Stat3 Signaling Pathways, I.-Y. Lin, Y.-S. Chiou, L.-C. Wu, C.-Y. Tsai, C.-T. Chen, W.-C. Chuang, M.-C. Lee, C.-C. Lin, T.-T. Lin, S.-C. Chen, M.-H. Pan, N. Ma
Journal of Food and Drug Analysis
CCM111 is an aqueous extract of Antrodia cinnamomea (AC) that has exhibited anti-liver fibrosis functions. However, the detailed mechanisms of AC action against liver fibrosis have not been elucidated yet. The present research showed that CCM111 significantly lowered the levels of the hepatic enzyme markers glutamate oxaloacetate transaminase (GOT) and glutamic pyruvic transaminase (GPT), prevented liver damage and collagen deposition, and downregulated TGF-β/Smad signaling in a dose-dependent manner compared with CCl4 treatment alone. CCM111 markedly inhibited TGF-β Wnt and STAT3 signaling pathway-regulated downstream genes in the liver by next-generation sequencing. The antifibrotic mechanisms of CCM111 were further demonstrated in HSC-T6 …
Simultaneous Quantification Combined With Multivariate Statistical Analysis Of Multiple Chemical Markers Of Wu Ji Bai Feng Pill By Uhplc–Ms/Ms, S.-N. Duan, W. Qi, S.-W. Zhang, K.-K. Huang, D. Yuan
Simultaneous Quantification Combined With Multivariate Statistical Analysis Of Multiple Chemical Markers Of Wu Ji Bai Feng Pill By Uhplc–Ms/Ms, S.-N. Duan, W. Qi, S.-W. Zhang, K.-K. Huang, D. Yuan
Journal of Food and Drug Analysis
Wu Ji Bai Feng Pill (WJBFP) is a traditional Chinese medicine (TCM) complex formula, which has been widely used in the treatment of various gynecological disorders. However, the quality control of multiple components in WJBFP is challengeable by using the methods applicable to analysis of several phytochemicals in single herbs or simple herbal preparations. The purpose of this study is to establish an ultra-high performance liquid chromatography coupled with triple quadrupole mass spectrometry (UHPLC–MS/MS) method for the quantitative determination of 20 bioactive compounds in WJBFP. The modified chromatographic conditions were achieved on an Agilent Poroshell 120 EC-C18 column with a …
Shenmai-Yin Decreased The Clearance Of Nifedipine In Rats: The Involvement Of Time-Dependent Inhibition Of Nifedipine Oxidation, H.-J. Wang, C.-K. Lu, W.-C. Chen, A.-C. Chen, Y.-F. Ueng
Shenmai-Yin Decreased The Clearance Of Nifedipine In Rats: The Involvement Of Time-Dependent Inhibition Of Nifedipine Oxidation, H.-J. Wang, C.-K. Lu, W.-C. Chen, A.-C. Chen, Y.-F. Ueng
Journal of Food and Drug Analysis
The traditional Chinese herbal formula Shenmai-Yin (SY) and nifedipine have both been used to treat patients with cardiovascular disorders. Nifedipine is primarily oxidized by cytochrome P450 (CYP) 3A. The oxidation and pharmacokinetics of nifedipine were studied in rats in vitro and in vivo to illustrate the interaction of SY with nifedipine. Schisandrol A, schisandrin A and schisandrin B were identified as the main lignans in SY. In the study in vitro, the ethanolic extract of SY was used due to the solubility and the extract inhibited nifedipine oxidation (NFO) activity in a time-dependent manner. Among lignans, schisandrin B caused the …
Comparative Investigation For Raw And Processed Aconiti Lateralis Radix Using Chemical Uplc-Ms Profiling And Multivariate Classification Techniques, L. Sun, G. You, X. Cao, M. Wang, X. Ren
Comparative Investigation For Raw And Processed Aconiti Lateralis Radix Using Chemical Uplc-Ms Profiling And Multivariate Classification Techniques, L. Sun, G. You, X. Cao, M. Wang, X. Ren
Journal of Food and Drug Analysis
A strategy combining chemical UPLC-MS profiling and multivariate classification techniques has been used for the comparison of raw and processed Aconiti Lateralis Radix. UPLC-MS was used to identify 18 characteristic compounds, which were selected for discrimination of the raw and two processed products (Heishunpian and Baifupian). Chemometric analyses, including the combination of a heat map and hierarchical cluster analysis (HCA) and principal component analysis (PCA), were used to visualize the discrimination of raw and two processed products. HCA and PCA provided a clear discrimination of raw Aconiti Lateralis Radix, Heishunpian and Baifupian. Finally, the counter-propagation artificial neural network (CP-ANN) was …
The Regulation Of Drug-Metabolizing Enzymes And Membrane Transporters By Inflammation: Evidences In Inflammatory Diseases And Age-Related Disorders, K.-C. Wu, C.-J. Lin
The Regulation Of Drug-Metabolizing Enzymes And Membrane Transporters By Inflammation: Evidences In Inflammatory Diseases And Age-Related Disorders, K.-C. Wu, C.-J. Lin
Journal of Food and Drug Analysis
Drug-metabolizing enzymes (DMEs) and membrane transporters play important roles in the absorption, distribution, metabolism, and excretion processes that determine the pharmacokinetics of drugs. Inflammation has been shown to regulate the expression and function of these drug-processing proteins. Given that inflammation is a common feature of many diseases, in this review, the general mechanisms for inflammation-mediated regulation of DMEs and transporters are described. Also, evidences regarding the aberrant expression of these drug-processing proteins in several inflammatory diseases and age-related disorders are provided. © 2018
Antcins, Triterpenoids From Antrodia Cinnamomea, As New Agonists For Peroxisome Proliferator-Activated Receptor Α, Y.-J. Wang, S.-C. Lee, C.-H. Hsu, Y.-H. Kuo, C.-C. Yang, F.-J. Lin
Antcins, Triterpenoids From Antrodia Cinnamomea, As New Agonists For Peroxisome Proliferator-Activated Receptor Α, Y.-J. Wang, S.-C. Lee, C.-H. Hsu, Y.-H. Kuo, C.-C. Yang, F.-J. Lin
Journal of Food and Drug Analysis
Peroxisome proliferator-activated receptor α (PPARα) is a nuclear hormone receptor that transcriptionally regulates lipid metabolism and inflammation; therefore, PPARα agonists are promising agents to treat dyslipidemia and metabolic disorders. PPARα full agonists, such as fibrates, are effective anti-hypertriglyceride agents, but their use is limited by adverse side effects. Hence, the aim of this study was to identify small molecules that can activate PPARα while minimizing the adverse effects. Antrodia cinnamomea, a rare medical mushroom, has been used widely in Asian countries for the treatment of various diseases, including liver diseases. Antcin B, H and K (antcins) and ergostatrien-3β-ol (EK100) are …