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Articles 811 - 840 of 1632
Full-Text Articles in Biology
Towards Understanding The Function Of An Ets-Like Gene In Nematostella Vectensis: Generation Of A Knockout Mutant Line And A Transgenic Reporter Line, Emily Bullock
Biological Sciences Undergraduate Honors Theses
Due to their unique phylogenic position as sister to Bilateria, Cnidaria are often credited with the utility of allowing for reconstruction of ancestral biology based on characteristics shared with bilaterians and other animals. This factor makes investigation into the nervous systems of cnidarians critical in understanding early neural evolution. Wamides, a class of neuropeptides, have been shown to play a regulatory role in life cycle transitions across many different species. The cnidarian specific Wamide neuropeptide, GLWamide, has previously been identified to play an accelerator role in the metamorphic timing of a specific species of sea anemone, Nematostella vectensis. However, …
Cross-Pollination: Building A Co-Taught Course To Examine Art And Sex Through The Lens Of Botany, Christopher T. Martine, Diamanda A. Zizis, Anna K. Kell
Cross-Pollination: Building A Co-Taught Course To Examine Art And Sex Through The Lens Of Botany, Christopher T. Martine, Diamanda A. Zizis, Anna K. Kell
Faculty Journal Articles
Driven by overlapping interests in plants, art, and diversity in sex expression, Anna Kell (Department of Art and Art History) and Chris Martine (Department of Biology) developed a course that integrates the perspectives of a visual artist and a botanist. Art & Sex Through the Lens of Botany seeks to impart the importance of making connections across disciplines and the value of visual literacy across academic lines. The course introduces foundational concepts in each field and encourages students to integrate and explore these different systems of knowledge and their intersections. In addition to developing fluencies related to both general botany …
Genetic Analysis Of Global Sawfish Populations, Kylie Faulkner
Genetic Analysis Of Global Sawfish Populations, Kylie Faulkner
Honors Theses
Family Pristidae contains five of the most critically endangered elasmobranch species: Anoxypristis cuspidata, Pristis pristis, Pristis pectinata, Pristis zijsron, and Pristis clavata. The species of this family have suffered drastic population declines and range reductions due to historic patterns of overexploitation, accidental entanglement, and habitat disruption. The conservation of this taxa has been historically complicated by taxonomic uncertainty, as similar morphologies across species make them exceedingly difficult to identify. A morphological and genetic comparison of sawfish specimens collected globally was conducted in 2013, which supported a reduction in the number of described species from seven to …
Defining The Phylogenetics And Resistome Of The Major Clostridioides Difficile Ribotypes Circulating In Australia, Keeley O’Grady, Stacey Hong, Papanin Putsathit, Narelle George, Christine Hemphill, Peter G. Huntington, Tony M. Korman, Despina Kotsanas, Monica Lahra, Rodney Mcdougall, Andrew Mcglinchey, Avram Levy, Casey V. Moore, Graeme Nimmo, Louise Prendergast, Jennifer Robson, David J. Speers, Lynette Waring, Michael C. Wehrhahn, Gerhard F. Weldhagen, Richard M. Wilson, Thomas V. Riley, Daniel R. Knight
Defining The Phylogenetics And Resistome Of The Major Clostridioides Difficile Ribotypes Circulating In Australia, Keeley O’Grady, Stacey Hong, Papanin Putsathit, Narelle George, Christine Hemphill, Peter G. Huntington, Tony M. Korman, Despina Kotsanas, Monica Lahra, Rodney Mcdougall, Andrew Mcglinchey, Avram Levy, Casey V. Moore, Graeme Nimmo, Louise Prendergast, Jennifer Robson, David J. Speers, Lynette Waring, Michael C. Wehrhahn, Gerhard F. Weldhagen, Richard M. Wilson, Thomas V. Riley, Daniel R. Knight
Research outputs 2022 to 2026
Clostridioides difficile infection (CDI) remains a significant public health threat globally. New interventions to treat CDI rely on an understanding of the evolution and epidemiology of circulating strains. Here we provide longitudinal genomic data on strain diversity, transmission dynamics and antimicrobial resistance (AMR) of C. difficile ribotypes (RTs) 014/020 (n=169), 002 (n=77) and 056 (n=36), the three most prominent C. difficile strains causing CDI in Australia. Genome scrutiny showed that AMR was uncommon in these lineages, with resistance-conferring alleles present in only 15/169 RT014/020 strains (8.9 %), 1/36 RT056 strains (2.78 %) and none of 77 RT002 strains. Notably, ~90 …
