Biology Commons^™

How Medical Students Address Mental Health During Standardized Patient Interactions, Bhoomi S. Shah, Laura Weingartner, Emily J. Noonan

The Cardinal Edge

How Medical Students Address Mental Health during Standardized Patient Interactions

Bhoomi Shah B.S. Candidate; Emily J Noonan, PhD, MA; Laura A. Weingartner, PhD, MS

BACKGROUND:

As mental health needs are increasingly recognized around the world, it has become an increasingly important topic within medical education to ensure that medical professionals are well-prepared to address these concerns and provide adequate mental health care to patients. Our research examines the language that medical students used to assess and address mental health concerns during clinical skills training.

METHODS:

We observed standardized patient interactions with 85 medical students from the University of Louisville School …

The Effect Of Prenatal Vape Exposure On Liver Gene Expression In Weanling Mice, Mindy Yin, Selma Podbicanin, Bella Fieger, Nina Pauig, Katelyn Chism, Lucas Georges, Isaiah Burciaga, Cynthia Corbitt, Rachel Neal

The Cardinal Edge

The use of E-cigarettes is a fairly recent phenomenon. Vaping is thought of as the “healthier” alternative to smoking cigarettes, yet we know little about the developmental toxicity of commercially available vaping products. The Barker Hypothesis (or the Developmental Basis of Adult Disease Hypothesis) proposes that developmental nutrient restriction or toxicant exposure increases the risk of diseases later in life such as cardiovascular disease, fatty liver, and metabolic diseases. In this study, adult female C57Bl/6 mice were exposed to Vuse™ Alto Golden Tobacco pods (5% nicotine) 4 days before mating and throughout gestation (GD19) for 1 hour/day each day. Offspring …

The Role Of Adhd As A Risk Factor In Alzheimer's Disease, Evelyn Fulmer

The Cardinal Edge

In recent years, the prevalence of attention-deficit/hyperactivity disorder (ADHD) and Alzheimer’s disease (AD) has increased significantly. While these disorders initially seem unrelated, ADHD and AD pose similarities that indicate a more involved relationship between them. To understand this relationship, this review delves into the current research proposing ADHD as a potential risk factor in the development of Alzheimer's disease, examining genetic predispositions, shared risk factors, and affected mechanistic pathways that influence the aging process.

A Hopeful Overview On Aging, Rafael Demarco

The Cardinal Edge

N/A

Sdf-1Α Mediates Primary Tumor Escape In Glioblastoma Through Activation Of Mesenchymal Transitions, Charles T. Froman-Glover

The Cardinal Edge

Glioblastoma (GBM), a highly aggressive primary brain tumor originating in glial cells, poses a significant challenge due to its rapid growth and invasive nature within healthy brain tissue.

Current treatments involve surgical resection, chemotherapy, and radiation. These treatments alone are not enough to cure this disease, and a better understanding of the mechanics of the tumor's micro-environment is imperative to furthering the field of cancer research. This research focuses on understanding the tumor microenvironment's impact, specifically investigating the role of stromal cell-derived factor 1 (SDF-1) mechanics on GBM aggressiveness. SDF-1 is known to facilitate disease progression by facilitating chemotaxis toward …

Largemouth Bass Neurocranium, Owen Duerbeck, Ian Thelwell, Oliva Weeks

All Scans: Kerstetter Fisheries and Avian Ecology 3D Scan Series

No abstract provided.

Black Grouper Neurocranium, Angelina Trapani-Banyra, Victoria Bruno, Mason Schleicher

All Scans: Kerstetter Fisheries and Avian Ecology 3D Scan Series

No abstract provided.

Tissue Proteomics Of Feline Mammary Carcinoma: Identification Of Potential Biomarkers Based On Metastatic Status And Histopathological Characteristics, Weejarin Paphussaro, Sittiruk Roytrakul, Narumon Phaonakrop, Sawanya Charoenlappanit, Anudep Rungsipipat, Theerawat Tharasanit, Gunnaporn Suriyaphol Assoc. Prof.

