Biology Commons^™

Addressing The Productivity-Susceptibility Analysis In Data-Limited Fisheries For Understudied Fish In The Marine Aquarium Trade, Alice Wynn, Jemelyn Baldisimo, Gabrielle Baillargeon, Michael Tlusty, Andrew Rhyne

Biological Sciences Faculty Publications

The marine aquarium trade (MAT) harvests millions of coral reef fishes from the wild yearly. While the MAT supports fishers, hobbyists and marine education, harvested fishes are crucial in maintaining coral reef health and balanced marine cycles within their native habitats. Understanding the impact of the MAT on fish populations is critical for sustaining the trade in the long-term. Productivity-susceptibility analyses (PSAs) offer semiquantitative methods of analyzing the productive capacity of each fish stock, as well as its susceptibility to overfishing. The present study revises and expands upon a PSA conducted by Baillargeon et al. (2020) that focused on 32 …

Analyzing Microbial Communities In Porites Astreoides, Sanaa Caldwell, Katie Parker, Daniel Barshis

Biological Sciences Faculty Publications

Coral reefs are vital marine ecosystems that support many different species and ecosystem services through protecting coastlines from storms and erosion, providing raw materials for medication, and facilitating diversity amongst marine species. Anthropogenic climate change is causing ocean temperatures to exceed the range of coral thermal tolerance resulting in more coral bleaching events globally. However, some corals have the capacity to withstand high temperatures through different thermal tolerance strategies. A balanced microbial community plays a critical role in coral health and recent studies have indicated that a balanced microbiome is associated with temperature-stress tolerant corals. Yet, there is a severe …

A Blueprint To Greener Shorelines: Advancing The Effectiveness, Sustainability, And Widespread Adoption Of Coastal Nature-Based Solutions Through Transdisciplinary Research, Taylor M. Sloey, Sierra Hildebrandt, Rebecca L. Morris, Matthew V. Bilskie, Aaron Bland, David Bushek, Gabriella Dipetto, Daniel Elefant, Vincent Encomio, Ramin Familkhalili, Christine Hladik, Danielle Kreeger, Avery B. Paxton, Cindy M. Palinkas, Latina Steele, Andrew Scheld, Daisuke Taira, Jason D. Toft, Armando J. Ubeda, Christine Whitcraft, Donna Marie Bilkovic

Biological Sciences Faculty Publications

Coastal nature-based solutions (NbS) have emerged as powerful tools to enhance sustainable development and ecological restoration goals. As a rapidly growing field spanning across social, political, ecological, economic, and engineering disciplines, it is critical that researchers working in coastal NbS regularly attempt to identify emerging focal areas for scientific inquiry. Following the 27th Biennial meeting of the Coastal and Estuarine Research Federation, we provide a transdisciplinary perspective (including biologists, engineers, oceanographers, geoscientists, economists, and facilitators of workforce training programs) of pertinent research questions that, if answered, will advance the effectiveness, sustainability, and widespread adoption of coastal NbS. These suggestions for …

Thermal Tolerance Limits Of Mesophotic Corals In American Samoa, Daniel Barshis, Veronica Z. Radice, Katherine E. Parker, Nicholas Evensen

Biological Sciences Faculty Publications

We analyzed the thermal tolerances of multiple coral species from an upper mesophotic (38–40m) and a shallow reef (5–10m) with our portable Coral Bleaching Automated Stress System (CBASS). Depth generalist Montipora grisea (deep and shallow) and depth specialists Pachyseris speciosa and Leptoseris sp. (deep only) were assayed from Leone, located on the western coast of Tutuila in American Samoa. Fragments from 10 genotypes of each species were exposed to a 17-hour thermal stress assay reaching four maximum temperatures ranging from 30–38°C under in situ light conditions (150 μmol photons m⁻² s⁻¹ under a Lee Filters “deep …

Herpetofauna Richness, Diversity, And Occurrence At The Northern Ecotone Of Longleaf Pine, Julianne Jones, Dylan Bryant, Erik Yando