Changes In Zooplankton Community Structure In A Wetland Metacommunity Following Homogenization From Flooding, Kevin Peteroy
Changes In Zooplankton Community Structure In A Wetland Metacommunity Following Homogenization From Flooding, Kevin Peteroy
Theses, Dissertations and Culminating Projects
Wetlands in urban areas provide ecosystem services that benefit the environment and society. Through these services, wetlands are able to help mitigate consequences of human activities such as flooding by increasing permeable surface coverage and contaminant filtering from polluted runoff. One such type of wetland, vernal pools, provide important temporary habitat for many organisms, including myriad zooplankton species. For planktonic organisms, flooding events might be disruptive or allow them to disperse to areas that would be otherwise inaccessible. I observed changing abiotic conditions and zooplankton communities in 20 vernal pools at a wetland in Wayne, New Jersey, USA over a …
Limited Interspecific Gene Flow In The Evolutionary History Of The Icefish Genus Chionodraco, Luca Schiavon, Santiago G. Ceballos, Michael Matschiner, Emiliano Trucchi, Mario La Mesa, Emilio Riginella, Magnus Lucassen, Felix C. Mark, Kevin Bilyk, Rafaella Franch, Andreas Wallberg, Elisa Boscari, Lorenzo Zane, Chiara Papetti
Limited Interspecific Gene Flow In The Evolutionary History Of The Icefish Genus Chionodraco, Luca Schiavon, Santiago G. Ceballos, Michael Matschiner, Emiliano Trucchi, Mario La Mesa, Emilio Riginella, Magnus Lucassen, Felix C. Mark, Kevin Bilyk, Rafaella Franch, Andreas Wallberg, Elisa Boscari, Lorenzo Zane, Chiara Papetti
Department of Biology Faculty Scholarship and Creative Works
Hybridization and introgression are recognized as mechanisms promoting genetic variability during evolutionary radiations. We examined the impact of introgression in the process of speciation, focusing on the Antarctic icefish genus Chionodraco. Our analyses confirmed that the three Chionodraco species (Chionodraco hamatus, Chionodraco myersi, and Chionodraco rastrospinosus) were genetically distinctive, despite signals of past interspecific gene flow between C. hamatus and C. myersi that likely occurred during interglacial periods. However, in this study, no recent hybrids were identified. The lack of contemporary hybridization may be due to life-history traits and the type of marker used in the analysis. Our study emphasizes …
A Survey Of The Biodiversity And Phylogeny Of Pucciniales Collected In Puerto Rico, Catherine Liana Rock
A Survey Of The Biodiversity And Phylogeny Of Pucciniales Collected In Puerto Rico, Catherine Liana Rock
Undergraduate Honors Thesis Collection
Rust fungi (Pucciniales) are a diverse group of fungi belonging to the phylum Basidiomycota. Rusts are obligate biotrophic parasites that infect vascular plants many of which have economic and agricultural importance such as legumes, wheat, and coffee crops (Helfer, 2013, Kolmer et al., 2009). In tropical regions of the world, only about 3-4% of the estimated Pucciniales species diversity is known (Piepenbring et al., 2011). This study aims to determine phylogenetic groupings of Pucciniales collected in Puerto Rico using molecular data and to compare this data to rust species previously identified in Cuba, a closely related tropical location in terms …
Investigating And Modeling The Rate Of Syncytia Formation In Respiratory Syncytial Virus (Rsv), Emily Hope Landwehr
Investigating And Modeling The Rate Of Syncytia Formation In Respiratory Syncytial Virus (Rsv), Emily Hope Landwehr
Undergraduate Honors Thesis Collection
Respiratory syncytial virus (RSV) is a common virus that infects humans and causes a range of symptoms similar to a common cold. Severe cases result in pneumonia and hospitalization. A critical mechanism for RSV spread is lateral cell-cell transmission that can result in the formation of multinucleated syncytia, a single cell containing multiple nuclei. Syncytia formation is known to influence RSV transmission in vitro. Previous studies have contributed to the development of a current viral kinetic model that shows a representation for the progression of viral infections. A limitation to this model is that it does not account for syncytia …
