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Full-Text Articles in Cancer Biology
Prostate Field Cancerization – Thinking Outside The Tumor, Dor Shoshan
Prostate Field Cancerization – Thinking Outside The Tumor, Dor Shoshan
Student Scholar Symposium Abstracts and Posters
Analysis of tumor adjacent tissue is assumed to reveal a temporal record of molecular pathways that define oncogenesis. The present study determines expression of the key transcription factor and potential marker of field cancerization early growth response 1 (EGR-1) in human prostate tissues derived from prostatectomies and biopsies. Expression was detected using immunofluorescence and quantified using ImageJ software. Accordingly, EGR-1 expression was similar in cancerous and in histologically normal adjacent tissues from prostatectomy and biopsy specimens. EGR-1 could be exploited as pre-surgical disease indicator in false negative biopsies, identify areas of repeat biopsy, and add molecular information to surgical margins.