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2025

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Articles 1171 - 1200 of 1655

Full-Text Articles in Biology

Experimental Approaches To Investigate Biophysical Interactions Between Homeodomain Transcription Factors And Dna, Fadwa Mekkaoui, Robert A. Drewell, Jacqueline M. Dresch, Donald E. Spratt Mar 2025

Experimental Approaches To Investigate Biophysical Interactions Between Homeodomain Transcription Factors And Dna, Fadwa Mekkaoui, Robert A. Drewell, Jacqueline M. Dresch, Donald E. Spratt

Chemistry

Homeodomain transcription factors (TFs) bind to specific DNA sequences to regulate the expression of target genes. Structural work has provided insight into molecular identities and aided in unraveling structural features of these TFs. However, the detailed affinity and specificity by which these TFs bind to DNA sequences is still largely unknown. Qualitative methods, such as DNA footprinting, Electrophoretic Mobility Shift Assays (EMSAs), Systematic Evolution of Ligands by Exponential Enrichment (SELEX), Bacterial One Hybrid (B1H) systems, Surface Plasmon Resonance (SPR), and Protein Binding Microarrays (PBMs) have been widely used to investigate the biochemical characteristics of TF-DNA binding events. In addition to …


The Influence Of Historical Climate Cycles On The Diversification And Demography Of Species From The Neotropical Lizard Group Anolis Chrysolepis, Tony Gamble Mar 2025

The Influence Of Historical Climate Cycles On The Diversification And Demography Of Species From The Neotropical Lizard Group Anolis Chrysolepis, Tony Gamble

Biological Sciences Faculty Research and Publications

Historical shifts in climate have significantly influenced the establishment of ecosystems and the evolution of species. Phylogeographical studies integrated with niche modelling can provide insights into divergence events and demography. This study explores the evolutionary history, demographic patterns, and spatiotemporal dynamics of seven South American lizard species of the Anolis chrysolepis species group, which has been proposed to be strongly impacted by Pleistocene climatic fluctuations under the Refugia Hypothesis. We utilized mitochondrial and nuclear DNA sequences to delineate lineages, estimate divergence times, and examine demographic dynamics. Ecological niche models were employed to assess historical range shifts and identify climatic stability …


A High-Lipid Diet Leads To Greater Pathology And Lower Tolerance During Infection, Weston Gerald Perrine, Erin Sauer, Ashley C. Love, Ashley Morris, Johnathan Novotny, Sarah Durant Mar 2025

A High-Lipid Diet Leads To Greater Pathology And Lower Tolerance During Infection, Weston Gerald Perrine, Erin Sauer, Ashley C. Love, Ashley Morris, Johnathan Novotny, Sarah Durant

Biological Sciences Faculty Publications and Presentations

Altered food landscapes contribute importantly to wildlife disease dynamics and may play a critical role in host heterogeneity in disease outcomes through changes in host diet composition. We explored the effects of dietary macronutrient composition on disease pathology and feeding behavior of canaries (Serinus canaria domestica) infected with Mycoplasma gallisepticum (MG). In the first experiment, we provided canaries with isocaloric diets composed of identical ingredients that varied in macronutrient content (high protein or high lipid) then MG- or sham-inoculated birds. In the second experiment, we offered both diets to canaries before and after MG or sham inoculation. In experiment one, …


House Flies (Musca Domestica) In Abu Dhabi Emirate: Assessing Deltamethrin Insecticide Resistance And Associated Microbial Communities, Mohamad Abdelrahim Hamdan Mar 2025

House Flies (Musca Domestica) In Abu Dhabi Emirate: Assessing Deltamethrin Insecticide Resistance And Associated Microbial Communities, Mohamad Abdelrahim Hamdan

Theses

This study investigates the common house fly (Musca domestica), a globally important insect that serves as both a decomposer and a mechanical vector for pathogens. The emergence of insecticide resistance, particularly knockdown resistance (kdr) mutations, has been reported in house fly populations, raising concerns for pest control. Additionally, house flies exhibit diverse bacterial communities, influencing pathogen transmission and environmental microbial dynamics. The primary objective of this study was to assess the prevalence of kdr mutations associated with insecticide resistance in house flies collected from the Abu Dhabi Emirate and to analyze their microbial composition using metagenomic approaches. House flies were …