Exploring Immune Related Alterations In Ops/Bin2 Interactions And Investigating Tcp8 Localization Patterns To Enhance Understanding Of The Brassinosteroid Signaling Pathway, Maura Adare Donnelly
Exploring Immune Related Alterations In Ops/Bin2 Interactions And Investigating Tcp8 Localization Patterns To Enhance Understanding Of The Brassinosteroid Signaling Pathway, Maura Adare Donnelly
Undergraduate Honors Thesis Collection
The brassinosteroid (BR) signaling pathway is vital in regulating development and stress response in plants. The hormone BR binds a receptor kinase at the plasma membrane forming a receptor complex, causing an intracellular signal transduction carried out through protein interactions within the pathway. These interactions allow for transcription factors to bind to and regulate BR regulated genes within the nuclei; this is important as their expression is important for growth and development. The project's proteins of interest, including Arabidopsis thaliana proteins OPS and BIN2, along with transcription factors TCP8 and BZR2, are involved in these pathway interactions. Recent research has …
Invasive Shrubs Differentially Alter Autumnal Activity For Three Common Small-Mammal Species, Brian M. Connolly, Chad Zirbel, Carson Keller, Mark Fuka, John L. Orrock
Invasive Shrubs Differentially Alter Autumnal Activity For Three Common Small-Mammal Species, Brian M. Connolly, Chad Zirbel, Carson Keller, Mark Fuka, John L. Orrock
Biology Faculty Scholarship
Seasonal variation in animal activity influences fitness and the intensity of ecological interactions (e.g., competition, predation), yet aspects of global change in the Anthropocene may catalyze shifts in seasonal activity. Invasive plants are components of global change and can modify animal daily activity, but their influence on animal seasonal activity is less understood. We examined how invasive woody shrubs (Autumn olive [Elaeagnus umbellata] and Amur honeysuckle [Lonicera maackii]) affect seasonal activity of three common small-mammal species by coupling experimental shrub removal with autumnal camera trapping for two consecutive years at six paired forest sites (total 12 …
Determining The Roles Of Whib-Like Transcription Factors In Mycobacterium Abscessus, Charity Lynn Mcmanaman
Determining The Roles Of Whib-Like Transcription Factors In Mycobacterium Abscessus, Charity Lynn Mcmanaman
Legacy Theses & Dissertations (2009 - 2024)
Mycobacterium abscessus is a non-tuberculous mycobacteria that causes lung infections or skin and soft tissue infections. M. abscessus is innately resistant to antibiotics, requiring a long multi-antibiotic treatment regimen, with a low 45% cure rate for lung infections. The WhiB-like transcription factors are limited to the actinomycete class, which includes Mycobacteria. These proteins regulate multiple cellular processes, including growth and division, responses to oxidative, nitrosative or pH stress, and antibiotic resistance. Our work describes three WhiB-like transcription factors: WhiB7, which regulates antibiotic resistance, WhiB2, with a role in cell division, and Mab1756, an unstudied regulator similar to WhiB2. We used …
Comparative Population Genomics Of Bloodstream-Derived Staphylococcus Aureus From Disparate Geographic Origins In The United States, Milan Pfister
Comparative Population Genomics Of Bloodstream-Derived Staphylococcus Aureus From Disparate Geographic Origins In The United States, Milan Pfister
Legacy Theses & Dissertations (2009 - 2024)
Staphylococcus aureus is a commensal and an opportunistic pathogen that causes a variety of diseases in humans, from minor skin and soft tissue infections to life-threatening invasive diseases. The emergence and spread of multidrug-resistant and methicillin-resistant S. aureus (MRSA) complicate treatment options, which can lead to significant morbidity and mortality of patients. In this study, we compared the clonal lineages and genomic features of bloodstream-derived S. aureus populations from different locations. We leveraged 957 previously published genomes derived from bloodstream infections across six hospitals located in Illinois, Minnesota, Missouri, New Hampshire, and New York, USA. We carried out pan-genome analysis, …
Searching For Regulators Of Catalase Activity Using Enzymatic Screens, Aram Joseph Alaxanian
Searching For Regulators Of Catalase Activity Using Enzymatic Screens, Aram Joseph Alaxanian
Legacy Theses & Dissertations (2009 - 2024)
