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2023

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Articles 121 - 150 of 1823

Full-Text Articles in Biology

Linking Microbial Community Assembly In Flowers With Function Under Diverse Environmental Conditions: A Case Study Involving Erwinia Amylovora, Christopher Skylar Mcdaniel Dec 2023

Linking Microbial Community Assembly In Flowers With Function Under Diverse Environmental Conditions: A Case Study Involving Erwinia Amylovora, Christopher Skylar Mcdaniel

All Graduate Theses and Dissertations, Fall 2023 to Present

Fire blight, a devastating disease of pome fruit trees caused by the bacterium Erwinia amylovora, can cause millions of dollars in losses for producers each year around the globe. Management approaches that involve use of antibiotics, such as streptomycin, can be effective; although concerns exist over pollinator and crop health when using them regularly. Recently, there have been developments that allow for biological agents such as microbes to curtail fire blight infection. These agents work by competing with Erwinia for resources or space, producing antibacterial compounds, or even killing Erwinia cells on contact. Unfortunately, these agents do not yet …

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Geographic Variation In Blue Orchard Bee (Osmia Lignaria) Development And Performance As A Managed Pollinator In The Western United States, Morgan B. Scalici Dec 2023

Geographic Variation In Blue Orchard Bee (Osmia Lignaria) Development And Performance As A Managed Pollinator In The Western United States, Morgan B. Scalici

All Graduate Theses and Dissertations, Fall 2023 to Present

Most flowering plants, including many cultivated food crops, will only produce well-developed fruits and seeds if pollen is transferred from one flower to another with the help of an animal pollinator. Honey bees are the most well-known and ubiquitous but are poor pollinators of some commercially important crops, or are in poor supply during crop bloom. In such cases, farmers will employ other managed pollinators such as bumble bees or solitary bees like mason and leafcutting bees. The blue orchard bee is North America's most agriculturally important native mason bee as effective pollinators of spring-blooming fruit crops. Differences in developmental …

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The Impacts Of Maturation And Experience On Volumetric Neuroplasticity In Solitary And Social Bees, Mallory A. Hagadorn Dec 2023

The Impacts Of Maturation And Experience On Volumetric Neuroplasticity In Solitary And Social Bees, Mallory A. Hagadorn

All Graduate Theses and Dissertations, Fall 2023 to Present

Some animals are incredibly social, living and working together as one cohesive group. Alternatively, many animals are solitary, never living with and rarely interacting with others. A large body of biological research has focused on understanding the role that brains play in promoting these behavioral differences across species. Even so, it remains unclear why some brains facilitate social behavior while others do not. My dissertation aims to advance our understanding of this concept by characterizing bees’ brains and how they change over a lifetime. Bees are beneficial for investigating relationships between the brain and social behavior because some species are …

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Phenology Of The Invasive Balsam Woolly Adelgid, Adelges Piceae (Ratz.) (Hemiptera: Adelgidae), On Subalpine Fir In Northern Utah, Elizabeth L. Rideout Dec 2023

Phenology Of The Invasive Balsam Woolly Adelgid, Adelges Piceae (Ratz.) (Hemiptera: Adelgidae), On Subalpine Fir In Northern Utah, Elizabeth L. Rideout

All Graduate Theses and Dissertations, Fall 2023 to Present

Balsam woolly adelgid (BWA) is an invasive true fir pest in North America. Native to Europe, BWA was first discovered in Utah attacking subalpine fir in 2017. Recent BWA-caused subalpine fir mortality in northern Utah has prompted the need for baseline biological research to support pest management. Small-bodied and blending easily with its environment, BWA is a challenging pest to detect and study. Phenology, or the timing and characteristics of life stages through the year, of BWA varies depending on elevation and climate and is unstudied in Utah. This research focuses on defining aspects of BWA’s phenology, including the number …

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Fly-Cure, A Multi-Institutional Cure Using Drosophila, Increases Students' Confidence, Sense Of Belonging, And Persistence In Research, Julia A. Markle, Olivier Devergne, Seth M. Kelly, Paula A. Croonquist, Cory J. Evans, Melanie A. Hwalek, Victoria L. Straub, Danielle R. Hamill, Alexandra Peister, David P. Puthoff Dec 2023

