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Articles 1 - 10 of 10
Full-Text Articles in Cancer Biology
Three-Dimensional Confocal Microscopy Indentation Method For Hydrogel Elasticity Measurement, Donghee Lee, Md Mahmudur Rahman, You Zhou, Sangjin Ryu
Three-Dimensional Confocal Microscopy Indentation Method For Hydrogel Elasticity Measurement, Donghee Lee, Md Mahmudur Rahman, You Zhou, Sangjin Ryu
Md Mahmudur Rahman
No abstract provided.
Another Armed Cd4(+) T Cell Ready To Battle Hepatocellular Carcinoma, Roniel Cabrera, Gyongyi Szabo
Another Armed Cd4(+) T Cell Ready To Battle Hepatocellular Carcinoma, Roniel Cabrera, Gyongyi Szabo
Gyongyi Szabo
No abstract provided.
Brca1 Dna-Binding Activity Is Stimulated By Bard1, Amanda Simons, Andrew Horwitz, Lea Starita, Karen Griffin, R Williams, J.N. Glover, Jeffrey Parvin
Brca1 Dna-Binding Activity Is Stimulated By Bard1, Amanda Simons, Andrew Horwitz, Lea Starita, Karen Griffin, R Williams, J.N. Glover, Jeffrey Parvin
Amanda Simons
The breast- and ovarian-specific tumor suppressor BRCA1 has been implicated in numerous cellular processes, including transcription, ubiquitination, and DNA repair. Its tumor suppression activity is tightly linked to that of BARD1, a protein that heterodimerizes with BRCA1. It has been previously shown that BRCA1 binds to DNA, an interesting functional observation in light of the genetic data linking BRCA1 to DNA repair pathways. In this work, we reexamine the DNA-binding properties of BRCA1, comparing them with the DNA-binding properties of the BRCA1/BARD1 heterodimer. Because nuclear BRCA1 exists as a heterodimer with BARD1, it is likely that in vitro studies of …
Micrornas Are Independent Predictors Of Outcome In Diffuse Large B-Cell Lymphoma Patients Treated With R-Chop, Goldi Kozloski
Micrornas Are Independent Predictors Of Outcome In Diffuse Large B-Cell Lymphoma Patients Treated With R-Chop, Goldi Kozloski
Goldi A Kozloski
Sfrp1 Reduction Results In An Increased Sensitivity To Tgf-Β Signaling, Sallie Smith Schneider, Kelly Gauger, Kerry Chenausky, Molly Murray
Sfrp1 Reduction Results In An Increased Sensitivity To Tgf-Β Signaling, Sallie Smith Schneider, Kelly Gauger, Kerry Chenausky, Molly Murray
Sallie W Smith Schneider
Background Transforming growth factor (TGF)-β plays a dual role during mammary gland development and tumorigenesis and has been shown to stimulate epithelial-mesenchymal transition (EMT) as well as cellular migration. The Wnt/β-catenin pathway is also implicated in EMT and inappropriate activation of the Wnt/β-catenin signaling pathway leads to the development of several human cancers, including breast cancer. Secreted frizzled-related protein 1 (SFRP1) antagonizes this pathway and loss of SFRP1 expression is frequently observed in breast tumors and breast cancer cell lines. We previously showed that when SFRP1 is knocked down in immortalized non-malignant mammary epithelial cells, the cells (TERT-siSFRP1) acquire characteristics …
Mechanistic And Signaling Analysis Of Muc4-Erbb2 Signaling Module: New Insights Into The Mechanism Of Ligand-Independent Erbb2 Activity, Goldi Kozloski
Mechanistic And Signaling Analysis Of Muc4-Erbb2 Signaling Module: New Insights Into The Mechanism Of Ligand-Independent Erbb2 Activity, Goldi Kozloski
Goldi A Kozloski
Muc4/Muc4 Functions And Regulation In Cancer., Goldi Kozloski
Muc4/Muc4 Functions And Regulation In Cancer., Goldi Kozloski
Goldi A Kozloski
Conformational Changes In Receptor Tyrosine Kinase Signaling: An Erbb Garden Of Delights., Goldi Kozloski
Conformational Changes In Receptor Tyrosine Kinase Signaling: An Erbb Garden Of Delights., Goldi Kozloski
Goldi A Kozloski
Oncogenesis And Cancer Stem Cells: Current Opinions And Future Directions., Xiaoyu Cheng, Helen O'Neill
Oncogenesis And Cancer Stem Cells: Current Opinions And Future Directions., Xiaoyu Cheng, Helen O'Neill
Helen O'Neill
There is increasing evidence to show that only a subset of cancer cells drives the growth and progression of a tumour. These cells share similar properties with normal stem cells and are termed 'cancer stem cells'. Cancer stem cells have been identified in acute myeloid leukaemia and in some solid tumours by their distinct expression of cell surface antigens. Their long-term, self-renewing capacity is thought to be a determining factor in the maintenance and regrowth of the tumour. Studies on haematopoietic cancers show that important signalling pathways and genes for normal haematopoiesis, such as Wnt, NF-kappaB, Notch, hedgehog (Hh) and …
Characterization Of Microrna Expression Levels And Their Biological Correlates In Human Cancer Cell Lines., Caifu Chen, Arti Gaur, David Jewell, Yu Liang, Dana Ridzon, Jason Moore, Victor Ambros, Mark Israel
Characterization Of Microrna Expression Levels And Their Biological Correlates In Human Cancer Cell Lines., Caifu Chen, Arti Gaur, David Jewell, Yu Liang, Dana Ridzon, Jason Moore, Victor Ambros, Mark Israel
Victor R. Ambros
MicroRNAs are small noncoding RNAs that function by regulating target gene expression posttranscriptionally. They play a critical role in developmental and physiologic processes and are implicated in the pathogenesis of several human diseases including cancer. We examined the expression profiles of 241 human microRNAs in normal tissues and the NCI-60 panel of human tumor-derived cell lines. To quantify microRNA expression, we employed a highly sensitive technique that uses stem-loop primers for reverse transcription followed by real-time PCR. Most microRNAs were expressed at lower levels in tumor-derived cell lines compared with the corresponding normal tissue. Agglomerative hierarchical clustering analysis of microRNA …