Open Access. Powered by Scholars. Published by Universities.®
- Discipline
-
- Laboratory and Basic Science Research (2)
- Animal Experimentation and Research (1)
- Biochemistry (1)
- Biochemistry, Biophysics, and Structural Biology (1)
- Biology (1)
-
- Biotechnology (1)
- Cellular and Molecular Physiology (1)
- Computational Biology (1)
- Developmental Biology (1)
- Genetics (1)
- Genetics and Genomics (1)
- Genomics (1)
- Medical Cell Biology (1)
- Medical Sciences (1)
- Medicine and Health Sciences (1)
- Molecular Biology (1)
- Molecular Genetics (1)
- Neuroscience and Neurobiology (1)
- Physiology (1)
- Research Methods in Life Sciences (1)
- Structural Biology (1)
- Keyword
-
- AML (1)
- Astrocytes (1)
- BRAF (1)
- BRAFV600E mutation (1)
- Biosensor (1)
-
- Brain cancer (1)
- Brain development (1)
- Cell (1)
- Embryonic mice (1)
- Epilepsy (1)
- FRET (1)
- Fluorophore (1)
- Force (1)
- GFP (1)
- Glioma (1)
- Iba-1 (1)
- Immunohistochemistry (1)
- In-utero electroporation (1)
- Interneurons (1)
- LEAT (1)
- LGNT (1)
- Low grade glioma (1)
- Low grade neuroepithelial tumor (1)
- MTX (1)
- Mechanotransduction (1)
- Microglia (1)
- Microglia activation (1)
- Modeling (1)
- Mouse brain tissue (1)
- Mouse model (1)
Articles 1 - 3 of 3
Full-Text Articles in Cancer Biology
Single-Fluorophore Sensors For Mechanical Force In Living Cells, Sarah Kricheff
Single-Fluorophore Sensors For Mechanical Force In Living Cells, Sarah Kricheff
Honors Scholar Theses
Mechanotransduction is the process by which a mechanical stimulus is converted to a cellular signal. This process is heavily influential of cell morphology, differentiation, and behavior. However, altered levels of mechanical stimuli are also found in many pathological contexts. For example, cancerous cells have stiffer surrounding tissue than healthy cells, and research suggests that this alters cell behavior and promotes metastasis. Despite these findings, the cellular processes behind these signaling alterations remain widely unknown. Understanding these cascades is critical, as involved proteins can give us a deeper understanding of the role of mechanotransduction, and certain proteins can potentially be targeted …
The Anti-Proliferative Effects Of Methotrexate And Novel Ucp1162 On Acute Myeloid Leukemia Cell Lines, Jacqueline Klepinger, Charles Giardina, Didem Ozcan
The Anti-Proliferative Effects Of Methotrexate And Novel Ucp1162 On Acute Myeloid Leukemia Cell Lines, Jacqueline Klepinger, Charles Giardina, Didem Ozcan
Honors Scholar Theses
Cancer cells proliferate at rapid rates due to the aberrant activity of proteins involved in regulating the cell cycle. This characteristic allows mutated cancer cells to spread and metastasize, causing lesions to form throughout the body. Two treatment conditions, one classical antifolate methotrexate (MTX) and non-classical, novel antifolate UCP1162, were tested on a panel of acute myeloid leukemia (AML) cell lines to determine if UCP1162 has higher anti-proliferative activity. High dose MTX is used as a first line chemotherapy in common childhood malignancies such as acute lymphoid leukemia (ALL). Methotrexate is excluded from acute myeloid leukemia (AML) treatments based on …
Microglia-Neuron Interactions In A Mouse Model Of Low Grade Neuroepithelial Tumors, Veolette Hanna
Microglia-Neuron Interactions In A Mouse Model Of Low Grade Neuroepithelial Tumors, Veolette Hanna
Honors Scholar Theses
Microglia are the macrophages of the brain and spinal cord, playing an important role in the immune response to disease states of the nervous system. This study conducts an investigation on the activity of microglia in response to low grade neuroepithelial tumors. Using mouse models and microglial markers, a qualitative and quantitative analysis of microglia activation, migration, and invasion within the brain cortex during early stages of tumor development was conducted. It was found that the presence of a low grade neuroepithelial tumor in the cortex of one hemisphere of the brain causes significant microglia activation in comparison to the …