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Full-Text Articles in Cancer Biology
Features Of Dormancy In Metastatic Ovarian Cancer Cells, Rohann Jm Correa
Features Of Dormancy In Metastatic Ovarian Cancer Cells, Rohann Jm Correa
Electronic Thesis and Dissertation Repository
The most prevalent subtype of ovarian cancer – high-grade serous (HGS) carcinoma – is also the most lethal, since the majority of cases are characterized by advanced-stage (metastatic) presentation. Metastasis of this cancer proceeds by an intra-peritoneal route, involving detachment of cells from the primary tumour and dissemination throughout the peritoneal cavity as multicellular aggregates, or spheroids. Herein, we demonstrate that HGS patient-derived tumour cells cultured to form in vitro spheroids exhibit features of cancer dormancy, a cellular state known to promote therapeutic resistance and disease recurrence. We discovered that upon spheroid formation, cells became non-proliferative, exhibiting a cell cycle …