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Articles 691 - 720 of 1632
Full-Text Articles in Biology
Synthesis Of Dyes Sulfamidazole: Characterization, Evaluation, Molecular Docking And Global Descriptors By Density Functional Theory (Dft)., Athra G. Sager, Jawad Kadhim Abaies, Zeena R. Katoof
Synthesis Of Dyes Sulfamidazole: Characterization, Evaluation, Molecular Docking And Global Descriptors By Density Functional Theory (Dft)., Athra G. Sager, Jawad Kadhim Abaies, Zeena R. Katoof
Karbala International Journal of Modern Science
In the present work, novel azo compounds of sulfamidazole were created via the reaction of diazonium salt of sulfamidazole with several aromatic molecules including (resorcinol, 2-nitro phenol, 3-nitro phenol, and 4-nitro phenol)) (Z1–Z4). The new compounds (Z1-Z4) were identified using FTIR, 1HNMR techniques, in addition to melting point measurements. The biological activity of compounds (Z1-Z4) was studied against four kinds of bacteria including E. coli, Klebsiella pneumonia, Salmonella, and Staphylococcus aureus. The findings showed that all compounds (Z1-Z4) were active against the examined bacteria. Theoretical studies of the antibacterial ability of the prepared compound against DNA gyrase enzyme …
Using Rapid Protein Degradation To Determine The Effect Of Runx1 Loss-Of- Function On Dna Damage Accumulation And Repair., Jackriel Pina Morales
Using Rapid Protein Degradation To Determine The Effect Of Runx1 Loss-Of- Function On Dna Damage Accumulation And Repair., Jackriel Pina Morales
Theses and Dissertations
Germline mutations in RUNX1 are associated with familial platelet disorder with a predisposition to myeloid malignancy (RUNX1-FPDMM), in which patients present with low platelet counts,excessive bleeding and bruising, and an increased risk of Acute Myeloid Leukemia (AML)/Myelodysplastic Syndrome (MDS) development throughout their lifetime. To understand how these loss-of-function mutations in RUNX1 drive predispose to malignancy, it is important to develop a detailed understanding of the molecular basis of RUNX1 function. While RUNX1 is a transcription factor, preliminary data from our group and work from others suggests that RUNX1 also interacts with proteins that are critical for DNA damage …
Long-Term Post-Fire Succession Of Reptiles In An Urban Remnant In South-Western Australia, Robert A. Davis, Michael D. Craig
Long-Term Post-Fire Succession Of Reptiles In An Urban Remnant In South-Western Australia, Robert A. Davis, Michael D. Craig
Research outputs 2022 to 2026
Background: Reptile responses to fire may differ between remnants and contiguous vegetation but this is poorly understood. Aims: We aimed to explore long-term (≤15 years) post-fire responses of reptiles in an urban Banksia woodland remnant. Methods: We trapped reptiles for 10 nights in November and December each year between 2009 and 2023 inclusive (except 2014 and 2019) to estimate relative abundance. We used mixed models to explore differences between unburnt and burnt sites and changes in both over time. Key results and conclusions: The reptile community showed short-term negative responses to fire, but communities had returned to their pre-fire state …
Draft Genome Sequences Of Three Lactobacillus Crispatus Strains, Isolated From The Female Urinary Tract, Cerena Sedano, Natalie Stegman, Maria Steiling, Briana Jackson, Catherine Putonti
Draft Genome Sequences Of Three Lactobacillus Crispatus Strains, Isolated From The Female Urinary Tract, Cerena Sedano, Natalie Stegman, Maria Steiling, Briana Jackson, Catherine Putonti
Biology: Faculty Publications and Other Works
Lactobacillus crispatus is a frequent member of the female urogenital microbiota. Here, we present the draft genome assemblies of three L. crispatus strains: UMB4356, UMB5661, and UMB6244. All strains were isolated from voided urine samples from females with type 2 diabetes.