Biological Sciences Faculty Publications

Habitat suitability commonly differs between the core and periphery of ecosystems. The longleaf pine ecosystem is recognized for its value in providing habitat to a variety of specialist and endemic species, especially herpetofauna. However, at the northernmost extent of longleaf pine (in southeastern Virginia) little is known about the denizen reptiles and amphibians. Moreover, the remaining longleaf pine ecosystem at the latitudinal ecotone is fragmented amongst a mosaic of other ecosystems. We examined herpetofauna diversity, richness, and capture rates between four focal habitat types—mature longleaf pine, restored longleaf pine, maple-gum swamp, and pocosin-bog—in the Zuni Pine Barrens of southeastern Virginia. …

Form And Function In Mobulids: A Comparative Analysis Of Filter Morphology With Bioinspiration Applications, J. B. Teeple, S. R. Kahane-Rapport, K. E. Cohen, L. Hamann, J. A. Strother, E. W. M. Paig-Tran

Biological Sciences Faculty Publications

Mobulas (manta and devil rays) are large-scale ram filter feeders that separate planktonic food particles from large volumes of water with minimal clogging. This contrasts with most human-made filters that can suffer from problematic clogging requiring additional mechanisms for clearing blocked surfaces and maintaining performance. Prior studies have shown that mobulas employ a unique mechanism referred to as ricochet separation to filter feed, whereby captive vortices in filter pores cause particles to bounce off the filter surfaces and away from the filter pores. This mechanism enables the filtration of particles smaller than the pore size and reduced clogging. However, few …

The Pluralistic Natural Capital Values Of A Tropical City, Adrienne Grêt-Regamey, Justine Saunders, Peter Edwards, Daniel Richards, Jahson I. Alemu, Natasha Bhatia, Roman Carrasco, Zuzana Drillet, Tze Kwan Fung, Yan Feng Leon Gaw, Wanggi Jaung, Andrea Law, Rachel Ai Ting Leong, Aikeen Youu Ming Lim, Mahyar Masoudi, Yudhishthra Nathan, Rachel Rui Ying Oh, Wen Ting Ooi, Fairul Edros Ahmad Shaikh Shaikh, Xiao Ping Song, Claudia L.Y. Tan, Puay Yok Tan, Sergio Wicki, Lynn-Wei Wong, Yanyun Yan, Erik Yando, Alex Thiam Koon Yee, Jingyuan Zhang, Daniel A. Friess

Biological Sciences Faculty Publications

Nature in cities is essential for human well-being. Quantifying and valuing the goods and services provided by nature to city dwellers is missing in tropical contexts. Yet, as cities worldwide face similar challenges, understanding the services provided by tropical urban ecosystems becomes imperative for effective management. Here, we present the first Natural Capital Assessment of a tropical city, unveiling three critical insights. Firstly, we demonstrate the vital reliance of a developed tropical city on nature, particularly for climate change mitigation through regulating services. Secondly, we identify intact natural areas as Singapore’s most valuable assets, stressing the significance of the quality …

Preservation Of Genetic Diversity And Selection Over A Century In A Coral Reef Fish (Taeniamia Zosterophora) In The Philippines, Kyra S. Fitz, Rene A. Abesamis, Jemelyn Grace P. Baldisimo, Abner A. Bucol, René D. Clark, Eric Garcia, Ivan R. Lopez, Sharon F. Magnuson, Marial J. Malabag, Richard N. Muallil, Lynne R. Parenti, Brendan R. Reid, Mudjekeewis D. Santos, Christopher E. Bird, Kent E. Carpenter, Malin L. Pinsky