Fly-Cure, A Multi-Institutional Cure Using Drosophila, Increases Students' Confidence, Sense Of Belonging, And Persistence In Research, Julia A. Markle, Olivier Devergne, Seth M. Kelly, Paula A. Croonquist, Cory J. Evans, Melanie A. Hwalek, Victoria L. Straub, Danielle R. Hamill, Alexandra Peister, David P. Puthoff

Biology Faculty Works

The Fly-CURE is a genetics-focused multi-institutional Course-Based Undergraduate Research Experience (CURE) that provides undergraduate students with hands-on research experiences within a course. Through the Fly-CURE, undergraduate students at diverse types of higher education institutions across the United States map and characterize novel mutants isolated from a genetic screen in Drosophila melanogaster. To date, more than 20 mutants have been studied across 20 institutions, and our scientific data have led to eleven publications with more than 500 students as authors. To evaluate the impact of the Fly-CURE experience on students, we developed and validated assessment tools to identify students’ perceived research …

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Placental Co-Culture Model Reveals Listeria Monocytogenes Utilization Of Monocytes For Vertical Transmission, Breanna Mackenzie Amelunke Dec 2023

Placental Co-Culture Model Reveals Listeria Monocytogenes Utilization Of Monocytes For Vertical Transmission, Breanna Mackenzie Amelunke

Online Theses and Dissertations

Listeria monocytogenes is an opportunistic pathogen that can cross the protective placental barrier and infect the fetus, leading to congenital disabilities or death. Extracellular L. monocytogenes infection of the placenta has been well studied; however, the bacteria have not been observed translocating this barrier intracellularly. As an intracellular pathogen, L. monocytogenes could infect phagocytic cells that can be transported across the placental barrier. A novel cell co-culture system comprised of BeWo and HPVEC cell lines was established to model the human placental barrier. Barrier integrity was confirmed using immunostaining of tight junctions and a FITC-dextran permeability assay. The model was …

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Variation In Bat Activity Across Upland Embedded Wetlands In The Cumberland Ranger District Of The Daniel Boone National Forest, Brittany Ryan Dec 2023

Variation In Bat Activity Across Upland Embedded Wetlands In The Cumberland Ranger District Of The Daniel Boone National Forest, Brittany Ryan

Online Theses and Dissertations

Within the Daniel Boone National Forest (DBNF) in Kentucky, over 800 upland-embedded wetlands (UEWs) have been constructed in past decades to provide habitat for bats and other wildlife. This research focused on identifying differences in bat activity and occupancy across natural and constructed UEWs. Acoustic detectors were deployed at 9 natural and 31 constructed UEWs across the Cumberland Ranger District of the DBNF. Each UEW was surveyed across 3 intervals from May – August 2022, and each recording session spanned >3 consecutive nights, yielding a total of 413 detector nights. Occupancy modeling and AIC model selection were used to evaluate …

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Climate Change And The Shifting Geography Of Coral-Reef Development, Victor Rodriguez-Ruano Dec 2023

Climate Change And The Shifting Geography Of Coral-Reef Development, Victor Rodriguez-Ruano

Theses and Dissertations

Coral-reef development is modulated by growth processes that deposit calcium carbonate onto the reef, such as calcification, and destructive processes that remove calcium carbonate from the reef, such as bioerosion. Wherever calcification rates exceed bioerosion rates, there is a net accretion of the reef through time, but where bioerosion rates exceed calcification rates, there is a net destruction of the reef through time. A reef’s framework is the legacy of the interaction of these processes throughout a reef’s history. Studying the fossil frameworks of reefs can shed light on the environmental factors that have controlled reef development in the past, …

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Effect Of Macrophage Expressed Α7 Nicotinic Acetylcholine Receptor (Α7nachr) On Migration Of Macrophages During Inflammation, Kasey Keever Dec 2023

Effect Of Macrophage Expressed Α7 Nicotinic Acetylcholine Receptor (Α7nachr) On Migration Of Macrophages During Inflammation, Kasey Keever

