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Hematology/Oncology and Stem Cell Therapy
AGvHD; heparanase/HPSE; HSCT; Risk factors; Single nucleotide polymorphisms/ SNP; Sinusoidal obstruction syndrome/ SOS transplantassociated systemic vasculopathies/ TASV
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Full-Text Articles in Cancer Biology
Heparanase Wildtype Is Associated With A Reduced Incidence Of Transplant-Associated Systemic Vasculopathies, Raphaela Mueckenhausen, Ju¨Rgen Fo¨Ll, Katharina Kleinschmidt, Anja Tro¨Ger, Muriel Malaise´, Daniel Wolff, Ernst Holler, Marie Matthes, Tilman Heise, Gunhild Sommer, Selim Corbacioglu
Heparanase Wildtype Is Associated With A Reduced Incidence Of Transplant-Associated Systemic Vasculopathies, Raphaela Mueckenhausen, Ju¨Rgen Fo¨Ll, Katharina Kleinschmidt, Anja Tro¨Ger, Muriel Malaise´, Daniel Wolff, Ernst Holler, Marie Matthes, Tilman Heise, Gunhild Sommer, Selim Corbacioglu
Hematology/Oncology and Stem Cell Therapy
Some of the early complications of hematopoietic stem cell transplantation (HSCT) concerning the small vessels can be summarized as transplant-associated systemic vasculopathies (TASV). One enzyme known to play a major role in inflammation, tissue remodeling, and repair processes as well as tumor metastasis is heparanase (HPSE). HPSE genetic variants have recently been associated with significant influence on the risk of developing certain TASV such as a sinusoidal obstruction syndrome. This study aimed to validate the two known HPSE single nucleotide polymorphisms (SNPs)—rs4693608 and rs4364254—as a genetic predictor of TASV in a cohort of 494 patients and were correlated retrospectively with …