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Biology News 2024, University Of Northern Iowa. Department Of Biology.

Biology News

Contents:

Letter from the Department Head --- 2
Bolton Award Winner --- 3
Goldwater Scholarship Winner --- 3
Purple and Old Gold Award Winner --- 3
Faculty News Roundup --- 4
New Hires --- 6
UNI Botanical Center --- 7
Alumni Information Request --- 7
Support Our Programs --- 8
Floyd Fellowship Award Winner --- 8

The Effectiveness Of Constructed Treatment Wetland Systems At Removing Microplastic Pollution, Katherine L. Johnsen

Honors Undergraduate Theses

Plastics are a highly utilized material in modem society, leading to environmental concerns surrounding plastic pollution. Microplastics, which are defined as plastic particles less than 5mm in size, have additionally become increasingly recognized as a harmful pollutant in aquatic systems. Constructed treatment wetland systems (CTWSs) are highly effective at removal and mitigation of pollutants, including anthropogenic nutrient inputs. This study aims to understand the potential of a CTWS to remove microplastic pollution from tertiary-treated municipal wastewater before discharge into a local natural water body. Microplastic percent removal was determined through the manual quantification of microplastics in triplicate 500mL surface water …

Transient Interactions Modulate The Affinity Of Nf-Κb Transcription Factors For Dna, Tianjie Li, Shandy Shahabi, Tapan Biswas, Oleg V. Tsodikov, Wenfei Pan, De-Bin Huang, Vivien Ya-Fan Wang, Yi Wang, Gourisankar Ghosh

Biology Faculty Publications

The dimeric nuclear factor kappa B (NF- κB) transcription factors (TFs) regulate gene expression by binding to a variety of κB DNA elements with conserved G:C-rich flanking sequences enclosing a degenerate central region. Toward defining mechanistic principles of affinity regulated by degeneracy, we observed an unusual dependence of the affinity of RelA on the identity of the central base pair, which appears to be noncontacted in the complex crystal structures. The affinity of κB sites with A or T at the central position is ~10- fold higher than with G or C. The crystal structures of neither the complexes nor …

Ai Is A Viable Alternative To High Throughput Screening: A 318-Target Study, Martin St. Maurice

Biological Sciences Faculty Research and Publications

High throughput screening (HTS) is routinely used to identify bioactive small molecules. This requires physical compounds, which limits coverage of accessible chemical space. Computational approaches combined with vast on-demand chemical libraries can access far greater chemical space, provided that the predictive accuracy is sufficient to identify useful molecules. Through the largest and most diverse virtual HTS campaign reported to date, comprising 318 individual projects, we demonstrate that our AtomNet® convolutional neural network successfully finds novel hits across every major therapeutic area and protein class. We address historical limitations of computational screening by demonstrating success for target proteins without known binders, …

Bacillus Subtilis-Derived Peptides Disrupt Quorum Sensing And Biofilm Assembly In Multidrug-Resistant Staphylococcus Aureus, Kyle R. Leistikow, Daniel S. May, Won Se Suh, Gabriel Vargas Asensio, Adam J. Schaenzer, Cameron R. Currie, Krassimira R. Hristova

Biological Sciences Faculty Research and Publications

Multidrug-resistant Staphylococcus aureus is one of the most clinically important pathogens in the world, with infections leading to high rates of morbidity and mortality in both humans and animals. The ability of S. aureus to form biofilms protects cells from antibiotics and promotes the transfer of antibiotic resistance genes; therefore, new strategies aimed at inhibiting biofilm growth are urgently needed. Probiotic species, including Bacillus subtilis, are gaining interest as potential therapies against S. aureus for their ability to reduce S. aureus colonization and virulence. Here, we search for strains and microbially derived compounds with strong antibiofilm activity against multidrug-resistant S. …

Targeting Ocean Conservation Outcomes Through Threat Reduction, Joseph A. Turner, Malcolm Starkey, Nicholas K. Dulvy, Frank Hawkins, Louise Mair, Adeline Serckx, Thomas Brooks, Beth Polidoro, Stuart H. M. Butchart, Kent Carpenter, Minna Epps, Rima W. Jabado, Nicholas B. W. Macfarlane, Leon Bennun

Biological Sciences Faculty Publications

Nations have committed to reductions in the global rate of species extinctions through the Sustainable Development Goals 14 and 15, for ocean and terrestrial species, respectively. Biodiversity loss is worsening despite rapid growth in the number and extent of protected areas, both at sea and on land. Resolving this requires targeting the locations and actions that will deliver positive conservation outcomes for biodiversity. The Species Threat Abatement and Restoration (STAR) metric, developed by a consortium of experts, quantifies the contributions that abating threats and restoring habitats in specific places offer towards reducing extinction risk based on the IUCN Red List …

