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Full-Text Articles in Cancer Biology
Glioblastoma Derived Exosomes Induce Apoptosis In Cytotoxic T Cells Through A Fas Ligand Mediated Mechanism, Keith Sabin, Richard Rovin, Johnathan Lawrence, Robert Belton, Robert Winn
Glioblastoma Derived Exosomes Induce Apoptosis In Cytotoxic T Cells Through A Fas Ligand Mediated Mechanism, Keith Sabin, Richard Rovin, Johnathan Lawrence, Robert Belton, Robert Winn
Johnathan Lawrence
INTRODUCTION: Glioblastoma multiforme deploy s a number of weapons to thwart the immune system. Within the tumor microenvironment, cytotoxic T cells fall victim to Fas ligand (FasL) induced apoptosis. In prostate and colorectal cancer, exosomes can mediate this FasL induced T cell apoptosis. Exosomes are tiny, membrane bound vesicles that are released from a cell. They contain functional mRNA and protein and have cell surface molecules representative of their parent cell. It is not known if GBM derived exosomes can also mediate FasL triggered apoptosis. In this study, the role of tumor derived exosomes as the delivery vehicle for FasL …
Leptin Promotes Glioblastoma, Johnathan Lawrence, Nicholas Cook, Richard Rovin, Robert Winn
Leptin Promotes Glioblastoma, Johnathan Lawrence, Nicholas Cook, Richard Rovin, Robert Winn
Johnathan Lawrence
The hormone leptin has a variety of functions. Originally known for its role in satiety and weight loss, leptin more recently has been shown to augment tumor growth in a variety of cancers. Within gliomas, there is a correlation between tumor grade and tumor expression of leptin and its receptor. This suggests that autocrine signaling within the tumor microenvironment may promote the growth of high-grade gliomas. Leptin does this through stimulation of cellular pathways that are also advantageous for tumor growth and recurrence: antiapoptosis, proliferation, angiogenesis, and migration. Conversely, a loss of leptin expression attenuates tumor growth. In animal models …
Effects Of Ss3-Adrenergic Receptor Agonist On Gene Expression Of Leptin In Glioblastoma, Johnathan E. Lawrence, Nicholas J. Cook, Richard A. Rovin, Robert J. Belton, Robert J. Winn
Effects Of Ss3-Adrenergic Receptor Agonist On Gene Expression Of Leptin In Glioblastoma, Johnathan E. Lawrence, Nicholas J. Cook, Richard A. Rovin, Robert J. Belton, Robert J. Winn
Johnathan Lawrence
In the 25 years since temozolomide entered phase I clinical trials, few new primary or adjuvant therapies have been developed for the treatment of glioblastoma multiforme (GBM) tumors. Our laboratory has been exploring novel methods for the treatment of GBMs. Recent studies indicate that the expression of the hormone leptin and its receptor (OBR) increases in gliomas and positively correlates with the malignancy of the tumor. Interestingly, ß3-adrenergic receptor agonists are known to decrease leptin expression in adipocytes but have not been examined in GBM cells. We hypothesized that b3-adrenergic agonists downregulate the expression of leptin and its receptor. In …
7 Alpha-Hydroxy-Beta-Sitosterol From Chisocheton Tomentosus Induces Apoptosis Via Dysregulation Of Cellular Bax/Bcl-2 Ratio And Cell Cycle Arrest By Downregulating Erk1/2 Activation, Noor Hasima Nagoor
Noor Hasima Nagoor
In continuation of our interest towards the elucidation of apoptotic pathways of cytotoxic phytocompounds, we have embarked upon a study on the anticancer effects of 7 alpha-hydroxy-beta-sitosterol (CT1), a rare natural phytosterol oxide isolated from Chisocheton tomentosus. CT1 was found to be cytotoxic on three different human tumor cell lines with minimal effects on normal cell controls, where cell viability levels were maintained >= 80% upon treatment. Our results showed that cell death in MCF-7 breast tumor cells was achieved through the induction of apoptosis via downregulation of the ERK1/2 signaling pathway. CT1 was also found to increase proapoptotic Bax …