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Full-Text Articles in Cancer Biology
Microrna-200 Regulates Ecm-Dependent Β1-Integrin/Fak Signaling And Cancer Cell Invasion, Christin Ungewiss
Microrna-200 Regulates Ecm-Dependent Β1-Integrin/Fak Signaling And Cancer Cell Invasion, Christin Ungewiss
Dissertations & Theses (Open Access)
The microRNA-200 family is known to be a master regulator of the epithelial-to-mesenchymal transition, partially through its double-negative feedback loop with the transcriptional repressor Zeb1, yet the mechanisms on how miR-200 controls the invasive phenotype are not fully understood. Recent studies have shown that the miR-200/Zeb1 axis regulates cell-cell and cell-matrix interactions, but it has also been demonstrated that cell-intrinsic changes are insufficient to drive cancer cell invasion, leading us to focus on specific cell-matrix interactions required to activate tumor cell invasion and metastases. We have shown through 3D studies that the Integrin β1-collagen I contact is critical in mediating …
Cancer Stem Cells In Recurrent And Drug-Resistant Lung Cancers, Raagini Suresh, Shadan Ali, Aamir Ahmad, Philip Philip, Fazlul Sarkar
Cancer Stem Cells In Recurrent And Drug-Resistant Lung Cancers, Raagini Suresh, Shadan Ali, Aamir Ahmad, Philip Philip, Fazlul Sarkar
Honors College Theses
With a 5-year survival rate of less than 20%, lung cancer is a leading cause of cancer-related deaths worldwide. Considering the treatments currently in place, this statistic is frankly shocking. A possible explanation for the disconnect between sophisticated treatments and the survival rate can be found in the Cancer Stem Cell (CSC) hypothesis. The CSC hypothesis suggests the idea of a subpopulation of tumor cells with the abilities of self-renewal, cancer initiation, and further maintenance of tumors. Lung CSCs have been associated with resistance to radiation and chemotherapeutic treatments. CSCs have also been implicated in recurrent cancers; …
Inhalable Nanocomposites And Anticancer Agents For Cancer Therapy, Nathanael A. Stocke
Inhalable Nanocomposites And Anticancer Agents For Cancer Therapy, Nathanael A. Stocke
Theses and Dissertations--Chemical and Materials Engineering
Cancer is designated as the leading cause of mortality worldwide and lung cancer is responsible for nearly 30% of all cancer related deaths. Over the last few decades mortality rates have only marginally increased and rates of recurrence remain high. These factors, among others, suggest the need for more innovative treatment modalities in lung cancer therapy. Targeted pulmonary delivery is well established for treating pulmonary diseases such as asthma and provides a promising platform for lung cancer therapy. Increasing local deposition of anticancer agents (ACAs) and reducing systemic exposure of these toxic moieties could lead to better therapeutic outcomes and …
The Role Of Brct-Containing Proteins Brca1 And Paxip1 In Cancer, Ankita Jhuraney
The Role Of Brct-Containing Proteins Brca1 And Paxip1 In Cancer, Ankita Jhuraney
USF Tampa Graduate Theses and Dissertations
Modular domains of proteins are important in cellular signaling processes. Eukaryotic cells are constantly undergoing DNA damage due to exogenous and endogenous sources of damage. The DNA damage response (DDR) involves a complex network of signaling events mediated by modular domains such as the BRCT (BRCA1 C-terminal) domains. Therefore, proteins containing BRCT domains are important for DNA damage detection and signaling. In this dissertation, we focus on two BRCT-containing proteins BRCA1 and PAXIP1. BRCA1 is a gene that is known to be associated with increased risk of hereditary breast and ovarian cancer. Germline variants of BRCA1 are assessed to determine …