When And Where Can Coastal Wetland Restoration Increase Carbon Sequestration As A Natural Climate Solution, Scott F. Jones, Ariane Arias-Ortiz, Dennis Baldocchi, Meagan Eagle, Daniel A. Friess, Catrina Gore, Greg Noe, Stefanie Nolte, Patty Oikawa, Adina Paytan, Jacqueline L. Raw, Brian J. Roberts, Kerrylee Rogers, Charles Schutte, Camille L. Stagg, Karen M. Thorne, Eric J. Ward, Lisamarie Windham-Myers, Erik S. Yando

Biological Sciences Faculty Publications

Coastal wetlands are hotspots of carbon sequestration, and their conservation and restoration can help to mitigate climate change. However, there remains uncertainty on when and where coastal wetland restoration can most effectively act as natural climate solutions (NCS). Here, we synthesize current understanding to illustrate the requirements for coastal wetland restoration to benefit climate, and discuss potential paths forward that address key uncertainties impeding implementation. To be effective as NCS, coastal wetland restoration projects will accrue climate cooling benefits that would not occur without management action (additionality), will be implementable (feasibility) and will persist over management-relevant timeframes (permanence). Several issues …

Response Of Helenium Amarum To Environmental Stressors In The Presence Of Mycorrhizal Fungi And Its Role As A Pollinator Resource, Austin Jameson, Lisa Horth

Biological Sciences Faculty Publications

Globally, climate change is causing shifts in precipitation patterns. Shifting precipitation patterns can be a stressor for many species. One species that is experiencing such stress is Helenium amarum Raf (H. Rock). H. amarum, thrives in dry upland pastures and low-lying grassy and sandy habitat in the mid-Atlantic (USA), where it persists despite storm-driven standing water. Helenium amarum is a species that is toxic to livestock and has been found outside its native range. Temperature and light impacts on germination are already known, but the role of water availability and potential ameliorating effects of mycorrhizae during water stress have …

Environmental Implications Of Modern Food Production: An Analysis For The Conscious Consumer, Jessica T. Coming

Cal Poly Humboldt theses and projects

This project explores the pathways by which agriculture affects the environment and determines which foods have the greatest climate, water, and land impacts. Agricultural effects on the environment are extensive, from loss of habitat and declines in regional biodiversity to disruption of global nutrient cycles and climate change. Global food production accounts for 26-34% of annual anthropogenic greenhouse gas emissions, makes up 38-46% of habitable land, and is responsible for 70% of freshwater extraction. The effect of agriculture on the environment is most significantly dictated by what type of food is being produced. Animal-based food products consistently have the highest …

Estimating Steelhead Smolt Abundance From A Mixed Resident/Anadromous Oncorhynchus Mykiss Population, Gabriel Temple

All Master's Theses

Effective management of fish populations in inland waters requires, at the most fundamental level, a basic understanding of population abundance. This is especially important for critically depressed species having high conservation value. Unfortunately, due to their critically depressed abundance, the anadromous form of Oncorhynchus mykiss, known as Steelhead Trout, has high conservation value in the upper Yakima Basin located in central Washington State. However, the resident form of O. mykiss, known as Rainbow Trout, are numerous in the watershed. We used a juvenile tagging study coupled with a long-term population monitoring study to disaggregate this mixed O. mykiss …

Drosophila Parasitoids Go To Space: Unexpected Effects Of Spaceflight On Hosts And Their Parasitoids, Jennifer Chou, Johnny R. Ramroop, Amanda M. Saravia-Butler, Brian Wey, Matthew P. Lera, Medaya L. Torres, Mary Ellen Heavner, Janani Iyer, Siddhita D. Mhatre, Sharmila Bhattacharya, Shubha Govind

Publications and Research

While fruit flies (Drosophila melanogaster) and humans exhibit immune system dysfunction in space, studies examining their immune systems’ interactions with natural parasites in space are lacking. Drosophila parasitoid wasps modify blood cell function to suppress host immunity. In this study, naive and parasitized ground and space flies from a tumor-free control and a blood tumor-bearing mutant strain were examined. Inflammation-related genes were activated in space in both fly strains. Whereas control flies did not develop tumors, tumor burden increased in the space-returned tumor-bearing mutants. Surprisingly, control flies were more sensitive to spaceflight than mutant flies; many of their …

