Open Access. Powered by Scholars. Published by Universities.®
- Keyword
-
- Aggregation (1)
- Antibacterial (1)
- Antimicrobial coatings (1)
- Aptamer (1)
- Biopolymer (1)
-
- Biosensor (1)
- Colloid mill (1)
- Electrospinning (1)
- Emulsion drop size distributions (1)
- Essential Oil (1)
- Food contaminant (1)
- Food safety (1)
- High pressure homogenization (1)
- In vitro (1)
- Intestine (1)
- Microbial inactivation (1)
- Microbiome (1)
- Microfluidic (1)
- Mucosal (1)
- Mucus (1)
- N-halamines (1)
- Nanofibers (1)
- Nanostructured lipid carriers (1)
- Polymorphic transformation (1)
- Population balance modeling (1)
- Population balance models (1)
- Product design (1)
- Raman (1)
- Rapid detection (1)
- Rheology (1)
Articles 1 - 6 of 6
Full-Text Articles in Food Science
Micro-Physiological Models To Mimic Mucosal Barrier Complexity Of The Human Intestine In Vitro, Abhinav Sharma
Micro-Physiological Models To Mimic Mucosal Barrier Complexity Of The Human Intestine In Vitro, Abhinav Sharma
Doctoral Dissertations
The mucosal barrier in the intestine is vital to maintain selective absorption of nutrients while protecting internal tissues and maintaining symbiotic relationship with luminal microbiota. This bio-barrier consists of a cellular epithelial barrier and an acellular mucus barrier. Secreted mucus regulates barrier function via in situ biochemical and biophysical interaction with luminal content that continually evolves during digestion and absorption. Increasing evidence suggests that a mucus barrier is indispensable to maintain homeostasis in the gastrointestinal tract. However, the importance of mucus barrier is largely underrated for in vitro mucosal tissue modeling. The major gap is the lack of experimental material …
Biopolymer Electrospun Nanofiber Mats To Inactivate And Remove Bacteria, Katrina Ann Rieger
Biopolymer Electrospun Nanofiber Mats To Inactivate And Remove Bacteria, Katrina Ann Rieger
Doctoral Dissertations
The persistence of antibiotic resistance in bacterial pathogens remains a primary concern for immunocompromised and critically-ill hospital patients. Hospital associated infections can be deadly and reduce the successes of medical advancements, such as, cancer therapies and medical implants. Thus, it is imperative to develop materials that can (i) deliver new antibiotics with accuracy, as well as (ii) uptake pathogenic microbes. In this work, we will demonstrate that electrospun nanofiber mats offer a promising platform for both of these objectives because of their high surface-to-volume ratio, interconnected high porosity, gas permeability, and ability to contour to virtually any surface. To provide …
Label-Free And Aptamer-Based Surface Enhanced Raman Spectroscopy For Detection Of Food Contaminants, Shintaro Pang
Label-Free And Aptamer-Based Surface Enhanced Raman Spectroscopy For Detection Of Food Contaminants, Shintaro Pang
Doctoral Dissertations
The development of analytical methods to detect food contaminants is a critical step for improving food safety. Surface enhanced Raman spectroscopy (SERS) is an emerging detection technology that has the potential to rapidly, accurately and sensitively detect a wide variety of food contaminants. However, SERS detection becomes a challenge in real complex matrix, such as food, since non-specific matrix signals have the potential to drown out target associated Raman peaks. In this dissertation, we focused on the development and application of label-free, aptamer-based SERS in order to improve the accuracy and specificity of target contaminant detection in food. To accomplish …
Experimental And Modeling Studies On The Formulation Of Stable Lipid Nanoparticle Dispersions, Yihui Yang
Experimental And Modeling Studies On The Formulation Of Stable Lipid Nanoparticle Dispersions, Yihui Yang
Doctoral Dissertations
This thesis presents both experimental and modeling studies on the formulation of stable lipid nanoparticle dispersions. A population balance equation (PBE) model was developed for prediction of the average polymorph content and aggregate size distribution to better understand the undesirable SLN aggregation behavior. Experimental and modeling studies showed that the polymorphic transformation was the rate determining step for my system, SLNs with smaller initial size distributions aggregated more rapidly, and aggregates contained particles with both alpha and beta crystals. Next the effect of different liquid carrier oils on the crystallization and aggregation behavior of tristearin NLC dispersions was investigated. I …
Prediction Of Emulsion Drop Size Distributions With Population Balance Equation Models To Enable Emulsified Product Design, Shashank Maindarkar
Prediction Of Emulsion Drop Size Distributions With Population Balance Equation Models To Enable Emulsified Product Design, Shashank Maindarkar
Doctoral Dissertations
Oil-in-water emulsions are ubiquitous dispersed phase systems with diverse applications in consumer products, processed foods, and the pharmaceutical industry. Emulsion formulation variables and process operating conditions both impact the drop size distribution, a key property that influences emulsion rheology, stability, texture, and appearance. A typical emulsified product requires the drop size distribution to be maintained within acceptable limits. Due to a lack of quantitative understanding, emulsified products are currently manufactured by combining a broad knowledge of previous product formulations with empirical scientific experimentation. An alternative to trial-and-error experimentation is to utilize a suitable mathematical model to predict the drop size …
Layer-By-Layer Antimicrobial N-Halamine Polymer Coatings For Food Contact Materials, Luis J. Bastarrachea Gutierrez
Layer-By-Layer Antimicrobial N-Halamine Polymer Coatings For Food Contact Materials, Luis J. Bastarrachea Gutierrez
Doctoral Dissertations
Cross contamination during food processing represents a risk for public health and financial burden. Surface modification of food contact materials to render them antimicrobial can be effective against such risk. The objective of the present work was to develop antimicrobial coatings with the potential to be applied in a variety of food contact materials. The polymer coatings developed became antimicrobial by incorporation of a type of chlorinated compounds called N-halamines, capable of regenerating their antimicrobial activity. Two layer-by-layer (LbL) assembly surface modification procedures were followed. In the first procedure, bilayers of branched polyethyleneimine (PEI) and poly(acrylic acid) (PAA) were applied …