The Biology Of The Facultative Halophyte Atriplex Patula L., Richard Stalter, Robert I. Lonard
The Biology Of The Facultative Halophyte Atriplex Patula L., Richard Stalter, Robert I. Lonard
School of Integrative Biological & Chemical Sciences (Formerly Dept. of Biology)
Atriplex patula L. is a facultative halophyte that tolerates low to moderate levels of salinity and occurs on the margins of coastal salt marshes, roadsides, in agricultural fields, and in other areas where disturbance has occurred. The genus Atriplex L. is represented by about 250 species globally and has recently been included in the family Amaranthaceae subfamily Chenopodioidae. Atriplex patula was possibly introduced in North America from Europe, Asia or North Africa in the 18th century. Because the stems and leaves accumulate and store heavy metal pollutants, A. patula has been suggested for use in habitat remediation.
Novel In Situ Synthesis Of Copper Oxide Nanoparticles In Epoxy Network: Kinetics, Composite Mechanical And Dielectric Properties, Elena Bobina, Maxim Danilaev, Safaa.M.R.H. Hussein, Sergey Karandashov, Vladimir Kuklin, Ivan Lounev, Konstantin Faizullin
Novel In Situ Synthesis Of Copper Oxide Nanoparticles In Epoxy Network: Kinetics, Composite Mechanical And Dielectric Properties, Elena Bobina, Maxim Danilaev, Safaa.M.R.H. Hussein, Sergey Karandashov, Vladimir Kuklin, Ivan Lounev, Konstantin Faizullin
Karbala International Journal of Modern Science
>Mechanical properties of polymer composites with dispersed nanoparticles (CDNP) depend on interaction between the nanoparticles and the polymer matrix. Strength of polymer composites significantly decreases when there is no interaction between dispersed nanoparticles and the polymer. This limits the application of functional polymer composites with dispersed nanoparticles. In this study, CDNP based on ED-20 epoxy resin with dispersed copper oxide nanoparticles was obtained.These nanoparticles were synthesized in epoxy resin before curing: the nanoparticles were obtained by decomposition of copper hydroxide by heating its solution in ED-20 resin.The kinetics of copper oxide nanoparticles formation in CDNP samples were studied using two …
Elm And Lightgbm: A Hybrid Machine Learning Technique With Intelligent Iot To Predict The Cardiovascular Disease, Gorapalli Srinivasa Rao, G Muneeswari
Elm And Lightgbm: A Hybrid Machine Learning Technique With Intelligent Iot To Predict The Cardiovascular Disease, Gorapalli Srinivasa Rao, G Muneeswari
Karbala International Journal of Modern Science
Cardiologists can more accurately classify a patient's condition by performing an accurate diagnostic and prognosis of cardiovascular disease (CVD). The clinical diagnosis, and therapies processes within the medical field have been substantially accelerated by ML-based approaches enabled by IoT-based systems. This structure is based on IoT-based system with enabled ML approach. This study investigates an approach known as ensemble categorization, which enhances the precision of weak algorithms by integrating multiple classifiers. For effective CVD classification, we utilized Ensemble learning machine (ELM) and Light GBM. The appropriate traits are chosen to speed up the categorization process using the Gorilla Troops Optimizer …
Effect Of Sex On The Accumulation Of Hepatic Mercury In Mallards Wintering In Louisiana, Latorya E. Mason
Effect Of Sex On The Accumulation Of Hepatic Mercury In Mallards Wintering In Louisiana, Latorya E. Mason
Master's Theses
The increase in mercury production through anthropogenic activities has led to a global crisis of mercury pollution that poses a significant threat to the health of both humans and wildlife. Aquatic ecosystems are especially at risk due to the creation of methylmercury, a toxic form of mercury, by sulfate-reducing bacteria in anoxic sediments and soils. Methylmercury enters the food chain where it bioaccumulates in individual organisms and then biomagnified with increasing trophic level. Aquatic birds are useful bioindicators of many pollutants, including mercury, due to their abundance and position in the food chain. Previous studies have primarily focused on mercury …
Chronic High-Salt Diet Activates Tumor-Initiating Stem Cells Leading To Breast Cancer Proliferation, Lisa Tucker, Umer Ali, Deborah A. Lannigan, Jeffrey C. Rathmell, Venkataswarup Tiriveedhi