Evolution Of Mate Guarding Intensity In Crickets As A Possible Adaptation To Sexual Conflict Over Sperm Transfer, Bert Foquet, Jack Thomas Mckermitt, John Hunt, Ben M. Sadd, Scott K. Sakaluk Mar 2025

Evolution Of Mate Guarding Intensity In Crickets As A Possible Adaptation To Sexual Conflict Over Sperm Transfer, Bert Foquet, Jack Thomas Mckermitt, John Hunt, Ben M. Sadd, Scott K. Sakaluk

Faculty Publications – Biological Sciences

Mate guarding is a common behavioral adaptation in males to ensure mating or to hinder current partners from remating with rival males. In the decorated cricket, Gryllodes sigillatus, males transfer a spermatophore to females at mating, comprising a sperm-containing ampulla enveloped in a large gelatinous mass, the spermatophylax, that serves as a nuptial food gift for the female. Males guard the female while she feeds on the nuptial gift and while sperm are evacuated from the ampulla into her reproductive tract. Mate guarding behavior functions to prevent competitors from mating with the female but may also represent a behavioral …


The Cure-Comm Framework: A Guide For Infusing Cures With Science Communication, Rebekka Darner, Ebenezer Korkor Mar 2025

The Cure-Comm Framework: A Guide For Infusing Cures With Science Communication, Rebekka Darner, Ebenezer Korkor

Faculty Publications – Biological Sciences

Researchers have employed diverse instructional strategies to impart science communication (SciComm) skills, a cherished 21st-century skill into undergraduate students. We reviewed the pedagogical strategies used in developing SciComm skills in undergraduates. This review revealed that analyzing data and scientific literature, increasing exposure to multiple writing contexts, providing multiple opportunities to present findings orally, and providing feedback are used to teach SciComm skills. Many instructors who implement course-based undergraduate research experiences (CURE) report improved SciComm skills as one of the benefits of CUREs. To decipher points of intersection among CUREs and SciComm pedagogical strategies, we also reviewed the literature on pedagogical …


Segregating Sites Enhance Accuracy Of Species Abundance Estimates From Edna, Kara J. Andres Mar 2025

Segregating Sites Enhance Accuracy Of Species Abundance Estimates From Edna, Kara J. Andres

Faculty Publications – Biological Sciences

Species abundance is a fundamental metric in ecology and conservation. Assessing how populations change across space time enables the identification of population trends and informs management and conservation decisions. However, measuring species abundance can be a challenging task, with logistical constraints, sampling biases, and detection limits inhibiting meaningful abundance estimates. Environmental DNA (eDNA) approaches have improved our ability to monitor species presence and biodiversity and may also serve as a tool for measuring species abundance. However, abundance estimates from eDNA typically rely on the correlation between species abundance and the concentration of target species' DNA in a sample, which may …


Edge Feathering Across Forest-Meadow Ecotones Increases Light Heterogeneity And Understory Plant Diversity, Aruni Kadawatha, Jean H. Burns Feb 2025

Edge Feathering Across Forest-Meadow Ecotones Increases Light Heterogeneity And Understory Plant Diversity, Aruni Kadawatha, Jean H. Burns

Faculty Scholarship

Ecotones, the transitional zones between distinct habitats, are vital for ecosystem functioning and habitat diversity. Traditional management practices frequently create abrupt boundaries, leading to stressful conditions for organisms. To address this challenge, an underutilized land management technique called “edge feathering”, which involves gradual thinning of the canopy along the forest edge, has been introduced. This study, con- ducted at Holden Arboretum in Kirtland, Ohio, investigated the effects of edge feathering on light availability and understory plant diversity in edge feathered and control treatments. We calculated the coefficient of variation in light availability as light heterogeneity and plant diversity indices at …


Leveraging Arginine Catabolism To Treat Metabolic Complications, Yiming Zhang Feb 2025

Leveraging Arginine Catabolism To Treat Metabolic Complications, Yiming Zhang

Arts & Sciences Graduate Student Theses and Dissertations

Fasting and caloric restriction are effective to treat patients with pre-diabetes or metabolic dysfunction-associated steatotic liver disease (MASLD), previously known as non-alcoholic fatty liver disease (NAFLD), but intensive lifestyle changes are difficult for many to implement and sustain. Therefore, by identifying and studying fasting-mediated signals, we hope to elicit and convey the therapeutic effects of fasting against MASLD without actual physiological fasting. We discovered a key pathway in the liver through unbiased transcriptomic screening in fasted mice, a novel glucose fasting-activated effector: the amino acid hydrolase, arginase 2 (ARG2). Our previously published data demonstrates that forced hepatocyte-specific Arg2 overexpression is …


