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Cancer Biology Commons

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Full-Text Articles in Cancer Biology

Numerical Simulation Of Terahertz Wave Interaction With Breast Cancer Tumor Tissue Sections, Abayomi Omotola Omolewu Jul 2015

Numerical Simulation Of Terahertz Wave Interaction With Breast Cancer Tumor Tissue Sections, Abayomi Omotola Omolewu

Graduate Theses and Dissertations

This thesis presents numerical simulation of terahertz (THz) wave interaction with breast cancer tumor tissue sections. The obtained results are expressed in THz images of heterogeneous material that mimics the excised breast cancer tissue sections. The finite-element software package ANSYS High Frequency Structural Simulator (HFSS) was used in this work. HFSS is a full wave frequency domain three-dimensional (3D) electromagnetic simulation package. In this work, four breast cancer tissue models based on pathology images were simulated and images of the models were obtained at 1 THz. An incident Gaussian beam was raster scanned over tissue model configurations and the reflected …


Growth Of Breast Tumors In Vitro To Characterize A Terahertz Imaging Platform, Scarlett-Marie Acklin May 2015

Growth Of Breast Tumors In Vitro To Characterize A Terahertz Imaging Platform, Scarlett-Marie Acklin

Biological Sciences Undergraduate Honors Theses

In this research, different methods were investigated to grow in-vitro breast cancer tumors embedded in gel using the 4T1 cell line. The goal of this research was to test a new medical imaging modality available at the University of Arkansas using terahertz (THz) waves. The THz imaging and spectroscopy system has shown capability of high-resolution imaging and characterization of human breast tumors fixed in formalin and embedded in paraffin. In order to further examine this new imaging system in a laboratory environment, attempts to grow breast tumors in-vitro were conducted. Results were produced in two different environments, flat-bottomed plates and …


Terahertz Imaging Platform To Characterize The Growth Of In-Vitro Breast Tumors, Scarlett-Marie Acklin Jan 2015

Terahertz Imaging Platform To Characterize The Growth Of In-Vitro Breast Tumors, Scarlett-Marie Acklin

Inquiry: The University of Arkansas Undergraduate Research Journal

This study aimed at evaluating the ideal plating method and density for imaging with the terahertz (THz) spectrometer. In this study, different methods were used to grow in-vitro tumors using the 4T1 cell line. Here, attempts to grow breast tumors in-vitro were conducted. Results were produced in two environments, flat-bottomed plates and round-bottomed multiwell plates. The second method allowed for faster clumping and increased cell aggregation, producing tumors up to 7mm. Terahertz spectroscopy produced images that correlated well to photomicrographs taken of the in-vitro tumors. This methodology shows great promise for providing a reliable, parameter-controlled source of in-vitro breast tumors …