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2019

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Articles 451 - 480 of 1118

Full-Text Articles in Ecology and Evolutionary Biology

American White Pelicans, Tommy King May 2019

American White Pelicans, Tommy King

Wildlife Damage Management Technical Series

American white pelicans (Pelecanus erythrorhynchos, Figure 1) threaten aquaculture producers by direct predation and the spread of disease. They are also considered competition and a nuisance by some sports fishermen. Pelicans can also damage pond levees and crops, such as rice, by trampling the vegetation and depositing guano. A combination of wildlife damage management techniques is often necessary to reduce pelican damage to these resources. Aquaculture Prior to the winter of 1992, American white pelican depredations at catfish facilities in the Delta regions of Arkansas and Mississippi were limited, and birds were easily dispersed from the area. Since 1992, however, …


Percussive Behavior In The Southern Resident Killer Whale (Orcinus Orca) Population At Lime Kiln Point State Park, Rylee Jensen May 2019

Percussive Behavior In The Southern Resident Killer Whale (Orcinus Orca) Population At Lime Kiln Point State Park, Rylee Jensen

Undergraduate Honors Capstone Projects

The endangered Southern Resident Killer Whale (Orcinus orca, SRKW) is an iconic species in the Pacific Northwest. Although many ecological aspects of this population have been studied, including population dynamics, genealogy, diet, and habitat-use patterns, why SRKW perform above-surface "percussive" behavior such as breaching, cartwheeling, pectoral fin slapping, tail lobbing, and dorsal fin slapping remains unclear. In the present study, a) individual percussive behavioral data was recorded during the summer of 2016 to evaluate trends by age and sex class, and b) an existing long-term data set on SRKW was analyzed to compare the relationship between the seasonal …


The Effect Of A Surfactant Seed Coating On The Germination And Growth Of Three Native Bulrushes, Anders Hart May 2019

The Effect Of A Surfactant Seed Coating On The Germination And Growth Of Three Native Bulrushes, Anders Hart

Undergraduate Honors Capstone Projects

Great Salt Lake (GSL) wetlands provide vital ecosystem services, including habitat for migratory birds. Alkali bulrush (Bolboschoenus maritimus), hardstem bulrush (Schoenoplectus acutus), and three-square bulrush (Schoenoplectus americanus) play an important role in providing these services, but invasion by Phragmites australis has reduced the extent these species in GSL wetlands. Restoring these native bulrushes following Phragmites removal is a primary goal for GSL managers. However, climate change and increasing human water demands upstream may alter the hydropattem of GSL wetlands, leading to lower soil moisture availability and potentially inhibiting germination and establishment of these species. …


The Spatial Ecology Of Predator-Prey Interactions: A Case Study Of Yellowstone Elk, Wolves, And Cougars, Michel T. Kohl May 2019

The Spatial Ecology Of Predator-Prey Interactions: A Case Study Of Yellowstone Elk, Wolves, And Cougars, Michel T. Kohl

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

The loss of large apex predators, and their subsequent reintroduction, has been identified as a substantial driver on the structure and function of ecological communities through behavioral mediated trophic cascades (BMTCs). The reintroduction of wolves (Canis lupus) to Yellowstone National Park (YNP) has served as foundational case study of BMTCs. In our system, it has been suggested that wolves have established a ‘landscape of fear’ in which the primary prey, elk (Cervus elaphus), now avoid risky places, which ultimately led to the recovery of the vegetation community. Although this case is frequently cited as a well-understood …


Intraspecific Variation In Plant-Plant Interactions And Belowground Zone Of Influence Of Big Sagebrush (Artemisia Tridentata), Andrii Zaiats May 2019

Intraspecific Variation In Plant-Plant Interactions And Belowground Zone Of Influence Of Big Sagebrush (Artemisia Tridentata), Andrii Zaiats

Boise State University Theses and Dissertations

Post-fire restoration of degraded sagebrush ecosystems over large areas of the Great Basin is challenging, in part due to unpredictable outcomes. Low rates of restoration success are attributed to increasing frequencies of wildfires, biological invasions, and climate variability. Quantifying restoration outcomes by accounting for sources of biotic and abiotic variability will improve restoration as a predictive science. One source of biotic variability is neighbor interactions, which can regulate demographic parameters of coexisting species and are an important determinant of community structure, ecosystem functions, and population dynamics. Our objective was to quantify how intraspecific variability in big sagebrush, Artemisia tridentata, …