Electronic Theses and Dissertations

Sepsis is a life-threatening condition characterized by overwhelming inflammation, resulting in organ system damage, leading to a high mortality rate. Care in the clinical setting is supportive, and there are no approved sepsis-specific treatments. In septic mice, activation of the cholinergic anti-inflammatory pathway decreases cytokine secretion by leukocytes and improves survival. The cholinergic anti-inflammatory pathway is a reflex of the parasympathetic nervous system, converging on the α7 nicotinic acetylcholine (α7nAChR) at the surface of macrophages. Signaling through the receptor blocks NF-kB activation, thus cytokine secretion. Receptor activation has other effects on macrophages, including modulating their migration to …

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Mutation Of The Pebp-Like Domain Of The Mitoribosomal Mrpl35/Ml38 Protein Results In Production Of Nascent Chains With Impaired Capacity To Assemble Into Oxphos Complexes, Jodie M. Box, Jessica M. Anderson, Rosemary A. Stuart Dec 2023

Mutation Of The Pebp-Like Domain Of The Mitoribosomal Mrpl35/Ml38 Protein Results In Production Of Nascent Chains With Impaired Capacity To Assemble Into Oxphos Complexes, Jodie M. Box, Jessica M. Anderson, Rosemary A. Stuart

Biological Sciences Faculty Research and Publications

Located in the central protuberance region of the mitoribosome and mitospecific mL38 proteins display homology to PEBP (Phosphatidylethanolamine Binding Protein) proteins, a diverse family of proteins reported to bind anionic substrates/ligands and implicated in cellular signaling and differentiation pathways. In this study, we have performed a mutational analysis of the yeast mitoribosomal protein MrpL35/mL38 and demonstrate that mutation of the PEBP-invariant ligand binding residues Asp(D)232 and Arg(R)288 impacted MrpL35/mL38’s ability to support OXPHOS-based growth of the cell. Furthermore, our data indicate these residues exist in a functionally important charged microenvironment, which also includes Asp(D)167 of MrpL35/mL38 and Arg(R)127 of the …

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Telomeric Regulation Of Chromosomal Instability In Colorectal Cancer, Kyle Labella, Kyle A Labella Dec 2023

Telomeric Regulation Of Chromosomal Instability In Colorectal Cancer, Kyle Labella, Kyle A Labella

Dissertations and Theses (Open Access)

Telomere dysfunction drives chromosomal instability (CIN) during the transition from benign adenoma to malignant adenocarcinoma. While CIN provides a mutator mechanism for cancer-relevant genomic events, its role in shaping tumor biology during carcinogenesis is not well understood. Here, we explored the molecular and biological impact of telomere dysfunction and associated CIN in vivo in a faithful model of CRC. In vivo lineage tracing revealed that CIN increased neoplastic cell competition and clonal expansion through accelerated differentiation of neighboring stem cells, resulting in increased number of adenomas and decreased survival in CIN-high Apcmin mice. Mechanistically, CIN represses EZH2 leading to …

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Unlocking The Mysteries Of Opportunism: Neuroendocrine Insights From An Aseasonal Breeder (Taeniopygia Guttata), Jessica A. Moodie Dec 2023

Unlocking The Mysteries Of Opportunism: Neuroendocrine Insights From An Aseasonal Breeder (Taeniopygia Guttata), Jessica A. Moodie

Graduate Theses and Dissertations (2019 - present)

The regulation of reproductive physiology in animals is mediated by the Hypothalamus-Pituitary-Gonad (HPG) axis. In seasonal breeders, a conserved reciprocal switching of deiodinase enzymes alters thyroid hormone signaling, which controls HPG activity. This study tested the hypothesis that neural regulation of the HPG axis as described in seasonal systems is conserved and repurposed to respond to other cues in aseasonal species. Using water deprivation and nest restriction in the opportunistic Zebra Finch, we were able to create a breeding group and non-breeding group, confirmed by egg laying and changes in ovarian anatomy. Breeding females had clear follicular hierarchy, increased ovary …

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Preparing Teaching Assistants To Facilitate Course-Based Undergraduate Research Experiences (Cures) In The Biological Sciences: A Call To Action, Erin Shortlidge, Amie M. Kern, Emma Goodwin, Jeffrey T. Olimpo Dec 2023