The Thai Journal of Veterinary Medicine

Feline mammary carcinoma (FMC) is a prevalent and aggressive cancer with high metastatic potential. Few tissue biomarkers have been reported to help evaluate disease progression in FMC. This study aimed to analyze the tissue proteomic profiles of metastatic feline mammary carcinoma (mFMC) and non-metastatic FMC (NmFMC) across various histological grades (HGs) and histological types (HTs) using liquid chromatography-tandem mass spectrometry (LC-MS/MS). Tissue samples were collected from 13 NmFMC, 26 mFMC and 13 healthy controls (CTRL). Samples were trypsinized and subjected to LC-MS/MS. Proteome results were analyzed based on the metastatic status, HGs and HTs of the samples. The findings revealed …

Phagolysosomes Break Down The Membrane Of A Non-Apoptotic Corpse Independent Of Macroautophagy, Shruti Kolli, Cassidy J. Kline, Kimya M. Rad, Ann M. Wehman

Biological Sciences: Faculty Scholarship

Cell corpses must be cleared in an efficient manner to maintain tissue homeostasis and regulate immune responses. Ubiquitin-like Atg8/LC3 family proteins promote the degradation of membranes and internal cargo during both macroautophagy and corpse clearance, raising the question how macroautophagy contributes to corpse clearance. Studying the clearance of non-apoptotic dying polar bodies in Caenorhabditis elegans embryos, we show that the LC3 ortholog LGG-2 is enriched inside the polar body phagolysosome independent of autophagosome formation. We demonstrate that ATG-16.1 and ATG-16.2, which promote membrane association of lipidated Atg8/LC3 proteins, redundantly promote polar body membrane breakdown in phagolysosomes independent of their role …

Dog Sniffing Biomechanic Responses In An Odor Detection Test Of Odorants With Differing Physical Properties, Lydia Burnett, Nicholas Hebdon, Pete A. Stevens, Monica Moljo, Lindsay D. Waldrop, Lauryn Degreeff

Biology, Chemistry, and Environmental Sciences Faculty Articles and Research

Dogs are utilized in forensic science for their extensive scent detection capabilities. They are often considered the “gold standard” in field detection for targets such as illicit drugs and explosives. Despite their prevalence in the field, relatively little is known about how dogs interact with and transport volatile organic compounds through their olfactory system. In this study, two groups of dogs were utilized – Sport detection dogs (n=19) that participate in the National Association of Canine Scent Work and have achieved advanced standing through training and successful search competitions and law enforcement explosive detection dogs (n=8) which were included for …

Exploring Pcat3 Expression In Arthritis: Proinflammatory Marker Patterns And P53 Involvement, Aida H. Alobaidi, Entkhab M. A. Alanisi, Khalid A. Alyodawi

AUIQ Complementary Biological System

This study investigated the role of long non-coding RNA (lncRNA) PCAT3 in arthritis, focusing on its impact on proinflammatory markers. Researchers analyzed both mRNA and protein levels of various proinflammatory markers (TNF-α, IL-1β, IL-4, IL-6, IL-8, IL-10, and IL-13) in arthritis patients and compared them to healthy controls. Additionally, PCAT3 expression was assessed in both patient groups and further investigated using siRNA knockdown in the human synovial cell line SW982. Results revealed distinct expression patterns of proinflammatory markers in arthritis patients, with TNF-α and IL-6 showing the highest levels. PCAT3 expression was significantly elevated in arthritis patients compared to controls. …

Snakehead Neurocranium, Alexis K. Crass, Megan E. Martiello, Matthew D. Gassmann, David Kerstetter

All Scans: Kerstetter Fisheries and Avian Ecology 3D Scan Series

No abstract provided.

Structural Stability Comparisons Between Natural And Engineered Group Ii Chaperonins: Are Crenarchaeal “Heat Shock” Proteins Also “Ph Shock” Resistant?, Mercede Furr, Shadi A. Badiee, Sreenivasulu Basha, Shilpi Agarwal, Zeina Ismael Ibrahem Alraawi, Sobroney Heng, Carson L. Stacy, Yeasin Ahmed, Mahmoud Moradi, Thallapuranam Krishnaswamy Suresh Kumar, Ruben Michael Ceballos