Biological Sciences Faculty Publications

Evaluating the evolutionary impacts of anthropogenic activity on populations is key to understanding species resiliency and to designing effective conservation strategies. Sequencing DNA from historical specimens provides the opportunity to establish a historical baseline and empirically assess changes in genetic diversity, changes in effective population size, and selection over time. Here, we sequenced historical and contemporary samples of the cardinalfish Taeniamia zosterophora collected in 1908 and in 2021-2022 across two sites with differing human impact in the Philippines. At both sites, genetic diversity increased over time, with contemporary samples having significantly higher Watterson's Θ than historical samples. This diversity increase …

Description Of All Stages Of A New Tick Species From California Haemaphysalis Vespertina (Acari: Ixodidae), With Redescription Of H. Leporispalustris Packard, 1869 Adults And Phylogenetic Relationships Among Related U.S. Taxa, Andrea Egizi, Santiago Nava, Angie Nakano, Megan E. M. Saunders, Lauren P. Maestas, Autumn D. Angelus, Bruce Noden, Robyn M. Nadolny, Waheed I. Bajwa, Charles Lubelcyzk, Chanakya R. Bhosale, Susan Paskewitz, Holly D. Gaff, Lorenza Beati

Biological Sciences Faculty Publications

All active stages of Haemaphysalis vespertina sp. nov. (Acari: Ixodidae), a tick previously identified as H. leporispalustris Packard, 1869, are described from specimens collected on the vegetation and from leporids in California and Oregon. The adults of H. leporispalustris Packard, 1969 are redescribed based on type material. Adults of the two species can be distinguished by their overall size, the dorsal shape of palpal segment II, the number and shape of dorsal and ventral setae on palpal segment II, the number of spurs on coxae II, the length of setae on scutum, legs and coxae, and the pattern of scutal …

Tick Responses To Diverse Chemical Attractants To Enhance Tick Surveillance Methods' Efficacy, Pamela Kelman, Tyler Chavers, Emily Owens Pickle, Daniel Sonenshine, Melissa S. Nolan, Holly Gaff

Biological Sciences Faculty Publications

Amblyomma maculatum Koch (Acari: Ixodidae), Ixodes scapularis Say, and Dermacentor variabilis Say are three hard-bodied ticks responsible for vectoring pathogens that cause most human tick-borne diseases in the United States of America (USA). Tick surveillance is critical to elucidate high-risk areas for targeted vector control and public health interventions. Despite tick-borne diseases having a higher annual incidence compared to mosquito-borne diseases in the USA, tick traps used for surveillance are grossly under-developed compared to the suite of sophisticated mosquito traps available on the commercial market. This study sought to identify potential prospective tick trap improvements by evaluating the relative attraction …

Summer Temperature Maxima Already Challenge Thermal Capacities Of Coral In The Southern Persian/Arabian Gulf, Rachel Alderdice, Gabriela Perna, Hannah Manns, Anna Fiesinger, Luigi Colin, Kathryn Stankiewicz, Kelly Gomez-Campo, Samantha Goyen, Line Bayse, Nitin Baliga, Jake Valenzuela, Iliana B. Baums, Daniel J. Barshis, John A. Burt, Christian R. Voolstra

Biological Sciences Faculty Publications

The future of coral reefs remains uncertain as intensifying ocean warming continues to drive coral decline and demise worldwide. Corals occurring in extreme environments such as the Persian/Arabian Gulf (PAG), the world’s warmest sea, represent a promising resource to study the genetic architecture of thermal tolerance. However, their thermal capacities remain unresolved. We applied short-term heat stress assays using the Coral Bleaching Automated Stress System (CBASS) to determine signatures of thermal tolerance from three common species (Porites harrisoni, Platygyra daedalea, and Cyphastrea microphthalma) across three sites (two in the extreme southern PAG and a more benign …

Carbon Dynamics Across The Mangrove-Tidal Flat Ecotone In A Tropical Seascape, E. S. Yando, I. J.B. Alemu, L. Kiah Eng, T. M. Sloey, M. Van Breugel, Bhatia N. Friess