Catalase is found in a plethora of organisms and plays a crucial role in safeguarding cells against oxidative stress-induced damage to proteins, RNA, and DNA. Catalase catalyzed the decomposition of hydrogen peroxide (H2O2) into oxygen and water. Deficiencies in catalase have been linked to pathological conditions such as Diabetes, Alzheimer's, and Cancer, underscoring its significance in cellular health. In bacteria like Escherichia coli, catalase is encoded by two genes, KatG and KatE, both subject to regulation through transcription, translation, and post-translational modification. Our study focused on assessing the catalase activity of mutants lacking stress response genes (e.g., lexA, soxR, soxS, …
Senescence And The Senescence Associated Secretory Phenotype In Salivary Hypofunction, Quetsia Jean-Baptiste
Senescence And The Senescence Associated Secretory Phenotype In Salivary Hypofunction, Quetsia Jean-Baptiste
Legacy Theses & Dissertations (2009 - 2024)
Cellular senescence, a triggered permanent cycle arrest, occurs with aging and is a component of many aging-related diseases. Triggers for senescence may include pathways involving DNA damage, telomere dysfunction, release of reactive oxygen species, and other additional internal/external stimuli. Senescence can have a positive effect as it plays a fundamental role in wound healing, tumor suppression, and promoting embryonic development. However, a prolonged consequence of senescence is the production of the senescence-associated secretory phenotype (SASP), in which the cell secretes pro-inflammatory and pro-tumorigenic factors that can have adverse effects on surrounding cells, which is known as the bystander effect. Eliminating …
Interplay Between Cellular Stress Mechanisms And Immune Responses In Restricting Zika Virus Infection, Pheonah Badu
Interplay Between Cellular Stress Mechanisms And Immune Responses In Restricting Zika Virus Infection, Pheonah Badu
Legacy Theses & Dissertations (2009 - 2024)
Flavivirus infections pose significant global health risks, often leading to serious neurological and congenital complications such as microcephaly. These viruses induce complex cellular stress responses pathways encompassing the Unfolded Protein Response (UPR), Integrated Stress Response (ISR), autophagy, apoptosis, and the antiviral immune response, which dictate cell fate by either promoting survival to combat virus-induced damage or initiating cell death under prolonged stress. Despite the antagonizing functions, flaviviruses employ various subversion strategies, facilitated by viral proteins, to ensure successful infections even in the presence of activated cellular responses. Recent studies highlight dynamic interactions among stress response pathways during infection, emphasizing the …
Testing The Impact Of Actinomyces Naeslundii On The Proliferation Dynamics Of Corynebacterium And Revealing The Prescence Or Absence Of Inhibitory Properties, Quintin Hodge
ALL - Honors Theses
The gram-positive bacterium Actinomyces naeslundii is a core member of the oral microbiome and has been associated with states of health. In early human life, researchers unraveled the involvement of several different taxa of microbes present within the oral cavity in contributing to diseases including tooth destruction. Periodontitis is a prevalent oral disease that is proposed to be caused by dysbiosis, which is characterized by microbial shifts within the bacterial community resulting from changes in relative microbial abundance and spatial organization in the dental plaque microbiome, causing immense gum pain and inflammation. Corynebacterium matruchotii is also a gram-positive bacterium like …
Bilateral Asymmetry In The First Metacarpal: The Influence Of Handedness In Humans And Non-Human Primates, Lucyna A. Bowland
Bilateral Asymmetry In The First Metacarpal: The Influence Of Handedness In Humans And Non-Human Primates, Lucyna A. Bowland
Graduate Theses and Dissertations
Muscle attachment sites (entheses) are often used to infer soft tissue anatomy and reconstruct behaviors within skeletal populations, but there remains a significant debate about whether and to what degree muscle use is accurately reflected in bony morphology. One of the most difficult problems in establishing the relationship between variation in muscle use and entheseal development is the inability to exclude a variety of external factors thought to influence enthesis development, including age, sex, body mass, and activity patterns. One way around this is to take advantage of the fact that humans are handed (preferentially using one hand over another, …
