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Full-Text Articles in Cancer Biology
Phospho Tensin Homolog In Human And Lipid Peroxides In Peripheral Blood Mononuclear Cells Following Exposure To Flavonoids, William Y. Boadi, Elbert L. Myles, Alekzander S. Garcia
Phospho Tensin Homolog In Human And Lipid Peroxides In Peripheral Blood Mononuclear Cells Following Exposure To Flavonoids, William Y. Boadi, Elbert L. Myles, Alekzander S. Garcia
Biology Faculty Research
Objectives: Studies have shown that human and peripheral blood mononuclear cells (PBMCs) are mostly used for research purposes to study several biochemical endpoints. The effects of the flavonoids, genistein, kaempferol, and quercetin on phospho tensin homolog (PTEN) levels in cancer cells (i.e., breast [BT549], lung [A549]), human embryonic kidney cells (HEK293), and the levels of lipid peroxides (LP) in PBMCs were respectively investigated.
Materials and methods: Cancer, kidney, and PBMCs from several donors were each exposed to each of the flavonoids at concentrations of 0, 5, 10, 15, 20, and 25 µM. Our hypotheses were that exposure of cancer and …