Chronic High-Salt Diet Activates Tumor-Initiating Stem Cells Leading To Breast Cancer Proliferation, Lisa Tucker, Umer Ali, Deborah A. Lannigan, Jeffrey C. Rathmell, Venkataswarup Tiriveedhi
Biology Faculty Research
Several chronic inflammatory diseases have been linked to high-salt (HS) diets. Chronic inflammation is an established causative hallmark of cancer. However, a direct role of HS diets in tumorigenesis is yet to be defined. Previous orthotopic murine breast tumor studies have shown that short-term HS diets caused inhibition of tumor growth through the activation of cytotoxic adaptive immune responses. However, there have been experimental challenges in developing a viable chronic HS-diet-based murine tumor model. To address this, we have developed a novel chronic HS diet tumor model through the sequential passaging of tumor cells in mice under HS dietary conditions. …
Post-Stocking Predation And Dispersal Of Stocked Juvenile Chinook Salmon (Oncorhynchus Tshawytscha) In Lake Oahe, South Dakota, Dylan Alan Jon Gravenhof
Post-Stocking Predation And Dispersal Of Stocked Juvenile Chinook Salmon (Oncorhynchus Tshawytscha) In Lake Oahe, South Dakota, Dylan Alan Jon Gravenhof
Biology Theses, Dissertations, and Student Creative Activity
Acoustic telemetry is a tool commonly used to better understand the fates of fish following a stocking event. Until recently, predation on stocked fish could only be inferred by observing and identifying abrupt changes in tag detection histories. Recently, a novel predation transmitter has provided better insight into how predation affects post-stocking survival. The main objectives of this study were to use these transmitters to 1) estimate predation rates on stocked juvenile Chinook Salmon in a landlocked system (Lake Oahe, South Dakota) and 2) estimate dispersal rates and residency times of the Chinook Salmon after stocking. Additionally, our secondary objectives …
Assessing The Influences Of Stocking And Introduced Alewife On Walleye Recruitment In Lake Mcconaughy, Nebraska, Logan Zebro
Assessing The Influences Of Stocking And Introduced Alewife On Walleye Recruitment In Lake Mcconaughy, Nebraska, Logan Zebro
Biology Theses, Dissertations, and Student Creative Activity
Lake McConaughy is an important socioeconomic reservoir in Nebraska and Walleye is the priority management species. Walleye have been stocked annually since 1989 to support the Walleye population, however, adult Walleye relative abundance has steadily declined since the early 1990s. Additionally, in 1986, Alewives were introduced to improve the growth and body condition of adult Walleye, which subsequently increased the population size structure. However, Alewives can have negative influences on the recruitment of other fish species through predation and competition. Although Alewives have been in this reservoir for nearly 40 years, there have been no evaluations on the influence of …
Diversity Of Cellular Slime Molds (Dictyostelids) In The Fanjing Mountain Nature Reserve And Geographical Distribution Comparisons With Other Representative Nature Reserves In Different Climate Zones Of China, Zhaojuan Zhang, Meng Li, Shufei Zhiang, Yue Qin, Jing Zhao, Yu Li, Steven L. Stephenson, Junzhi Qiu, Pu Liu
Diversity Of Cellular Slime Molds (Dictyostelids) In The Fanjing Mountain Nature Reserve And Geographical Distribution Comparisons With Other Representative Nature Reserves In Different Climate Zones Of China, Zhaojuan Zhang, Meng Li, Shufei Zhiang, Yue Qin, Jing Zhao, Yu Li, Steven L. Stephenson, Junzhi Qiu, Pu Liu
Biological Sciences Faculty Publications and Presentations
Protected areas are widely considered an essential strategy for biodiversity conservation. Dictyostelids are unique protists known to have important ecological functions in promoting soil and plant health through their top-down regulation of ecosystem processes, such as decomposition, that involve bacterial populations. But the relationship between dictyostelid diversity within protected areas remains poorly understood, especially on a large scale. Herein, we report data on the distribution of dictyostelids, identified with ITS + SSU rRNA molecular and morphology-based taxonomy, from soil samples collected in the Fanjing Mountain protected area of Guizhou Province, Southwest China. We compared the biodiversity data of dictyostelids in …