Fecal Microbiota Of Healthy Arabian Camels (Camelus Dromedarius): A Comprehensive Study Investigating Various Factors (Food, Camel Type, And Drinking Water) And Their Influence On Fecal Microbiome Diversity In Arabian Camels, Ruqaiah Ali Qarwan Feb 2025

Fecal Microbiota Of Healthy Arabian Camels (Camelus Dromedarius): A Comprehensive Study Investigating Various Factors (Food, Camel Type, And Drinking Water) And Their Influence On Fecal Microbiome Diversity In Arabian Camels, Ruqaiah Ali Qarwan

Thesis/ Dissertation Defenses

In UAE, dromedary camels (Camelus dromedarius) are considered as vital sources of meat and milk, and they also symbolize the cultural heritage of the region. Understanding healthy dromedary camel’s core microbiome and microbiome diversity is essential for their conservation and sustainable management. To explore the fecal microbiome diversity and core fecal microbiome of healthy dromedary camels, in this study, we analyzed 150 fecal samples from camels collected across 10 different farms in the Dubai region. Each farm maintains healthy camels and provides specific diets and water types, with some farms also focusing on camels for racing purposes. In this study, …


Variation In Thermal Tolerance Plasticity And The Costs Of Heat Exposure In The Estuarine Sea Hare, Phyllaplysia Taylori, Richelle L. Tanner, Rauri C. K. Bowie, Cynthia Y. Wang-Claypool, Jonathan H. Stillman Feb 2025

Variation In Thermal Tolerance Plasticity And The Costs Of Heat Exposure In The Estuarine Sea Hare, Phyllaplysia Taylori, Richelle L. Tanner, Rauri C. K. Bowie, Cynthia Y. Wang-Claypool, Jonathan H. Stillman

Biology, Chemistry, and Environmental Sciences Faculty Articles and Research

Climate change is increasing average temperatures and the frequency and intensity of thermal extremes in coastal marine environments. Organisms in coastal marine habitats are accustomed to environmental fluctuations and possess physiological plasticity that may be advantageous in response to increased occurrence of extremes. To examine whether such plasticity is locally adapted to environmental conditions, we investigated the relationship between genetic diversity and thermal tolerance plasticity in 11 populations of the direct-developing intertidal sea hare, Phyllaplysia taylori, on the western coast of the United States. Using whole-organism metrics of muscle function and metabolic rate and a ddRADseq genomic approach, we …


Survey Of Mosquito Larval Habitats At The Ksu Field Station, Rose Sofia, Eli Lovvorn, Aspen Hartman, Andrew Haddow Feb 2025

Survey Of Mosquito Larval Habitats At The Ksu Field Station, Rose Sofia, Eli Lovvorn, Aspen Hartman, Andrew Haddow

Symposium of Student Scholars

The greater Atlanta metropolitan area hosts numerous mosquito species that are nuisance biters and can transmit arthropod-borne diseases to humans. We surveyed the Kennesaw State University (KSU) Field Station – an incredibly biodiverse location – where student, staff, and faculty-led groups engage in outdoor research and teaching activities. The KSU Field Station located in Cobb County, GA is a heavily trafficked 25-acre property that may attract various mosquito species capable of transmitting pathogens to humans and animals alike. On August 27th, 2024, our team investigated the KSU Field Station to quantify and record potential water-holding containers that serve as mosquito …


Gubic: The Global Urban Biological Invasions Compendium For Plants, Daijiang Li, Luke J. Potgieter, Myla F. J. Aronson, Irena Axmanová, Benjamin Baiser, Marta Carboni, Laura Celesti-Grapow, Sonja Knapp, Ingolf Kühn, Ana Carolina Lacerda De Matos, Zdeňka Lososová, Flavia A. Montaño-Centellas, Petr Pyšek, David M. Richardson, Lauren B. Trotta, Rafael D. Zenni, Sarel S. Cilliers, Bruce D. Clarkson, Amy J. S. Davis, Rebecca W. Dolan, Marcin M. Dyderski, Franz Essl, Orou G. Gaoue, Joanne Gui, Charly Géron, Gustavo Heringer, Cang Hui, Anzar A. Khuroo, Stefan Klotz, Peter M. Kotanen, Holger Kreft, Frank A. Sorte, Jonas J. Lembrechts, Bernd Lenzner, Christopher A. Lepczyk, Scott Macivor, Cristina Martínez-Garza, Akira S. Mori, Charles Nilon, Jan Pergl, Stefan J. Siebert, Alyona S. Tretyakova, Toby P. N. Tsang, Kei Uchida, Mark Van Kleunen, Montserrat Vilà, Hua-Feng Wang, Patrick Weigelt, Peter Werner, Nicholas S. G. Williams, Marten Winter, Marc Cadotte Feb 2025