Season Of Grazing Interacts With Soil Texture, Selecting For Associations Of Biocrust Morphogroups, Lea A. Condon, Roger Rosentreter, Kari E. Veblen, Peter S. Coates
Season Of Grazing Interacts With Soil Texture, Selecting For Associations Of Biocrust Morphogroups, Lea A. Condon, Roger Rosentreter, Kari E. Veblen, Peter S. Coates
Biology Faculty Publications and Presentations
Livestock grazing, a widespread land use in semi-arid systems, is often placed in opposition to the perpetuation of biological soil crusts (“biocrusts”: lichens, mosses, and algal crusts including cyanobacteria) that live on the soil surface and provide ecosystem functions. The composition of biocrusts and vascular plants varies with climate, soils, and disturbance. In general, ruderal mosses and light algal crusts make up greater proportions of biocrusts in the presence of disturbance, although morphogroups of biocrusts respond differently to various disturbances. It is unknown if there are scenarios under which grazing can occur and ruderal components of biocrust could be maintained. …
Testing Functional Homology Of The Lga2 And Rga2 Genes Of Sporisorium Reilianum In Ustilago Maydis, Joshua Thomas
Testing Functional Homology Of The Lga2 And Rga2 Genes Of Sporisorium Reilianum In Ustilago Maydis, Joshua Thomas
College of Arts & Sciences Senior Theses
Ustilago maydis, a basidiomycete fungus, infects corn and displays dimorphism, transitioning between nonpathogenic and pathogenic stages. Its life cycle involves mating of haploids with different alleles, resulting in the formation of galls/tumors filled with teliospores. The a1 and a2 alleles regulate pheromone recognition and mating. The lga2 and rga2 genes in the a2 allele are crucial for uniparental mitochondrial inheritance. Sporisorium reilianum, a related fungus, has homologs of lga2 and rga2 with U. maydis. To test the functional homology of the S. reilianum genes, protoplasts of U. maydis strains deleted for lga2 or lga2 and rga2 were transformed …
A Phylogenetic Analysis Of The Population Dynamics Of A Captive Colony Of Diploptera Punctata., Nick Peterson
A Phylogenetic Analysis Of The Population Dynamics Of A Captive Colony Of Diploptera Punctata., Nick Peterson
Theses/Capstones/Creative Projects
The unique milk production of Diploptera punctata makes this species a promising model species in entomology for studying the evolution of milk production and for insect endocrinology. Despite this, the genetic diversity of captive populations of the species is not well studied. To better evaluate the captive diversity and population dynamics of Diploptera punctata at UNO we extracted the DNA of 20 random individuals and amplified their DNA using 4 different primers before cleaning the amplified products and sequencing the genes of the samples for use in both individual and concatenated phylogenetic trees. Our results indicate the UNO colony of …
The Anti-Diabetic Drug Metformin Disrupts Feeding And Sleeping Behaviors In Drosophila Melanogaster., Lucas Fitzgerald
The Anti-Diabetic Drug Metformin Disrupts Feeding And Sleeping Behaviors In Drosophila Melanogaster., Lucas Fitzgerald
College of Arts & Sciences Senior Theses
Dimethylbiguanide, also known as metformin, is the single most prescribed oral treatment for non-insulin dependent diabetes mellitus, or type 2 diabetes, in Western countries. The primary mechanism of action that metformin acts through is the activation of AMP kinase, an important regulator of energy homeostasis. While the anti-diabetic effects of metformin are well documented, its effects on feeding and sleeping behaviors are not well characterized. Using the model organism Drosophila melanogaster, the mean daily quantity of food consumed was measured and compared between groups treated with several dosages of metformin. Feeding interactions such as meal frequency and length were …
Persistence And Evolution Of Pseudomonas Aeruginosa Following Initiation Of Highly Effective Modulator Therapy In Cystic Fibrosis, Catherine R. Armbruster, Yasmin K. Hilliam, Anna C. Zemke, Samar Atteih, Christopher Marshall, John Moore, Junu Koirala, Leah Krainz, Jordan R. Gaston, Stella E. Lee, Vaughn S. Cooper, Jennifer M. Bomberger