Review Of Birds Of Prey Of The West: A Field Guide, By Brian K. Wheeler, Daniel Casey May 2019

Review Of Birds Of Prey Of The West: A Field Guide, By Brian K. Wheeler, Daniel Casey

The Prairie Naturalist

Birds of prey epitomize much of what attracts us to birding. Many are large and easy to observe, particularly in open landscapes. Their predatory nature and behavior give them an added aura of wildness; their migrations can be spectacular. And even veteran birders should enjoy the challenge of identifying the myriad of plumage variations shown by different ages, sexes, subspecies, and color morphs. With his newest effort, Birds of Prey of the West, Brian Wheeler has compiled a comprehensive and enhanced field guide with illustrations that stunningly capture that variation, combined with enough additional context to make it a valuable …


The Diversity Of Terrestrial Mammals Surrounding Waterfall At Billy Barquedier National Park, Kelsey Johnson May 2019

The Diversity Of Terrestrial Mammals Surrounding Waterfall At Billy Barquedier National Park, Kelsey Johnson

Animal Science Undergraduate Honors Theses

Billy Barquedier is a National Park located in the Stann Creek district of Belize that contains Neotropical vegetation and wildlife. This study was performed in order to provide a baseline inventory and appearance frequency patterns of the terrestrial mammals located within Zone 1 of the park near a waterfall. The goal of the data and information collected during this study is to gain a greater understanding of the biodiversity and activity patterns of terrestrial mammals within the park and across Belize as a whole. The use of camera traps, small Sherman live traps, large live traps, and tracking methods were …


Hiding In The Lianas Of The Tree Of Life: Molecular Phylogenetics And Species Delimitation Reveal Considerable Cryptic Diversity Of New World Vine Snakes, Robert C. Jadin, Christopher Blair, Michael J. Jowers, Anthony Carmona, John C. Murphy May 2019

Hiding In The Lianas Of The Tree Of Life: Molecular Phylogenetics And Species Delimitation Reveal Considerable Cryptic Diversity Of New World Vine Snakes, Robert C. Jadin, Christopher Blair, Michael J. Jowers, Anthony Carmona, John C. Murphy

Publications and Research

The Brown Vine Snake, Oxybelis aeneus, is considered a single species despite the fact its distribution covers an estimated 10% of the Earth’s land surface, inhabiting a variety of ecosystems throughout North, Central, and South America and is distributed across numerous biogeographic barriers. Here we assemble a multilocus molecular dataset (i.e. cyt b, ND4, cmos, PRLR) derived from Middle American populations to examine for the first time the evolutionary history of Oxybelis and test for evidence of cryptic lineages using Bayesian and maximum likelihood criteria. Our divergence time estimates suggest that Oxybelis diverged from its sister genus, Leptophis …


Beaver And Aspen: Synergy Among Keystone Species, Stephen N. Bennett, Nicolaas Bouwes, Paul C. Rogers May 2019

Beaver And Aspen: Synergy Among Keystone Species, Stephen N. Bennett, Nicolaas Bouwes, Paul C. Rogers

Aspen Bibliography

In the West, climate change is likely to increase the frequency, intensity, and duration of drought. Restoration of soils and water storage capacity can help create resilient uplands and riverscapes (i.e., streams and the valley bottoms). Over the past two centuries, common land uses, the removal of beaver and wood, straightening of streams, and damage to riparian areas have created simplified, structurally starved, riverscapes. Degraded streams are very efficient at transporting water, sediment, and nutrients downstream. Aspen forests are also biological hotspots that have been degraded by past land uses such as overbrowsing ungulates, land clearing, fire suppression, and outright …


Biodiversity Within Aspen Forests, Paul C. Rogers May 2019

Biodiversity Within Aspen Forests, Paul C. Rogers

Aspen Bibliography

Aspen have long been known for supporting lush vegetation and rich wildlife habitat. These features, alongside brilliant green and gold seasonal coloration, accompany a broadly appreciated aesthetic for aspen forests by the public-at-large. However, in earlier times timber producers in many locales considered aspen to have low value and actively eliminated them. More recent research has pointed out that relative moisture held within aspen communities facilitates a wide array of species – collectively, biodiversity – compared to surrounding vegetation types. Aspen groves in the Intermountain West, for example, are known to be second only to riparian forests is supporting the …