Gubic: The Global Urban Biological Invasions Compendium For Plants, Daijiang Li, Luke J. Potgieter, Myla F. J. Aronson, Irena Axmanová, Benjamin Baiser, Marta Carboni, Laura Celesti-Grapow, Sonja Knapp, Ingolf Kühn, Ana Carolina Lacerda De Matos, Zdeňka Lososová, Flavia A. Montaño-Centellas, Petr Pyšek, David M. Richardson, Lauren B. Trotta, Rafael D. Zenni, Sarel S. Cilliers, Bruce D. Clarkson, Amy J. S. Davis, Rebecca W. Dolan, Marcin M. Dyderski, Franz Essl, Orou G. Gaoue, Joanne Gui, Charly Géron, Gustavo Heringer, Cang Hui, Anzar A. Khuroo, Stefan Klotz, Peter M. Kotanen, Holger Kreft, Frank A. Sorte, Jonas J. Lembrechts, Bernd Lenzner, Christopher A. Lepczyk, Scott Macivor, Cristina Martínez-Garza, Akira S. Mori, Charles Nilon, Jan Pergl, Stefan J. Siebert, Alyona S. Tretyakova, Toby P. N. Tsang, Kei Uchida, Mark Van Kleunen, Montserrat Vilà, Hua-Feng Wang, Patrick Weigelt, Peter Werner, Nicholas S. G. Williams, Marten Winter, Marc Cadotte

Scholarship and Professional Work - LAS

Abstract Urban areas are foci for the introduction of non-native plant species, and they often act as launching sites for invasions into the wider environment. Although interest in biological invasions in urban areas is growing rapidly, and the extent and complexity of problems associated with invasions in these systems have increased, data on the composition and numbers of non-native plants in urbanized areas remain scattered and idiosyncratic. We assembled data from multiple sources to create the Global Urban Biological Invasions Compendium (GUBIC) for vascular plants representing 553 urban centres from 61 countries across every continent except Antarctica. The GUBIC repository …


Determining The Optimal Antioxidant Strategy: A Comparative Analysis Of Extractionmethods In Cistus Villosus L. Extracts Revealed By Lc-Hrms And Computationalmodeling, Hicham Bouakkaz, Ebru Erol, Khedidja Benarous, Gülaçti Topçu, Reguia Mahfoudi, Amar Djeridane, Mohamed Yousfi Feb 2025

Determining The Optimal Antioxidant Strategy: A Comparative Analysis Of Extractionmethods In Cistus Villosus L. Extracts Revealed By Lc-Hrms And Computationalmodeling, Hicham Bouakkaz, Ebru Erol, Khedidja Benarous, Gülaçti Topçu, Reguia Mahfoudi, Amar Djeridane, Mohamed Yousfi

Turkish Journal of Biology

Background/aim: Cistus villosus L., a beloved tea herb, contains a treasure trove of potent antioxidants. Our research unveils thisancient ally’s potential to shield against oxidative stress, a modern health threat.Materials and methods: Antioxidant assays were conducted to evaluate the potency of ethyl acetate extract. IC50 values were determinedfor the extract in various antioxidant assays. Furthermore, molecular docking was employed for the examination of the 22 compoundsanalyzed through LC-HRMS. Additionally, ADMET and PASS investigations were conducted to evaluate their capability as antioxidantsand inhibitors of oxidant formation.Results: Each identified compound boasts a history of antioxidant prowess, building the natural defense arsenal of …


Enhanced Formulation And Comprehensive Analysis Of Novel Natural Ointments Withgrape Seed And Pomegranate Peel Infused In Olive Oil, Mebarka Imane Benguechoua, Madjda Benguechoua, Khedidja Benarous, Alaeddine Kaouka, Mohamed Yousfi Feb 2025

