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Full-Text Articles in Cancer Biology
Investigations Into The Modification Of Dna By Doxorubicin Analogs, Hannah Kulm, Stephanie Torres, Chris Mallory, Kenneth Cornell (Mentor), Don Warner (Mentor)
Investigations Into The Modification Of Dna By Doxorubicin Analogs, Hannah Kulm, Stephanie Torres, Chris Mallory, Kenneth Cornell (Mentor), Don Warner (Mentor)
Idaho Conference on Undergraduate Research
Doxorubicin (DOX) is an anthracycline chemotherapeutic that has seen widespread use to treat numerous cancer types. Its mechanism of action is still unclear, but is thought to include the intercalation of DNA, halting transcription and inducing apoptosis. Although DOX has shown strong antitumor activity, its usage is limited due to a dose-dependent onset of cumulative and irreversible life-threatening cardiac damage. Consequently, the harmful side effects necessitate the need for the production of new, less harmful anthracycline chemotherapeutics with greater effectiveness for the treatment of cancer. Three analogs of DOX (P-DOX, GPX-150 and GPX-160) have been synthesized and determined to have …