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Full-Text Articles in Cancer Biology
Host Cell Responses Modulate Oncolytic Viral Treatment Of Neuroblastoma Cells, Kritika Kedarinath
Host Cell Responses Modulate Oncolytic Viral Treatment Of Neuroblastoma Cells, Kritika Kedarinath
Electronic Theses and Dissertations, 2020-
Neuroblastoma is an aggressive pediatric cancer that is poorly responsive to traditional cancer therapies. Oncolytic viral (OV) vectors such as Zika virus (ZIKV) and Parainfluenza virus type 5 (P/V virus) are promising neuroblastoma therapeutics, but the role of innate immune responses in the effectiveness of OV killing is not well understood. Previous studies showed the neuroblastoma cell line SK-N-AS (expressing low CD24) had low permissivity for ZIKV infection, and this restriction was relieved by ectopic CD24 expression (CD24-high cells). Compared to permissive CD24-high cells, the non-permissive CD24-low cells had elevated basal levels of IRF-1, NF?B and phosphorylated STAT1; these cells …