Role Of Wildfire And Topography In Shaping Aspen Regeneration After The Hayman Fire, Co, Usa, Arianna A. B. Porter May 2019

Role Of Wildfire And Topography In Shaping Aspen Regeneration After The Hayman Fire, Co, Usa, Arianna A. B. Porter

Aspen Bibliography

Unusually rapid and widespread mortality in Quaking aspen (Populus tremuloides) has been documented throughout the 21st century primarily as a result of warm, dry weather conditions. Although aspen are not drought-adapted, aspen are well adapted to wildfire. Increases in wildfire severity and extent as a result of climate change may provide opportunities for aspen regeneration, especially at mid- and high-elevation sites. Aspen's sensitivity to drought suggests that regeneration following fire might be constrained to cooler and wetter topographic locations on the landscape which reduce drought stress on vegetation. While aspen mortality is demonstrated to occur at low elevation sites, aspen …


Burn Severity And Fire History In The Northwestern Canadian Boreal Forest: Drivers And Ecological Outcomes, Ellen Whitman May 2019

Burn Severity And Fire History In The Northwestern Canadian Boreal Forest: Drivers And Ecological Outcomes, Ellen Whitman

Aspen Bibliography

Wildfire is the dominant stand-renewing disturbance in the northwestern Canadian boreal forest. Fires burn extensive areas in Canada, disturbing an average of 1.96 Mha yr−1, primarily in the boreal zone. Fires generally occur every ~30 – > 200 years in this region, due in part to a lack of fuel that allows young stands to resist reburning. Boreal understory plants and trees are adapted to stand-renewing wildfire through mechanisms such as serotiny, seed banking, and resprouting from roots and rhizomes of top-killed individuals. Such adaptations confer resilience to boreal forests, and post-fire vegetation communities generally resemble the pre-fire ones, following a …


Insect Populations Across An Urban-To-Suburban Land Use Gradient., Jacob T. Lawson May 2019

Insect Populations Across An Urban-To-Suburban Land Use Gradient., Jacob T. Lawson

College of Arts & Sciences Senior Theses

Insect populations, especially those of pollinators, have been steadily declining across the globe in recent decades, a trend that is intensified in cities. Since the conservation of pollinators is crucial for maintaining ecosystems and ecological processes, new approaches are being promoted beyond those of conserving large natural areas. Urban native plant gardens could potentially offset some of these losses locally. This research attempts to set a local baseline for the insect diversity in urban gardens in Louisville and determine whether differences exist in garden insects in cities versus suburbs in Jefferson County, Kentucky. To address the land-use question we established …


A Biotelemetric Study Comparing Diving Behavior And Brumation Sites Of Translocated And Resident Northern Map Turtles (Graptemys Geographica) And Their Response To Replica Model Turtles On Artificial Basking/Nesting Platforms In The Upper Niagara River, Jesse M. Karcher May 2019

A Biotelemetric Study Comparing Diving Behavior And Brumation Sites Of Translocated And Resident Northern Map Turtles (Graptemys Geographica) And Their Response To Replica Model Turtles On Artificial Basking/Nesting Platforms In The Upper Niagara River, Jesse M. Karcher

Biology Theses

Anthropogenic shoreline development leading to a lack of access to terrestrial nesting sites is one of the causes for northern map turtle decline in the upper Niagara River. Translocation of adult map turtles and the development of floating basking/nesting platforms were proposed as possible remedies for this population decline. Biotelemetry along with aerial and underwater drones were used to assess habitat preferences between resident and translocated turtles. It was expected that the platforms would be used for basking and nesting and that a platform located in a natural location would be more successful than one in a developed area, due …


Implementing The North American Bat Monitoring Program In Nebraska: An Assessment Of Nebraska Bats With An Emphasis On Citizen Science, Baxter Seguin May 2019

Implementing The North American Bat Monitoring Program In Nebraska: An Assessment Of Nebraska Bats With An Emphasis On Citizen Science, Baxter Seguin

School of Natural Resources: Dissertations, Theses, and Student Research

Over the past decade bat species in North America have been under immense stress due to anthropogenic activities throughout the continent along with severe declines from foreign invaders. Though many specific anthropogenic related activities such as deforestation, land-use alteration, and hibernacula disturbance/modification were the primary culprits of negative impacts on bat species in the past, they pale in comparison to the threats bats face today. White nose syndrome a disease caused by the fungus Pseudogymnoascus destructans and wind energy development have caused declines and disruptions to the bat populations of North America at an unprecedented rate.