Preparing Teaching Assistants To Facilitate Course-Based Undergraduate Research Experiences (Cures) In The Biological Sciences: A Call To Action, Erin Shortlidge, Amie M. Kern, Emma Goodwin, Jeffrey T. Olimpo

Biology Faculty Publications and Presentations

Course-based undergraduate research experiences (CUREs) offer an expanding avenue to engage students in real-world scientific practices. Increasingly, CUREs are instructed by graduate teaching assistants (TAs), yet TAs may be underprepared to facilitate and face unique barriers when teaching CUREs. Consequently, unless TAs are provided professional development (PD) and resources to teach CUREs effectively, they and their students may not reap the assumed benefits of CURE instruction. Here, we describe three perspectives – that of the CURE TA, the CURE designer/facilitator, and the CURE student – that are collectively intended to inform the development of tentative components of CURE TA PD. …

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Activity Patterns Of Whiptail Lizards (Aspidoscelis) Found In The Northern Chihuahuan Desert, Guillermo Alvarez Dec 2023

Activity Patterns Of Whiptail Lizards (Aspidoscelis) Found In The Northern Chihuahuan Desert, Guillermo Alvarez

Open Access Theses & Dissertations

Traditional lizard pitfall traps were modified to allow organisms to escape, while collecting valuable ecological data. Modified camera traps were capable of detecting the same species as traditional traps in a semi-arid environment, without posing the associated mortality risks. Pitfall-camera traps were used to sample the activity of the Side-blotched Lizard (Uta stansburiana) and the Southwestern Fence Lizard (Sceloporus cowlesi) in an urban wetland during four continuous years. Evaluations on activity pattern and the activity overlap between the two species revealed extensive overlap, with minor but significant seasonal shifts mediating coexistence. Traps were also effective at detecting other reptiles, invertebrates, …

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Development Of Synthetic Glycobiomarkers For The Follow-Up Of Chagas Disease Chemotherapy And Serological And Molecular Assays For Evaluation Of Trypanosoma Cruzi Infections In The U.S-Mexico Border, Igor L. Estevao Dec 2023

Development Of Synthetic Glycobiomarkers For The Follow-Up Of Chagas Disease Chemotherapy And Serological And Molecular Assays For Evaluation Of Trypanosoma Cruzi Infections In The U.S-Mexico Border, Igor L. Estevao

Open Access Theses & Dissertations

Chagas disease (CD), caused by the protozoan parasite Trypanosoma cruzi, affects 7-8 million people worldwide. Lately, the disease has been spread to nonendemic countries and regions, like the U.S. and Europe. The disease can be divided into two phases: the acute and chronic phases, which continue for years or even decades. There are two available drugs for CD treatment: benznidazole (BNZ) and nifurtimox (NFX). These drugs are highly effective in the acute phase but less efficient in the chronic stage. Other limitations of these drugs are their toxicity, leading to serious adverse events and premature treatment termination. Newer clinical trial …

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The Role Of The Cholesterol Synthesis Pathway In Primitive Erythropoiesis, Jose Hernandez Dec 2023

The Role Of The Cholesterol Synthesis Pathway In Primitive Erythropoiesis, Jose Hernandez

Open Access Theses & Dissertations

Erythropoiesis is the process by which new red blood cells (RBCs) are formed and defects in this process can lead to anemia or thalassemia. The GATA1 transcription factor is an established mediator of RBC development. However, the upstream mechanisms that regulate the expression of GATA1 are not completely characterized. Cholesterol is 1 potential upstream mediator of GATA1 expression because previously published studies suggest that defects in cholesterol synthesis disrupt RBC differentiation. Here we characterize RBC development in a zebrafish harboring a single missense mutation in the hmgcs1 gene (Vu57 allele). Hmgcs1 encodes the first enzyme in the cholesterol synthesis pathway …

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Repositioning Propranolol To Block Mitogenic Signaling In Breast Cancer, Alexa Noel Montoya Dec 2023

Repositioning Propranolol To Block Mitogenic Signaling In Breast Cancer, Alexa Noel Montoya

