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Full-Text Articles in Biology
Cooperative And Antagonistic Contributions Of Two Heterochromatin Proteins To Transcriptional Regulation Of The Drosophila Sex Determination Decision, Hui Li, Janel Rodriguez, Youngdong Yoo, Momin Mohammed Shareef, Ramakrishna Badugu, Jamila I. Horabin, Rebecca Kellum
Cooperative And Antagonistic Contributions Of Two Heterochromatin Proteins To Transcriptional Regulation Of The Drosophila Sex Determination Decision, Hui Li, Janel Rodriguez, Youngdong Yoo, Momin Mohammed Shareef, Ramakrishna Badugu, Jamila I. Horabin, Rebecca Kellum
Biology Faculty Publications
Eukaryotic nuclei contain regions of differentially staining chromatin (heterochromatin), which remain condensed throughout the cell cycle and are largely transcriptionally silent. RNAi knockdown of the highly conserved heterochromatin protein HP1 in Drosophila was previously shown to preferentially reduce male viability. Here we report a similar phenotype for the telomeric partner of HP1, HOAP, and roles for both proteins in regulating the Drosophila sex determination pathway. Specifically, these proteins regulate the critical decision in this pathway, firing of the establishment promoter of the masterswitch gene, Sex-lethal (Sxl). Female-specific activation of this promoter, Sxl(Pe), is essential to females, as it provides SXL …
Expression Of Human Amyloid Precursor Protein In The Skeletal Muscles Of Drosophila Results In Age- And Activity-Dependent Muscle Weakness, Lawrence M. Schwartz, Chul Kim, Sapeckshita Srivastava, Marian Rice, Tanja A. Godenschwege, Brooke Bentley, Saranya Ravi, Shuang Shao, Ig T. Woodard
Expression Of Human Amyloid Precursor Protein In The Skeletal Muscles Of Drosophila Results In Age- And Activity-Dependent Muscle Weakness, Lawrence M. Schwartz, Chul Kim, Sapeckshita Srivastava, Marian Rice, Tanja A. Godenschwege, Brooke Bentley, Saranya Ravi, Shuang Shao, Ig T. Woodard
Lawrence M. Schwartz
Background One of the hallmarks of Alzheimer's disease, and several other degenerative disorders such as Inclusion Body Myositis, is the abnormal accumulation of amyloid precursor protein (APP) and its proteolytic amyloid peptides. To better understand the pathological consequences of inappropriate APP expression on developing tissues, we generated transgenic flies that express wild-type human APP in the skeletal muscles, and then performed anatomical, electrophysiological, and behavioral analysis of the adults. Results We observed that neither muscle development nor animal longevity was compromised in these transgenic animals. However, human APP expressing adults developed age-dependent defects in both climbing and flying. We could …
Plasma Membrane Dynamics In The Drosophila Embryo, Amelia E. Zommer
Plasma Membrane Dynamics In The Drosophila Embryo, Amelia E. Zommer
Electronic Theses and Dissertations
Convergent extension is a highly conserved process among mammals, in which the tissue narrows in one axis, and extends across another. Tissue elongation is directed by the regulation of cell interface behaviors, which guides cell intercalation and rosette formation. Rosette formation occurs through the contraction of vertically oriented cell interfaces, and the subsequent elongation of new horizontal interfaces. It has been shown that actomyosin-generated tension functions to direct rosette formation. In this thesis, I have tested the function of regulators of F-actin networks, as well as endocytic and exocytic mechanisms, to identify new components that control interface behaviors and cell …
The Effect Of Diazinon On Egg Fertility And Development In Drosophila Melanogaster, Ayla Karataş, Zafer Bahçeci̇, Ensar Başpinar
The Effect Of Diazinon On Egg Fertility And Development In Drosophila Melanogaster, Ayla Karataş, Zafer Bahçeci̇, Ensar Başpinar
Turkish Journal of Biology
This study investigated the effects of diazinon, an organic phosphoric insecticide, on some developmental features of Drosophila melanogaster. The aim was to determine if any developmental inhibition occurs when diazinon is applied and if so, to determine which developmental stages are affected. Therefore, diazinon was applied to Drosophila melanogaster eggs, larvae, and adults, and its effects were observed. During the experiments 3 concentrations with values lower than LC_{50} were utilized (6 × 10^{-5}, 6 × 10^{-6}, 6 × 10^{-7} ppm). Diazinon solution was applied to Drosophila melanogaster by means of nutrition, adding it to the culture medium. The results show …