Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 1 of 1
Full-Text Articles in Cancer Biology
Regulation Of The Wnt/Β-Catenin Pathway By Steroid Hormones In Danio Rerio Ovarian Tissue, Macaulie Casey
Regulation Of The Wnt/Β-Catenin Pathway By Steroid Hormones In Danio Rerio Ovarian Tissue, Macaulie Casey
Summer Research
The Wnt/β-catenin signaling pathway regulates genes involved in proliferation (cell growth) and apoptosis (cell death). It has been implicated in ovarian cancer, where higher levels of β-catenin may be involved in the development of tumors. Steroid hormones play a significant role in female reproductive tissue, and studies have shown that estrogens and progestins may regulate the Wnt/β-catenin pathway. My past research suggested testosterone may also affect the pathway. Few studies have investigated how steroid hormone mimics, such as Bisphenol A (BPA), affect these regulatory patterns. This study investigated the affect of estrogen and BPA on the Wnt/β-catenin pathway in Danio …