Biological Sciences Faculty Publications and Presentations

Archaeal group II chaperonins, also known as heat shock proteins (HSPs), are abundantly expressed in Sulfolobales. HSPα and HSPβ gene expression is upregulated during thermal shock. HSPs form large 18-mer complexes that assist in folding nascent proteins and protecting resident proteins during thermal stress. Engineered HSPs have been designed for industrial applications. Since temperature flux in the geothermal habitats of Sulfolobales impacts intracellular temperature, it follows that HSPs have developed thermotolerance. However, despite the low pH (i.e., pH < 4) typical for these habitats, intracellular pH in Sulfolobales is maintained at ~6.5. Therefore, it is not presumed that HSPs have evolved acid-tolerance. To test tolerance to low pH, HSPs were studied at various pH and temperature values. Both circular dichroism and intrinsic fluorescence indicate that HSPα and HSPβ retain structural integrity at neutral pH over a wide range of temperatures. Structural integrity is compromised for all HSPs at ultra-low pH (e.g., pH 2). Secondary structures in HSPs are resilient under mildly acidic conditions (pH 4) but Anilino naphthalene 8-sulfonate binding shows shifts in tertiary structure at lower pH. Trypsin digestion shows that the HSPβ-coh backbone is the most flexible and HSPβ is the most resilient. Overall, results suggest that HSPα and HSPβ exhibit greater thermostability than HSPβ-coh and that there are limits to HSP acid-tolerance. Molecular dynamics (MD) simulations complement the wet lab data. Specifically, MD suggests that the HSPβ secondary structure is the most stable. Also, despite similarities in pH- and temperature-dependent behavior, there are clear differences in how each HSP subtype is perturbed.

Place, Space, And Shifting Views Of Nature, Rachel Tracey

Runkle Woods Symposia

In her reflective presentation, Rachel Tracy explores her evolving relationship with nature and wilderness. Initially disinterested and uncomfortable in natural settings, she describes how her perspective shifted through class discussions, personal reflection, and immersive experiences in the outdoors. Concepts such as “space versus place” helped her understand the emotional and historical significance of natural environments. Through this journey, she discovered joy in simply being present in nature, ultimately gaining a deeper appreciation for the natural world and its ability to exist and thrive without human involvement.

Culture, Nature, And Reflection: The Settler’S Impact On Life Today, Erin Thomas

Runkle Woods Symposia

Erin Thomas, a senior English major at Wright State University, reflects on the intersection of wilderness, identity, and cultural erasure. Drawing from her Indigenous heritage and experiences in the course Woods and Wilderness, she critiques the romanticized, Eurocentric view of nature as untouched and separate from humanity. Instead, Thomas highlights how wilderness has been shaped by settler colonialism and exclusionary narratives that often ignore Indigenous presence and histories. Her presentation calls for a more inclusive and honest understanding of wilderness—one that honors marginalized voices and acknowledges the land’s complex cultural past.

Wilderness Myth And Reality: Human Views And Uses Of Nature, Evan Hardern

Runkle Woods Symposia

In his essay and presentation, Wright State English major Evan Harder critically examines modern conceptions of wilderness and challenges the Romantic ideal that moral purity and personal virtue are inherently tied to time spent in nature. Drawing on writers such as Wordsworth, Emerson, and Thoreau, Harder interrogates the cultural myth of wilderness as a pristine, untouched realm separate from civilization. He argues that our understanding of nature is a constructed concept—born from the development of cities and agriculture—and often overlooks the long histories of human habitation in places now designated as “natural” or “wild.” Through examples like Cuyahoga Valley National …

The Concept Of Wilderness In Western Culture And Its Sacredness, Shannon Doyal

Runkle Woods Symposia

Shannon Doyal, a Professional Writing student at Wright State, explores how wilderness has been perceived throughout American history—as both a physical space and a powerful spiritual symbol. Drawing from Indigenous perspectives, early settler narratives, Transcendentalist writings, and American literature, she traces the evolving cultural and emotional significance of wilderness. From a place of fear and survival to one of introspection and sacred connection, wilderness reflects our changing relationship with nature and ourselves. As someone whose spirituality honors the cycles of nature, Doyal argues that reclaiming wilderness as a sacred and emotional space is vital—not only for environmental preservation but also …

Endangered Bats In The Runkle Woods, Volker Bahn

Runkle Woods Symposia

Since 2019, Dr. Volker Bahn’s lab has been monitoring bat populations in the Runkle Woods and nearby sites, using acoustic detectors to track species presence and activity over time. With bats representing about 20% of all mammal species globally, their ecological role—particularly in insect control—is vital. The presentation highlights the diversity of local bat species, with 10 of Ohio's 11 expected species documented, ranging from the abundant big brown and red bats to the federally endangered Indiana and northern long-eared bats. Dr. Bahn discusses patterns in bat activity across years, potential drivers such as precipitation, and the concerning declines in …