South America Holds The Greatest Diversity Of Native Daisies (Asteraceae) In The World: An Updated Catalogue Supporting Continental-Scale Conservation, Andrés Moreira-Muñoz, Marcelo Monge, Mariana A. Grossi, Fabio Andrés Ávila, Vanezza Morales-Fierro, Gustavo Heiden, Berni Britto, Stephan Beck, Jimi N. Nakajima, Vanina G. Salgado, Juan Facundo Rodríguez-Cravero, Diego G. Gutiérrez

Publications and Research

Asteraceae is the world’s richest plant family and is found on all continents, in environments ranging from the coast to the highest mountains. The family shows all growth forms and, as in other angiosperm families, species richness is concentrated in tropical regions. South America has the highest diversity of Asteraceae in the world, yet taxonomic and distributional knowledge gaps remain. This study compiles an updated catalog of Asteraceae native to South America, based on national and regional checklists and ongoing large-scale flora projects. The resulting checklist includes a total of 6,940 species and 564 genera native to South America to …

Advanced Detection Of Sars-Cov-2 And Omicron Variants Via Mxene-Graphene Hybrid Biosensors Utilizing Nucleic Acid Probes, Jiaoli Li, Yuwei Zhang, Congjie Wei, Yanxiao Li, Zhekun Peng, Hsin Yin Chuang, Logan Pearce, Adrianus Boon, Yue-Wern Huang, Dong Hyun Kim, Risheng Wang, Chenglin Wu

Biological Sciences Faculty Research & Creative Works

Low-cost biosensors that can rapidly and widely detect viruses are critical for faster diagnosis and treatment decision-making, especially for infections. The commonly used field-effect transistor is sensitive to the biomarker's detection but struggles with precise detection, particularly of nontargets such as ions and proteins. To overcome this limitation, we developed a field-effect transistor biosensor design based on MXene-graphene materials to increase the accuracy and sensitivity of virus detection. Based on the hybridization process between two complementary DNA strands, single-stranded nucleic acids were immobilized on the sensing surface via 3-aminopropyltriethoxysilane and glutaraldehyde to capture the nucleic acids of the target virus. …

Calcium Permeability Of Rat Trpv1 In A Close State When Expressed In Xenopus Laevis Oocytes, Zinnia Adhikary

Theses and Dissertations

Transient Receptor Potential V1 (TRPV1) is a nonselective cation channel, which is expressed in nociceptors/ pain detecting receptors. Activated by a wide variety of exogenous and endogenous physical and chemical stimuli such as heat, TRPV1 is involved in temperature detection, body temperature regulation, and pain perception. It is generally accepted that TRPV1's conductance to cations, including Ca2+, depends on its conformational change from a closed to an open state following gating. In the current study, I observed that the plasma membrane of Xenopus laevis oocytes, upon exogenous expression of rat TRPV1, exhibited weak permeability to Ca2+, as evidenced by the …

Searching For Novel Mutations That Regulates The Mouse Polycystin-2 (Trpp2) Ion Channel, Akhilraj Rajan Pillai

Theses and Dissertations

Polycystin-2 (PC2) is an ion channel belonging to the polycystin subfamily of the transient receptor potential (TRP) cation channel superfamily. Mutations in PC2 are associated with autosomal dominant polycystic kidney disease (ADPKD), one of the most common genetic diseases in humans. Despite extensive studies over the past decades, the role of PC2 in normal and ADPKD kidneys remains largely unknown, and the activation and regulation of this ion channel are elusive. To gain a better understanding of the structure and function of the mouse PC2 channel, this study focused on generating five pore mutations in a gain-of-function (GOF) mutant of …

Long Term Trends In Mortality Rates Of A Smallmouth Bass Population, Caleb D. Anderson

Journal of Earth and Life Science

Smallmouth bass Micropterus dolomieu are known as a popular sport fish for anglers. When a known smallmouth bass fishery appears to have a dwindling population, it raises questions about the population health. A common indicator of the health of the population is the mortality rate. By comparing mortality, conclusions can be made on whether smallmouth bass are dying at a different rate in the system over time. Therefore, the objective of this study was to see if there had been a significant change in smallmouth bass mortality over a span of thirty years in Round Lake (DOW:010204), Aitkin County, Minnesota. …

Relationship Between Northern Pike And Walleye Cpue In Minnesota Lakes, Simon Oslund

Journal of Earth and Life Science

Northern pike Esox lucius and walleye Sander vitreus are both top predators in freshwater systems. Due to their predatorial nature, high populations of one species can prohibit populations of the other species from thriving, specifically northern pike foraging on walleye. This information is tracked by the Minnesota Department of Natural Resources through catch per unit effort (CPUE). CPUE data was gathered for all lakes in Beltrami County, Minnesota, and a regression analysis was done to test for a relationship between pike and walleye. It was found that the relationship between northern pike and walleye CPUE was significant (P = 0.02). …