Open Access Theses & Dissertations

Breast cancer is the second most diagnosed cancer among women and is about 30% of all new cases of female cancers each year. It is projected that 1 in 8 every U.S. woman (about 13%) develop invasive breast cancer over the course of her lifetime. While advances in cancer research have made it possible to elucidate several breast cancer genomic subtypes, and develop new novel therapies, many of these agents are associated with significant toxicity, as well as high costs. A retrospective cross-sectional study of 404 breast cancer patients was performed to determine the effect of β-blocker usage on tumor …

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Lizard Communities In A Shifting Landscape: The Current State Of Insectivorous Lizard Communities In The Jornada Basin Between Grassland, Mesquite Dune, And Creosote Bush Habitats In A Semi-Arid Landscape Undergoing Shrubification, Julie Marie Schlichte Dec 2023

Lizard Communities In A Shifting Landscape: The Current State Of Insectivorous Lizard Communities In The Jornada Basin Between Grassland, Mesquite Dune, And Creosote Bush Habitats In A Semi-Arid Landscape Undergoing Shrubification, Julie Marie Schlichte

Open Access Theses & Dissertations

Lizard communities in arid lands can act as model systems of how diversity and abundance are impacted in the face of ongoing climate variability and change, as they are sensitive to shifts in precipitation, temperature, and changing vegetation structure. The main research question we hope to answer is how the community composition of lizards varies between dominant vegetation types (Mesquite dunes, grasslands, and Creosote Bush flats). Nine sites (3 of each dominant vegetation type) with 16 pitfall traps each (n = 144) were surveyed from June 2016 -- June 2017. 12 lizard species were captured, consisting of 923 total captures …

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Effects Of Landcover On Mesocarnivore Density And Detection Rate Along An Urban To Rural Gradient, Leah E. Mctigue, Brett Degregorio Dec 2023

Effects Of Landcover On Mesocarnivore Density And Detection Rate Along An Urban To Rural Gradient, Leah E. Mctigue, Brett Degregorio

Biological Sciences Faculty Publications and Presentations

Human development has major implications for wildlife populations. Urban-exploiter species can benefit from human subsidized resources, whereas urban-avoider species can vanish from wildlife communities in highly developed areas. Therefore, understanding how the density of different species varies in response to landcover changes associated with human development can provide important insight into how wildlife communities are likely to change and provide a starting point for predicting the consequences of those changes. Here, we estimated the population density of five common mesocarnivore species (coyote (Canis latrans), bobcat (Lynx rufus), red fox (Vulpes vulpes), raccoon (Procyon …

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Mesenchymal Stem Cells In The Treatment Of Osteogenesis Imperfecta, Erica Lang, Julie A. Semon Dec 2023

Mesenchymal Stem Cells In The Treatment Of Osteogenesis Imperfecta, Erica Lang, Julie A. Semon

Biological Sciences Faculty Research & Creative Works

Osteogenesis Imperfecta (OI) is a Disease Caused by Mutations in Different Genes Resulting in Mild, Severe, or Lethal Forms. with No Cure, Researchers Have Investigated the Use of Cell Therapy to Correct the Underlying Molecular Defects of OI. Mesenchymal Stem Cells (MSCs) Are of Particular Interest Because of their Differentiation Capacity, Immunomodulatory Effects, and their Ability to Migrate to Sites of Damage. MSCs Can Be Isolated from Different Sources, Expanded in Culture, and Have Been Shown to Be Safe in Numerous Clinical Applications. This Review Summarizes the Preclinical and Clinical Studies of MSCs in the Treatment of OI. Altogether, the …

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A Review Of Threat Vectors To Dna Sequencing Pipelines, Tyler Rector Dec 2023

A Review Of Threat Vectors To Dna Sequencing Pipelines, Tyler Rector

Cybersecurity Undergraduate Research Showcase

Bioinformatics is a steadily growing field that focuses on the intersection of biology with computer science. Tools and techniques developed within this field are quickly becoming fixtures in genomics, forensics, epidemiology, and bioengineering. The development and analysis of DNA sequencing and synthesis have enabled this significant rise in demand for bioinformatic tools. Notwithstanding, these bioinformatic tools have developed in a research context free of significant cybersecurity threats. With the significant growth of the field and the commercialization of genetic information, this is no longer the case. This paper examines the bioinformatic landscape through reviewing the biological and cybersecurity threats within …

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Hyperoxidized Prdx3 As A Specific Ferroptosis Marker, Yuelong Yan, Boyi Gan Dec 2023

Hyperoxidized Prdx3 As A Specific Ferroptosis Marker, Yuelong Yan, Boyi Gan

Faculty, Staff and Student Publications

The lack of a reliable and specific marker for ferroptosis has hindered the advancement of treatments related to this cell death mechanism toward clinical application. A recent study published in Molecular Cell has identified hyperoxidized peroxiredoxin 3 (PRDX3) as a promising marker for ferroptosis, opening up new avenues for monitoring and targeting ferroptosis in disease treatment.

