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Full-Text Articles in Cancer Biology
Modeling Vascular Diffusion Of Oxygen In Breast Cancer, Tina Giorgadze
Modeling Vascular Diffusion Of Oxygen In Breast Cancer, Tina Giorgadze
Senior Projects Spring 2023
Oxygen is a vital nutrient necessary for tumor cells to survive and proliferate. Oxygen is diffused from our blood vessels into the tissue, where it is consumed by our cells. This process can be modeled by partial differential equations with sinks and sources. This project focuses on adding an oxygen diffusion module to an existing 3D agent-based model of breast cancer developed in Dr. Norton’s lab. The mathematical diffusion module added to an existing agent-based model (ABM) includes deriving the 1-dimensional and multi-dimensional diffusion equations, implementing 2D and 3D oxygen diffusion models into the ABM, and numerically evaluating those equations …