Enhanced Formulation And Comprehensive Analysis Of Novel Natural Ointments Withgrape Seed And Pomegranate Peel Infused In Olive Oil, Mebarka Imane Benguechoua, Madjda Benguechoua, Khedidja Benarous, Alaeddine Kaouka, Mohamed Yousfi

Turkish Journal of Biology

Background/aim: The global shift toward sustainable and organic alternatives in cosmetics and personal care has created a demandfor innovative and environmentally conscious formulations. This study aimed to develop novel natural ointments using beeswax andgrape seed (GS) and pomegranate peel (PP) extracts infused in extra virgin olive oil (EVOO), and determine the physicochemicalcharacteristics, microbiological properties, and antioxidant activity as a way to valorize organic waste toward its application in thecosmetic industry. The research aimed to promote sustainability and effectiveness in the cosmetic industry.Materials and methods: Microbial analysis was performed on the oils and ointments, followed by the extraction of active compoundsusing …


The Therapeutic Potential Of Salvia Aegyptiaca Extracts In Ethanol-Induced Gastric Ulcer:Insights Into Macroscopic, Histopathological, And Biochemical Mechanisms, Walid Mamache, Smain Amira, Fatima Benchikh, Hassiba Benabdallah, Amor Bencheikh, Hind Amira, Roumaissa Ounis, Mohammed Abdallah Torki, Chahrazed Kaoudoune Feb 2025

The Therapeutic Potential Of Salvia Aegyptiaca Extracts In Ethanol-Induced Gastric Ulcer:Insights Into Macroscopic, Histopathological, And Biochemical Mechanisms, Walid Mamache, Smain Amira, Fatima Benchikh, Hassiba Benabdallah, Amor Bencheikh, Hind Amira, Roumaissa Ounis, Mohammed Abdallah Torki, Chahrazed Kaoudoune

Turkish Journal of Biology

Background/aim: This study explores the antiulcer activity of different doses of Salvia aegyptiaca (SAE) methanol (ME) and decoctedextracts (DE) on ethanol-induced gastric ulcers in rats.Materials and methods: Female Wistar rats weighing 180–200 g were divided into five groups: control, omeprazole (positive control),and extract-treated (100, 200, and 400 mg/kg). Ulcers were induced with absolute ethanol 30 min after treatment with the extracts.The experiment was followed by macroscopic and histopathological examination. In vitro tests were also conducted to assess lipidperoxidation, catalase activity, mucus content, glutathione, and protein levels.Results: The study found that 100% ethanol caused significant damage, including colour and mucus loss, …


Phytochemical Profile And Nematicidal Potential Of Essential Oil From Algerian Wildoriganum Vulgare Subsp. Glandulosum Defs., Amina Mezerket, Juan Emilio Palomares Rius, Souad Bouasla, Henia Saib Feb 2025

Phytochemical Profile And Nematicidal Potential Of Essential Oil From Algerian Wildoriganum Vulgare Subsp. Glandulosum Defs., Amina Mezerket, Juan Emilio Palomares Rius, Souad Bouasla, Henia Saib

Turkish Journal of Biology

Background/aim: The root gall nematode Meloidogyne incognita constitute the most damaging species that infects many crops inAlgeria. The intense use of harmful agricultural chemical products has incited research to develop alternative methods with natural andecological advantages like essential oils extracted from plants. The objective of this study was to evaluate the efficacy of Origanum vulgaresubsp. glandulosum Desf. (Lamiaceae) essential oil on the development of the root-knot nematode M. incognita in potted tomatoes.Materials and methods: In pot trials, we assess the activity of O. vulgare subsp. glandulosum essential oil at two concentrations of0.75 and 0.37 mg /L against M . incognita. …


Antidiabetic Potential Of Polysaccharides From Algerian Saharan Zygophyllum Geslini Instreptozotocin-Induced Diabetic Rats, Houria Medjdoub, Waffa Bouali, Arezki Azzi, Nacera Belkacem, Nabila Benariba, Nawel Meliani Feb 2025

Antidiabetic Potential Of Polysaccharides From Algerian Saharan Zygophyllum Geslini Instreptozotocin-Induced Diabetic Rats, Houria Medjdoub, Waffa Bouali, Arezki Azzi, Nacera Belkacem, Nabila Benariba, Nawel Meliani