Evolution Repeats Itself In Replicate Long-Term Studies In The Wild, Patrik Nosil, Clarissa F. De Carvalho, Romain Villoutreix, Laura S. Zamorano, Marion Sinclair-Waters, Nicholas P. Planidin, Thomas L. Parchman, Jeffrey Feder, Zach Gompert
Evolution Repeats Itself In Replicate Long-Term Studies In The Wild, Patrik Nosil, Clarissa F. De Carvalho, Romain Villoutreix, Laura S. Zamorano, Marion Sinclair-Waters, Nicholas P. Planidin, Thomas L. Parchman, Jeffrey Feder, Zach Gompert
Biology Faculty Publications
The extent to which evolution is repeatable remains debated. Here, we study changes over time in the frequency of cryptic color-pattern morphs in 10 replicate long-term field studies of a stick insect, each spanning at least a decade (across 30 years of total data). We find predictable “up-and-down” fluctuations in stripe frequency in all populations, representing repeatable evolutionary dynamics based on standing genetic variation. A field experiment demonstrates that these fluctuations involve negative frequency-dependent natural selection (NFDS). These fluctuations rely on demographic and selective variability that pushes populations away from equilibrium, such that they can reliably move back toward it …
The Stability Of Epigenetic Variants That Can Act As Loci Causing Phenotypic Change, Raul Faburrieta
The Stability Of Epigenetic Variants That Can Act As Loci Causing Phenotypic Change, Raul Faburrieta
Biology Theses
Epigenetic variations are a possible source of heritable phenotypic variation. In this study I focus on phenotypic alterations seen in epigenetic Recombinant Inbred Lines (epiRILs) of Arabidopsis thaliana. These epiRILs allow me to study the effects differentially methylated regions (DMRs) have on phenotypic variance. In a study performed in 2014 by Cortijo et al., they found that DMR’s affect flowering time and root length when grown under greenhouse conditions. In this study, I replicated the Cortijo et al. (2014) study, with some changes, to see whether the same significant eQTL regions are found. I found that, some of the eQTLs …
Sex Differences In Innate Immune Response Following Peanut Exposure, Sunanda Rajput
Sex Differences In Innate Immune Response Following Peanut Exposure, Sunanda Rajput
Biology Theses, Dissertations, and Student Creative Activity
Knowledge of the immunological mechanisms involved in the development of peanut (PN) allergy remains unclear. Analysis of US adults showed that females were twice as likely to develop PN allergy during childhood, indicating sex hormones may regulate PN allergic responses. This study aims to understand the role of sex hormones in the response of mast cells (MCs) and Type 2 innate lymphoid cells (ILC2s) to PN. Previously, androgen receptor-deficient (ARTfm) mice showed higher levels of PN-specific antibody and worse anaphylactic response to PN than wild type (WT) males. WT males also displayed less severe anaphylactic response compared to ARTfm and …
Synthetic Biology Enablement: From Academic Development To Industrial Transformation, Yan Xiong, Xueqing Ma, Daming Chen, Xiao Liu, Guoping Zhao
Synthetic Biology Enablement: From Academic Development To Industrial Transformation, Yan Xiong, Xueqing Ma, Daming Chen, Xiao Liu, Guoping Zhao
Bulletin of Chinese Academy of Sciences (Chinese Version)
Synthetic biology revolutionizes the comprehension of life systems from an engineering perspective, employing a “bottomup” approach in life science research. It adopts an iterative research paradigm of “design-build-test-learn” in life science research and creates engineered new life systems grounded in genomics and systems biology. This provides a new pathway of “from creation to understanding” for life sciences, departing from the traditional reductionist research strategy of “study the whole to understand the parts” and opening up a new culture of “building to understand” the essence of life. Additionally, synthetic biology elevates existing biotechnologies previously based on “simulating natural processes” and “genetic …
Analysing An Imbalanced Stroke Prediction Dataset Using Machine Learning Techniques, Viswapriya Subramaniyam Elangovan, Rajeswari Devarajan, Osamah I. Khalaf, Mhd Saeed Sharif, Wael Elmedany