Persistence And Evolution Of Pseudomonas Aeruginosa Following Initiation Of Highly Effective Modulator Therapy In Cystic Fibrosis, Catherine R. Armbruster, Yasmin K. Hilliam, Anna C. Zemke, Samar Atteih, Christopher Marshall, John Moore, Junu Koirala, Leah Krainz, Jordan R. Gaston, Stella E. Lee, Vaughn S. Cooper, Jennifer M. Bomberger
Biological Sciences Faculty Research and Publications
Today, more than 90% of people with cystic fibrosis (pwCF) are eligible for the highly effective cystic fibrosis transmembrane conductance regulator (CFTR) modulator therapy called elexacaftor/tezacaftor/ivacaftor (ETI) and its use is widespread. Given the drastic respiratory symptom improvement experienced by many post-ETI, clinical studies are already underway to reduce the number of respiratory therapies, including antibiotic regimens, that pwCF historically relied on to combat lung disease progression. Early studies suggest that bacterial burden in the lungs is reduced post-ETI, yet it is unknown how chronic Pseudomonas aeruginosa populations are impacted by ETI. We found that pwCF remain infected throughout their …
Indoor Tent Management For Extending Honey Bee Research Season: Benefits And Caveats, Trevor Bawden, Adam G. Dolezal, Chelsea N. Cook
Indoor Tent Management For Extending Honey Bee Research Season: Benefits And Caveats, Trevor Bawden, Adam G. Dolezal, Chelsea N. Cook
Biological Sciences Faculty Research and Publications
Honey bees are important organisms for research in many fields, including physiology, behavior, and ecology. Honey bee colonies are relatively easy and affordable to procure, manage, and replace. However, some difficulties still exist in honey bee research, specifically that honey bee colonies have a distinct seasonality, especially in temperate regions. Honey bee colonies transition from a large society in which workers have a strict temporal division of labor in the summer, to a group of behaviorally flexible workers who manage the colony over winter. Furthermore, opening colonies or collecting bees when they are outside has the potential to harm the …
Dispersal Movement And Overwintering Ecology Of A Cryptic Migratory Forest Owl, Mitchell Lee Pruitt
Dispersal Movement And Overwintering Ecology Of A Cryptic Migratory Forest Owl, Mitchell Lee Pruitt
Graduate Theses and Dissertations
Understanding species’ distributions and how a species uses its environment is a vital aspect of ecology and important for the development and implementation of conservation planning. In migratory species, with distinct breeding and nonbreeding ranges, understanding distributions is a complex endeavor. Nevertheless, evaluating movement behavior by linking seasonal distributions and identifying source areas is vital for understanding a species’ full annual cycle ecology. Understanding distributions is particularly important for predators, like birds of prey, that can exert top-down effects on community structure and ecosystem function through their influence on prey populations. Among raptors, owls are severely understudied in large part …
The Study Of Dmrt1 In Zebrafish And How It Impacts Sex Determination, Raymond Michael Poirier
The Study Of Dmrt1 In Zebrafish And How It Impacts Sex Determination, Raymond Michael Poirier
Graduate Masters Theses
The dmrt1 gene is common amongst most animals and functions to determine or maintain male sex during development. Similarly, in zebrafish dmrt1 is important for male sex determination and maintaining proper testis morphology. This gene is expressed in two different cell types of the testis in zebrafish, germ cells and Sertoli cells. While we know where this gene is expressed and what its role is, it is not known if it is sufficient to drive male fate. If so, then in which cells is it sufficient to drive male fate in the testis? I aimed to answer this question by …
The Influence Of Researcher Disturbance On Raccoon Predation Of American Alligator Nests, Clarissa Tuten
The Influence Of Researcher Disturbance On Raccoon Predation Of American Alligator Nests, Clarissa Tuten
Electronic Theses and Dissertations
Raccoons (Procyon lotor) are a dominant predator of American alligator (Alligator mississippiensis) nests in the southeastern United States, using a combination of olfactory, visual, and tactile cues to identify nest locations. Studies on alligator nesting ecology typically require researchers to create paths through marsh habitat, potentially introducing visual and olfactory cues raccoons may use to locate nests. The purpose of this study was to evaluate the effect of human visitation to alligator nests on the frequency of raccoon nest predation at two sites in coastal South Carolina, Tom Yawkey Wildlife Center (TYWC) and Santee Coastal Reserve (SCR). We hypothesized that …