Turkish Journal of Biology

Background/aim: Zygophyllum geslini, an endemic Algerian species, has numerous properties, especially as an antidiabeticdrug. In Algeria, this herb serves as condiment in Saharan dishes and as animal feed (Sheep, Goat and Camel). However, fewscientific studies have reported on the medicinal properties of this Saharan species. The aims of the present work were to study 1) thechemical aspects of polysaccharides extracted from this plant, 2) their inhibitory effect on pancreatic α-amylase in vitro, and 3) theirantihyperglycemic effect in streptozotocin-induced diabetic rats in vivo.Materials and methods: First, polysaccharides were extracted from Z. geslini aerial part (ZGAP) in hot water and precipitated withethanol …


Antilipase Activities Of Cultivated Peppermint And Rosemary Essential Oils:In Vitro And In Silico Studies, Khadidja Bengana, Talia Serseg, Khedidja Benarous, Ari̇f Mermer, Yakup Şi̇ri̇n, Alaeddine Kaouka Feb 2025

Antilipase Activities Of Cultivated Peppermint And Rosemary Essential Oils:In Vitro And In Silico Studies, Khadidja Bengana, Talia Serseg, Khedidja Benarous, Ari̇f Mermer, Yakup Şi̇ri̇n, Alaeddine Kaouka

Turkish Journal of Biology

Background/aim: The growing interest in essential oils clearly indicates the power of nature and aligns with our increasing need to findtherapeutic solutions in the natural world. This study aimed to investigate the inhibitory effects of the essential oils of Mentha × piperitaand Salvia rosmarinus, harvested from the Laghouat region of Algeria, against Candida rugosa lipase (CRL) and pancreatic lipasethrough both in vitro and in silico studies.Materials and methods: Essential oils were extracted via hydrodistillation and analyzed using gas chromatography–mass spectrometryand spectrophotometry. Their antilipase activities were assessed using an inhibition assay, and molecular docking was performed withAutoDock Vina to explore interactions …


Investigating The Composition Of Fatty Acid, Tocopherol, And Sterol Contents Andantioxidant Capacity Of Oils From The Seeds Of Abelmoschus Esculentus L. Growing Inalgeria, Samira Nia, Madjda Benguechoua, Toufik Hadj Mahammed, Khatir Reggagui, Mohamed Yousfi Feb 2025

Investigating The Composition Of Fatty Acid, Tocopherol, And Sterol Contents Andantioxidant Capacity Of Oils From The Seeds Of Abelmoschus Esculentus L. Growing Inalgeria, Samira Nia, Madjda Benguechoua, Toufik Hadj Mahammed, Khatir Reggagui, Mohamed Yousfi

Turkish Journal of Biology

Background/aim: Vegetable oils are considered a vital source of energy when glucose cannot be utilized. Therefore, research on newsources of oil that demonstrate nutritional value is necessary. Okra (Abelmoschus esculentus), a member of the Malvaceae family, isa remarkable botanical specimen due to its various uses; its roots, stem, leaves, fruits, and seeds are all valued for their nutritional,therapeutic, and industrial value. This study aims to demonstrate okra’s fatty acid (FA) composition, tocopherol content, and sterolcontent and evaluate the antioxidant activity of the oils extracted from okra using three solvents.Materials and methods: The initial part of this study involved oil extraction …


Inhibitory Effects Of Carvacrol On Glucansucrase From Streptococcus Mutans And Salivaryα-Amylase: In Silico And In Vitro Studies, Samet Kocabay, M. Abdullah Alagöz, Bi̇rnur Akkaya Feb 2025

Inhibitory Effects Of Carvacrol On Glucansucrase From Streptococcus Mutans And Salivaryα-Amylase: In Silico And In Vitro Studies, Samet Kocabay, M. Abdullah Alagöz, Bi̇rnur Akkaya

Turkish Journal of Biology

Background/aim: Streptococcus mutans produces glucansucrase, an enzyme that converts sucrose into lactic acid, which lowers the pH in the oral environment and leads to tooth enamel demineralization, a key factor in dental caries. Additionally, glucansucrase facilitates the formation of extracellular polysaccharides, which promote bacterial adhesion to tooth surfaces. This study investigates the inhibitory effects of carvacrol, a natural compound, on glucansucrase activity both in vitro and in silico. Materials and methods: Glucansucrase enzyme was purified from S. mutans. The inhibitory effects of carvacrol against glucansucrase enzyme were investigated both in vitro and in silico. Results: In the presence of 50 …