Analysing An Imbalanced Stroke Prediction Dataset Using Machine Learning Techniques, Viswapriya Subramaniyam Elangovan, Rajeswari Devarajan, Osamah I. Khalaf, Mhd Saeed Sharif, Wael Elmedany
Karbala International Journal of Modern Science
A stroke is a medical condition characterized by the rupture of blood vessels within the brain which can lead to brain damage. various symptoms may be exhibited when the brain's supply of blood and essential nutrients is disrupted. To forecast the possibility of brain stroke occurring at an early stage using Machine Learning and Deep Learning is the main objective of this study. Timely detection of the various warning signs of a stroke can significantly reduce its severity. This paper performed a comprehensive analysis of features to enhance stroke prediction effectiveness. A reliable dataset for stroke prediction is taken from …
Potential Enhancement Of Microbial Disinfection Using Oxygen Enriched Cold Atmospheric-Pressure Argon (Ar/O2) Plasma Jet, Waleed O. Younis, Mahmoud M. Berekaa, Mostafa A. Ellbban, Abdel-Sattar S. Gadallah, Jamal Q. Almarashi, Abdel-Aleam H. Mohamed
Potential Enhancement Of Microbial Disinfection Using Oxygen Enriched Cold Atmospheric-Pressure Argon (Ar/O2) Plasma Jet, Waleed O. Younis, Mahmoud M. Berekaa, Mostafa A. Ellbban, Abdel-Sattar S. Gadallah, Jamal Q. Almarashi, Abdel-Aleam H. Mohamed
Karbala International Journal of Modern Science
Oxygen activated cold-atmospheric-pressure-argon plasma jet (APPJ) has gained prominence over the regular argon plasma especially in disinfection and decontamination. As an objective of the current research, an oxygen-enriched argon system was built, where plasma produced through a vessel metallic tube that is introduced into alumina one. A sinusoidal high voltage signal of 25 kHz was used to generate plasma jet. Potential impact of oxygen enriched APP jet (Ar/O2) in decontamination of different microbial cells was observed. For examination, suspension of each tested microbe was placed in contact with plasma jet nearly 10 mm away from the jet nozzle …
A Potential Of Watercress Nasturtium Officinale Bioactive Compounds In Inhibiting Infectious Myonecrosis Virus (Imnv) By Targeting Rna-Dependent Rna Polymerase (Rdrp) Virus From Several Countries: In Silico Approach, Qurrota A’Yunin, Fatchiyah Fatchiyah, Maftuch Maftuch, Feri Eko Hermanto, Muhammad Hermawan Widyananda, Narendra Santika Hartana, Muhaimin Rifa’I, Yoga Dwi Jatmiko
A Potential Of Watercress Nasturtium Officinale Bioactive Compounds In Inhibiting Infectious Myonecrosis Virus (Imnv) By Targeting Rna-Dependent Rna Polymerase (Rdrp) Virus From Several Countries: In Silico Approach, Qurrota A’Yunin, Fatchiyah Fatchiyah, Maftuch Maftuch, Feri Eko Hermanto, Muhammad Hermawan Widyananda, Narendra Santika Hartana, Muhaimin Rifa’I, Yoga Dwi Jatmiko
Karbala International Journal of Modern Science
Infectious myonecrosis virus (IMNV) disease causes mass mortality and decreased shrimp production. The RdRp region projects to the interior, where it may function in transcription. The focus of this study was to determine the effect of amino acid polymorphisms from several countries on the structure of RdRp and identify the potential of watercress in inhibiting IMNV by targeting the RdRp protein of IMNV through an in silico approach. The results showed that the structure of the IMNV RdRp protein from Indonesia was similar to Mexico, and the protein structure from India_QDN was identical to India_QIL. Ligand binding affinity values showed …
Extraction Of Morphometric Features The Shape Of Mangrove Leaves Based On Digital Images And Classification Using The Support Vector Machine, Ishak Ariawan, Della Ayu Lestari, Luthfi Anzani, Tri Yanti, Cakra Rahardjo, M. Saleh, Sahril Angga Permana, Dea Aisyah Rusmawati
Extraction Of Morphometric Features The Shape Of Mangrove Leaves Based On Digital Images And Classification Using The Support Vector Machine, Ishak Ariawan, Della Ayu Lestari, Luthfi Anzani, Tri Yanti, Cakra Rahardjo, M. Saleh, Sahril Angga Permana, Dea Aisyah Rusmawati
Karbala International Journal of Modern Science
