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Articles 1 - 6 of 6
Full-Text Articles in Biology
Regulation Of Gene Expression Through Ribosome-Associated Proteins, Clare Margaret Miller
Regulation Of Gene Expression Through Ribosome-Associated Proteins, Clare Margaret Miller
Legacy Theses & Dissertations (2009 - 2024)
Translation is a crucial mechanism for generating proteins to carry out cellular processes and for ensuring proper cell functions. Ribosomes are at the center of translation and are complex pieces of machinery. They consist of at least 80 core eukaryotic ribosomal proteins, which are conserved from prokaryotes, and four ribosomal RNAs (rRNAs): 18S, 28S, 5,8A 5S. In addition, numerous translation factors aid the ribosome in protein production. While ribosomes are typically described by these core features, they are known to exist in a heterogenous pool with variations in protein composition, modifications of rRNA, and an assortment of non-ribosomal proteins that …
Understanding Plant Response To Stress Using Gene Model Quality Evaluation And Transcriptome Analysis, Karthik Ramaswamy Padmanabhan
Understanding Plant Response To Stress Using Gene Model Quality Evaluation And Transcriptome Analysis, Karthik Ramaswamy Padmanabhan
Open Access Dissertations
The overall aim of the project was to understand how plants reacted to environmental stress and evolved to overcome it. The land plants that we see today evolved from a green algal ancestor around 510 million years ago. Plants had to make significant changes to their cellular, morphological, regulatory and physiological processes during their adaptation to the terrestrial environment from an aquatic environment. The first part of the project was to find out how these changes were reflected on the protein makeup of the early land plants. The gene model sequence data of two early land plants, Physcomitrella patens (moss) …
Degradation By Cullin 3 And Effect On Wnk Kinases Suggest A Role Of Klhl2 In The Pathogenesis Of Familial Hyperkalemic Hypertension, Chong Zhang, Nicholas P. Meermeier, Andrew Terker, Katharina I. Blankenstein, Jeffrey D. Singer, Juliette Hadchouel, David Ellison, Chao-Ling Yang
Degradation By Cullin 3 And Effect On Wnk Kinases Suggest A Role Of Klhl2 In The Pathogenesis Of Familial Hyperkalemic Hypertension, Chong Zhang, Nicholas P. Meermeier, Andrew Terker, Katharina I. Blankenstein, Jeffrey D. Singer, Juliette Hadchouel, David Ellison, Chao-Ling Yang
Biology Faculty Publications and Presentations
Mutations in WNK1 and WNK4, and in components of the Cullin-Ring Ligase system, kelch-like 3 (KLHL3) and Cullin 3 (CUL3), can cause the rare hereditary disease, Familial Hyperkalemic Hypertension (FHHt). The disease is characterized by overactivity of the renal sodium chloride cotransporter (NCC), which is phosphorylated and activated by the WNK-stimulated Ste20-type kinases, SPAK and OSR1. WNK kinases themselves can be targeted for ubiquitination and degradataion by the CUL3-KLHL3 E3 ubiquitin ligase complex. It is unclear, however, why there are significant differences in phenotypic severity among FHHt patients with mutations in different genes. It was reported that kelch-like 2 (KLHL2), …
Selective Processing By The L3 Auditory Interneuron In Acheta Domesticus : Juvenile Hormone Iii And Protein Kinase C, Ashley Ranae Lynch
Selective Processing By The L3 Auditory Interneuron In Acheta Domesticus : Juvenile Hormone Iii And Protein Kinase C, Ashley Ranae Lynch
Master's Theses
Juvenile Hormone III (JHIII) is a prolific and essential hormone in insects, controlling many aspects of insect physiology such as egg development, nymphal and larval maturation, diapause and metamorphosis. In female crickets, Acheta domesticus, JHIII increases selectivity in phonotactic behavior, narrowing phonotactic choices for Syllable Periods (SPs) of the Calling Songs (CSs) that most closely resemble the natural call of the male. JHIII has been suggested to work through a pathway that activates the protein kinase C (PKC) molecule. Chelerythrine Chloride (CC) is a potent inhibitor of PKC action. This study analyzes the responses of the L3 auditory interneuron, which …
Two-Component Elements Mediate Interactions Between Cytokinin And Salicylic Acid In Plant Immunity, Cristiana T. Argueso, Fernando J. Ferreira, Petra Epple, Jennifer P.C To, Claire E. Hutchison, G. Eric Schaller, Jeffrey L. Dangl, Joseph J. Kieber
Two-Component Elements Mediate Interactions Between Cytokinin And Salicylic Acid In Plant Immunity, Cristiana T. Argueso, Fernando J. Ferreira, Petra Epple, Jennifer P.C To, Claire E. Hutchison, G. Eric Schaller, Jeffrey L. Dangl, Joseph J. Kieber
Dartmouth Scholarship
Recent studies have revealed an important role for hormones in plant immunity. We are now beginning to understand the contribution of crosstalk among different hormone signaling networks to the outcome of plant–pathogen interactions. Cytokinins are plant hormones that regulate development and responses to the environment. Cytokinin signaling involves a phosphorelay circuitry similar to two-component systems used by bacteria and fungi to perceive and react to various environmental stimuli. In this study, we asked whether cytokinin and components of cytokinin signaling contribute to plant immunity. We demonstrate that cytokinin levels in Arabidopsis are important in determining the amplitude of immune responses, …
Ampk Directly Inhibits Ndpk Through A Phosphoserine Switch To Maintain Cellular Homeostasis, R. U. Onyenwoke, L. J. Forsberg, L. Liu, Tyisha Williams, O. Alzate, J. E. Brenman
Ampk Directly Inhibits Ndpk Through A Phosphoserine Switch To Maintain Cellular Homeostasis, R. U. Onyenwoke, L. J. Forsberg, L. Liu, Tyisha Williams, O. Alzate, J. E. Brenman
Biology Faculty Research
AMP-activated protein kinase (AMPK) is a key energy sensor that regulates metabolism to maintain cellular energy balance. AMPK activation has also been proposed to mimic benefits of caloric restriction and exercise. Therefore, identifying downstream AMPK targets could elucidate new mechanisms for maintaining cellular energy homeostasis. We identified the phosphotransferase nucleoside diphosphate kinase (NDPK), which maintains pools of nucleotides, as a direct AMPK target through the use of two-dimensional differential in-gel electrophoresis. Furthermore, we mapped the AMPK/NDPK phosphorylation site (serine 120) as a functionally potent enzymatic “off switch” both in vivo and in vitro. Because ATP is usually the most abundant …