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Hematology/Oncology and Stem Cell Therapy
Brain metastases; Immune checkpoint inhibitors; Melanoma; Meta-analysis; Radiotherapy
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Full-Text Articles in Cancer Biology
Radiotherapy And Immunotherapy In Melanoma Brain Metastases, Amir Anvari, Pegah Sasanpour, Mania Rajabzadeh Kheradmardi
Radiotherapy And Immunotherapy In Melanoma Brain Metastases, Amir Anvari, Pegah Sasanpour, Mania Rajabzadeh Kheradmardi
Hematology/Oncology and Stem Cell Therapy
Background and objective: Melanoma brain metastasis (MBM) generally portends a dismal prognosis. Simultaneous use of radiotherapy (RT) and immune checkpoint inhibitor (ICI) therapy demonstrated tremendous promise and emerged as the new standard. This meta-analysis was conducted to evaluate survival outcomes and toxicities of this combination in patients with MBM. Data analyses were performed using Comprehensive Meta-Analysis software (version 2) and IBM SPSS software (version 27). Methods: A systematic literature search of PubMed, EMBASE, and the Cochrane Library (via Wiley) was conducted using PICOS/PRISMA selection protocol and included studies to evaluate survival and safety-associated outcomes of ICI + RT for the …