Due to the significant …


Ecosystem Services Provided By Soundscapes Link People And Wildlife, Mitchell Jerome Levenhagen May 2019

Ecosystem Services Provided By Soundscapes Link People And Wildlife, Mitchell Jerome Levenhagen

Boise State University Theses and Dissertations

Protected natural areas are not free from noise exposure, both external to and within park boundaries. Natural soundscapes are important in animal life histories, provide positive visitor experiences, and may increase motivation to protect natural areas. To examine the potential coupling of natural and human systems via the soundscape and the use of signs as an effective anthropogenic noise mitigation strategy, we experimentally introduced educational and enforcement signage along a trail and road system in an alternating, weeklong block design within Muir Woods National Monument, CA and Grand Teton National Park, WY, respectively. In Grand Teton National Park, speed limits …


Dispersal And Distributions In The Era Of Global Change: Patterns And Mechanisms Of Individual Dispersal And Distributional Shifts In North American Birds, Hanna Marie Mccaslin May 2019

Dispersal And Distributions In The Era Of Global Change: Patterns And Mechanisms Of Individual Dispersal And Distributional Shifts In North American Birds, Hanna Marie Mccaslin

Boise State University Theses and Dissertations

Dispersal is a critical process influencing population dynamics, and patterns of dispersal movement impact species distribution and abundance and have important evolutionary and ecological consequences. In particular, long-distance dispersal (LDD) can be especially important for gene flow and adaptability, although little is known about the mechanisms of LDD because of the challenges of studying large-scale animal movement. Global change is driving selection for new movement patterns in animals by stressing physiological tolerances and affecting the dynamics of biotic interactions. This is resulting in shifts in species distributions that are widespread across taxa. The distributions of migratory bird species are shifting …


Comparative Thermal Ecology Of Coastal And Inland Pacific Rattlesnakes (Crotalus Oreganus), Hayley Layne Crowell May 2019

Comparative Thermal Ecology Of Coastal And Inland Pacific Rattlesnakes (Crotalus Oreganus), Hayley Layne Crowell

Master's Theses

Global biodiversity is declining as a direct result of anthropogenic climate change. Ectothermic species have become focal organisms for studying the ecological effects of altered climates due to the clear relationship between environmental temperatures and ectotherms’ basic physiological functions. Historically, examinations of these effects have focused heavily on heliothermic lizards, and most others have tended to focus on single populations or sympatric species within a single community. Addressing the longterm energetic implications of environmental temperature variation will provide valuable insight into the cascading physiological effects that certain populations or species may experience as a result of altered climates.

In this …


Correlation Between Sei Whale Distribution And Chlorophyll-A Concentration In The Western North Atlantic, Dawn Parry May 2019

Correlation Between Sei Whale Distribution And Chlorophyll-A Concentration In The Western North Atlantic, Dawn Parry

Senior Honors Projects

The sei whale (Balaenoptera borealis) is an endangered baleen whale species whose distribution and migratory movements are poorly understood. Sei whale populations were decimated by commercial whaling in the 19th and 20th centuries. Much of what is currently known about their distributions comes from historical whaling records. Visual sightings, which may be sporadic and limited by weather and access to remote locations, are the primary source of data for recent research. It is thought that sei whale distributions may be influenced by the distribution of their food, which consists of zooplankton (small crustaceans, like shrimp), small fish, and …


Circadian Rhythms Of The Spider Pholcus Phalangeoides In Activity Monitors And Web Boxes, Steven Dirmeyer May 2019

Circadian Rhythms Of The Spider Pholcus Phalangeoides In Activity Monitors And Web Boxes, Steven Dirmeyer

Undergraduate Honors Theses

Circadian rhythms are endogenous molecular clocks that correspond to the 24-hour day and are regulated by light stimulus, allowing organisms to entrain to the dawn-dusk cycle. These clocks may allow organisms to anticipate daily events, influencing their behavior. In arthropods, including spiders, circadian rhythmicity is tested using activity monitors, which house individuals in tubes. However, this does not reflect the natural habitat of many spiders. We compared the locomotor activity of the cellar spider Pholcus phalangiodes in activity monitors with the locomotor activity in web boxes. After being entrained to a 12:12 light:dark cycle, the spiders were recorded in constant …