The Effects Of Length, Weight, Age, And Gender On Mercury Concentrations In Burbot In North-Central Minnesota Lakes, Liam Hanley

Journal of Earth and Life Science

Burbot Lota lota in north-central Minnesota lakes have the potential to reach large sizes and consume large volumes of prey. This caveat may make burbot susceptible to higher rates of biocontamination, bioaccumulation and biomagnification. The objective of this study was to determine how changes in age, length, gender, weight, and lake affect total mercury concentrations in burbot. In this experiment 28 burbot were angled from three lakes: Cass (n = 17), Winnibigoshish (n = 4), and Bad Medicine (n = 7). Then tissue samples were taken from each fish and were lyophilized and homogenized. Homogenized tissue samples were analyzed by …

Relationship Between Fishing Hours And Number Of Fish Harvested From Upper Red Lake, Dylan Ohlenkamp

Journal of Earth and Life Science

Total hours fishermen spend fishing and total amount of fish harvested per year are some of the most important pieces of knowledge gained from creel surveys. They provide crucial information that assesses fisheries mortality and pressure. MN DNR uses their results from creel surveys to improve or impose regulations, and to maintain healthy fisheries. Based on results from similar studies, there is expected to be a positive relationship between hours fished and fish harvested. To determine the relationship between these two variables on Upper Red Lake, data from two years were selected when the variables were at their highest and …

A Guide To Otoliths Of Minnesota Fishes, Baylor J. Short

Journal of Earth and Life Science

Investigations into the diet patterns of piscivores can provide crucial information on predator-prey relationships, population dynamics, and responses to changing ecosystems. However, digestive processes often remove or alter physical characteristics that are traditionally used to identify consumed fish. This problem has been addressed to some degree with advances in molecular technologies, although these methods can be costly and require specific training and equipment to do so. In contrast, bony structures such as otoliths, vertebrae, cleithra, and others frequently have morphologies that are unique among families, genera, and species. Because these structures are resistant to digestion, they can be used to …

The Effect Of Triaenophorus Crassus On The Condition Of Coregonus Artedi, Alexander Surma

Journal of Earth and Life Science

Cisco Coregonus artedi is, historically, the largest commercial fishery in the Great Lakes. The species is also important to commercial and recreational fisheries in inland lakes. Tapeworm Triaenophorus crassus larvae embed themselves into the flesh of Ciscoes, rendering the fish unmarketable to humans. Triaenophorus crassus is common in inland waters such as Leech Lake and Cass Lake, MN. One Canadian researcher has suggested that the parasite negatively affects the growth and weight of Ciscoes. Poor condition can reduce fecundity, leading to lower recruitment rates. This would mean a detrimental impact on not only individual fish, but the health of …

Quantifying The Ecological Effects Of Salix Fragilis On Riparian Habitat In Kittitas County, Washington, Landon Shaffer

All Master's Theses

Invasive species threaten plant community structure and function globally. Riparian areas, the zone near streams where water influences vegetation, are especially sensitive to invasive species colonization, suffering large-scale shifts in community composition. Salix fragilis (crack willow) is a nonnative riparian species abundant in the lower elevation tributaries of central Washington. Some speculate whether this willow should be listed as invasive in Washington, despite a lack of regional supporting evidence. I studied riparian communities dominated by either S. fragilis or native species in the Kittitas Valley and measured biodiversity, quantified differences in solar attenuation, and compared leaf decomposition rates to learn …

University Biology Classrooms As Spaces For Anti-Racist Work: Instructor Motivations For Incorporating Race, Racism, And Racial Equity Content., Nicole L. Scheuermann, Candice Idlebird, Sayali Kukday, Vance J. Mccracken, Rachel E. Bradley, Heather E. Bergan-Roller

Faculty Articles, Papers, and Other Scholarship

Science is often portrayed as a meritocratic endeavor, but university biology programs exhibit high rates of student attrition, particularly among students of Color, despite similar interest and aptitude for science, technology, engineering, and mathematics (STEM) as White students. Culturally relevant pedagogy is associated with student persistence in STEM. One way to practice culturally relevant pedagogy in biology courses is to engage students in discussions of race, racism, or racial equity. Guidance exists to help instructors incorporate race-related topics into the biology curriculum, but the reasoning behind the decision of whether to adopt this practice is not well characterized. Understanding instructors’ …