At present, several botanists still rely on the use of manual estimating methods to assess the carbon content in mangrove. However, these methods have been reported to be extremely time-consuming, showing the need to develop a system for prediction. An effective solution lies in the creation of an artificial intelligence application, which can provide rapid and cost-effective results. In constructing this application, careful consideration must be given to the selection of parameters or attributes. Species is an essential parameter for the assessment of carbon content, but its determination has proven to be challenging due to the similarities of mangrove. The …
On The Importance Of Sequence Alignment Inspections In Plastid Phylogenomics – An Example From Revisiting The Relationships Of The Water-Lilies, Jessica A. Roestel, John H. Wiersema, Robert K. Jansen, Thomas Borsch, Michael Gruenstaeudl
On The Importance Of Sequence Alignment Inspections In Plastid Phylogenomics – An Example From Revisiting The Relationships Of The Water-Lilies, Jessica A. Roestel, John H. Wiersema, Robert K. Jansen, Thomas Borsch, Michael Gruenstaeudl
Biological Sciences Faculty Publications
The water-lily clade represents the second earliest-diverging branch of angiosperms. Most of its species belong to Nymphaeaceae, of which the “core Nymphaeaceae”—comprising the genera Euryale, Nymphaea and Victoria—is the most diverse clade. Despite previous molecular phylogenetic studies on the core Nymphaeaceae, various aspects of their evolutionary relationships have remained unresolved. The length-variable introns and intergenic spacers are known to contain most of the sequence variability within the water-lily plastomes. Despite the challenges with multiple sequence alignment, any new molecular phylogenetic investigation on the core Nymphaeaceae should focus on these noncoding plastome regions. For example, a new plastid phylogenomic study on …
Downregulation Of Dax-1 Expression Via Mirna Overexpression As A Mechanism To Potentiate Breast Cancer, Nicholas C. Devito
Downregulation Of Dax-1 Expression Via Mirna Overexpression As A Mechanism To Potentiate Breast Cancer, Nicholas C. Devito
Master's Theses
The orphan nuclear receptor DAX-1 (Dosage Sensitive Sex Reversal, Adrenal Hypoplasia Congenita, critical region on the X chromosome, gene 1) plays a key role in mammalian sex determination and steroidogenesis. In addition to these canonical examples, DAX-1 has been shown to play a contradictory role in cancer development. While DAX-1 is overexpressed in lung and prostate cancer, it is downregulated in breast cancer. One of the explanations for the paradoxical role of DAX-1 in cancer development could be microRNA (miRNA) dysregulation. After broadly surveying over 96 miRNAs historically upregulated in MCF7 breast cancer cells, we compared the expression of DAX-1 …
Impact Of Toll-Like Receptor 10 Mutations On Tuberculosis Infections, Adriana Nicole Rafael, Sangman Kim
Impact Of Toll-Like Receptor 10 Mutations On Tuberculosis Infections, Adriana Nicole Rafael, Sangman Kim
Master's Theses
Tuberculosis (TB), caused by the intracellular pathogen Mycobacterium tuberculosis (M. tb), is a leading global health crisis causing millions of cases and deaths each year. Though it affects individuals of any race, ethnicity, or cultural group, research shows the disease disproportionately affects individuals with Asian ancestry. Immunity to M. tb starts with its recognition by pattern recognition receptors such as Toll-like receptors (TLRs), which are key players in immune responses. TLR-10, an understudied toll-like receptor due to its inability to be studied through mouse models, is thought to play a key role in the clearance of inflammatory diseases. SNP I775V, …
Towards A New Role Of Mitochondrial Hydrogen Peroxide In Synaptic Function, Cliyahnelle Z. Alexander
Towards A New Role Of Mitochondrial Hydrogen Peroxide In Synaptic Function, Cliyahnelle Z. Alexander
Student Theses and Dissertations
Aerobic metabolism is known to generate damaging ROS, particularly hydrogen peroxide. Reactive oxygen species (ROS) are highly reactive molecules containing oxygen that have the potential to cause damage to cells and tissues in the body. ROS are highly reactive atoms or molecules that rapidly interact with other molecules within a cell. Intracellular accumulation can result in oxidative damage, dysfunction, and cell death. Due to the limitations of H2O2 (hydrogen peroxide) detectors, other impacts of ROS exposure may have been missed. HyPer7, a genetically encoded sensor, measures hydrogen peroxide emissions precisely and sensitively, even at sublethal levels, during …