Biological Sciences Faculty Publications

Mangroves and other blue carbon ecosystems are important for climate through the storage and sequestration of carbon. Most research estimates carbon dynamics by subsampling central portions of the ecosystem and are then upscales using habitat maps to patch, landscape, or regional levels. However, heterogeneity is rarely accounted for - particularly at edges. Further, adjacent tidal flat ecosystems have only recently been considered for carbon storage, but may be undervalued if areas where they transition with vegetated systems are not accounted for. To address the lack of information at coastal ecotones, we examined both soil carbon storage and carbon dioxide flux …

The Prize Biter Of Modernity? Investigating Killer Whale Bite Mechanics, Daniel Hong

West Chester University Graduate Theses, Dissertations, and Final Projects

Although the killer whale (Orcinus orca) is a cosmopolitan apex predator, very little work has been done on its feeding biomechanics. Here I use finite element analysis to investigate the mandibular stiffness of a juvenile male Bigg’s killer whale, and compare it to that of the false killer whale (Pseudorca crassidens) and the saltwater crocodile (Crocodylus porosus). Full mandibles and left and right halves of mandibles are simulated under FEA. I also estimate the total jaw muscle force produced by the Bigg’s killer whale using the dry skull method. The killer whale lacks an …

Involvement Of Integrated Stress Response In Primary And Secondary Dystonia, Tricia Aleena Dulice Simon

Theses and Dissertations

ABSTRACT Dystonia is the third most common movement disorder in the United States of America , the first two being essential tremor and Parkinson’s disease. Gaining mechanistic knowledge about pathobiology of dystonia is essential for development of effective therapies. As the only therapies currently available are invasive procedures such as deep brain stimulation (DBS) or frequent botulinum toxin injections, it is critical to understand the underlying molecular mechanisms leading to dystonia. A maladaptive integrated stress response (ISR) involving dysregulation of the eukaryotic translation initiation factor  (eIF2) mediated signaling is observed in DYT-PRKRA patient cells. Mutations in PRKRA gene, which …

Spatial And Temporal Patterns In Short-Term Surface Sediment Deposition And Accretion At The Guana Tolomato Matanzas National Estuarine Research Reserve: Implications For Resilience Of Coastal Wetlands To Sea-Level Rise, Jacob Michael Berna

UNF Graduate Theses and Dissertations

Coastal wetlands are at risk of drowning due to the increasing threat of rising sea levels. Wetlands will have to build in elevation vertically or migrate horizontally to survive. Previous research has demonstrated that some wetlands have the potential to naturally build in elevation over time if deposition and accretion rates from allochthonous sediment delivery are substantial, but work in this area has been limited, and many coastal wetlands remain understudied. Portions of Northeast Florida are especially lacking in short-term surface deposition and accretion data. Without surface rates it is difficult to determine the vulnerability of different wetlands to rising …

The Presence Of Mercury (Hg) And Perfluoroalkyl Substances (Pfas) In The Guana And Tolomato Rivers, Morgan E. Lattomus

UNF Graduate Theses and Dissertations

The Guana and Tolomato Rivers provide essential habitat for several ecologically and economically important species and is a well-loved and recreated area. Spanning the northeastern Florida coast, the rivers are home to over 50 endangered or threatened species and host several habitat restoration projects due to their ecological significance and proximity to development along the coast. The effects of human influence and pollution, and specifically toxic metal mercury (Hg) and perfluoroalkyl substances (PFAS), are not well known within the system. Hg is known to biomagnify within food webs, and there is a considerable lack of literature concerning PFAS behavior within …

Disposal Of Nanoplastics By The Brain: Plastic Persistence And Upregulation Of A Putative Plastic-Degrading Enzyme After Exposure To Polystyrene-Infused Food, Callie C. Mauersberg