Evaluating The Multifaceted Bioactivity Of Syzygium Aromaticum Essential Oil:The Central Role Of Eugenol, Noureddine Rahim, Chamseddine Derabli, Amina Bramki, Sara Mahdjoub, Sandrine Rup-Jacques, Ghozlane Barboucha, Stephani Hesse, Houssem Boulebd Feb 2025

Evaluating The Multifaceted Bioactivity Of Syzygium Aromaticum Essential Oil:The Central Role Of Eugenol, Noureddine Rahim, Chamseddine Derabli, Amina Bramki, Sara Mahdjoub, Sandrine Rup-Jacques, Ghozlane Barboucha, Stephani Hesse, Houssem Boulebd

Turkish Journal of Biology

Background/aim: Syzygium aromaticum L. is a versatile plant traditionally used to treat digestive and respiratory issues, improve oral health, and relieve pain, particularly in regions such as Southeast Asia, South Asia, and parts of the Middle East. Its essential oil (EO), predominantly composed of eugenol, is rich in bioactive compounds. This study aims to clarify the specific contribution of eugenol to the antioxidant, antibacterial, antifungal, and insecticidal activities of S. aromaticum EO by comparing their individual effects. Additionally, density functional theory (DFT) calculations were employed to examine the antioxidant mechanism of eugenol and its role in enhancing the overall activity …


Phytochemical Analysis And Antioxidant, Antimicrobial, And Cytotoxic Activities Ofxanthium Strumarium L. (Asteraceae), Ahmet Beyatli Feb 2025

Phytochemical Analysis And Antioxidant, Antimicrobial, And Cytotoxic Activities Ofxanthium Strumarium L. (Asteraceae), Ahmet Beyatli

Turkish Journal of Biology

Background/aim: Medicinal plants are considered an important source of novel antioxidant, antimicrobial, and anticancer agents. The main goal of this study was to define the beneficial properties of various extracts obtained from Xanthium strumarium. Materials and methods: Evaluations were conducted on the total phenolic and flavonoid contents of the extracts. High-performance liquid chromatography and diode-array detection (HPLC-DAD) was used to determine the phenolic profiles of the extracts. DPPH, ABTS, and FRAP assays were used to evaluate the free radical scavenging properties of the X. strumarium extracts. The broth dilution method was used for antimicrobial activity assessments, the MTT assay was …


Metal Complexes Of Sulfamethazine/Benzoin-Based Schiff Base Ligand: Synthesis,Characterization, Dft Calculations, And Antimicrobial Activities, Kerem Buran Feb 2025

Metal Complexes Of Sulfamethazine/Benzoin-Based Schiff Base Ligand: Synthesis,Characterization, Dft Calculations, And Antimicrobial Activities, Kerem Buran

Turkish Journal of Biology

Background/aim: The global rise in bacterial resistance poses a significant challenge, exacerbated by the overuse of antibacterial agents. Schiff base-metal complexes have gained attention for their potential antimicrobial properties, attributed to their unique three-dimensional structures and modes of action, such as cell wall inhibition and membrane disruption. The aim of this study was to synthesize and characterize a novel Schiff base (L) derived from sulfamethazine and benzoin, and to develop metal complexes of it with Cu2+, Co2+, Ni2+, and Cd2+. This research sought to evaluate the antibacterial and antifungal activities of the synthesized Schiff base and its metal complexes to …


Environmental Stability Of The Simulated Forest Immersion Therapy (Sfit) Intervention, Amy Miner Ross, Reo J. F. Jones, Kylee Deterding, Ella Rasmussen Feb 2025

Environmental Stability Of The Simulated Forest Immersion Therapy (Sfit) Intervention, Amy Miner Ross, Reo J. F. Jones, Kylee Deterding, Ella Rasmussen

Biology Faculty Publications and Presentations

Background: Shinrin-yoku, forest bathing, has been shown to improve the pain experience in arthritis patients and the immune system in normal healthy patients. Yet, a simulated forest immersion therapy (SFIT) experience has not been tested in these two populations and specifically not in cancer patients. If SFIT complementary therapy in these two populations progresses, the intervention environment as designed needs to be tested. The purpose of this paper is to describe the SFIT setting and test the stability of the interventional environment. Methods: To operationalize SFIT, a protocol of dose delivery was designed and measured. Ambient and surface room temperatures, …


