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Full-Text Articles in Cancer Biology
Oncogene Characterization And Mapping, John Evans
Oncogene Characterization And Mapping, John Evans
Summer Research
New oncogenes can be uncovered using the UAS/GAL4 system in the model organism Drosophila Melanogaster. P-elements allow both UAS and GAL4 to insert into the genome of parental flies. When crossed, both UAS/GAL4 are transferred to the progeny and express both sequence and protein that result in cancerous phenotypes that are easily identifiable using light microscopy. Inverse PCR, sequence analysis and comparison to online databases, e.g. flybase.org, provides simple identification of the culprit gene.
Effect Of Altered Cellular Redox Environment On Oncogenic Activity Of The Drosophila Prl Protein, Frances Welsh
Effect Of Altered Cellular Redox Environment On Oncogenic Activity Of The Drosophila Prl Protein, Frances Welsh
Summer Research
Aberrant expression of members of the phosphatase of regenerating liver (PRL) family has been implicated as a key factor in the progression of several forms of human cancers. However, despite a wide range of studies supporting the role of the enzyme PRL as an oncogene, it has also been identified as a growth suppressor when tested under different conditions. One proposed explanation for this change in function is that redox regulation controls the accessibility of the active site of PRLs, which is necessary for oncogenic output. In this study, cellular redox environment was altered in vivo using Drosophila melanogaster, …