College of Graduate Studies: Theses & Dissertations

Plastic is a ubiquitous material used in many domestic and commercial applications. Widespread use of plastic has led to environmental accumulation of plastic waste, and microplastics have inundated human food and water sources. Once consumed, it is well established that microplastics translocate from the gut to other tissues, including the brain, via the circulatory system. However, it is unknown if nanoplastics persist permanently in the brain. Additionally, it is not known if microplastics can be enzymatically degraded by phagocytic cells in the CNS, such as microglia and astrocytes. Alkane monooxygenase-homolog 7 (Alkbh7) is a mitochondrial enzyme that may …

Bugs In The Flux: Links Between Arthropod Diversity And Spatial Variation Of Soil Respiration In A Temperate Forest, Erin-Darby H. Mcclain

Theses and Dissertations

Soil respiration (Rs) is the largest terrestrial flux of carbon (C) to the atmosphere, with heterotrophic contributions to Rs varying spatially and temporally. While microbes are the primary and most thoroughly studied source of soil heterotrophic respiration (Rh), contributions from higher trophic organisms, including arthropods, are rarely quantified and poorly understood. Arthropod abundance and diversity correspond with variation in soil microclimate, which is influenced by site factors including canopy structure, site productivity, and disturbance. However, the extent to which these site factors influence arthropod abundance and diversity, and consequently, spatial variation in Rs is not known. The objective of our …

Factors Influencing The Discovery And Use Of Carrion By Vertebrate Scavengers From Human-Induced Mass-Mortality Events, Samantha J. Leivers, Michael J. Bodenchuk, Tyler A. Campbell, John M. Tomeček

Human–Wildlife Interactions

Scavengers play critical roles in ecosystem health and stability, and both biotic and abiotic factors can influence scavenger guild dynamics. Carrion is often limited both temporally and spatially on the landscape, but mass mortality events (MMEs)—in which there is an influx of carrion biomass on the landscape—may result in different scavenger community dynamics compared to when carrion is scarcely distributed. In this study, we investigated factors affecting the discovery and use of carrion by a natural, unharrassed scavenger guild during wild pig (Sus scrofa) MMEs conducted at East Foundation’s San Antonio Viejo Ranch in South Texas, USA. We …

Bio-Inspired Airfoil Design Based On The Aerodynamic Analysis Of A Bird Feather Microstructure, Jack C. Ihm

College of Graduate Studies: Theses & Dissertations

This study investigates the aerodynamic effects of a bio-inspired airfoil design based on the microstructure of a secondary feather from a female wood duck. The research hypothesized that incorporating barbs and barbules into an airfoil design would modify boundary layer behavior by introducing localized flow disturbances. To test this, a bio-inspired airfoil was developed by integrating the microstructure into a NACA 0012 airfoil and analyzed using computational fluid dynamics (CFD) simulations at angles of attack of 0°, 5°, 10°, and 15°. The results showed that the bio-inspired airfoil influenced boundary layer behavior, producing localized flow disturbances near x/c = 0.7 …

Survey And Identification Of Entomopathogenic Fungi In Millipede Species In Coastal Georgia, Kristin L. Campbell Bailey

College of Graduate Studies: Theses & Dissertations

Entomopathogenic fungi are well-known, species-specific pathogens of a wide diversity of insects that infect, manipulate, and kill their insect hosts to complete their life cycle. Recently in Savannah, Georgia, millipedes belonging to the genus Eurymerodesmus were observed exhibiting pre-death climbing behaviors associated with pathogenic fungal infection. Dying millipedes summited vegetation and subsequently died in elevated positions along edge habitat transitioning a recreational field and forest. Upon inspection, fungal structures found emerging from dead millipedes anatomically resembled Arthrophaga myriapodina, which is the first documented entomophthoralean fungus to infect millipedes. The goal of this research was to obtain species-level identification of the …

Helminth Parasites Of Galápagos Mammals: A New Cestode Of The Genus Raillietina From The Endemic Rice Rat Nesoryzomys Swarthi And A Summary Of Parasites From Both Endemic And Invasive Rodents, Scott Lyell Gardner, Emma K. Chesley, Michael C. Friedle, Altangerel Tsogtsaikhan Dursahinhan