Investigating Diel Periodicity In Export Flux In The Gulf Of Mexico Using A Particulate Imaging System, Justin Edward Blancher May 2019

Investigating Diel Periodicity In Export Flux In The Gulf Of Mexico Using A Particulate Imaging System, Justin Edward Blancher

Master's Theses

To estimate the diurnal periodicity in the biological pump, a floating array with a marine snow camera system at 150 m depth was used, and particles were imaged at a 40 second interval for a 24 to 30 hour period at five sites in the Gulf of Mexico in June 2017. Each image was processed to identify and size all the particles within the frame, which was then processed to determine diameter, an estimated volume, and settling speed for each particle. Using these parameters, particle mass was estimated using algebraically rearranged calculations for settling speed. Each hour during the deployment …


Conservation Of Threatened Canada-Usa Trans-Border Grizzly Bears Linked To Comprehensive Conflict Reduction, Michael F. Proctor, Wayne F. Kasworm, Kimberly M. Annis, A. Grant Machutchon, Justin E. Teisberg, Thomas G. Radandt, Chris Servheen May 2019

Conservation Of Threatened Canada-Usa Trans-Border Grizzly Bears Linked To Comprehensive Conflict Reduction, Michael F. Proctor, Wayne F. Kasworm, Kimberly M. Annis, A. Grant Machutchon, Justin E. Teisberg, Thomas G. Radandt, Chris Servheen

Human–Wildlife Interactions

Erratum to "Conservation of Threatened Canada-USA Trans-border Grizzly Bears Linked to Comprehensive Conflict Reduction". https://doi.org/10.26077/yjy6-0m57


Age-Related Tick Infestation Patterns In Springtime Migratory Passerines, Matthew Dunning May 2019

Age-Related Tick Infestation Patterns In Springtime Migratory Passerines, Matthew Dunning

Honors Theses

To test the hypothesis that younger migrants are more prone to arrive at stopover sites on the northern coast of the Gulf of Mexico with ticks than adult migrants, 2177 migratory passerines were screened for ticks at Gulf Coast sites in Texas and Louisiana. Fifty eight (2.7%) were infested with ticks with 28 (1.3%) being young birds and 30 (1.4%) being adult birds. The body condition of the birds was assessed to determine if tick infestation had negative consequences and if the severity of consequences varied between ages. I found no relationship of age with the prevalence of a tick …


Bottlenose Dolphin (Tursiops Truncatus) Vocal Responses To Sonar And Spectrally Pink Background Noise, Maria Zapetis May 2019

Bottlenose Dolphin (Tursiops Truncatus) Vocal Responses To Sonar And Spectrally Pink Background Noise, Maria Zapetis

Dissertations

As human populations rise, the level of man-made noise increases globally. Naval sonar and boat traffic are underwater sound sources of particular concern to marine mammal welfare. To better understand the impact of these noise increases on cetaceans, studies can explore animals’ behavioral changes in response to noise. Studies have investigated the ‘dose-response’ relationship between the received sound pressure level of sonar signals and the behavior of cetaceans in the wild, but exposure studies in controlled environments are limited. The studies in this dissertation examined bottlenose dolphin vocal modifications during various experimental noise treatments. Acoustic recordings previously obtained for bottlenose …


Seasonal Changes In Black-Capped Chickadee (Poecile Atricapillus) Social Structure And Gargle Vocalizations, James Vanorman May 2019

Seasonal Changes In Black-Capped Chickadee (Poecile Atricapillus) Social Structure And Gargle Vocalizations, James Vanorman

All NMU Master's Theses

Many organisms form social groups for many different reasons. Individuals within a group gain benefits from having a way of effectively communicating with their group, especially in organisms that maintain their social affiliations for long periods of time. In birds, vocalizations are the main means of communicating among individuals. When there are multiple groups of birds in an area, each group could share vocalizations. This sharing can then create local dialects. Black-capped chickadees (Poecile atricapillus) are small songbirds of temperate habitats of North America that group together in larger flocks every winter. Dialects of the gargle vocalization have …


Reassessment Of The Extinction Risk Of The Neotropical Freshwater Crabs Of The Family Pseudothelphusidae, Ada Acevedo Alonso May 2019

Reassessment Of The Extinction Risk Of The Neotropical Freshwater Crabs Of The Family Pseudothelphusidae, Ada Acevedo Alonso