How New Communication Behaviors Evolve: Androgens As Modifiers Of Neuromotor Structure And Function In Foot-Flagging Frogs, Lisa A. Mangiamele, Allex Andrya Dawn, Kerry M. Lecure, Gina E. Mantica, Riccardo Racicot, Matthew J. Fuxjager, Doris Preininger
How New Communication Behaviors Evolve: Androgens As Modifiers Of Neuromotor Structure And Function In Foot-Flagging Frogs, Lisa A. Mangiamele, Allex Andrya Dawn, Kerry M. Lecure, Gina E. Mantica, Riccardo Racicot, Matthew J. Fuxjager, Doris Preininger
Biological Sciences: Faculty Publications
How diverse animal communication signals have arisen is a question that has fascinated many. Xenopus frogs have been a model system used for three decades to reveal insights into the neuroendocrine mechanisms and evolution of vocal diversity. Due to the ease of studying central nervous system control of the laryngeal muscles in vitro, Xenopus has helped us understand how variation in vocal communication signals between sexes and between species is produced at the molecular, cellular, and systems levels. Yet, it is becoming easier to make similar advances in non-model organisms. In this paper, we summarize our research on a group …
Clonal Plants' Traits And Responses Following Fire Disturbance In Ponderosa Pine Ecosystems In The Colorado Front Range, Raymond Erskine
Clonal Plants' Traits And Responses Following Fire Disturbance In Ponderosa Pine Ecosystems In The Colorado Front Range, Raymond Erskine
Master's Theses
Mountain ecosystems are currently experiencing increasing impacts of disturbances (e.g., wildfire) due to global changes in climate and land use, leading to significant changes in vegetation composition and landscape dynamics. Clonal plants, characterized by their vegetative reproduction strategies, offer a range of ecologically important traits to cope with disturbances. However, clonality is often excluded in studies of post-fire vegetation dynamics in mountain ecosystems, and our knowledge of the ability of clonal plants to respond to differing disturbance regimes is limited. Therefore, I examined the response of understory vegetation following fire disturbance in burned and unburned ponderosa pine stands of the …
Simvastatin Induces Autophaghy-Mediated Cell Death In Metastatic Breast Cancer Cells, Jessica Allagoa
Simvastatin Induces Autophaghy-Mediated Cell Death In Metastatic Breast Cancer Cells, Jessica Allagoa
Theses (2016-Present)
Breast cancer remains one of the leading causes of cancer deaths among women. Due to the limited effectiveness of current anticancer drugs, ongoing research has extended towards alternative drug categories for potential treatments. Recent findings indicate that statins possess the ability to suppress tumors across various cell types. Traditionally, statins are known as a class of cholesterol-lowering agents and function by inhibiting 3-hydroxy-3-methyl-glutaryl-coenzyme A reductase, a key enzyme in the mevalonate pathway. However, statins can also suppress cell proliferation and ultimately lead to cell death, which includes Type I apoptosis-induced cell death or Type II autophagy-induced cell death. Autophagy is …
Foxo1 Inhibitor, As1842856, Induces Cell Cycle Arrest And Reverses Anticancer Drug-Induced Cytotoxicity In Osteosarcoma Cells, Antanay Hall
Foxo1 Inhibitor, As1842856, Induces Cell Cycle Arrest And Reverses Anticancer Drug-Induced Cytotoxicity In Osteosarcoma Cells, Antanay Hall
Theses (2016-Present)
Forkhead box class O (FOXO)-1 transcription factor controls cell proliferation, apoptosis, oxidative stress, and other cellular activities; FOXO1 has also been implicated in cell cycle regulation. This research project aims to determine the contribution of FOXO1 to cell cycle regulation and response to anticancer drug treatment in osteosarcoma. Osteosarcoma is the most common bone cancer, with most cases occurring in people younger than 30 years old. The study explores the impact of FOXO1 inhibitor AS1842856 on the cytotoxic effects of anticancer drugs in CCHOSD, Hos, and LM7 osteosarcoma (OGS) cell lines. Following chemical inhibition of FOXO1 and anticancer drug treatment, …