Scott L. Gardner Publications

In this first report of endoparasites from endemic land-mammals of the Galápagos Islands, we describe a new species of cestode of the genus Raillietina (Cyclophyllidea: Davaineidae) from a species of Nesoryzomys and summarize the extent of helminth parasitism in both oryzomyine endemics and introduced species of Rattus. Up to the current time, no helminth parasites have been reported from rodents of the Galápagos, and little work has yet been done describing and synthesizing Galápagos parasite diversity. In historical times, several species of autochthonous rodents have occupied the islands including: Nesoryzomys narboroughi Heller 1904, N. fernandinae Hutterer and Hirsch …

Isolating Confounding Abiotic And Biotic Effects On The Phenotype On Physa Acuta Snails, Ashley M. Bauer

Theses and Dissertations

Organisms match their phenotypes to prevailing environmental conditions leading to habitat specific polymorphisms. Polymorphisms arise from genetic divergence, phenotypic plasticity, or a combination of both processes. I examined the presence of habitat-specific polymorphism in Physa acuta snails collected from three streams and their corresponding downstream reservoir. In lotic systems shells were rotund with larger apertures, while those from lentic systems were more elongate with smaller apertures. In a reciprocal transplant lab experiment that crossed flow regime and crayfish predator cues, I tested for the underlying mechanisms responsible for the observed phenotypic differences. I found no evidence for plasticity in relation …

Diabetes Potentiates The Emergence And Expansion Of Antibiotic Resistance, John C. Shook, Benjamin P. Darwitz, Kaleb J. Tyson, Amanda Z. Velez, Sophia K. Bridwell, Joshua B. Parsons, Sarah E. Rowe, Christopher Marshall, Brian P. Conlon, Lance R. Thurlow

Biological Sciences Faculty Research and Publications

Individuals with diabetes mellitus frequently develop severe skin and soft tissue infections (SSTIs) that are recalcitrant to antibiotic treatment. We examined how diabetes affects the emergence of antibiotic resistance in a Staphylococcus aureus SSTI. We determined that S. aureus evolves antibiotic resistance rapidly in diabetic mice, while resistance did not occur in nondiabetic mice over the course of infection. Diabetes-associated immune cell dysfunction plays a minor role in the emergence of resistance, while hyperglycemia plays a dominant role facilitating the expansion and takeover of resistant mutants in diabetic infections. Furthermore, vancomycin intermediate resistant isolates display a pronounced fitness defect in …

The Rad6-Like Ubiquitin Conjugase Gene Osubc7 Has A Positive Role In The Early Cold Stress Tolerance Response Of Rice, Huy Phan, Michael Schläppi

Biological Sciences Faculty Research and Publications

Background/Objectives: Cold stress poses a significant threat to Asian rice cultivation, disrupting important physiological processes crucial for seedling establishment and overall plant growth. It is, thus, crucial to elucidate genetic pathways involved in cold stress tolerance response mechanisms. Methods: We mapped OsUBC7, a Radiation-sensitive 6 (RAD6)-type homolog of rice, to a low-temperature seedling survivability (LTSS) QTL and used genomics, molecular genetics, and physiological assays to assess its role in plant resilience against low-temperature stress. Results: OsUBC7 is cold responsive and has higher expression levels in cold-tolerant japonica than cold-sensitive indica. Overexpression of OsUBC7 enhances LTSS of indica and freezing tolerance …

Editorial: Women In Antimicrobials, Resistance And Chemotherapy: 2023, Cindy Shuan Ju Teh, Krassimira R. Hristova, Ana R. Freitas

Biological Sciences Faculty Research and Publications

No abstract provided.

