Biology Commons^™

Tolerance Of Novel Toxins Through Generalized Mechanisms: Simulating Gradual Host Shifts Of Butterflieskristin, Kristin L. Sikkink, Reilly Hostager, Megan E. Kobiela, Nathan Fremling, Katherine Johnston, Amod Zambre, Emilie C. Snell-Rood

School of Biological Sciences: Faculty Publications

Organisms encounter a wide range of toxic compounds in their environments, from chemicals that serve anticonsumption or anticompetition functions to pollutants and pesticides. Although we understand many detoxification mechanisms that allow organisms to consume toxins typical of their diet, we know little about why organisms vary in their ability to tolerate entirely novel toxins. We tested whether variation in generalized stress responses, such as antioxidant pathways, may underlie variation in reactions to novel toxins and, if so, their associated costs. We used an artificial diet to present cabbage white butterfly caterpillars (Pieris rapae) with plant material containing toxins not experienced …

Reproductive And Mutagenic Effects Of 5-Thio-D-Glucose Injections In Male Mice, Mus Musculus, Icr Strain, Mary E. Mcmanaway

Master's Theses

Adult male ICR mice of proven fertility were intraperitoneally injected daily with 60 mg/kg of 5-thio-D-glucose for 28 days. Body weights of treated male mice were unaffected during the experimental period. Relative testicular weights were significantly reduced at 121 days after initial injections in 5-thio treated males, but no significant decrease was observed at 28 days.

Onset of sterility was estimated to occur at approximately 4 weeks and persisted for 5 to 6 weeks after cessation of treatment at which time fertility was restored.

Beginning with the first injections and continuing for 121 days, the males were mated with untreated …