Water Quality Management In The Runkle Woods, Krystal Demarco, Donavon Mishler-Laporte, Cassie Dunn, Parneet Dhillon, Reagan Hardyman

Runkle Woods Symposia

This project addresses the growing issue of salt pollution in Wright State Woods, with a specific focus on sodium chloride runoff from deicing agents. Elevated salt levels, stemming from university parking lots and surrounding infrastructure, have been linked to soil degradation, vegetation stress, and aquatic habitat damage. By analyzing salt flow patterns and assessing ecological impacts, including EPA-reported chloride violations, the team identified critical areas of concern such as Outfall #2. Proposed mitigation strategies include the use of salt-tolerant tree species, alternative deicers (e.g., acetate- or carbohydrate-based), physical barriers, and expanded retention ponds and filter dams.

Invertebrates As Indicators Of Water Quality In The Runkle Woods, Dillynn Blevins, Bhavishya Ratnavelu, Lauren Stetz, Corey Walls

Runkle Woods Symposia

This project investigates water quality and aquatic invertebrate habitat health in the Wright State Woods, aiming to assess current conditions and implement targeted conservation strategies. Using indicators such as dissolved oxygen, nutrient concentrations, and the presence of sensitive macroinvertebrates (e.g., mayflies, stoneflies, caddisflies), the team evaluates stream health. Data collection follows established protocols, including EPT indexing and seasonal surveys. Conservation recommendations include stream aeration maintenance, removal of non-native vegetation, soil inoculation, and the construction of rain gardens and green roofs to reduce runoff.

An Accessible Trail For The Runkle Woods, Sarah Bingham, Terri Dozier, Logan Huber, Nicole Owino, Nathan Shafer

Runkle Woods Symposia

This presentation outlines a student-led initiative to enhance a pre-existing trail in the Runkle Woods with educational conservation projects and signage. The project aims to increase accessibility and student engagement with Wright State’s natural areas. Three key conservation efforts are highlighted along the trail: prairie restoration to support native biodiversity and pollinators, erosion and runoff mitigation using native vegetation and riff-raff, and bat conservation through habitat preservation and installation of artificial roosts. The project emphasizes experiential learning, sustainability, and community involvement in environmental stewardship.

Management Of The Invasive Honeysuckle (Lonicera Maackii), Mesa Grine, Daniel Hazelett, Cassie Healy, Padma Deepika Kandregula

Runkle Woods Symposia

This presentation addresses the ecological threat posed by invasive honeysuckle in the Runkle Woods on Wright State's campus. Originally from Europe and Asia, honeysuckle aggressively outcompetes native flora due to its rapid growth, shade tolerance, and allelopathic properties. The students observed widespread honeysuckle in both new and old growth forest areas, with greater density in younger regions. Ineffective control methods—such as cutting without herbicide—often worsen infestations. Drawing on a regional study, the students propose a targeted management plan involving cutting and herbicide application, stem injection for larger plants, and reintroducing native species like spicebush. Their strategy aims to reduce honeysuckle …

Old Growth In The Runkle Woods, Madeline Greene, Lindsay Smith, Matt Tyren, Leif Walters

Runkle Woods Symposia

In this conservation proposal, Wright State students focus on protecting the old growth areas of Runkle Woods—a rare and ecologically significant habitat in the Eastern United States, where only about 1% of such forests remain. Home to trees over 200 years old and critical species like endangered bats and white oaks, this 100-acre area faces threats from invasive species, deer overpopulation, littering, and urban runoff. Currently, only 15 acres are legally protected. The students propose expanding the easement, involving experts and graduate students in ongoing research and stewardship, and increasing public engagement through educational walks and increased and updated signage. …

Up In Smoke: Indigenous Techniques To Combat Climate Change And Increase Biodiversity, Brad Kerry

Runkle Woods Symposia

Brad Kerry explores how Indigenous land management practices—particularly the use of prescribed fire—can be reintroduced to restore the Runkle Woods to its pre-colonial ecological state. Drawing on archaeological evidence, historical tree surveys, and ecological data, the presentation highlights how periodic, low-intensity fires historically maintained the forest’s biodiversity, promoted fire-adapted species like oak and hickory, and suppressed invasive plants. Kerry advocates for carefully planned, small-scale burns to combat "mesophication"—a shift toward shade-tolerant, fire-averse species—while increasing forest resilience to drought, invasive species, and climate change. The presentation underscores the ecological benefits of fire and outlines practical considerations for reintroducing controlled burns as …