Molecular Mechanisms Of Niemann-Pick Type C: Investigating Gene Expression, Lipid Metabolism, And Mitochondrial Dysfunction In Fibroblasts, Sarah Kim Feb 2025

Molecular Mechanisms Of Niemann-Pick Type C: Investigating Gene Expression, Lipid Metabolism, And Mitochondrial Dysfunction In Fibroblasts, Sarah Kim

Theses and Dissertations

Niemann-Pick Disease Type C (NPC) is a progressive lysosomal storage disorder characterized by the accumulation of lipids, particularly cholesterol, within cells, leading to severe neurological manifestations and developmental issues. This study employs RNA-seq to compare gene expression profiles between fibroblasts derived from a healthy individual and a patient with the NPC1 mutation. A total of 12,978 genes were analyzed, revealing 191 differentially expressed genes. Functional enrichment analysis disclosed significant associations with biological processes related to development, lipid metabolism, embryonic organ development, vascularization, and neuroinflammation. Additionally, the connection between mitochondrial function and lysosomal impairment was explored, revealing that NPC1 mutant fibroblasts …


From The Garden To The Lab, Harli Smith, Hannah Scruggs, Lindsey Whaley Feb 2025

From The Garden To The Lab, Harli Smith, Hannah Scruggs, Lindsey Whaley

JSU Student Symposium 2025

As a part of BY107 (Honors Introductory Biology Lab I), all students are tasked with creating a group presentation outlining the procedures conducted throughout the course. The purpose of the lab was to discover antibiotic producers in local, Alabama soil. Finding antibiotic producers is important due to the increasing prevalence of ESKAPE pathogens, or strains of bacterial infections that have evolved to be resistant to most mainstream antibiotics. By utilizing methods such as streaking for isolation, testing for zones of inhibition, gram staining, and Kirby Bauer Assays, we were able to prove that our soil sample, which was found in …


Is Spring Break Coming Early? Effects Of Climate Change On Alabama's Native Plant Phenology, Kathleen Madden, Madisyn Barksdale, Kelly Pruitt, Summer Zamora Feb 2025

Is Spring Break Coming Early? Effects Of Climate Change On Alabama's Native Plant Phenology, Kathleen Madden, Madisyn Barksdale, Kelly Pruitt, Summer Zamora

JSU Student Symposium 2025

Please note: no video is available for this presentation.

Climate change has significantly impacted biodiversity, prompting many species to adapt by altering their phenology—the timing of life cycle events. Shifts in plant phenology can have far-reaching ecological consequences, particularly for species that rely on these plants directly or indirectly. One critical consequence is the temporal mismatch between plants and their pollinators, a phenomenon observed in multiple species. Studies using satellite imagery have documented advances in spring phenology across the United States, but species-specific data remain limited, especially in the biodiverse and ecologically vulnerable Southeastern region.

To address this gap, we …


Escape From Diabetes, J E. Jochum, J Carmack, J Toon Feb 2025

Escape From Diabetes, J E. Jochum, J Carmack, J Toon

Clinical Practice in Athletic Training

Introduction: In the past decade, interprofessional education (IPE) to promote interprofessional collaborative practice has become an integral component of pre-licensure education in the health professions. Research shows that IPE activities involving problem-solving in patient care that requires cooperation and communication among the professions is most effective. An effective activity to meet interprofessional competencies is the use of escape rooms. Escape rooms are team-based games where groups of individuals solve puzzles to accomplish a specific goal, typically in a limited amount of time. There are many benefits to using escape rooms in education, including promoting problem-solving, teamwork, and creativity, improving focus …


Modification Of Ergonomics For A World-Class Brass Instrumentalist With A Congenital Limb Difference: Level 3 Case, O G. Newhouse Feb 2025

Modification Of Ergonomics For A World-Class Brass Instrumentalist With A Congenital Limb Difference: Level 3 Case, O G. Newhouse

Clinical Practice in Athletic Training

Background: A drum and bugle corps is a musical marching organization that consists of approximately 160 brass, percussion, and color guard performers. There are currently twenty-one drum corps organizations at the world-class level that compete. Organizations learn their 8–10-minute show in the late spring and begin traveling the country performing and competing in the early summer until August. Rehearsal days can be up to 10 hours of practice including visual and music. It has been reported that the incidence of upper limb pain is higher in those who have longer practice times, in which is a symptom of overuse. These …