All NMU Master's Theses

The Neotropical region is one of the world’s biodiversity hotspots, and its freshwater crabs are notably diverse, and are represented by two families, Pseudothelphusidae and Trichodactylidae. This study focuses on this region’s highly diverse Pseudothelphusidae which includes 48 genera and 289 species. The 2008 IUCN global conservation assessment found 15.5% of the Pseudothelphusidae to be threatened with extinction and projected that in the worst-case scenario (if all of the Data Deficient species turned out to be threatened), the number of threatened species would be significantly higher. In the last decade several new species of pseudothelphusids have been described, and more …


Contributions Of Historical Ecology To Ecological Services Assessments In The Lower Rio Grande Valley Texas, Julianna Katherine Schaefer Kurpis May 2019

Contributions Of Historical Ecology To Ecological Services Assessments In The Lower Rio Grande Valley Texas, Julianna Katherine Schaefer Kurpis

Theses and Dissertations

Historic and current anthropogenic land-use activities affect ecological functions and ecosystem services quality. The clearing of native Tamaulipan thorn forest and riparian forests for agricultural use and expansion followed by rapid urbanization and population growth resulted in profound ecological impacts to the Lower Rio Grande Valley (LRGV), Texas. The goals of this study are 1) document trends in land use change and vegetation health in the LRGV 2) evaluate and demonstrate the application of the Ecosystem Services Identification & Inventory Tool (ESII Tool) for collecting ecological data and measuring percent ecological performance and 3) use historical ecology indicators to compare …


Differentiating Black Bears (Ursus Americanus) And Brown Bears (U. Arctos) Using Linear Tooth Measurements And Identification Of Ursids From Oregon Caves National Monument, Emily Bogner May 2019

Differentiating Black Bears (Ursus Americanus) And Brown Bears (U. Arctos) Using Linear Tooth Measurements And Identification Of Ursids From Oregon Caves National Monument, Emily Bogner

Electronic Theses and Dissertations

North American black bears and brown bears can be difficult to distinguish in the fossil record due to similar dental and skeletal morphologies. Challenges identifying ursid material from Oregon Caves National Monument (ORCA) called for an accurate tool to distinguish the species. This study utilized a large database of lower tooth lengths and ratios in an attempt to differentiate black and brown bears in North America. Further, this project examined how these linear measurements differ geographically. Analysis of variance (ANOVA) found significant differences between black and brown bears from across North America for every variable studied. Stepwise discriminant analyses (DA) …


Antipredator Mechanisms Of Post-Metamorphic Anurans: A Global Database And Classification System, Rodrigo B. Ferreira, Ricardo Lourenço-De-Moraes, Cássio Zocca, Charles Duca, Karen H. Beard, Edmund D. Brodie Jr. May 2019

Antipredator Mechanisms Of Post-Metamorphic Anurans: A Global Database And Classification System, Rodrigo B. Ferreira, Ricardo Lourenço-De-Moraes, Cássio Zocca, Charles Duca, Karen H. Beard, Edmund D. Brodie Jr.

Ecology Center Publications

A crucial step in any ethological study is to distinguish and classify the observed behavior into categories. The literature on anuran antipredator mechanisms is largely scattered and descriptive due to the opportunistic nature of the observations and the lack of a simple, widely accepted classification scheme. We propose an explanatory classification system of antipredator mechanisms for post-metamorphic anurans (i.e., juveniles and adults) based on a thorough review of the literature and observations made during fieldwork and in the laboratory since 1970. In addition, we provide a freely available global database on antipredator mechanisms of post-metamorphic anurans. The classification system is …


The Role Of Gene Expression Noise In Mammalian Cell Survival, Kevin Farquhar May 2019

The Role Of Gene Expression Noise In Mammalian Cell Survival, Kevin Farquhar

Dissertations and Theses (Open Access)

Drug resistance and metastasis remain obstacles to effective cancer treatment. A major challenge contributing to this problem is cellular heterogeneity. Even in the same environment, cells with identical genomes can display cell-to-cell differences in gene expression, also known as gene expression noise. Gene expression noise can vary in magnitude in a population or in fluctuation time scales, which is influenced by gene regulatory networks.

Currently, it is unclear how gene expression noise from gene regulatory networks contributes to drug survival outcomes in mammalian cells. An isogenic cell line with a noise-modulating genetic system tuned to the same mean is required. …