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Evolution And Natural Selection Of Olfactory Receptor Genes In Hawaiian Drosophila, Ngoc H. Ly Dec 2023

Evolution And Natural Selection Of Olfactory Receptor Genes In Hawaiian Drosophila, Ngoc H. Ly

UNLV Theses, Dissertations, Professional Papers, and Capstones

The olfactory system is a powerful tool for sensing countless odorants. In Drosophila, the olfactory system is critical for detecting food, finding mates, laying eggs, avoiding predators, and adapting to new environments. Understanding the olfactory system in Drosophila will advance our knowledge of sensory biology in various insects and vertebrates, including humans. Drosophila has been a valuable model for biology since the early 1900s, and the Drosophila melanogaster olfactory system is well-studied. The Hawaiian Drosophila represent approximately 1/3 of the world’s Drosophila, however, there is limited research on Hawaiian Drosophila olfactory genes. We conducted a comparative analysis of …

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Age-Related Oligodendrocyte Lineage And Learning Abnormalities Driven By Nf1 Mutation In Mice, Saul Lopez Dec 2023

Age-Related Oligodendrocyte Lineage And Learning Abnormalities Driven By Nf1 Mutation In Mice, Saul Lopez

Theses and Dissertations

Neurofibromatosis Type 1 (NF1) is an autosomal dominant disease caused by mutations in the NF1 gene, on chromosome 17. NF1 patients suffer from a number of neurological issues including learning deficits and increased risk of age-related dementia. Additionally, NF1 patients present with multiple white matter and myelin abnormalities. Whether and how myelin abnormalities impact learning in NF1 is not known; therefore, we aimed to gain insights on potential links between Nf1 mutation and learning issues Unpublished data indicate that NF1 female-but not male- mice with Nf1+/- germline mutation show defects in a myelin-regulated learning/memory test (the complex wheel; CW) at …

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Exploring The Interrelationships Among Structural Complexity, Multi-Trophic Biodiversity, And Ecosystem Productivity In Forested Ecosystems., Ayanna St. Rose Dec 2023

Exploring The Interrelationships Among Structural Complexity, Multi-Trophic Biodiversity, And Ecosystem Productivity In Forested Ecosystems., Ayanna St. Rose

Graduate Theses and Dissertations

Forests play a pivotal role in sustaining global biodiversity and mitigating the global climate, as they serve as the primary refuge for terrestrial biodiversity and effectively capture and store atmospheric carbon dioxide. However, changing climate and land use are altering the geographic distribution, physical structure, and productivity of forested ecosystems that can have profound impacts on biodiversity conservation, forest productivity, and global climate. This dissertation contributes to our understanding of multifaceted interactions between the physical and biological structural complexity and ecosystem functions in forested landscapes across the United states by using openly available data from two national networks: the National …

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Human-Bat Interactions In A Disease Emergence Hotspot: Implications For Human Health And Bat Conservation, Reilly Tempest Jackson Dec 2023

Human-Bat Interactions In A Disease Emergence Hotspot: Implications For Human Health And Bat Conservation, Reilly Tempest Jackson

Graduate Theses and Dissertations

Bats are an ecologically important taxon that can host zoonotic pathogens. Globally, many bat species are synanthropic and live closely with humans, often roosting in man-made structures. The spatial overlap between humans and bats creates opportunities for human-bat contact, which can lead to human exposure to bat-borne pathogens and conflicts that cause bat mortality. Despite this risk, little is known about the drivers and characteristics of these human-bat interactions in buildings and work is needed to understand this aspect of the wildlife-urban interface. In Chapter I, I present a literature review that identifies the geographic and taxonomic trends in reported …