Methyl-Cpg-Binding Domain As A Protein Interaction Partner In Promoter Regulation And Neurodevelopment Through Evolutionary Expanded Entanglement, Stephanie M. Bilinovich, Surya B. Chhetri, Jackson T. Mitchell, Gage O. Leighton, Vladislav Jdanov, Jacob K. Zieba, Taylor W. Cook, Krysta L. Engel, Robert M. Vaughan, Humza Bhatti, Sadie L. Heeringa, Amy M. Wilstermann, Sophie Vanderweele, Akansha S. Das, Emily C. Sherry, Stephen A. Duncan, Katie L. Uhl, David C. Hinds, Mark Mackiewicz, Sarah K. Meadows, Kimberly M. Newberry, E. Christopher Partridge, Sara G. Cline, C. Joy Shepard, D. Casey Smith, Antonio Bradley, Daniel Vogt, Daniel B. Campbell, Lucas Pozzo-Miller, Caleb P. Bupp, Austin J. Goodyke, Surender Rajasekaran, Rebecca C. Knickmeyer, Benjie Blair

Research, Publications & Creative Work

There is increasing evidence that the methyl-binding domain (MBD) is a protein-protein interaction motif that can function independently of methylated DNA binding. The MBD proteins found throughout plants and invertebrates duplicated into multiple vertebrate DNA and non-DNA-binding members (MBD1, MBD2, MBD3, MBD4, MBD5, MBD6, MECP2, BAZ2A, BAZ2B, SETDB1, andSETDB2). Although many invertebrate species possess MBD proteins that can bind and recognize DNA methylation, the DNA-binding function has been independently lost multiple times, with only minor alterations to the protein interaction residues. The nucleosome remodeling and deacetylase (NuRD) complex, which interacts with MBD2/3 and is colocalized with MBD1/4 ChIP-Seq, is maintained …

Elucidating The Effects Of Environmental And Physiological Conditions On Stem Cell Regulation In Vivo, Nimmy John

Electronic Theses & Dissertations (2024 - present)

The Notch signaling pathway is a highly conserved intercellular signaling pathway that any dysregulation can lead to a variety of human diseases. These diseases are further exacerbated by various environmental, pathological and genetic conditions. Previous studies have shown that these conditions have been known to affect the Notch transcriptional response. However, the molecular mechanisms by which such conditions influence Notch signaling remained largely unknown. Moreover, most Notch studies have relied on in vitro systems and indirect reporters, which can miss the dynamic and contextual nature of Notch signaling. Here, we systematically analyzed the effects of these conditions with single molecule …

Phylogenetic Analysis Of Metabolic Enzymes In Hypoxic/Anoxic Conditions In Cetaceans And Cancer, Samerna A. Masih

Electronic Theses & Dissertations (2024 - present)

Cancer cells often exhibit a Warburg-like metabolism, which includes increased fatty acid synthesis and storage that help them survive in hypoxic conditions. This shift is marked by the heightened synthesis and accumulation of fatty acids, acting as a survival mechanism in low-oxygen environments (Baumann et al., 2016). Interestingly, deep-diving whales may utilize a similar metabolic pathway to produce wax esters during their prolonged dives.

Our study focused on exploring the genetic and metabolic similarities between breast cancer cells and deep-diving whales, using computational analyses to investigate lipid metabolism genes. We looked for evolutionarily conserved variations that might reveal adaptive mechanisms …

The Role Of The Nasal Migratory Mass In Olfactory Bulb Formation And Fertility, Charisse Martin

Electronic Theses & Dissertations (2024 - present)

The olfactory migratory mass plays an essential role in the development of the olfactory bulb by facilitating the migration of the gonadotropin-releasing hormone neurons from the olfactory placode to the pre-optic hypothalamic area in the brain. In mammals, the migration of GnRH neurons is critical for establishing the hypothalamic-pituitary-gonadal axis (HPG axis), which regulates reproductive function through the production and secretion of gonadotropins. Luteinizing hormone (LH) and Follicle-stimulating hormone (FSH) instruct the gonads to function appropriately, ensuring sexual maturation and fertility. Disruptions in this migratory pathway have been linked with Kallmann syndrome, a condition characterized by low levels of GnRH, …