How Does Marijuana Affect Reproductive Health?, Miriam Blatner

The Science Journal of the Lander College of Arts and Sciences

Marijuana use has become prevalent worldwide, especially amongst men and women of reproductive age. Marijuana acts on Cannabinoid receptors, which are a part of the Endocannabinoid system. CB1 and CB2 receptors are most found in humans. Activation of Cannabinoid receptors in males cause a reduction in healthy sperm parameters and inhibits the acrosomal reaction, and therefore minimizes fertility potential. Researchers have not yet discovered any significant interactions between marijuana and the female reproductive system. There has also been limited evidence displaying the effects that marijuana has on pregnancy and breastfeeding of infants. Nevertheless, physicians have recommended against marijuana use while …

Full Issue: Volume 17, Number 2, Spring 2024

The Science Journal of the Lander College of Arts and Sciences

Complete .pdf file of Volume 17, Number 2 of The Science Journal of the Lander College of Arts and Sciences. Published Spring 2024.

Targeting Vs. Modulating: How To Confront Variation In Cystic Fibrosis?, Yechiel Muller

The Science Journal of the Lander College of Arts and Sciences

Cystic fibrosis is a genetic disease with over 2,000 reported mutation varieties. It affects a chloride channel called CFTR, which by the transmembrane transport of chlorine, maintains an apical membrane electrolyte equilibrium in luminal epithelial cells. Its malfunction results in cystic fibrosis which causes excess mucus in various organs and is associated with respiratory complications and salty sweat. Treatment of cystic fibrosis has primarily taken two approaches: a mutation-specific method, targeted at a particular mutation to restore its function, and a mutation-non-specific method, which modulates intracellular barriers to CFTR trafficking or cellular repression of mutant protein function. This paper presents …

Sibo And The Effectiveness Of Treatment Via Diet And Medication, Elizabeth C. Hersko

The Science Journal of the Lander College of Arts and Sciences

This study delves into small intestinal bacterial overgrowth (SIBO), exploring its origins, diagnosis, and treatment methods. The research illuminates the complexities of SIBO, a condition characterized by an abnormal surge of bacteria in the small intestine. Factors contributing to SIBO include impaired motility, anatomical abnormalities, and digestive system dysfunctions. Diagnosing SIBO proves challenging due to its nonspecific symptoms which often overlap with other conditions like irritable bowel syndrome (IBS). Various diagnostic approaches, including lactulose breath testing, blood tests, stool analysis, and imaging, aim to identify SIBO and its underlying causes. Treatment involves dietary modifications—such as low FODMAP, biphasic, or fast …

Non-Surgical Treatment Options For Male-Pattern Baldness, Robert Schiffer

The Science Journal of the Lander College of Arts and Sciences

Male pattern baldness affects nearly 50% of the world’s male population. It is associated with physiological conditions such as cardiovascular disease as well as psychological issues with self-image and self-esteem. Although surgical treatments exist, they are associated with risks and complications. Various non-surgical treatment modalities for male pattern baldness are available for patients. Topical and oral formulations of minoxidil, finasteride, and dutasteride can be used, in addition to low level light therapy (LLLT) and platelet rich plasma (PRP) therapy. As many treatment options exist, it may be challenging for patients to decide which to choose. Although there have been few …

What Is Aphthous Stomatitis? What Are The Possible Causes And Treatments?, Shirah Balakhane

The Science Journal of the Lander College of Arts and Sciences

The historical understanding of Recurrent Aphthous Stomatitis (RAS), also known as canker sores, has evolved. This paper aims to collect data that determines the underlying factors that can cause RAS and highlights treatments or preventive measures one should take. RAS is a common mucosal disease of the mouth that affects healthy people and presents atypically in immunocompromised people. Geographical, age, and gender-related factors can all affect the prevalence. RAS still has no known cause; however, several systemic, local, immunologic, genetic, dietary, allergy, and microbiological factors—including immunosuppressive medications and stress—have been suggested as potential culprits. Using topical and systemic medicines, the …

The Effects Of Electronic Cigarettes On The Oral Cavity, Batsheva Saposh

The Science Journal of the Lander College of Arts and Sciences

Electronic cigarettes, which became available for purchase in the United States in 2007, were initially touted as a harmless aid for smoking cessation. However, recent research into the impact of electronic cigarettes on the human body has shown potential deleterious effects. This paper aims to examine the effects electronic cigarette usage has on the oral cavity. The methods to compile research involved reading through many peer-reviewed articles to analyze the most current information on the topic. The findings indicate several potentially adverse effects on the oral cavity including oral cancer, periodontitis, dental caries, xerostomia, facial fractures, failed dental implants, and …