Optogenetic Induction Of Mitochondrial Oxidative Stress As A Potential Model To Study Non-Hereditary Als, Samia Alam
Optogenetic Induction Of Mitochondrial Oxidative Stress As A Potential Model To Study Non-Hereditary Als, Samia Alam
Student Theses and Dissertations
Mitochondrial dysfunction is a common denominator of neurodegenerative diseases, including hereditary and non-hereditary Amyotrophic Lateral Sclerosis (ALS). Ten percent of ALS cases are hereditary while a majority are sporadic, with no known hereditary link. For effective therapeutic approaches to be developed, there is a need for development of a sporadic animal model to better understand disease mechanism. In previous work, our laboratory developed an animal model (known as mitokiller flies) to study sporadic cases of ALS. The work reported in this honors thesis focuses on the use of optogenetics and electrophysiology recording to study the formation of excessive hydrogen peroxide …
Astrocyte Spatial Distribution Affects Growth Dynamics Of Breast Cancer Brain Metastases: An Agent-Based Modeling Study, Rupleen Kaur
Astrocyte Spatial Distribution Affects Growth Dynamics Of Breast Cancer Brain Metastases: An Agent-Based Modeling Study, Rupleen Kaur
Biology and Medicine Through Mathematics Conference
No abstract provided.
Tracking Food Quality In Algae-Daphnia Ecosystems Through Stage Structured Models And Colimitation, Tomas Ascoli
Tracking Food Quality In Algae-Daphnia Ecosystems Through Stage Structured Models And Colimitation, Tomas Ascoli
Biology and Medicine Through Mathematics Conference
No abstract provided.
Multiscale Modeling Of Microtubule Polarity Mechanisms Following Neuronal Axotomy, Hannah Scanlon
Multiscale Modeling Of Microtubule Polarity Mechanisms Following Neuronal Axotomy, Hannah Scanlon
Biology and Medicine Through Mathematics Conference
No abstract provided.
Increasing Bacterial Tolerance And Metabolism Of The Biofuel, N-Butanol Using Community-Level Evolution And Functional Genomics, Kayley T. You Mak
Increasing Bacterial Tolerance And Metabolism Of The Biofuel, N-Butanol Using Community-Level Evolution And Functional Genomics, Kayley T. You Mak
Biology ETDs
Bioremediation capability should be developed along with biofuel technology to mitigate the potential damage of future spills. Biobutanol is being developed since n-butanol is more energy dense and less volatile than ethanol. A bottleneck for industrial production of biobutanol is its toxicity; most microbes cannot survive ~1.5% v/v. Thus, microbial bioremediation of n-butanol would need microbes that can both tolerate and metabolize butanol. We used ecological and evolutionary biology approaches to find bacteria that could tolerate and metabolize butanol. Ecological community-level assays followed by 16S amplicon sequencing were completed to identify butanol-tolerant artificial bacterial communities. Secondly, we looked for bacteria …
Maturation Of An Off-Channel Habitat Concept To Conserve Native Fishes In The Lower Colorado River, Paul C. Marsh, Thomas E. Dowling, Thomas F. Turner, Megan J. Osborne, Brian R. Kesner
Maturation Of An Off-Channel Habitat Concept To Conserve Native Fishes In The Lower Colorado River, Paul C. Marsh, Thomas E. Dowling, Thomas F. Turner, Megan J. Osborne, Brian R. Kesner
Monographs of the Western North American Naturalist
Two endemic, “large river” fishes of the Colorado River basin of western North America, bonytail Gila elegans and razorback sucker Xyrauchen texanus, are among several critically endangered species in the system. Wild populations of bonytail are gone, and there are no self-sustaining populations of razorback sucker anywhere; reproduction occurs but recruitment does not. Both species have been under intensive management in the Lower Colorado River since the 1980s. Today, with the single exception of Lake Mead, remaining populations are composed entirely of repatriated individuals that depend on stocking for their continued existence. In 2003, a conceptual off-channel habitat (OCH) …