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Assessing Risks For Bovine And Zoonotic Tuberculosis Through Spatial Analysis And A Questionnaire Survey In Fiji – A Pilot Study, Jenny-Ann L. M. L. Toribio, Keresi Lomata, Sam Fullman, Aaron Jenkins, Elva Borja, Shumaila Arif, Jarrad Mckercher, David Blake, Anabel Garcia, Richard J. Whittington, Frank Underwood, Ben J. Marais Dec 2023

Assessing Risks For Bovine And Zoonotic Tuberculosis Through Spatial Analysis And A Questionnaire Survey In Fiji – A Pilot Study, Jenny-Ann L. M. L. Toribio, Keresi Lomata, Sam Fullman, Aaron Jenkins, Elva Borja, Shumaila Arif, Jarrad Mckercher, David Blake, Anabel Garcia, Richard J. Whittington, Frank Underwood, Ben J. Marais

Research outputs 2022 to 2026

Mycobacterium bovis causes tuberculosis in cattle and when transmitted to humans typically causes extra-pulmonary tuberculosis (EPTB). Bovine tuberculosis (bTB) has a global distribution and is controlled in most countries to protect animal and public health. Recent studies revealed that bTB is established on dairy farms in Fiji where EPTB cases have been reported in people. The aims of this pilot investigation were to look for putative zoonotic TB (EPTB) cases in people and to evaluate practices that might contribute to the persistence and transmission of M. bovis between cattle and to humans. Existing data sets were shared between the Fiji …

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Trehalose Enhances Mitochondria Deficits In Human Npc1 Mutant Fibroblasts But Disrupts Mouse Purkinje Cell Dendritic Growth Ex Vivo., Collin M Macleod, Fawad A K Yousufzai, Liam T Spencer, Sarah Kim, Lucianne A Rivera-Rosario, Zerian D Barrera, Lindsay Walsh, Claude Krummenacher, Benjamin Carone, Ileana Soto Nov 2023

Trehalose Enhances Mitochondria Deficits In Human Npc1 Mutant Fibroblasts But Disrupts Mouse Purkinje Cell Dendritic Growth Ex Vivo., Collin M Macleod, Fawad A K Yousufzai, Liam T Spencer, Sarah Kim, Lucianne A Rivera-Rosario, Zerian D Barrera, Lindsay Walsh, Claude Krummenacher, Benjamin Carone, Ileana Soto

College of Science & Mathematics Departmental Research

Lysosomes play important roles in catabolism, nutrient sensing, metabolic signaling, and homeostasis. NPC1 deficiency disrupts lysosomal function by inducing cholesterol accumulation that leads to early neurodegeneration in Niemann-Pick type C (NPC) disease. Mitochondria pathology and deficits in NPC1 deficient cells are associated with impaired lysosomal proteolysis and metabolic signaling. It is thought that activation of the transcription factor TFEB, an inducer of lysosome biogenesis, restores lysosomal-autophagy activity in lysosomal storage disorders. Here, we investigated the effect of trehalose, a TFEB activator, in the mitochondria pathology of NPC1 mutant fibroblasts in vitro and in mouse developmental Purkinje cells ex vivo. We …

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Lionfish (Pterois Volitans) Neurocranium, Kate Heffner, Hosanna Gattle, David Kerstetter Nov 2023

Lionfish (Pterois Volitans) Neurocranium, Kate Heffner, Hosanna Gattle, David Kerstetter

All Scans: Kerstetter Fisheries and Avian Ecology 3D Scan Series

Neurocranium from 30 cm total length (TL) Lionfish (Pterois volitans), collected from Second Reef on 15/10/2023 by Kate Heffner.

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Yellowtail Snapper Ocyurus Chrysurus, Kevin Rafferty, Manuel Ploner, David W. Kerstetter Nov 2023

Yellowtail Snapper Ocyurus Chrysurus, Kevin Rafferty, Manuel Ploner, David W. Kerstetter

All Scans: Kerstetter Fisheries and Avian Ecology 3D Scan Series

YELLOWTAIL SNAPPER OCYURUS CHRYSURUS 7.5CM Total length

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