Protecting Glen Helen With A Conservation Easement, Nick Boutis

Runkle Woods Symposia

Part 2 of the "Protecting Glen Helen with a Conservation Easement" presentation. This presentation offers an overview of Glen Helen, a 1,125-acre private nature preserve in Yellow Springs, Ohio, detailing its ecological significance, educational mission, and recent conservation efforts. Nick Boutis describes the preserve’s history, from ancient Indigenous use to its development as a resort and eventual donation to Antioch College. The focus centers on the complex, multi-year collaboration that led to establishing a permanent conservation easement, which now protects the land from development and subdivision. The presentation also highlights Glen Helen’s ongoing stewardship work, including habitat restoration, environmental education, …

Tecumseh Land Trust: Land Trusts And Land Preservation, Michele Burns

Runkle Woods Symposia

Part 1 of the "Protecting Glen Helen with a Conservation Easement" presentation. Michele Burns introduces the concept of land trusts—nonprofit organizations that protect various types of land, particularly through conservation easements, which are legally binding agreements that restrict development and preserve land forever. She explaines how Tecumseh Land Trust, founded in 1990, operates in southwest Ohio to protect farmland and natural areas without owning land directly and their work in protecting the Glen Helen preservation.

Opening Remarks, Volker Bahn

Runkle Woods Symposia

Dr. Volker Bahn welcomes everyone to the 2024 Runkle Woods Symposium. This year's symposium is held in collaboration with the REACH Native American Heritage Festival. The event began with a land acknowledgement written by Shane Creepingbear in collaboration with Chief Ben Barns and other, recognizing the Indigenouse peoples whose lands we occupy and emphasizing our reponsbility to protect and restore the natrual word.

In Vitro Investigation Of The Potential Therapeutic Implications Of Safranal On Gastric Cancer, Aisha Juma Al Otaibi

Thesis/ Dissertation Defenses

Despite the fact that gastric cancer patients are indispensable to conventional radiation and chemotherapy, the detrimental side effects of those approaches prompt cancer research to seek new integrative treatments. In this respect, safranal (SAF) stands out as a complementary phytotherapeutic drug with exceptional anticancer properties. Concurring studies have shown that SAF is negatively associated with several cancer types, yet its potential therapeutic impact on gastric cancer remains vastly obscure. Thus, this dissertation sought to investigate SAF's prospective tumoricidal ability and its underlying mechanisms of action on gastric cancer in vitro. Herein, the study evaluated the cytotoxicity of SAF on human …

Human Impacts On Mammal Diversity From The Pleistocene To The Present, Carson P. Hedberg

Biology ETDs

Humans have fundamentally altered the planet’s biodiversity. It is critical to characterize these changes, but also to understand how they impact the structure and function of modern ecosystems. This dissertation investigates how anthropogenically mediated species losses and/or introductions influence ecological function and community structure in mammals across multiple temporal and spatial scales. We found that selective loss of large-bodied mammals over the Late Quaternary has led to severe losses in functional diversity in modern ecosystems, suggesting megafaunal mammals contribute distinct ecological functions. These changes to mammal diversity and distribution over millennia have altered both global patterns in functional diversity and …

Clinical Outcomes Of Isoniazid Preventive Therapy Amongst Persons Living With Hiv Attending A Referral Hospital: A Cross-Sectional Study, Mwaka Dick Odong, Wafula Bossa, Muhwezi Loyce, Nangobi Christine Faith, Mbusa Chrispus, Bontu Aschale Abebe, Daniel Chans Mwandah, Silas Ojuka, Tadele Mekuriya Yadesa

AUIQ Complementary Biological System

Tuberculosis (TB) is the most common opportunistic infection amongst persons living with HIV (Human Immunodeficiency Virus) (PLWHIV). World Health Organisation recommends tuberculosis preventive therapy (TPT) to avert the effects of TB/HIV co-infection. This study aimed at determining the incidence of active tuberculosis infection, assessing the burden of adverse drug events (ADEs) and identifying the associated factors. In this study, records of 379 patients who started isoniazid preventive therapy at Mbarara Regional Referral Hospital (MRRH) between 1^st July, 2017 and 30^th June, 2022 were retrospectively reviewed. Data was analyzed using a statistical software (SPSS version 20.0) and presented using …