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Cancer Biology Commons™

Open Access. Powered by Scholars. Published by Universities.®

Selected Works

2009

Articles 1 - 4 of 4

Full-Text Articles in Cancer Biology

Muc4/Muc4 Functions And Regulation In Cancer., Goldi Kozloski Dec 2009

Muc4/Muc4 Functions And Regulation In Cancer., Goldi Kozloski

Goldi A Kozloski

The membrane mucin MUC4 (human) is abundantly expressed in many epithelia, where it is proposed to play a protective role, and is overexpressed in some epithelial tumors. Studies on the rat homologue, Muc4, indicate that it acts through anti-adhesive or signaling mechanisms. In particular, Muc4/MUC4 can serve as a ligand/modulator of the receptor tyrosine kinase ErbB2, regulating its phosphorylation and the phosphorylation of its partner ErbB3, with or without the involvement of the ErbB3 ligand neuregulin. Muc4/MUC4 can also modulate cell apoptosis via multiple mechanisms, both ErbB2 dependent and independent. Muc4/MUC4 expression is regulated by multiple mechanisms, ranging from transcriptional …

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Conformational Changes In Receptor Tyrosine Kinase Signaling: An Erbb Garden Of Delights., Goldi Kozloski Sep 2009

Conformational Changes In Receptor Tyrosine Kinase Signaling: An Erbb Garden Of Delights., Goldi Kozloski

Goldi A Kozloski

The ErbB family of receptor tyrosine kinases plays important roles in cell proliferation, differentiation, and apoptosis. Recent structural studies of these receptors have demonstrated dramatic conformational effects that are critical to their ligand binding and activation, and have shown that these receptors provide levels of control beyond the classic dimerization/activation mechanism. These results indicate that this class of receptors has evolved subtle regulatory mechanisms via genetic and protein structural changes to influence their effects on cell behaviors.


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Targeted Inhibition Of The Egfr Pathways Enhances Zn-Bc-Am Pdt-Induced Apoptosis In Well-Differentiated Nasopharyngeal Carcinoma Cells, Hk Koon, Ps Chan, Rns Wong, Zg Wu, Ml Lung, Ck Chang, N.K. Mak Dec 2008

Targeted Inhibition Of The Egfr Pathways Enhances Zn-Bc-Am Pdt-Induced Apoptosis In Well-Differentiated Nasopharyngeal Carcinoma Cells, Hk Koon, Ps Chan, Rns Wong, Zg Wu, Ml Lung, Ck Chang, N.K. Mak

Professor MAK, Nai Ki

No abstract provided.

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Oncogenesis And Cancer Stem Cells: Current Opinions And Future Directions., Xiaoyu Cheng, Helen O'Neill Dec 2008

Oncogenesis And Cancer Stem Cells: Current Opinions And Future Directions., Xiaoyu Cheng, Helen O'Neill

Helen O'Neill

There is increasing evidence to show that only a subset of cancer cells drives the growth and progression of a tumour. These cells share similar properties with normal stem cells and are termed 'cancer stem cells'. Cancer stem cells have been identified in acute myeloid leukaemia and in some solid tumours by their distinct expression of cell surface antigens. Their long-term, self-renewing capacity is thought to be a determining factor in the maintenance and regrowth of the tumour. Studies on haematopoietic cancers show that important signalling pathways and genes for normal haematopoiesis, such as Wnt, NF-kappaB, Notch, hedgehog (Hh) and …

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